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Acatalasia
Compromised glutathione synthesis results in high susceptibility to acetaminophen hepatotoxicity in acatalasemic mice.
Adenocarcinoma
Influence of buthionine sulfoximine and misonidazole on glutathione level and radiosensitivity of human tumor xenografts.
Adenocarcinoma
The modifier subunit of glutamate cysteine ligase (GCLM) is a molecular target for amelioration of cisplatin resistance in lung cancer.
Adenocarcinoma
[Gene expression profiling of human ovarian epithelial tumors by digo nucleotide microarray]
Adenocarcinoma of Lung
Glutamate-cysteine ligase catalytic subunit is associated with cisplatin resistance in lung adenocarcinoma.
Adenoma
Expression of heavy subunit of gamma-glutamylcysteine synthetase (gamma-GCSh) in human colorectal carcinoma.
Adenoma
[The correlation of ganglion cell layer thickness with visual field defect in non-functional pituitary adenoma with chiasm compression].
Ageusia
Optic nerve and macular optical coherence tomography in recovered COVID-19 patients.
Albinism
Assessing Ganglion Cell Layer Topography in Human Albinism Using Optical Coherence Tomography.
Alzheimer Disease
Glutathione metabolism during aging and in Alzheimer disease.
Alzheimer Disease
Retinal pathology in Alzheimer's disease. II. Regional neuron loss and glial changes in GCL.
Amblyopia
Macular capillary system and ganglion cell-layer complex of the amblyopic eye with optical cohorence tomography angiography and optical cohorence tomography.
Ancylostomiasis
Molecular cloning and analysis of Ancylostoma ceylanicum glutamate-cysteine ligase.
Anemia
Oxidative Stress and Suicidal Erythrocyte Death.
Anemia, Hemolytic
A missense mutation in the heavy subunit of gamma-glutamylcysteine synthetase gene causes hemolytic anemia.
Anemia, Hemolytic
A novel missense mutation in the gamma-glutamylcysteine synthetase catalytic subunit gene causes both decreased enzymatic activity and glutathione production.
Anemia, Hemolytic
Chronic non-spherocytic hemolytic anemia associated with severe neurological disease due to gamma-glutamylcysteine synthetase deficiency in a patient of Moroccan origin.
Anemia, Hemolytic
Clinical and molecular characterization of 6 children with glutamate-cysteine ligase deficiency causing hemolytic anemia.
Anemia, Hemolytic
Gamma-glutamylcysteine synthetase deficiency and hemolytic anemia.
Anemia, Hemolytic
Inborn errors in the metabolism of glutathione.
Anemia, Hemolytic
Patients with genetic defects in the gamma-glutamyl cycle.
Anemia, Hemolytic
Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias.
Anemia, Hemolytic
The molecular basis of a case of gamma-glutamylcysteine synthetase deficiency.
Anemia, Sickle Cell
Oxidative Stress and Suicidal Erythrocyte Death.
Anosmia
Optic nerve and macular optical coherence tomography in recovered COVID-19 patients.
Asthma
The relationship between polymorphisms in the glutamate cysteine ligase gene and asthma susceptibility.
Asthma
[Effects of Nrf2 on gamma-glutamylcysteine synthase in lung of guinea pigs with bronchial asthma].
Astrocytoma
Expression of antioxidant enzymes in astrocytic brain tumors.
Astrocytoma
Noradrenaline increases intracellular glutathione in human astrocytoma U-251 MG cells by inducing glutamate-cysteine ligase protein via ?3-adrenoceptor stimulation.
Astrocytoma
Purification and biochemical characterization of gamma-glutamylcysteine synthetase from a human malignant astrocytoma cell line.
Ataxia
Microvascular Breakdown Due to Retinal Neurodegeneration in Ataxias.
Atherosclerosis
Oxidative modulation of NF-kappaB signaling by oxidized low-density lipoprotein.
Berylliosis
Chronic beryllium disease and glutathione biosynthesis genes.
Blister
Cytotoxic Swelling of Sick Excitable Cells - Impaired Ion Homeostasis and Membrane Tension Homeostasis in Muscle and Neuron.
Brain Ischemia
Aged garlic extract and S-allylcysteine increase the GLUT3 and GCLC expression levels in cerebral ischemia.
Breast Neoplasms
A synthetic chalcone as a potent inducer of glutathione biosynthesis.
Breast Neoplasms
Co-administration of sulforaphane and doxorubicin attenuates breast cancer growth by preventing the accumulation of myeloid-derived suppressor cells.
Breast Neoplasms
Cul3 overexpression depletes Nrf2 in breast cancer and is associated with sensitivity to carcinogens, to oxidative stress, and to chemotherapy.
Breast Neoplasms
Glutamine affects glutathione recycling enzymes in a DMBA-induced breast cancer model.
Breast Neoplasms
Inhibition of glutamate cysteine ligase activity sensitizes human breast cancer cells to the toxicity of 2-deoxy-D-glucose.
Breast Neoplasms
Labelling of breast carcinoma, thyroid carcinoma and melanoma with manno- and galacto-specific lectins from marine invertebrates.
Breast Neoplasms
Multidrug Resistance-Associated Protein 1 Mediates 15-Deoxy-?(12,14)-prostaglandin J(2)-Induced Expression of Glutamate Cysteine Ligase Expression via Nrf2 Signaling in Human Breast Cancer Cells.
Breast Neoplasms
Nuclear Factor Erythroid-Derived 2-Like 2-Induced Reductive Stress Favors Self-Renewal of Breast Cancer Stem-Like Cells via the FoxO3a-Bmi-1 Axis.
Breast Neoplasms
Physiological melatonin inhibition of human breast cancer cell growth in vitro: evidence for a glutathione-mediated pathway.
Breast Neoplasms
[Interaction of body mass index and a polymorphism in gene of catalytic subunit of glutamate-cysteine ligase on breast cancer risk among Chinese women].
Bronchopulmonary Dysplasia
Distribution of antioxidant enzymes in developing human lung, respiratory distress syndrome, and bronchopulmonary dysplasia.
Bruxism
Investigation of neurodegenerative and inflammatory processes in sleep bruxism.
Carcinogenesis
Expression of heavy subunit of gamma-glutamylcysteine synthetase (gamma-GCSh) in human colorectal carcinoma.
Carcinogenesis
Frequent coordinated overexpression of the MRP/GS-X pump and gamma-glutamylcysteine synthetase genes in human colorectal cancers.
Carcinogenesis
Glutathione-deficient mice have increased sensitivity to transplacental benzo[a]pyrene-induced premature ovarian failure and ovarian tumorigenesis.
Carcinogenesis
Inhibitory effects of glutathione level-raising agents and D-alpha-tocopherol on ornithine decarboxylase induction and mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Carcinogenesis
Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG.
Carcinoma
Altered glutamate cysteine ligase expression and activity in renal cell carcinoma.
Carcinoma
Effect of Semecarpus anacardium Linn. nut milk extract on glutathione and its associated enzymes in experimentally induced mammary carcinoma.
Carcinoma
Expression of heavy subunit of gamma-glutamylcysteine synthetase (gamma-GCSh) in human colorectal carcinoma.
Carcinoma
Histone methyltransferase G9a drives chemotherapy resistance by regulating the glutamate-cysteine ligase catalytic subunit in head and neck squamous cell carcinoma.
Carcinoma
Increase in gamma-glutamylcysteine synthetase activity and steady-state messenger RNA levels in melphalan-resistant DU-145 human prostate carcinoma cells expressing elevated glutathione levels.
Carcinoma
Increased DT-diaphorase expression and cross-resistance to mitomycin C in a series of cisplatin-resistant human ovarian cancer cell lines.
Carcinoma
Induction of gamma-glutamyl transpeptidase mRNA by platinum complexes in a human ovarian carcinoma cell line.
Carcinoma
Nuclear localization of glutamate-cysteine ligase is associated with proliferation in head and neck squamous cell carcinoma.
Carcinoma
Transcriptional up-regulation of gamma-glutamylcysteine synthetase gene expression in melphalan-resistant human prostate carcinoma cells.
Carcinoma
Up-regulation of gamma-glutamylcysteine synthetase activity in melphalan-resistant human multiple myeloma cells expressing increased glutathione levels.
Carcinoma
[Gene expression profiling of human ovarian epithelial tumors by digo nucleotide microarray]
Carcinoma, Hepatocellular
Activation of Nrf2-Antioxidant Response Element Mediated Glutamate Cysteine Ligase Expression in Hepatoma Cell line by Homocysteine.
Carcinoma, Hepatocellular
Differential regulation of glutamate-cysteine ligase subunit expression and increased holoenzyme formation in response to cysteine deprivation.
Carcinoma, Hepatocellular
Glutathione synthesis in normal liver and in Yoshida AH-130 hepatoma.
Carcinoma, Hepatocellular
Inhibition of liver fibrosis by solubilized coenzyme Q10: Role of Nrf2 activation in inhibiting transforming growth factor-beta1 expression.
Carcinoma, Hepatocellular
Nrf2-mediated induction of detoxifying enzymes by alantolactone present in Inula helenium.
Carcinoma, Hepatocellular
Over expression of glutamate cysteine ligase increases cellular resistance to H2O2-induced DNA single-strand breaks.
Carcinoma, Hepatocellular
Specific differences in gene expression profile revealed by cDNA microarray analysis of glutathione S-transferase placental form (GST-P) immunohistochemically positive rat liver foci and surrounding tissue.
Carcinoma, Non-Small-Cell Lung
Inhibition of Thioredoxin/Thioredoxin Reductase Induces Synthetic Lethality in Lung Cancers with Compromised Glutathione Homeostasis.
Carcinoma, Non-Small-Cell Lung
The modifier subunit of glutamate cysteine ligase relates to cisplatin resistance in human small cell lung cancer xenografts in vivo.
Carcinoma, Non-Small-Cell Lung
The subunits of glutamate cysteine ligase enhance cisplatin resistance in human non-small cell lung cancer xenografts in vivo.
Carcinoma, Renal Cell
Altered glutamate cysteine ligase expression and activity in renal cell carcinoma.
Carcinoma, Squamous Cell
Histone methyltransferase G9a drives chemotherapy resistance by regulating the glutamate-cysteine ligase catalytic subunit in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Inhibition by 5-fluorouracil of ERCC1 and gamma-glutamylcysteine synthetase messenger RNA expression in a cisplatin-resistant HST-1 human squamous carcinoma cell line.
Carcinoma, Squamous Cell
Nuclear localization of glutamate-cysteine ligase is associated with proliferation in head and neck squamous cell carcinoma.
Cardiomyopathies
Specific activation of CD4(-) CD8(-) double-negative T cells by Trypanosoma cruzi-derived glycolipids induces a proinflammatory profile associated with cardiomyopathy in Chagas patients.
Cardiovascular Diseases
Heterozygosity in the glutathione synthesis gene Gclm increases sensitivity to diesel exhaust particulate induced lung inflammation in mice.
catalase deficiency
Compromised glutathione synthesis results in high susceptibility to acetaminophen hepatotoxicity in acatalasemic mice.
Cataract
Activity loss of glutathione synthesis enzymes associated with human subcapsular cataract.
Cataract
Cataractogenesis and lipid peroxidation in newborn rats treated with buthionine sulfoximine: preventive actions of melatonin.
Cataract
Glutathione and glutathione-related enzymes in human cataractous lenses.
Cataract
Glutathione synthesis in evolution: an Achilles' heel of human and other old world simian lenses.
Chagas Disease
Specific activation of CD4(-) CD8(-) double-negative T cells by Trypanosoma cruzi-derived glycolipids induces a proinflammatory profile associated with cardiomyopathy in Chagas patients.
Cholera
Aging and chloride channel regulation in rat fast-twitch muscle fibres.
Cholera
Chloride channel regulation in the skeletal muscle of normal and myotonic goats.
Cholera
Chloride channels in cultured human skeletal muscle are regulated by G proteins.
Colitis
Dimethyl Fumarate Alleviates Dextran Sulfate Sodium-Induced Colitis, through the Activation of Nrf2-Mediated Antioxidant and Anti-inflammatory Pathways.
Collagen Diseases
Cell-specific regulation of gamma-glutamylcysteine synthetase in human interstitial lung diseases.
Colonic Neoplasms
Hammerhead ribozyme against gamma-glutamylcysteine synthetase sensitizes human colonic cancer cells to cisplatin by down-regulating both the glutathione synthesis and the expression of multidrug resistance proteins.
Colonic Neoplasms
Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells.
Colonic Neoplasms
Involvement of glutathione and glutathione metabolizing enzymes in human colorectal cancer cell lines and tissues.
Colonic Neoplasms
Reversal of cisplatin and multidrug resistance by ribozyme-mediated glutathione suppression.
Colonic Neoplasms
The human multidrug resistance-associated protein (MRP) gene family: from biological function to drug molecular design.
Colorectal Neoplasms
Differential sensitivities of the MRP gene family and gamma-glutamylcysteine synthetase to prooxidants in human colorectal carcinoma cell lines with different p53 status.
Colorectal Neoplasms
Expression of heavy subunit of gamma-glutamylcysteine synthetase (gamma-GCSh) in human colorectal carcinoma.
Colorectal Neoplasms
Frequent coexpression of MRP/GS-X pump and gamma-glutamylcysteine synthetase mRNA in drug-resistant cells, untreated tumor cells, and normal mouse tissues.
Colorectal Neoplasms
Frequent coordinated overexpression of the MRP/GS-X pump and gamma-glutamylcysteine synthetase genes in human colorectal cancers.
Colorectal Neoplasms
Glutathione S-transferases--biomarkers of cancer risk and chemopreventive response.
Colorectal Neoplasms
Increased lipoperoxide levels and antioxidant system in colorectal cancer.
Colorectal Neoplasms
Induction of MRP1 and gamma-glutamylcysteine synthetase gene expression by interleukin 1beta is mediated by nitric oxide-related signalings in human colorectal cancer cells.
Colorectal Neoplasms
The human multidrug resistance-associated protein (MRP) gene family: from biological function to drug molecular design.
Coronary Artery Disease
Polymorphism in the 5'-flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction.
Coronary Disease
[The glutamate-cysteine ligase catalytic subunit gene C-129T and modifier subunit gene G-23T polymorphisms and risk for coronary diseases]
COVID-19
Optic nerve and macular optical coherence tomography in recovered COVID-19 patients.
Cystic Fibrosis
Activation of the cystic fibrosis transmembrane conductance regulator by cGMP in the human colonic cancer cell line, Caco-2.
Cystic Fibrosis
Heterotrimeric G proteins, vesicle trafficking, and CFTR Cl- channels.
Cystic Fibrosis
Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung disease.
Cysts
Baseline morphological characteristics as predictors of final visual acuity in patients with branch retinal vein occlusions: MARVEL report no. 3.
Deafness
The impact of deafness to the survival of the newborn cells in the brain of juvenile white-rumped munia, Lonchura striata.
Dementia
Retinal Nerve Fiber Layer Thinning in Alzheimer's Disease: A Case-Control Study in Comparison to Normal Aging, Parkinson's Disease, and Non-Alzheimer's Dementia.
Dementia
Visual tests predict dementia risk in Parkinson disease.
Diabetes Mellitus
Association of genetic variants in the promoter region of genes encoding p22phox (CYBA) and glutamate cysteine ligase catalytic subunit (GCLC) and renal disease in patients with type 1 diabetes mellitus.
Diabetes Mellitus
Effects of troxerutin on cognitive deficits and glutamate cysteine ligase subunits in the hippocampus of streptozotocin-induced type 1 diabetes mellitus rats.
Diabetes Mellitus
Long exposure to high glucose concentration impairs the responsive expression of gamma-glutamylcysteine synthetase by interleukin-1beta and tumor necrosis factor-alpha in mouse endothelial cells.
Diabetes Mellitus, Type 1
Association of genetic variants in the promoter region of genes encoding p22phox (CYBA) and glutamate cysteine ligase catalytic subunit (GCLC) and renal disease in patients with type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
Effects of troxerutin on cognitive deficits and glutamate cysteine ligase subunits in the hippocampus of streptozotocin-induced type 1 diabetes mellitus rats.
Diabetes Mellitus, Type 1
Glutamate cysteine ligase catalytic subunit promoter polymorphisms and associations with type 1 diabetes age-at-onset and GAD65 autoantibody levels.
Diabetes Mellitus, Type 2
Genetic variants in glutamate cysteine ligase confer protection against type 2 diabetes.
Diabetes Mellitus, Type 2
Microalbuminuria Is Associated With Early Retinal Neurodegeneration in Patients With Type 2 Diabetes.
Diabetic Angiopathies
Region-specific ischemia, neovascularization and macular oedema in treatment-naïve proliferative diabetic retinopathy.
Diabetic Retinopathy
Are there any changes in posterior ocular structure parameters in pediatric migraine patients?
Diabetic Retinopathy
Determination of Neurodegeneration in Polycystic Ovary Syndrome with Retinal Segmentation Analysis.
Diabetic Retinopathy
Epigenetic modifications of Nrf2-mediated glutamate-cysteine ligase: implications for the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued progression.
Diabetic Retinopathy
Foveal ganglion cell layer damage in ischemic diabetic maculopathy: correlation of optical coherence tomographic and anatomic changes.
Diabetic Retinopathy
Microalbuminuria Is Associated With Early Retinal Neurodegeneration in Patients With Type 2 Diabetes.
Diabetic Retinopathy
The Correlation of Inflammation and Microvascular Changes with Diabetic Retinal Neurodegeneration.
Dyslipidemias
Association of serum apolipoprotein B with retinal neurovascular structural alterations in patients with type 2 diabetes: an optical coherence tomography angiography study.
Encephalomyelitis, Western Equine
An assessment of the biological capacity of a Sacramento Valley population of Aedes melanimon to vector arboviruses.
Endometriosis
Alteration of Nrf2 and Glutamate Cysteine Ligase expression contribute to lesions growth and fibrogenesis in ectopic endometriosis.
Endotoxemia
Nitric oxide modulates glutathione synthesis during endotoxemia.
Epilepsy
Evaluation of retinal nerve fiber layer, ganglion cell layer and macular changes in patients with migraine.
Epilepsy
Evaluation of retinal nerve fibre layer, ganglion cell layer and choroidal thickness with optical coherence tomography in migraine patients: a case-control study.
Fatty Liver
Comparative transcriptomic analysis reveals an association of gibel carp fatty liver with ferroptosis pathway.
Fatty Liver
Hepatic metabolic adaptation in a murine model of glutathione deficiency.
Gastroparesis
Loss of NRF2 impairs gastric nitrergic stimulation and function.
Geographic Atrophy
REDUCED GANGLION CELL VOLUME ON OPTICAL COHERENCE TOMOGRAPHY IN PATIENTS WITH GEOGRAPHIC ATROPHY.
Glaucoma
Analyzing the impact of glaucoma on the macular architecture using spectral-domain optical coherence tomography.
Glaucoma
Asymmetry analysis of macular optical coherence tomography angiography in patients with glaucoma and healthy subjects.
Glaucoma
Characterization of intravitreally delivered capsid mutant AAV2-Cre vector to induce tissue-specific mutations in murine retinal ganglion cells.
Glaucoma
Comparison of diagnostic ability of standard automated perimetry, short wavelength automated perimetry, retinal nerve fiber layer thickness analysis and ganglion cell layer thickness analysis in early detection of glaucoma.
Glaucoma
Diagnostic accuracy of ganglion cell complex substructures in different stages of primary open-angle glaucoma.
Glaucoma
Diagnostic capacity of SD-OCT segmented ganglion cell complex versus retinal nerve fiber layer analysis for congenital glaucoma.
Glaucoma
Evaluation of Layer-by-Layer Segmented Ganglion Cell Complex Thickness for Detecting Early Glaucoma According to Different Macular Grids.
Glaucoma
Evaluation of Pupil Fields Using a Newly Developed Perimeter in Glaucoma Patients.
Glaucoma
Factors contributing to neuronal degeneration in retinas of experimental glaucomatous rats.
Glaucoma
Ganglion cell layer analysis with deep learning in glaucoma diagnosis.
Glaucoma
Ganglion Cell-Inner Plexiform Layer Thickness in Different Glaucoma Stages Measured by Optical Coherence Tomography.
Glaucoma
Glaucoma Diagnostic Ability of Layer-by-Layer Segmented Ganglion Cell Complex by Spectral-Domain Optical Coherence Tomography.
Glaucoma
Glaucoma Diagnostic Capability of Global and Regional Measurements of Isolated Ganglion Cell Layer and Inner Plexiform Layer.
Glaucoma
Measurable Aspects of the Retinal Neurovascular Unit in Diabetes, Glaucoma, and Controls.
Glaucoma
MicroRNA-145-5p targeting of TRIM2 mediates the apoptosis of retinal ganglion cells via the PI3K/AKT signaling pathway in glaucoma.
Glaucoma
New Normative Database of Inner Macular Layer Thickness Measured by Spectralis OCT Used as Reference Standard for Glaucoma Detection.
Glaucoma
Quantification of Retinal Ganglion Cell Morphology in Human Glaucomatous Eyes.
Glaucoma
Relationship of the Macular Ganglion Cell and Inner Plexiform Layers in Healthy and Glaucoma Eyes.
Glaucoma
Retinal ganglion cells recognized by serum autoantibody against gamma-enolase found in glaucoma patients.
Glaucoma
Structural evaluation of perimetrically normal and affected hemifields in open angle glaucoma.
Glaucoma
The neurosteroid allopregnanolone protects retinal neurons by effects on autophagy and GABRs/GABAA receptors in rat glaucoma models.
Glaucoma
Topographic correlation and asymmetry analysis of ganglion cell layer thinning and the retinal nerve fiber layer with localized visual field defects.
Glaucoma
Transplantation of reprogrammed peripheral blood cells differentiates into retinal ganglion cells in the mouse eye with NMDA-induced injury.
Glioblastoma
Glycation of glutamate cysteine ligase by 2-deoxy-d-ribose and its potential impact on chemoresistance in glioblastoma.
Glioblastoma
Hammerhead ribozyme against gamma-glutamylcysteine synthetase attenuates resistance to ionizing radiation and cisplatin in human T98G glioblastoma cells.
Glioblastoma
Nuclear factor kappa B dependent induction of gamma glutamylcysteine synthetase by ionizing radiation in T98G human glioblastoma cells.
Glioma
Depletion of glutathione up-regulates mitochondrial complex I expression in glial cells.
Glioma
Homonymous Retinal Ganglion Cell Layer Atrophy With Asymptomatic Optic Tract Glioma in Neurofibromatosis Type I.
Glioma
Insulin-like growth factor 1 specifically up-regulates expression of modifier subunit of glutamate-cysteine ligase and enhances glutathione synthesis in SH-SY5Y cells.
Glioma
Late-onset globoid cell leukodystrophy mimicking an infiltrating glioma.
Glioma
Posttranscriptional regulation of MRP/GS-X pump and gamma-glutamylcysteine synthetase expression by 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea and by cycloheximide in human glioma cells.
Glioma
Transient induction of the MRP/GS-X pump and gamma-glutamylcysteine synthetase by 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3- nitrosourea in human glioma cells.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Oxidative Stress and Suicidal Erythrocyte Death.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias.
Glucosephosphate Dehydrogenase Deficiency
Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias.
glutamate-cysteine ligase deficiency
A novel missense mutation in the gamma-glutamylcysteine synthetase catalytic subunit gene causes both decreased enzymatic activity and glutathione production.
glutamate-cysteine ligase deficiency
Chronic non-spherocytic hemolytic anemia associated with severe neurological disease due to gamma-glutamylcysteine synthetase deficiency in a patient of Moroccan origin.
glutamate-cysteine ligase deficiency
Clinical and molecular characterization of 6 children with glutamate-cysteine ligase deficiency causing hemolytic anemia.
glutamate-cysteine ligase deficiency
Enzymatic defects underlying hereditary glutamate cysteine ligase deficiency are mitigated by association of the catalytic and regulatory subunits.
glutamate-cysteine ligase deficiency
Gamma-glutamylcysteine synthetase deficiency and hemolytic anemia.
glutamate-cysteine ligase deficiency
Inborn errors in the metabolism of glutathione.
glutamate-cysteine ligase deficiency
L-pyroglutamic acid inhibits energy production and lipid synthesis in cerebral cortex of young rats in vitro.
glutamate-cysteine ligase deficiency
Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias.
glutamate-cysteine ligase deficiency
The molecular basis of a case of gamma-glutamylcysteine synthetase deficiency.
glutathione synthase deficiency
L-pyroglutamic acid inhibits energy production and lipid synthesis in cerebral cortex of young rats in vitro.
glutathione synthase deficiency
Patients with genetic defects in the gamma-glutamyl cycle.
Head and Neck Neoplasms
Association between expression of glutathione-associated enzymes and response to platinum-based chemotherapy in head and neck cancer.
Heart Failure
Chronic depletion of glutathione exacerbates ventricular remodelling and dysfunction in the pressure-overloaded heart.
Hemianopsia
Homonymous Retinal Ganglion Cell Layer Atrophy With Asymptomatic Optic Tract Glioma in Neurofibromatosis Type I.
Hemianopsia
Morphological and Functional Inner and Outer Retinal Layer Abnormalities in Eyes with Permanent Temporal Hemianopia from Chiasmal Compression.
Hemolytic-Uremic Syndrome
Oxidative Stress and Suicidal Erythrocyte Death.
Hepatitis C
Glutamate-Cysteine Ligase Catalytic Subunit Attenuated Hepatitis C Virus-Related Liver Fibrosis and Suppressed Endoplasmic Reticulum Stress.
Hepatolenticular Degeneration
Oxidative Stress and Suicidal Erythrocyte Death.
Hyperglycemia
Significance of glutathione depletion and oxidative stress in early embryogenesis in glucose-induced rat embryo culture.
Hypersensitivity
Molecular cloning and nucleotide sequencing of the gamma-glutamylcysteine synthetase gene of the fission yeast Schizosaccharomyces pombe.
Hypersensitivity
Polymorphism in glutamate cysteine ligase catalytic subunit (GCLC) is associated with sulfamethoxazole-induced hypersensitivity in HIV/AIDS patients.
Hypertension
Glutamate-cysteine ligase polymorphism, hypertension, and male sex are associated with cardiovascular events. Biochemical and genetic characterization of Italian subpopulation.
Hypertension
Retinal Thickness and Microvascular Pattern in Early Parkinson's Disease.
Hypertension, Malignant
Down-regulation of renal glutathione synthesis by systemic nitric oxide synthesis inhibition in spontaneously hypertensive rats.
Hypothyroidism
Thyroid hormone promotes glutathione synthesis in astrocytes by up regulation of glutamate cysteine ligase through differential stimulation of its catalytic and modulator subunit mRNAs.
Idiopathic Pulmonary Fibrosis
Cell-specific regulation of gamma-glutamylcysteine synthetase in human interstitial lung diseases.
Infections
Antimalarial efficacy of methylene blue and menadione and their effect on glutathione metabolism of Plasmodium yoelii-infected albino mice.
Infections
Combined administration of (L)-cystine and (L)-theanine enhances immune functions and protects against influenza virus infection in aged mice.
Infections
Dietary addition of rutin impairs inflammatory response and protects muscle of silver catfish (Rhamdia quelen) from apoptosis and oxidative stress in Aeromonas hydrophila-induced infection.
Infections
DNA vaccination against the parasite enzyme gamma-glutamylcysteine synthetase confers protection against Leishmania donovani infection.
Infections
gamma-glutamylcysteine synthetase from Plasmodium berghei.
Infections
Inhibition of NFE2L2-Antioxidant Response Element Pathway by Mitochondrial Reactive Oxygen Species Contributes to Development of Cardiomyopathy and Left Ventricular Dysfunction in Chagas Disease.
Infections
Opportunistic Pathogen Porphyromonas gingivalis Modulates Danger Signal ATP-Mediated Antibacterial NOX2 Pathways in Primary Epithelial Cells.
Infections
Plasmodium falciparum-infected red blood cells depend on a functional glutathione de novo synthesis attributable to an enhanced loss of glutathione.
Infections
Protein regulation strategies of the mouse spleen in response to Babesia microti infection.
Infections
RaxL regulates chick ganglion cell development.
Infections
Resistance of Leishmania donovani to sodium stibogluconate is related to the expression of host and parasite gamma-glutamylcysteine synthetase.
Infections
Vaccination with recombinant Leishmania donovani gamma-glutamylcysteine synthetase fusion protein protects against L. donovani infection.
Insulin Resistance
Determination of Neurodegeneration in Polycystic Ovary Syndrome with Retinal Segmentation Analysis.
Insulin Resistance
Dysregulated glutathione metabolism links to impaired insulin action in adipocytes.
Intestinal Volvulus
The gamma-glutamylcysteine synthetase of Onchocerca volvulus.
Iron Deficiencies
Oxidative Stress and Suicidal Erythrocyte Death.
Iron Overload
Cellular adaptation mediated through Nrf2-induced glutamate cysteine ligase up-regulation against oxidative stress caused by iron overload in ?-thalassemia/HbE patients.
Ischemic Attack, Transient
Relation Among Neuronal Death, Cell Proliferation and Neuronal Differentiation in the Gerbil Main Olfactory Bulb after Transient Cerebral Ischemia.
Ischemic Stroke
Genetic polymorphisms of Chinese patients with ischemic stroke and concurrent stenoses of extracranial and intracranial vessels.
Kidney Failure, Chronic
Oxidative Stress and Suicidal Erythrocyte Death.
Kidney Failure, Chronic
Retinal neurodegeneration in patients with end-stage renal disease assessed by spectral-domain optical coherence tomography.
Kidney Neoplasms
Altered glutamate cysteine ligase expression and activity in renal cell carcinoma.
Leukemia
Coordinated induction of MRP/GS-X pump and gamma-glutamylcysteine synthetase by heavy metals in human leukemia cells.
Leukemia
Frequent coexpression of MRP/GS-X pump and gamma-glutamylcysteine synthetase mRNA in drug-resistant cells, untreated tumor cells, and normal mouse tissues.
Leukemia
Frequent coordinated overexpression of the MRP/GS-X pump and gamma-glutamylcysteine synthetase genes in human colorectal cancers.
Leukemia
Indomethacin overcomes doxorubicin resistance by decreasing intracellular content of glutathione and its conjugates with decreasing expression of gamma-glutamylcysteine synthetase via promoter activity in doxorubicin-resistant leukemia cells.
Leukemia
Protection of acute myeloblastic leukemia cells against apoptotic cell death by high glutathione and gamma-glutamylcysteine synthetase levels during etoposide-induced oxidative stress.
Leukemia
Role of gamma-glutamyl cysteine synthetase (gamma-GCS) gene expression as marker of drug sensitivity in acute myeloid leukemias.
Leukemia
Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1.
Leukemia
[Glutathione synthesis inhibitor enhances arsenic trioxide-induced apoptosis]
Leukemia, Myeloid, Acute
Glutamate-cysteine ligase catalytic subunit as a therapeutic target in acute myeloid leukemia and solid tumors.
Leukemia, Myeloid, Acute
Protection of acute myeloblastic leukemia cells against apoptotic cell death by high glutathione and gamma-glutamylcysteine synthetase levels during etoposide-induced oxidative stress.
Leukemia, Myeloid, Acute
Role of gamma-glutamyl cysteine synthetase (gamma-GCS) gene expression as marker of drug sensitivity in acute myeloid leukemias.
Leukemia, Promyelocytic, Acute
Role of gamma-glutamyl cysteine synthetase (gamma-GCS) gene expression as marker of drug sensitivity in acute myeloid leukemias.
Leukodystrophy, Globoid Cell
Late-onset globoid cell leukodystrophy mimicking an infiltrating glioma.
Leukodystrophy, Globoid Cell
Retroviral-mediated transfer of the galactocerebrosidase gene in neural progenitor cells.
Liver Cirrhosis
Glutamate-Cysteine Ligase Catalytic Subunit Attenuated Hepatitis C Virus-Related Liver Fibrosis and Suppressed Endoplasmic Reticulum Stress.
Liver Diseases
Association of Polymorphisms in Glutamate-Cysteine Ligase Catalytic Subunit and Microsomal Triglyceride Transfer Protein Genes with Nonalcoholic Fatty Liver Disease.
Liver Diseases
Hepatic metabolic adaptation in a murine model of glutathione deficiency.
Liver Diseases
Nuclear factor erythroid 2-like 2 (Nrf2) expression in end-stage liver disease.
Liver Neoplasms
MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer.
Lung Diseases
Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung disease.
Lung Diseases, Interstitial
Cell-specific regulation of gamma-glutamylcysteine synthetase in human interstitial lung diseases.
Lung Injury
NO2-induced acute and chronic lung injury cause imbalance of glutathione metabolism in type II pneumocytes.
Lung Neoplasms
Analysis of Epithelial-Mesenchymal Transition Metabolism Identifies Possible Cancer Biomarkers Useful in Diverse Genetic Backgrounds.
Lung Neoplasms
Carboplatin AUC and gamma-glutamylcysteine synthetase gene expression in peripheral mononuclear cells of lung cancer patients.
Lung Neoplasms
Effect of glutathione depletion on cisplatin resistance in cancer cells transfected with the gamma-glutamylcysteine synthetase gene.
Lung Neoplasms
Expression of gamma-glutamylcysteine synthetase (gamma-GCS) and multidrug resistance-associated protein (MRP), but not human canalicular multispecific organic anion transporter (cMOAT), genes correlates with exposure of human lung cancers to platinum drugs.
Lung Neoplasms
Gamma-glutamylcysteine synthetase gene overexpression results in increased activity of the ATP-dependent glutathione S-conjugate export pump and cisplatin resistance.
Lung Neoplasms
gamma-Glutamylcysteine synthetase in lung cancer. Effect on cell viability.
Lung Neoplasms
Genetic determinants of lung cancer short-term survival: the role of glutathione-related genes.
Lung Neoplasms
Induction of gamma-glutamylcysteine synthetase gene expression by platinum drugs in peripheral mononuclear cells of lung cancer patients.
Lung Neoplasms
Inhibition of Thioredoxin/Thioredoxin Reductase Induces Synthetic Lethality in Lung Cancers with Compromised Glutathione Homeostasis.
Lung Neoplasms
Knockdown of glutamate cysteine ligase catalytic subunit by siRNA causes the gold nanoparticles-induced cytotoxicity in lung cancer cells.
Lung Neoplasms
Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis.
Lung Neoplasms
Proximal 5'-flanking sequence of the human gamma-glutamylcysteine synthetase heavy subunit gene is involved in cisplatin-induced transcriptional up-regulation in a lung cancer cell line SBC-3.
Lung Neoplasms
Redox regulation of matrix metalloproteinase gene family in small cell lung cancer cells.
Lung Neoplasms
The gamma-glutamylcysteine synthetase and glutathione regulate asbestos-induced expression of activator protein-1 family members and activity.
Lung Neoplasms
The modifier subunit of glutamate cysteine ligase (GCLM) is a molecular target for amelioration of cisplatin resistance in lung cancer.
Lung Neoplasms
The modifier subunit of glutamate cysteine ligase relates to cisplatin resistance in human small cell lung cancer xenografts in vivo.
Lung Neoplasms
The subunits of glutamate cysteine ligase enhance cisplatin resistance in human non-small cell lung cancer xenografts in vivo.
Lupus Erythematosus, Systemic
Altered glutamate cysteine ligase activity in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.
Lymphoma
[Glutathione synthesis inhibitor enhances arsenic trioxide-induced apoptosis]
Macular Degeneration
Cobalamin C Deficiency Shows a Rapidly Progressing Maculopathy With Severe Photoreceptor and Ganglion Cell Loss.
Macular Degeneration
Retinal and choroidal capillaries contribution to age-related macular degeneration (AMD) phenotypes in murine models of the disease.
Macular Degeneration
Retinal Structure Measurements as Inclusion Criteria for Stem Cell-Based Therapies of Retinal Degenerations.
Malaria
Assay of gamma-glutamylcysteine synthetase activity in Plasmodium berghei by liquid chromatography with electrochemical detection.
Malaria
gamma-glutamylcysteine synthetase from Plasmodium berghei.
Malaria
Glutathione synthetase from Plasmodium falciparum.
Malaria
Oxidative Stress and Suicidal Erythrocyte Death.
Malaria
Plasmodium falciparum-infected red blood cells depend on a functional glutathione de novo synthesis attributable to an enhanced loss of glutathione.
Melanoma
Gamma-glutamylcysteine synthetase mediates the c-Myc-dependent response to antineoplastic agents in melanoma cells.
Melanoma
Influence of buthionine sulfoximine and misonidazole on glutathione level and radiosensitivity of human tumor xenografts.
Mesothelioma
Antioxidant enzymes and redox regulating thiol proteins in malignancies of human lung.
Mesothelioma
Co-ordinated over-expression of the MRP and gamma-glutamylcysteine synthetase genes, but not MDR1, correlates with doxorubicin resistance in human malignant mesothelioma cell lines.
Mesothelioma
Structure and refinement of the physical mapping of the gamma- glutamylcysteine ligase regulatory subunit (GLCLR) gene to chromosome 1p22.1 within the critically deleted region of human malignant mesothelioma.
Mesothelioma, Malignant
Co-ordinated over-expression of the MRP and gamma-glutamylcysteine synthetase genes, but not MDR1, correlates with doxorubicin resistance in human malignant mesothelioma cell lines.
Mesothelioma, Malignant
Overexpression of gamma-glutamylcysteine synthetase in human malignant mesothelioma.
Metabolic Diseases
L-pyroglutamic acid inhibits energy production and lipid synthesis in cerebral cortex of young rats in vitro.
Metabolic Syndrome
[Therapeutic effect of glibenclamide contrasted with other oral antidiabetic agents]
Migraine Disorders
Evaluation of retinal nerve fiber layer, ganglion cell layer and macular changes in patients with migraine.
Migraine Disorders
Evaluation of retinal nerve fibre layer, ganglion cell layer and choroidal thickness with optical coherence tomography in migraine patients: a case-control study.
Migraine Disorders
Evaluation of white matter hyperintensities and retinal fiber layer, ganglion cell layer, inner-plexiform layer, and choroidal layer in migraine patients.
Migraine Disorders
Ocular pulse amplitude and retina nerve fiber layer thickness in migraine patients without aura.
Migraine Disorders
Relationship between white matter hyperintensities and retinal nerve fiber layer, choroid, and ganglion cell layer thickness in migraine patients.
Migraine without Aura
Evaluation of retinal nerve fiber layer, ganglion cell layer and macular changes in patients with migraine.
Multiple Myeloma
Up-regulation of gamma-glutamylcysteine synthetase activity in melphalan-resistant human multiple myeloma cells expressing increased glutathione levels.
Multiple Sclerosis
Leber's hereditary optic neuropathy - Case report.
Multiple Sclerosis
The role of Optical Coherence Tomography in optic neuropathies.
Muscle Cramp
Effects of chronic treatment with statins and fenofibrate on rat skeletal muscle: a biochemical, histological and electrophysiological study.
Muscle Spasticity
Retinal ganglion cell topography predicts visual field function in spastic cerebral palsy.
Muscular Atrophy
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin.
Muscular Diseases
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin.
Muscular Dystrophy, Emery-Dreifuss
Transcriptional repressor germ cell-less (GCL) and barrier to autointegration factor (BAF) compete for binding to emerin in vitro.
Myocardial Infarction
Association of polymorphism in glutamate-cysteine ligase catalytic subunit gene with coronary vasomotor dysfunction and myocardial infarction.
Myocardial Infarction
Glutathione (GSH) and the GSH synthesis gene Gclm modulate plasma redox and vascular responses to acute diesel exhaust inhalation in mice.
Myocardial Infarction
Polymorphism in glutamate-cysteine ligase modifier subunit gene is associated with impairment of nitric oxide-mediated coronary vasomotor function.
Myocardial Infarction
Polymorphism in the 5'-flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction.
Myocardial Ischemia
Association of GCLM -588C/T and GCLC -129T/C Promoter Polymorphisms of Genes Coding the Subunits of Glutamate Cysteine Ligase with Ischemic Heart Disease Development in Kazakhstan Population.
Myocardial Ischemia
C-588T polymorphism of the human glutamate-cysteine ligase modifier subunit gene is not associated with the risk and extent of ischemic heart disease in a German cohort.
Myotonia
20,25-diazacholesterol myotonia: an electrophysiological study.
Myotonia
The effects of taurine on pharmacologically induced myotonia.
Myotonia
The pathophysiology of myotonia produced by aromatic carboxylic acids.
Myotoxicity
Effects of chronic treatment with statins and fenofibrate on rat skeletal muscle: a biochemical, histological and electrophysiological study.
Neoplasms
A functional trinucleotide repeat polymorphism in the 5'-untranslated region of the glutathione biosynthetic gene GCLC is associated with increased risk for lung and aerodigestive tract cancers.
Neoplasms
A new aspect on glutathione-associated biological function of MRP/GS-X pump and its gene expression.
Neoplasms
Activation of the Nuclear Factor E2-Related Factor 2/Antioxidant Response Element Pathway is Neuroprotective Following Spinal Cord Injury.
Neoplasms
Altered antioxidant capacity in human renal cell carcinoma: Role of glutathione associated enzymes.
Neoplasms
Altered glutamate cysteine ligase expression and activity in renal cell carcinoma.
Neoplasms
Antioxidant enzymes and redox regulating thiol proteins in malignancies of human lung.
Neoplasms
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
Neoplasms
Brachychiton populneus (Schott & Endl.) R.Br. ameliorate carbon tetrachloride induced oxidative stress through regulation of endoplasmic reticulum stress markers and inflammatory mediators in Sprague-Dawley male rats.
Neoplasms
Buthionine sulfoximine-induced glutathione depletion. Its effect on antioxidants, lipid peroxidation and calcium homeostasis in the lung.
Neoplasms
Cell-specific regulation of gamma-glutamylcysteine synthetase in human interstitial lung diseases.
Neoplasms
Co-expression of gamma-glutamylcysteine synthetase sub-units in response to cisplatin and doxorubicin in human cancer cells.
Neoplasms
Consequences of selenite supplementation on the growth and metabolism of cultures of canine mammary cells.
Neoplasms
Crystal structure of gamma-glutamylcysteine synthetase: insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis.
Neoplasms
Dietary sulphur amino acid adequacy influences glutathione synthesis and glutathione-dependent enzymes during the inflammatory response to endotoxin and tumour necrosis factor-alpha in rats.
Neoplasms
Effect of glutathione depletion on cisplatin resistance in cancer cells transfected with the gamma-glutamylcysteine synthetase gene.
Neoplasms
Effects of the antiproliferative cyclopentenone prostaglandin A1 on glutathione metabolism in human cancer cells in culture.
Neoplasms
Elevation of glutathione in phenylalanine mustard-resistant murine L1210 leukemia cells.
Neoplasms
Evidence for altered regulation of gamma-glutamylcysteine synthetase gene expression among cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines.
Neoplasms
Evidence for functionally significant polymorphism of human glutamate cysteine ligase catalytic subunit: association with glutathione levels and drug resistance in the National Cancer Institute tumor cell line panel.
Neoplasms
Exploring cysteine regulation in cancer cell survival with a highly specific "Lock and Key" fluorescent probe for cysteine.
Neoplasms
Expression and purification of human gamma-glutamylcysteine synthetase.
Neoplasms
Expression of gamma-glutamylcysteine synthetase (gamma-GCS) and multidrug resistance-associated protein (MRP), but not human canalicular multispecific organic anion transporter (cMOAT), genes correlates with exposure of human lung cancers to platinum drugs.
Neoplasms
Expression of glutathione, glutathione peroxidase and glutathione S-transferase pi in canine mammary tumors.
Neoplasms
Expression of heavy subunit of gamma-glutamylcysteine synthetase (gamma-GCSh) in human colorectal carcinoma.
Neoplasms
Frequent coexpression of MRP/GS-X pump and gamma-glutamylcysteine synthetase mRNA in drug-resistant cells, untreated tumor cells, and normal mouse tissues.
Neoplasms
Frequent coordinated overexpression of the MRP/GS-X pump and gamma-glutamylcysteine synthetase genes in human colorectal cancers.
Neoplasms
Functional dissection of Nrf2-dependent phase II genes in vascular inflammation and endotoxic injury using Keap1 siRNA.
Neoplasms
GAGE cancer-germline antigens are recruited to the nuclear envelope by germ cell-less (GCL).
Neoplasms
Gamma-glutamyl cysteine synthetase up-regulates glutathione and multidrug resistance-associated protein in patients with chemoresistant epithelial ovarian cancer.
Neoplasms
Gamma-glutamylcysteine synthetase mediates the c-Myc-dependent response to antineoplastic agents in melanoma cells.
Neoplasms
Glutamate-cysteine ligase catalytic subunit as a therapeutic target in acute myeloid leukemia and solid tumors.
Neoplasms
Glutathione depletion by buthionine sulfoximine induces DNA deletions in mice.
Neoplasms
Glutathione depletion is associated with augmenting a proinflammatory signal: evidence for an antioxidant/pro-oxidant mechanism regulating cytokines in the alveolar epithelium.
Neoplasms
Glutathione S-transferase-P1 expression correlates with increased antioxidant capacity in transitional cell carcinoma of the urinary bladder.
Neoplasms
Glutathione-related enzymes contribute to resistance of tumor cells and low toxicity in normal organs to artesunate.
Neoplasms
Glycation of glutamate cysteine ligase by 2-deoxy-d-ribose and its potential impact on chemoresistance in glioblastoma.
Neoplasms
Hammerhead ribozyme against gamma-glutamylcysteine synthetase attenuates resistance to ionizing radiation and cisplatin in human T98G glioblastoma cells.
Neoplasms
Hammerhead ribozyme against gamma-glutamylcysteine synthetase sensitizes human colonic cancer cells to cisplatin by down-regulating both the glutathione synthesis and the expression of multidrug resistance proteins.
Neoplasms
High GCLC level in tumor tissues is associated with poor prognosis of hepatocellular carcinoma after curative resection.
Neoplasms
Increased lipoperoxide levels and antioxidant system in colorectal cancer.
Neoplasms
Induction of gamma-glutamyl transpeptidase mRNA by platinum complexes in a human ovarian carcinoma cell line.
Neoplasms
Influence of buthionine sulfoximine and misonidazole on glutathione level and radiosensitivity of human tumor xenografts.
Neoplasms
Influence of selenium on glutathione and some associated enzymes in rats with mammary tumor induced by 7,12-dimethylbenz(a)anthracene.
Neoplasms
Inhibition of cancer growth and selective glutathione depletion in Ehrlich tumour cells in vivo by extracellular ATP.
Neoplasms
Inhibition of glutamate cysteine ligase activity sensitizes human breast cancer cells to the toxicity of 2-deoxy-D-glucose.
Neoplasms
Inhibition of glutathione synthesis augments lysis of murine tumor cells by sulfhydryl-reactive antineoplastics.
Neoplasms
Inhibitory effects of glutathione level-raising agents and D-alpha-tocopherol on ornithine decarboxylase induction and mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Neoplasms
Long exposure to high glucose concentration impairs the responsive expression of gamma-glutamylcysteine synthetase by interleukin-1beta and tumor necrosis factor-alpha in mouse endothelial cells.
Neoplasms
Low tumor glutathione level as a sensitivity marker for glutamate-cysteine ligase inhibitors.
Neoplasms
Mercaptoethanol Protects the Aorta from Dissection by Inhibiting Oxidative Stress, Inflammation, and Extracellular Matrix Degeneration in a Mouse Model.
Neoplasms
Modulation of glutathione synthetic enzymes by acidic fibroblast growth factor.
Neoplasms
Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway.
Neoplasms
Over expression of glutamate cysteine ligase increases cellular resistance to H2O2-induced DNA single-strand breaks.
Neoplasms
Overcoming Cancer Cell Drug Resistance by a Folic Acid Targeted Polymeric Conjugate of Buthionine Sulfoximine.
Neoplasms
Overexpression of gamma-glutamylcysteine synthetase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappa B and activator protein-1.
Neoplasms
Overexpression of glutamate-cysteine ligase protects human COV434 granulosa tumour cells against oxidative and gamma-radiation-induced cell death.
Neoplasms
Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State.
Neoplasms
Proteasome Inhibition Induces a p38 MAPK Pathway-Dependent Antiapoptotic Program via Nrf2 in Thyroid Cancer Cells.
Neoplasms
Protection by glutathione against the antiproliferative effects of nitric oxide. Dependence on kinetics of no release.
Neoplasms
Red wine and black tea polyphenols modulate the expression of cycloxygenase-2, inducible nitric oxide synthase and glutathione-related enzymes in azoxymethane-induced f344 rat colon tumors.
Neoplasms
Redox control of G(1)/S cell cycle regulators during nitric oxide-mediated cell cycle arrest.
Neoplasms
Regulation of heavy subunit chain of gamma-glutamylcysteine synthetase by tumor necrosis factor-alpha in lens epithelial cells: role of LEDGF/p75.
Neoplasms
Regulation of nuclear factor-kappa B, activator protein-1, and glutathione levels by tumor necrosis factor-alpha and dexamethasone in alveolar epithelial cells.
Neoplasms
Reversal of cisplatin and multidrug resistance by ribozyme-mediated glutathione suppression.
Neoplasms
Specific activation of CD4(-) CD8(-) double-negative T cells by Trypanosoma cruzi-derived glycolipids induces a proinflammatory profile associated with cardiomyopathy in Chagas patients.
Neoplasms
Structure-based identification of novel human gamma-glutamylcysteine synthetase inhibitors.
Neoplasms
Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers.
Neoplasms
Temporal and spatial patterns of ovarian gene transcription following an ovulatory dose of gonadotropin in the rat.
Neoplasms
The human multidrug resistance-associated protein (MRP) gene family: from biological function to drug molecular design.
Neoplasms
The involvement of L-gamma-glutamyl-L-cysteinyl-glycine (glutathione/GSH) in the mechanism of redox signaling mediating MAPK(p38)-dependent regulation of pro-inflammatory cytokine production.
Neoplasms
Thiol regulation of pro-inflammatory cytokines reveals a novel immunopharmacological potential of glutathione in the alveolar epithelium.
Neoplasms
Transfection of complementary DNAs for the heavy and light subunits of human gamma-glutamylcysteine synthetase results in an elevation of intracellular glutathione and resistance to melphalan.
Neoplasms
Tumor necrosis factor increases hepatocellular glutathione by transcriptional regulation of the heavy subunit chain of gamma-glutamylcysteine synthetase.
Neoplasms
Unique action determinants of double acting topoisomerase inhibitor, TAS-103.
Neoplasms
Variable baseline gamma-glutamylcysteine synthetase messenger RNA expression in peripheral mononuclear cells of cancer patients, and its induction by buthionine sulfoximine treatment.
Neoplasms
[Changes of the activity and expression of gamma-glutamylcysteine synthetase in patients with chronic obstructive pulmonary disease.]
Neoplasms
[gamma-GCS and glutathione--new molecular targets in cancer treatment]
Neoplasms
[Gene expression profiling of human ovarian epithelial tumors by digo nucleotide microarray]
Neoplasms
[Role and mechanism of low-dose lipopolysaccharide-treated human periodontal ligament stem cells on the expression of macrophage pro-inflammatory factors].
Nephritis
Altered glutamate cysteine ligase activity in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.
Neuralgia
Combination of autophagy and NFE2L2/NRF2 activation as a treatment approach for neuropathic pain.
Neuroblastoma
Human neuroblastoma cells with MYCN amplification are selectively resistant to oxidative stress by transcriptionally up-regulating glutamate cysteine ligase.
Neuroblastoma
Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2-ARE pathway.
Neuroinflammatory Diseases
Comparison of optic coherence tomography results in patients with diagnosed epilepsy: Findings in favor of neurodegeneration.
Neuroinflammatory Diseases
Injury-Induced Neurogenesis: Consideration of Resident Microglia as Supportive of Neural Progenitor Cells.
Neuroinflammatory Diseases
Post-translational Activation of Glutamate Cysteine Ligase with Dimercaprol: A NOVEL MECHANISM OF INHIBITING NEUROINFLAMMATION
Neurologic Manifestations
Clinical and molecular characterization of 6 children with glutamate-cysteine ligase deficiency causing hemolytic anemia.
Neuromyelitis Optica
Factors Associated with Changes in Retinal Layers Following Acute Optic Neuritis: A Longitudinal Study Using Optical Coherence Tomography.
Non-alcoholic Fatty Liver Disease
Association of Polymorphisms in Glutamate-Cysteine Ligase Catalytic Subunit and Microsomal Triglyceride Transfer Protein Genes with Nonalcoholic Fatty Liver Disease.
Obesity
Binge ethanol exposure increases liver injury in obese rats.
Obesity
Dysregulated glutathione metabolism links to impaired insulin action in adipocytes.
Ocular Hypertension
The neurosteroid allopregnanolone protects retinal neurons by effects on autophagy and GABRs/GABAA receptors in rat glaucoma models.
Optic Atrophy, Hereditary, Leber
Leber's hereditary optic neuropathy - Case report.
Optic Atrophy, Hereditary, Leber
The role of Optical Coherence Tomography in optic neuropathies.
Optic Nerve Diseases
Bruch Membrane Opening Minimum Rim Width in Neuromyelitis Optica.
Optic Nerve Diseases
Leber's hereditary optic neuropathy - Case report.
Optic Nerve Diseases
The role of Optical Coherence Tomography in optic neuropathies.
Optic Nerve Injuries
Age-dependent susceptibility of the retinal ganglion cell layer to cell death.
Optic Nerve Injuries
Different follow-up OCT analyses of traumatic optic neuropathy. A case report.
Optic Nerve Injuries
Displaced amacrine cells in the ganglion cell layer of the hamster retina.
Optic Nerve Injuries
Protein gene product 9.5-immunoreactive retinal neurons in normal developing rats and rats with optic nerve or tract lesion.
Optic Nerve Injuries
Sick photoreceptors attract activated microglia from the ganglion cell layer: a model to study the inflammatory cascades in rats with inherited retinal dystrophy.
Optic Neuritis
Clinical trials to clinical use: using vision as a model for multiple sclerosis and beyond.
Optic Neuritis
Optic neuritis interferes with optical coherence tomography and magnetic resonance imaging correlations.
Optic Neuritis
Promising recovery biomarkers after first event acute demyelinating optic neuritis.
Optic Neuritis
The retinal ganglion cell layer predicts normal-appearing white matter tract integrity in multiple sclerosis: A combined diffusion tensor imaging and optical coherence tomography approach.
Optic Neuropathy, Ischemic
Acute changes in ganglion cell layer thickness in ischemic optic neuropathy compared to optic neuritis using optical coherence tomography.
Optic Neuropathy, Ischemic
Dual Specific Phosphatase 14 Deletion Rescues Retinal Ganglion Cells and Optic Nerve Axons after Experimental Anterior Ischemic Optic Neuropathy.
Optic Neuropathy, Ischemic
Optical imaging of the optic nerve: beyond demonstration of retinal nerve fiber layer loss.
Optic Neuropathy, Ischemic
The role of Optical Coherence Tomography in optic neuropathies.
Ovarian Neoplasms
Altered expression of gamma-glutamylcysteine synthetase, metallothionein and topoisomerase I or II during acquisition of drug resistance to cisplatin in human ovarian cancer cells.
Ovarian Neoplasms
Evidence for altered regulation of gamma-glutamylcysteine synthetase gene expression among cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines.
Ovarian Neoplasms
Gamma-glutamyl cysteine synthetase up-regulates glutathione and multidrug resistance-associated protein in patients with chemoresistant epithelial ovarian cancer.
Ovarian Neoplasms
Improvement of sensitivity to platinum compound with siRNA knockdown of upregulated genes in platinum complex-resistant ovarian cancer cells in vitro.
Ovarian Neoplasms
Variable baseline gamma-glutamylcysteine synthetase messenger RNA expression in peripheral mononuclear cells of cancer patients, and its induction by buthionine sulfoximine treatment.
Pancreatic Neoplasms
Silencing of NRF2 Reduces the Expression of ALDH1A1 and ALDH3A1 and Sensitizes to 5-FU in Pancreatic Cancer Cells.
Pancreatitis
Glutamate cysteine ligase up-regulation fails in necrotizing pancreatitis.
pantoate-beta-alanine ligase (amp-forming) deficiency
Patients with genetic defects in the gamma-glutamyl cycle.
Papilledema
Correlation Between Optic Disc Peripapillary Capillary Network and Papilledema Grading in Patients With Idiopathic Intracranial Hypertension: A Study of Optical Coherence Tomography Angiography.
Papilledema
Optical imaging of the optic nerve: beyond demonstration of retinal nerve fiber layer loss.
Pheochromocytoma
Regulation of gamma-glutamylcysteine synthetase activity by nerve growth factor.
Photophobia
Optical coherence tomography angiography in the multimodal assessment of the retinal posterior pole in autosomal dominant optic atrophy.
Pituitary Neoplasms
Assessment of inner retina layers thickness values in eyes with pituitary tumours before visual field defects occur.
Pituitary Neoplasms
Neuroretinal evaluation using optical coherence tomography in patients affected by pituitary tumors.
Pneumonia
Inflammation and the regulation of glutathione level in lung epithelial cells.
Pneumonia
Oxidative stress and regulation of glutathione in lung inflammation.
Pre-Eclampsia
Association of glutamate cystein ligase (GCL) activity Peroxiredoxin 4 (prxR4) and apelin levels in women with preeclampsia.
Primary Ovarian Insufficiency
Glutathione-deficient mice have increased sensitivity to transplacental benzo[a]pyrene-induced premature ovarian failure and ovarian tumorigenesis.
Prolactinoma
Retinal layers in prolactinoma patients: a spectral-domain optical coherence tomography study.
Prostatic Neoplasms
Xenobiotic-metabolizing gene variants, pesticide use, and the risk of prostate cancer.
Pulmonary Disease, Chronic Obstructive
Diminished immunoreactivity of gamma-glutamylcysteine synthetase in the airways of smokers' lung.
Pulmonary Disease, Chronic Obstructive
Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD.
Pulmonary Disease, Chronic Obstructive
Localization of gamma-glutamylcysteine synthetase messenger rna expression in lungs of smokers and patients with chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease.
Pulmonary Disease, Chronic Obstructive
Oxidative stress and Nrf2 expression in peripheral blood mononuclear cells derived from COPD patients: an observational longitudinal study.
Pulmonary Disease, Chronic Obstructive
Positive correlation between PPAR{gamma}/PGC-1{alpha} and {gamma}-GCS in lungs of rats and patients with chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
[Changes of the activity and expression of gamma-glutamylcysteine synthetase in patients with chronic obstructive pulmonary disease.]
Pulmonary Disease, Chronic Obstructive
[Effects of TCM treatment according to syndrome differentiation on expressions of nuclear factor-kappaB and gamma-glutamylcysteine synthetase in rats with chronic obstructive pulmonary disease of various syndrome types]
Pulmonary Disease, Chronic Obstructive
[Roles of NRF2 regulating gamma-glutamylcysteine synthetase in lung of rats with chronic obstructive pulmonary disease].
Pulmonary Disease, Chronic Obstructive
[The effect of transcription factor KLF2 in expression of gamma-GCS depend on regulation by Nrf2 in lung of rats with chronic obstructive pulmonary disease].
Pulmonary Disease, Chronic Obstructive
[The relationship between the polymorphism of glutamate cysteine ligase modulatory subunit gene and the susceptibility to chronic obstructive pulmonary disease]
pyruvate kinase deficiency
Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias.
Rectal Neoplasms
Increased lipoperoxide levels and antioxidant system in colorectal cancer.
Refractive Errors
Inner and outer retinal layer thickness alterations in pediatric and juvenile craniopharyngioma.
Reperfusion Injury
Early activation of caspase-1 after retinal ischemia and reperfusion injury in mice.
Reperfusion Injury
Mice lacking the glutamate-cysteine ligase modifier subunit are susceptible to myocardial ischemia-reperfusion injury.
Respiratory Distress Syndrome
Distribution of antioxidant enzymes in developing human lung, respiratory distress syndrome, and bronchopulmonary dysplasia.
Retinal Degeneration
Quantitative Assessment of Microstructural Changes of the Retina in Infants With Congenital Zika Syndrome.
Retinal Diseases
Transplantation of Retinal Progenitor Cells from Optic Cup-Like Structures Differentiated from Human Embryonic Stem Cells In Vitro and In Vivo Generation of Retinal Ganglion-Like Cells.
Retinitis Pigmentosa
Alterations in glutamate cysteine ligase content in the retina of two retinitis pigmentosa animal models.
Retinitis Pigmentosa
Morphometric analysis of the extramacular retina from postmortem eyes with retinitis pigmentosa.
Retinoblastoma
Structural changes of the macula and optic nerve head in the remaining eyes after enucleation for retinoblastoma: an optical coherence tomography study.
Retinoschisis
Different foveal schisis patterns in each retinal layer in eyes with hereditary juvenile retinoschisis evaluated by en-face optical coherence tomography.
Sarcoidosis
Cell-specific regulation of gamma-glutamylcysteine synthetase in human interstitial lung diseases.
Sarcoma
Elevation of glutathione and related enzyme activities in high-grade and metastatic extremity soft tissue sarcoma.
Seizures
Differential inhibition of glutamine and gamma-glutamylcysteine synthetases by alpha-alkyl analogs of methionine sulfoximine that induce convulsions.
Seizures
Effect of gamma-crotonolactone in experimental models of generalized absence seizures.
Seizures
Possible treatment of end-stage hyperammonemic encephalopathy by inhibition of glutamine synthetase.
Seizures
Seizure severity-dependent selective vulnerability of the granule cell layer and aberrant neurogenesis in the rat hippocampus.
Sepsis
Glutathione metabolism in sepsis.
Sepsis
Glutathione Synthesis Contributes to Virulence of Streptococcus agalactiae in a Murine Model of Sepsis.
Sepsis
Oxidative Stress and Suicidal Erythrocyte Death.
Septo-Optic Dysplasia
High-Resolution Imaging of the Optic Nerve and Retina in Optic Nerve Hypoplasia.
Small Cell Lung Carcinoma
Redox regulation of matrix metalloproteinase gene family in small cell lung cancer cells.
Small Cell Lung Carcinoma
The modifier subunit of glutamate cysteine ligase relates to cisplatin resistance in human small cell lung cancer xenografts in vivo.
Squamous Cell Carcinoma of Head and Neck
Histone methyltransferase G9a drives chemotherapy resistance by regulating the glutamate-cysteine ligase catalytic subunit in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Nuclear localization of glutamate-cysteine ligase is associated with proliferation in head and neck squamous cell carcinoma.
Starvation
An important role for glutathione and gamma-glutamyltranspeptidase in the supply of growth requirements during nitrogen starvation of the yeast Saccharomyces cerevisiae.
Starvation
Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis.
Sudden Unexpected Death in Epilepsy
Hippocampal morphometry in sudden and unexpected death in epilepsy.
Synucleinopathies
Impaired olfactory bulb neurogenesis depends on the presence of human wild-type alpha-synuclein.
Teratoma
CHAC2 is essential for self-renewal and glutathione maintenance in human embryonic stem cells.
Thalassemia
Endothelial dysfunction and oxidant status in pediatric patients with hemoglobin E-beta thalassemia.
Thalassemia
Oxidative Stress and Suicidal Erythrocyte Death.
Thymoma
Effect of prolonged phenytoin administration on rat brain gene expression assessed by DNA microarrays.
Thyroid Neoplasms
Proteasome Inhibition Induces a p38 MAPK Pathway-Dependent Antiapoptotic Program via Nrf2 in Thyroid Cancer Cells.
Tremor
Induction of the cell cycle regulatory gene p21 (Waf1, Cip1) following methylmercury exposure in vitro and in vivo.
Trypanosomiasis
Characterization of Trypanosoma brucei gamma-glutamylcysteine synthetase, an essential enzyme in the biosynthesis of trypanothione (diglutathionylspermidine).
Tuberculosis
All four Mycobacterium tuberculosis glnA genes encode glutamine synthetase activities but only GlnA1 is abundantly expressed and essential for bacterial homeostasis.
Tuberculosis, Pulmonary
Polymorphism of Glutamate-Cysteine Ligase Subunit Catalytic (GCLC) Gene in Pulmonary Tuberculosis Patients.
Tuberous Sclerosis
Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase.
Urinary Bladder Neoplasms
Enhanced expression of gamma-glutamylcysteine synthetase and glutathione S-transferase genes in cisplatin-resistant bladder cancer cells with multidrug resistance phenotype.
Uterine Cervical Neoplasms
Osthole promotes the suppressive effects of cisplatin on NRF2 expression to prevent drug-resistant cervical cancer progression.
Virus Diseases
Characterization of a Novel Mannose-Binding Lectin with Antiviral Activities from Red Alga, Grateloupia chiangii.
Vision Disorders
A morphometric and stereologic analysis of ganglion cells of the central human retina.
Vision Disorders
Lesions in the posterior visual pathway promote trans-synaptic degeneration of retinal ganglion cells.
Vision Disorders
Visual dysfunction and its correlation with retinal changes in patients with Parkinson's disease: an observational cross-sectional study.
Vitamin E Deficiency
Vitamin E affects cell death in adult rat dentate gyrus.
Whooping Cough
Chloride channels in cultured human skeletal muscle are regulated by G proteins.
Zika Virus Infection
Quantitative Assessment of Microstructural Changes of the Retina in Infants With Congenital Zika Syndrome.
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6.3.2.2 glutamate-cysteine ligase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
