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Synonyms
sucla2, succd, a-scs, cg11963, scact, adp-forming succinyl-coa synthetase, scs-betaa, a-stk, succinyl-coa synthetase (adp-forming), succinyl-coa ligase (atp-forming),
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ATP + D-malate + CoA
ADP + phosphate + D-malyl-CoA
-
-
-
r
ATP + itaconate + CoA
ADP + phosphate + itaconyl-CoA
-
-
-
r
ATP + L-malate + CoA
ADP + phosphate + L-malyl-CoA
-
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
r
ATP + D-malate + CoA
ADP + phosphate + D-malyl-CoA
-
-
-
r
ATP + itaconate + CoA
ADP + phosphate + itaconyl-CoA
-
-
-
r
ATP + L-malate + CoA
ADP + phosphate + L-malyl-CoA
-
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
r
additional information
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additional information
?
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substrate specificity, overview. Besides the preference for the physiological substrates succinate, itaconate, ATP, and CoA, high enzyme activity is additionally determined for both enantiomeric forms of malate, amounting to 10-21% of the activity with succinate, strong resemblance of SucCD to L-malate-CoA ligase, EC 6.2.1.9. No activity with sulfosuccinate, mercaptosuccinate, tartrate, acetate, butyrate, propionate, levulinate, valerate, malonate, glutarate, adipate, fumarate, maleate, and 2,2'-thiodiacetate
-
-
?
additional information
?
-
substrate specificity, overview. Besides the preference for the physiological substrates succinate, itaconate, ATP, and CoA, high enzyme activity is additionally determined for both enantiomeric forms of malate, amounting to 10-21% of the activity with succinate, strong resemblance of SucCD to L-malate-CoA ligase, EC 6.2.1.9. No activity with sulfosuccinate, mercaptosuccinate, tartrate, acetate, butyrate, propionate, levulinate, valerate, malonate, glutarate, adipate, fumarate, maleate, and 2,2'-thiodiacetate
-
-
?
additional information
?
-
-
substrate specificity, overview. Besides the preference for the physiological substrates succinate, itaconate, ATP, and CoA, high enzyme activity is additionally determined for both enantiomeric forms of malate, amounting to 10-21% of the activity with succinate, strong resemblance of SucCD to L-malate-CoA ligase, EC 6.2.1.9. No activity with sulfosuccinate, mercaptosuccinate, tartrate, acetate, butyrate, propionate, levulinate, valerate, malonate, glutarate, adipate, fumarate, maleate, and 2,2'-thiodiacetate
-
-
?
additional information
?
-
substrate specificity, overview. Besides the preference for the physiological substrates succinate, itaconate, ATP, and CoA, high enzyme activity is additionally determined for both enantiomeric forms of malate, amounting to 10-21% of the activity with succinate, strong resemblance of SucCD to L-malate-CoA ligase, EC 6.2.1.9. No activity with sulfosuccinate, mercaptosuccinate, tartrate, acetate, butyrate, propionate, levulinate, valerate, malonate, glutarate, adipate, fumarate, maleate, and 2,2'-thiodiacetate
-
-
?
additional information
?
-
substrate specificity, overview. Besides the preference for the physiological substrates succinate, itaconate, ATP, and CoA, high enzyme activity is additionally determined for both enantiomeric forms of malate, amounting to 10-21% of the activity with succinate, strong resemblance of SucCD to L-malate-CoA ligase, EC 6.2.1.9. No activity with sulfosuccinate, mercaptosuccinate, tartrate, acetate, butyrate, propionate, levulinate, valerate, malonate, glutarate, adipate, fumarate, maleate, and 2,2'-thiodiacetate
-
-
?
additional information
?
-
-
substrate specificity, overview. Besides the preference for the physiological substrates succinate, itaconate, ATP, and CoA, high enzyme activity is additionally determined for both enantiomeric forms of malate, amounting to 10-21% of the activity with succinate, strong resemblance of SucCD to L-malate-CoA ligase, EC 6.2.1.9. No activity with sulfosuccinate, mercaptosuccinate, tartrate, acetate, butyrate, propionate, levulinate, valerate, malonate, glutarate, adipate, fumarate, maleate, and 2,2'-thiodiacetate
-
-
?
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0.241
ATP
recombinant enzyme, pH 7.4, 30°C
0.004
CoA
recombinant enzyme, pH 7.4, 30°C
4.243
D-malate
recombinant enzyme, pH 7.4, 30°C
1.509
Itaconate
recombinant enzyme, pH 7.4, 30°C
3.27
L-malate
recombinant enzyme, pH 7.4, 30°C
0.157
succinate
recombinant enzyme, pH 7.4, 30°C
0.241
ATP
recombinant enzyme, pH 7.4, 30°C
0.004
CoA
recombinant enzyme, pH 7.4, 30°C
4.243
D-malate
recombinant enzyme, pH 7.4, 30°C
1.509
Itaconate
recombinant enzyme, pH 7.4, 30°C
3.27
L-malate
recombinant enzyme, pH 7.4, 30°C
0.157
succinate
recombinant enzyme, pH 7.4, 30°C
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3.6
ATP
recombinant enzyme, pH 7.4, 30°C
1.6
CoA
recombinant enzyme, pH 7.4, 30°C
1.7
D-malate
recombinant enzyme, pH 7.4, 30°C
0.5
Itaconate
recombinant enzyme, pH 7.4, 30°C
1.1
L-malate
recombinant enzyme, pH 7.4, 30°C
2.7
succinate
recombinant enzyme, pH 7.4, 30°C
3.6
ATP
recombinant enzyme, pH 7.4, 30°C
1.6
CoA
recombinant enzyme, pH 7.4, 30°C
1.7
D-malate
recombinant enzyme, pH 7.4, 30°C
0.5
Itaconate
recombinant enzyme, pH 7.4, 30°C
1.1
L-malate
recombinant enzyme, pH 7.4, 30°C
2.7
succinate
recombinant enzyme, pH 7.4, 30°C
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14.8
ATP
recombinant enzyme, pH 7.4, 30°C
372.3
CoA
recombinant enzyme, pH 7.4, 30°C
0.4
D-malate
recombinant enzyme, pH 7.4, 30°C
3.1
Itaconate
recombinant enzyme, pH 7.4, 30°C
0.3
L-malate
recombinant enzyme, pH 7.4, 30°C
17.2
succinate
recombinant enzyme, pH 7.4, 30°C
14.8
ATP
recombinant enzyme, pH 7.4, 30°C
372.3
CoA
recombinant enzyme, pH 7.4, 30°C
0.4
D-malate
recombinant enzyme, pH 7.4, 30°C
3.1
Itaconate
recombinant enzyme, pH 7.4, 30°C
0.3
L-malate
recombinant enzyme, pH 7.4, 30°C
17.2
succinate
recombinant enzyme, pH 7.4, 30°C
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Nolte, J.C.; Schuermann, M.; Schepers, C.L.; Vogel, E.; Wuebbeler, J.H.; Steinbuechel, A.
Novel characteristics of succinate coenzyme A (succinate-CoA) ligases: conversion of malate to malyl-CoA and CoA-thioester formation of succinate analogues in vitro
Appl. Environ. Microbiol.
80
166-176
2014
Escherichia coli K-12 (P0A836), Escherichia coli K-12 (P0AGE9), Alcanivorax borkumensis (Q0VPF7), Alcanivorax borkumensis (Q0VPF8), Alcanivorax borkumensis, Advenella mimigardefordensis (W0PAN5), Advenella mimigardefordensis (W0PFR9), Advenella mimigardefordensis, Alcanivorax borkumensis SK2 (Q0VPF7), Alcanivorax borkumensis SK2 (Q0VPF8), Alcanivorax borkumensis SK2, Advenella mimigardefordensis DPN7 (W0PAN5), Advenella mimigardefordensis DPN7 (W0PFR9), Escherichia coli K-12 BL21 (P0A836), Escherichia coli K-12 BL21 (P0AGE9)
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