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Information on EC 6.2.1.50 - 4-hydroxybenzoate adenylyltransferase FadD22

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EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.50 4-hydroxybenzoate adenylyltransferase FadD22
IUBMB Comments
This mycobacterial enzyme participates in the biosynthesis of phenolphthiocerols. Following the substrate's activation by adenylation, it is transferred to an acyl-carrier protein domain within the enzyme, from which it is transferred to EC 2.3.1.261, 4-hydroxyphenylalkanoate synthase.
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The expected taxonomic range for this enzyme is: Mycobacteriaceae
Reaction Schemes
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holo-[4-hydroxyphenylalkanoate synthase]
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4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
Synonyms
fadd22, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4-hydroxybenzoyl-adenylate + holo-[4-hydroxyphenylalkanoate synthase] = AMP + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
show the reaction diagram
(1b)
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ATP + 4-hydroxybenzoate + holo-[4-hydroxyphenylalkanoate synthase] = AMP + diphosphate + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
show the reaction diagram
overall reaction
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ATP + 4-hydroxybenzoate = 4-hydroxybenzoyl-adenylate + diphosphate
show the reaction diagram
(1a)
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