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Information on EC 6.2.1.71 - 2,3-dihydroxybenzoate-[aryl-carrier protein] ligase

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EC Tree
IUBMB Comments
The adenylation domain of the enzyme catalyses the activation of 2,3-dihydroxybenzoate to (2,3-dihydroxybenzoyl)adenylate, followed by the transfer the activated compound to the free thiol of a phosphopantetheine arm of an aryl-carrier protein domain of a specific non-ribosomal peptide synthase. For example, the EntE enzyme of Escherichia coli is part of the enterobactin synthase complex, the VibE enzyme of Vibrio cholerae is part of the vibriobactin synthase complex, and the DhbE enzyme of Bacillus subtilis is part of the bacillibactin synthase complex.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
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holo-[aryl-carrier protein]
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2,3-dihydroxybenzoyl-[aryl-carrier protein]
Synonyms
2,3-dihydroxybenzoate-amp ligase, vibriobactin-specific 2,3-dihydroxybenzoate-amp ligase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2,3-dihydroxybenzoyl)adenylate + holo-[aryl-carrier protein] = AMP + 2,3-dihydroxybenzoyl-[aryl-carrier protein]
show the reaction diagram
(1b)
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ATP + 2,3-dihydroxybenzoate + holo-[aryl-carrier protein] = AMP + diphosphate + 2,3-dihydroxybenzoyl-[aryl-carrier protein]
show the reaction diagram
overall reaction
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ATP + 2,3-dihydroxybenzoate = diphosphate + (2,3-dihydroxybenzoyl)adenylate
show the reaction diagram
(1a)
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