Information on EC 6.2.1.48 - carnitine-CoA ligase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
6.2.1.48
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RECOMMENDED NAME
GeneOntology No.
carnitine-CoA ligase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + L-carnitine + CoA = AMP + diphosphate + L-carnitinyl-CoA
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
L-carnitine degradation I
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carnitine metabolism
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SYSTEMATIC NAME
IUBMB Comments
L-carnitine:CoA ligase (AMP-forming)
The enzyme, originally characterized from the bacterium Escherichia coli, can catalyse the transfer of CoA to L-carnitine, crotonobetaine and gamma-butyrobetaine. In vitro the enzyme also exhibits the activity of EC 2.8.3.21, L-carnitine CoA-transferase.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + crotonobetaine + CoA
AMP + diphosphate + crotonobetainyl-CoA
show the reaction diagram
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?, ir
ATP + D-carnitine + CoA
AMP + diphosphate + d-carnitinyl-CoA
show the reaction diagram
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?, ir
ATP + gamma-butyrobetaine + CoA
AMP + diphosphate + gamma-butyrobetainyl-CoA
show the reaction diagram
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?, ir
ATP + L-carnitine + CoA
AMP + diphosphate + L-carnitinyl-CoA
show the reaction diagram
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?, ir
additional information
?
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no substrate: glycinebetaine, butanoate, crotonate, gamma-amino-butanoate and gamma-amino-3-hydroxybutanoate. CaiC exhibits an in vitro CoA-transferase-like activity
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + L-carnitine + CoA
AMP + diphosphate + L-carnitinyl-CoA
show the reaction diagram
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ir
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli; expression in Escherichia coli
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
the caiTABCDE operon is transcribed during anaerobic growth in the presence of carnitine
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