Information on EC 6.2.1.6 - glutarate-CoA ligase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
6.2.1.6
-
RECOMMENDED NAME
GeneOntology No.
glutarate-CoA ligase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + glutarate + CoA = ADP + phosphate + glutaryl-CoA
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acid-thiol ligation
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Fatty acid degradation
-
-
Lysine degradation
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-
SYSTEMATIC NAME
IUBMB Comments
glutarate:CoA ligase (ADP-forming)
GTP or ITP can act instead of ATP.
CAS REGISTRY NUMBER
COMMENTARY hide
9023-68-1
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Pigeon
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-
-
Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + alpha,alpha-dimethylglutarate + CoA
ADP + phosphate + alpha,alpha-dimethylglutaryl-CoA
show the reaction diagram
ATP + alpha-methylglutarate + CoA
ADP + phosphate + alpha-methylglutaryl-CoA
show the reaction diagram
ATP + beta,beta-dimethylglutarate + CoA
ADP + phosphate + beta,beta-dimethylglutaryl-CoA
show the reaction diagram
ATP + beta-methylglutarate + CoA
ADP + phosphate + beta-methylglutaryl-CoA
show the reaction diagram
ATP + glutaconate + CoA
ADP + phosphate + glutaconyl-CoA
show the reaction diagram
ATP + glutarate + CoA
ADP + phosphate + glutaryl-CoA
show the reaction diagram
GTP + glutarate + CoA
GDP + phosphate + glutaryl-CoA
show the reaction diagram
Pigeon
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-
-
-
-
ITP + glutarate + CoA
IDP + phosphate + glutaryl-CoA
show the reaction diagram
Pigeon
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-
-
-
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-18°C, inactivated after several days
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE