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Information on EC 6.2.1.3 - long-chain-fatty-acid-CoA ligase
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6.2.1.3 long-chain-fatty-acid-CoA ligaseIUBMB Comments
Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. The liver enzyme acts on acids from C6 to C20; that from brain shows high activity up to C24.
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Word Map
- 6.2.1.3
- peroxisome
- triglyceride
- palmitate
- adipose
-
acsls
-
ppars
- phospholipid
- cholesterol
- adipocytes
- obesity
-
arachidonic
- lipoprotein
- carnitine
- triacylglycerols
-
fatps
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beta-oxidation
-
proliferator-activated
- lipase
- acyltransferase
- droplet
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polyunsaturated
- triacsin
- translocase
-
high-fat
- palmitoyltransferase
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lipogenesis
- oleate
- diacylglycerol
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lipolysis
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lcfas
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docosahexaenoic
- steatosis
- esterification
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ferroptosis
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palmitoylation
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medium-chain
- adrenoleukodystrophy
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fabppm
- ichthyosis
- pparalpha
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lipotoxicity
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l-fabp
-
very-long-chain
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lignoceric
- arachidonoyl-coa
- coash
-
npc1l1
- cutin
- acaca
-
perilipin
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
acsl1, fatp4, fatty acid transport protein, acsl3, acsl5, long-chain acyl-coa synthetase, fatty acyl-coa synthetase, acsl6, fatp2, acyl-coa synthetase long-chain, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ACS3
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Acyl coenzyme A synthetase
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Acyl-activating enzyme
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Acyl-CoA ligase
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Acyl-CoA synthetase
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Acyl-CoA synthetase 3
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Acyl-coenzyme A ligase
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FAA1
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Fatty acid CoA ligase
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Fatty acid thiokinase (long chain)
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Fatty acyl-coenzyme A synthetase
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Fatty-acyl-CoA ligase
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LACS
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LCFA synthetase
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Long chain fatty acyl CoA ligase
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Long chain fatty acyl-CoA synthetase
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Long-chain acyl CoA synthetase
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Long-chain acyl-CoA synthetase I
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Long-chain acyl-CoA synthetase II
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Long-chain acyl-coenzyme A synthetase
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Long-chain fatty acyl coenzyme A synthetase
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mACS4
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Oleoyl-CoA synthetase
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Palmitoyl coenzyme A synthetase
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Palmitoyl-CoA ligase
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Palmityl-coenzyme A synthetase
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Pristanoyl-CoA synthetase
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Stearoyl-CoA synthetase
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Thiokinase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Acid-thiol ligation
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Phosphorylation
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PATHWAY SOURCE
PATHWAYS
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-, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -
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SYSTEMATIC NAME
IUBMB Comments
long-chain fatty acid:CoA ligase (AMP-forming)
Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. The liver enzyme acts on acids from C6 to C20; that from brain shows high activity up to C24.
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CAS REGISTRY NUMBER
COMMENTARY
9013-18-7
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
Extracellular Acidosis Modulates the Expression of Epithelial-Mesenchymal Transition (EMT) Markers and Adhesion of Epithelial and Tumor Cells.
Acidosis
Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions.
Acquired Immunodeficiency Syndrome
Preservation of Acyl Coenzyme A Attenuates Pathological and Metabolic Cardiac Remodeling Through Selective Lipid Trafficking.
Adenocarcinoma
Impaired expression of acyl-CoA synthetase 5 in sporadic colorectal adenocarcinomas.
Adenocarcinoma
Low acyl-CoA synthetase 5 expression in colorectal carcinomas is prognostic for early tumour recurrence.
Adenocarcinoma of Lung
Roles of acyl-CoA synthetase long-chain family member 5 and colony stimulating factor 2 in inhibition of palmitic or stearic acids in lung cancer cell proliferation and metabolism.
Adrenoleukodystrophy
A very long-chain acyl-CoA synthetase-deficient mouse and its relevance to X-linked adrenoleukodystrophy.
Adrenoleukodystrophy
Adrenoleukodystrophy protein enhances association of very long-chain acyl-coenzyme A synthetase with the peroxisome.
Adrenoleukodystrophy
Adrenoleukodystrophy: impaired oxidation of fatty acids due to peroxisomal lignoceroyl-CoA ligase deficiency.
Adrenoleukodystrophy
cDNA cloning and mRNA distribution of a mouse very long-chain acyl-CoA synthetase.
Adrenoleukodystrophy
Disruption of the Saccharomyces cerevisiae FAT1 gene decreases very long-chain fatty acyl-CoA synthetase activity and elevates intracellular very long-chain fatty acid concentrations.
Adrenoleukodystrophy
Expression of an acyl-CoA synthetase, lipidosin, in astrocytes of the murine brain and its up-regulation during remyelination following cuprizone-induced demyelination.
Adrenoleukodystrophy
Lessons from the gonadotropin-regulated long chain acyl-CoA synthetase (GR-LACS) null mouse model: a role in steroidogenesis, but not result in X-ALD phenotype.
Adrenoleukodystrophy
Molecular organization of peroxisomal enzymes: protein-protein interactions in the membrane and in the matrix.
Adrenoleukodystrophy
Mouse very long-chain acyl-CoA synthetase in X-linked adrenoleukodystrophy.
Adrenoleukodystrophy
Peroxisomal activation of long- and very long-chain fatty acids in the yeast Pichia pastoris.
Adrenoleukodystrophy
Peroxisomal fatty acid beta-oxidation in relation to the accumulation of very long chain fatty acids in cultured skin fibroblasts from patients with Zellweger syndrome and other peroxisomal disorders.
Adrenoleukodystrophy
Prenatal diagnosis of Zellweger syndrome by measurement of very long chain fatty acid (C26:0) beta-oxidation in cultured chorionic villous fibroblasts: implications for early diagnosis of other peroxisomal disorders.
Adrenoleukodystrophy
X-linked adrenoleukodystrophy: identification of the primary defect at the level of a deficient peroxisomal very long chain fatty acyl-CoA synthetase using a newly developed method for the isolation of peroxisomes from skin fibroblasts.
Adrenoleukodystrophy
X-linked adrenoleukodystrophy: role of very long-chain acyl-CoA synthetases.
Adrenoleukodystrophy
[Examination of very long chain fatty acids in diagnosis of x-linked adrenoleukodystrophy]
Amyotrophic Lateral Sclerosis
A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis.
Asthma
Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma.
Atherosclerosis
Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1.
Atherosclerosis
Genetic association of long-chain acyl-CoA synthetase 1 variants with fasting glucose, diabetes, and subclinical atherosclerosis.
Atherosclerosis
High expression of long chain acyl-coenzyme A synthetase 1 in peripheral blood may be a molecular marker for assessing the risk of acute myocardial infarction.
Atherosclerosis
Inflammation and diabetes-accelerated atherosclerosis: myeloid cell mediators.
Atherosclerosis
Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis.
Blindness
Inverse correlation between fatty acid transport protein 4 and vision in Leber congenital amaurosis associated with RPE65 mutation.
Brain Neoplasms
Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicity.
Breast Neoplasms
ACSL1 Regulates TNF?-Induced GM-CSF Production by Breast Cancer MDA-MB-231 Cells.
Breast Neoplasms
Association of long-chain acyl-coenzyme A synthetase 5 expression in human breast cancer by estrogen receptor status and its clinical significance.
Breast Neoplasms
Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer.
Breast Neoplasms
Evaluation of long-chain acyl-coenzyme A synthetase 4 (ACSL4) expression in human breast cancer.
Breast Neoplasms
Expression of Long-chain Fatty Acyl-CoA Synthetase 4 in Breast and Prostate Cancers Is Associated with Sex Steroid Hormone Receptor Negativity.
Breast Neoplasms
Fatty acid-binding protein 5 (FABP5) promotes lipolysis of lipid droplets, de novo fatty acid (FA) synthesis and activation of nuclear factor-kappa B (NF-?B) signaling in cancer cells.
Breast Neoplasms
Functional interaction between acyl-CoA synthetase 4, lipooxygenases and cyclooxygenase-2 in the aggressive phenotype of breast cancer cells.
Breast Neoplasms
HBXIP up-regulates ACSL1 through activating transcriptional factor Sp1 in breast cancer.
Breast Neoplasms
Long chain fatty Acyl-CoA synthetase 4 is a biomarker for and mediator of hormone resistance in human breast cancer.
Breast Neoplasms
LPS Induces GM-CSF Production by Breast Cancer MDA-MB-231 Cells via Long-Chain Acyl-CoA Synthetase 1.
Breast Neoplasms
Regulatory mechanisms leading to differential Acyl-CoA synthetase 4 expression in breast cancer cells.
Breast Neoplasms
Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer.
Breast Neoplasms
The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells.
Carcinogenesis
Differentially localized acyl-CoA synthetase 4 isoenzymes mediate the metabolic channeling of fatty acids towards phosphatidylinositol.
Carcinogenesis
Fatty acid activation in carcinogenesis and cancer development: Essential roles of long-chain acyl-CoA synthetases.
Carcinogenesis
Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis.
Carcinogenesis
High Membranous Expression of Fatty Acid Transport Protein 4 Is Associated with Tumorigenesis and Tumor Progression in Clear Cell Renal Cell Carcinoma.
Carcinogenesis
Involvement of fatty acid-CoA ligase 4 in hepatocellular carcinoma growth: roles of cyclic AMP and p38 mitogen-activated protein kinase.
Carcinogenesis
Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicity.
Carcinogenesis
Low acyl-CoA synthetase 5 expression in colorectal carcinomas is prognostic for early tumour recurrence.
Carcinogenesis
TP53 status regulates ACSL5-induced expression of mitochondrial mortalin in enterocytes and colorectal adenocarcinomas.
Carcinoma
High Membranous Expression of Fatty Acid Transport Protein 4 Is Associated with Tumorigenesis and Tumor Progression in Clear Cell Renal Cell Carcinoma.
Carcinoma
Levels of acyl-coenzyme A synthetase 5 in urothelial cells and corresponding neoplasias reflect cellular differentiation.
Carcinoma, Endometrioid
Expression of acyl-CoA synthetase 5 in human endometrium and in endometrioid adenocarcinomas.
Carcinoma, Hepatocellular
Activation of AMP-kinase by Policosanol Requires Peroxisomal Metabolism.
Carcinoma, Hepatocellular
Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner.
Carcinoma, Hepatocellular
Fatty acid-CoA ligase 4 is overexpressed in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Functional interaction between acyl-CoA synthetase 4, lipooxygenases and cyclooxygenase-2 in the aggressive phenotype of breast cancer cells.
Carcinoma, Hepatocellular
Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases.
Carcinoma, Hepatocellular
Involvement of fatty acid-CoA ligase 4 in hepatocellular carcinoma growth: roles of cyclic AMP and p38 mitogen-activated protein kinase.
Carcinoma, Hepatocellular
Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells.
Carcinoma, Hepatocellular
Long Noncoding RNA HULC Modulates Abnormal Lipid Metabolism in Hepatoma Cells through an miR-9-Mediated RXRA Signaling Pathway.
Carcinoma, Hepatocellular
MiR-205 modulates abnormal lipid metabolism of hepatoma cells via targeting acyl-CoA synthetase long-chain family member 1 (ACSL1) mRNA.
Carcinoma, Hepatocellular
Overexpression of acyl-CoA synthetase-1 increases lipid deposition in hepatic (HepG2) cells and rodent liver in vivo.
Carcinoma, Hepatocellular
Overexpression of CD36 and acyl-CoA synthetases FATP2, FATP4 and ACSL1 increases fatty acid uptake in human hepatoma cells.
Carcinoma, Hepatocellular
Rat long chain acyl-CoA synthetase 5 increases fatty acid uptake and partitioning to cellular triacylglycerol in McArdle-RH7777 cells.
Carcinoma, Hepatocellular
Regulation of cell growth by fatty acid-CoA ligase 4 in human hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
The functional interaction between Acyl-CoA synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth: a novel therapeutic target.
Carcinoma, Non-Small-Cell Lung
ACSL family: The regulatory mechanisms and therapeutic implications in cancer.
Carcinoma, Non-Small-Cell Lung
Metabolic enzyme ACSL3 is a prognostic biomarker and correlates with anticancer effectiveness of statins in non-small cell lung cancer.
Carcinoma, Renal Cell
High Membranous Expression of Fatty Acid Transport Protein 4 Is Associated with Tumorigenesis and Tumor Progression in Clear Cell Renal Cell Carcinoma.
Cardiomegaly
Cardiac energy dependence on glucose increases metabolites related to glutathione and activates metabolic genes controlled by mechanistic target of rapamycin.
Cardiomegaly
Deficiency of cardiac Acyl-CoA synthetase-1 induces diastolic dysfunction, but pathologic hypertrophy is reversed by rapamycin.
Cardiomegaly
Metabolic activation and major protein target of a 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonist.
Cardiomegaly
Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophy.
Cardiomyopathies
DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicity.
Cardiomyopathies
Fatty acid transport proteins in disease: New insights from invertebrate models.
Cardiomyopathies
Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy.
Cardiovascular Diseases
Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan.
Cholangiocarcinoma
Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases.
Cholelithiasis
Prevention of gallbladder hypomotility via FATP2 inhibition protects from lithogenic diet-induced cholelithiasis.
Colitis, Ulcerative
Alterations in intestinal fatty acid metabolism in inflammatory bowel disease.
Colonic Neoplasms
3'UTR Polymorphism in ACSL1 Gene Correlates with Expression Levels and Poor Clinical Outcome in Colon Cancer Patients.
Colonic Neoplasms
ColoLipidGene: signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients.
Colonic Neoplasms
Involvement of fatty acid-CoA ligase 4 in hepatocellular carcinoma growth: roles of cyclic AMP and p38 mitogen-activated protein kinase.
Colonic Neoplasms
Overexpression of DHX32 contributes to the growth and metastasis of colorectal cancer.
Colonic Neoplasms
Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer.
Colorectal Neoplasms
ACSL family: The regulatory mechanisms and therapeutic implications in cancer.
Colorectal Neoplasms
Acyl-CoA Synthetase 5 Promotes the Growth and Invasion of Colorectal Cancer Cells.
Colorectal Neoplasms
Low acyl-CoA synthetase 5 expression in colorectal carcinomas is prognostic for early tumour recurrence.
Colorectal Neoplasms
miR-497-5p mediates starvation-induced death in colon cancer cells by targeting acyl-CoA synthetase-5 and modulation of lipid metabolism.
Coma
Analysis of the role of COMATOSE and peroxisomal beta-oxidation in the determination of germination potential in Arabidopsis.
Coma
Arabidopsis SFAR4 is a novel GDSL-type esterase involved in fatty acid degradation and glucose tolerance.
Coronary Artery Disease
Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan.
Coronary Disease
Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan.
Crohn Disease
Expression of acyl-CoA synthetase 5 reflects the state of villus architecture in human small intestine.
Dehydration
Epidermal hyperproliferation in mice lacking fatty acid transport protein 4 (FATP4) involves ectopic EGF receptor and STAT3 signaling.
Dehydration
Fatty acid transport protein 1 can compensate for fatty acid transport protein 4 in the developing mouse epidermis.
Dehydration
Keratinocyte-specific expression of fatty acid transport protein 4 rescues the wrinkle-free phenotype in Slc27a4/Fatp4 mutant mice.
Dehydration
Requirement of fatty acid transport protein 4 for development, maturation, and function of sebaceous glands in a mouse model of ichthyosis prematurity syndrome.
Demyelinating Diseases
Expression of an acyl-CoA synthetase, lipidosin, in astrocytes of the murine brain and its up-regulation during remyelination following cuprizone-induced demyelination.
Diabetes Mellitus
Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan.
Diabetes Mellitus, Type 1
Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1.
Diabetes Mellitus, Type 1
Inflammation and diabetes-accelerated atherosclerosis: myeloid cell mediators.
Diabetes Mellitus, Type 2
Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan.
Diabetes Mellitus, Type 2
Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity.
Diabetes Mellitus, Type 2
Skeletal muscle fatty acid transporter protein expression in type 2 diabetes patients compared with overweight, sedentary men and age-matched, endurance-trained cyclists.
Diabetes Mellitus, Type 2
The type 2 diabetes presumed causal variant within TCF7L2 resides in an element that controls the expression of ACSL5.
Diabetes, Gestational
Gestational diabetes mellitus decreases placental uptake of long-chain polyunsaturated fatty acids: involvement of long-chain acyl-CoA synthetase.
Diabetic Angiopathies
Inflammation and diabetes-accelerated atherosclerosis: myeloid cell mediators.
Diabetic Nephropathies
HMGB1 regulates ferroptosis through Nrf2 pathway in mesangial cells in response to high glucose.
Dyslipidemias
Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity.
Erythema
Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema.
Fatty Liver
Alteration of Hepatic Gene Expression along with the Inherited Phenotype of Acquired Fatty Liver in Chicken.
Fatty Liver
ApoB siRNA-induced Liver Steatosis is Resistant to Clearance by the Loss of Fatty Acid Transport Protein 5 (Fatp5).
Fatty Liver
Bile acids mediated potential functional interaction between FXR and FATP5 in the regulation of Lipid Metabolism.
Fatty Liver
Low Expression of Sirtuin 1 in the Dairy Cows with Mild Fatty Liver Alters Hepatic Lipid Metabolism.
Fatty Liver
Molecular cloning of the goose ACSL3 and ACSL5 coding domain sequences and their expression characteristics during goose fatty liver development.
Fatty Liver
Osthole improves fat milk-induced fatty liver in rats: modulation of hepatic PPAR-alpha/gamma-mediated lipogenic gene expression.
Fatty Liver
Prevention Mechanism of 2,3,5,4'-Tetrahydroxy-stilbene-2-O-?-D-glucoside on Lipid Accumulation in Steatosis Hepatic L-02 Cell.
Fatty Liver
Regular exposure to non-burning ultraviolet radiation reduces signs of non-alcoholic fatty liver disease in mature adult mice fed a high fat diet: results of a pilot study.
Fatty Liver
Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia.
Fatty Liver
[The expression and the significance of L-FABP and FATP4 in the development of nonalcoholic fatty liver disease in rats]
Fibrosarcoma
The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells.
Gallstones
Prevention of gallbladder hypomotility via FATP2 inhibition protects from lithogenic diet-induced cholelithiasis.
Glioblastoma
Very long-chain acyl-CoA synthetase 3 mediates onco-sphingolipid metabolism in malignant glioma.
Glioblastoma
Very long-chain acyl-CoA synthetase 3: overexpression and growth dependence in lung cancer.
Glioma
Acyl-CoA synthetase as a cancer survival factor: its inhibition enhances the efficacy of etoposide.
Glioma
Acyl-CoA synthetase VL3 knockdown inhibits human glioma cell proliferation and tumorigenicity.
Glioma
Fatty acid induced glioma cell growth is mediated by the acyl-CoA synthetase 5 gene located on chromosome 10q25.1-q25.2, a region frequently deleted in malignant gliomas.
Glioma
Integrated metabolomics and lipidomics analyses reveal metabolic reprogramming in human glioma with IDH1 mutation.
Glioma
Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions.
Glioma
Very long-chain acyl-CoA synthetase 3 mediates onco-sphingolipid metabolism in malignant glioma.
Glioma
Very long-chain acyl-CoA synthetase 3: overexpression and growth dependence in lung cancer.
Granuloma
Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism.
Hepatitis B
MiR-205 modulates abnormal lipid metabolism of hepatoma cells via targeting acyl-CoA synthetase long-chain family member 1 (ACSL1) mRNA.
Hypercholesterolemia
Inhibition of miR-27b Regulates Lipid Metabolism in Skeletal Muscle of Obese Rats During Hypoxic Exercise by Increasing PPAR? Expression.
Hyperglycemia
The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise.
Hyperglycemia
Transcriptome Changes of Skeletal Muscle RNA-Seq Speculates the Mechanism of Postprandial Hyperglycemia in Diabetic Goto-Kakizaki Rats During the Early Stage of T2D.
Hyperlipidemias
Elevation of blood lipids in hepatocyte-specific fatty acid transport 4-deficient mice fed with high glucose diets.
Hyperlipidemias
The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise.
Hypersensitivity
Long-Chain acyl-CoA Synthetase LACS2 Contributes to Submergence Tolerance by Modulating Cuticle Permeability in Arabidopsis.
Hyperthyroidism
Effects of experimental hypo- and hyperthyroidism on hepatic long-chain fatty acyl-CoA synthetase and hydrolase.
Hypertriglyceridemia
Transcriptional activation of hepatic ACSL3 and ACSL5 by oncostatin m reduces hypertriglyceridemia through enhanced beta-oxidation.
Hypertrophy, Left Ventricular
A variant in the heart-specific fatty acid transport protein 6 is associated with lower fasting and postprandial TAG, blood pressure and left ventricular hypertrophy.
Ichthyosis
A spontaneous Fatp4/Scl27a4 splice site mutation in a new murine model for congenital ichthyosis.
Ichthyosis
Epidermal hyperproliferation in mice lacking fatty acid transport protein 4 (FATP4) involves ectopic EGF receptor and STAT3 signaling.
Ichthyosis
FATP4 missense and nonsense mutations cause similar features in Ichthyosis Prematurity Syndrome.
Ichthyosis
Fatty acid transport protein 1 can compensate for fatty acid transport protein 4 in the developing mouse epidermis.
Ichthyosis
Fatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols.
Ichthyosis
Ichthyosis prematurity syndrome caused by a novel fatty acid transport protein 4 gene mutation in a German infant.
Ichthyosis
Ichthyosis prematurity syndrome caused by a novel missense mutation in FATP4 gene-a case report from India.
Ichthyosis
Ichthyosis prematurity syndrome in two Omani siblings, caused by homozygous c.1A > G mutation in the FATP4 gene.
Ichthyosis
Identification of novel FATP4 mutations in a Japanese patient with ichthyosis prematurity syndrome.
Ichthyosis
Impacts of deletion and ichthyosis prematurity syndrome-associated mutations in fatty acid transport protein 4 on the function of RPE65.
Ichthyosis
Interactions between FATP4 and ichthyin in epidermal lipid processing may provide clues to the pathogenesis of autosomal recessive congenital ichthyosis.
Ichthyosis
Mutations in the fatty acid transport protein 4 gene cause the ichthyosis prematurity syndrome.
Ichthyosis
Novel compound heterozygous FATP4 mutations caused ichthyosis prematurity syndrome in Spanish sisters.
Ichthyosis
Novel mutations in FATP4 gene in two families with ichthyosis prematurity syndrome.
Ichthyosis
Requirement of fatty acid transport protein 4 for development, maturation, and function of sebaceous glands in a mouse model of ichthyosis prematurity syndrome.
Ichthyosis
Role of fatty acid transporters in epidermis: Implications for health and disease.
Infections
Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice.
Infections
Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells.
Infections
Microarray analysis reveals the inhibition of intestinal expression of nutrient transporters in piglets infected with porcine epidemic diarrhea virus.
Infections
Modulation of triglyceride and cholesterol ester synthesis impairs assembly of infectious hepatitis C virus.
Infections
Reduction of serum free fatty acids and triglycerides by liver-targeted expression of long chain acyl-CoA synthetase 3.
Infertility
Activity of Long-Chain Acyl-CoA Synthetase Is Required for Maintaining Meiotic Arrest in Xenopus laevis.
Infertility, Male
Acyl-CoA synthetase 6 regulates long-chain polyunsaturated fatty acid composition of membrane phospholipids in spermatids and supports normal spermatogenic processes in mice.
Insulin Resistance
A null mutation in skeletal muscle FAT/CD36 reveals its essential role in insulin- and AICAR-stimulated fatty acid metabolism.
Insulin Resistance
ACSL1 Is Associated With Fetal Programming of Insulin Sensitivity and Cellular Lipid Content.
Insulin Resistance
Acyl CoA synthetase 5 (ACSL5) ablation in mice increases energy expenditure and insulin sensitivity and delays fat absorption.
Insulin Resistance
An Essential Role of the N-Terminal Region of ACSL1 in Linking Free Fatty Acids to Mitochondrial ?-Oxidation in C2C12 Myotubes.
Insulin Resistance
Effects of Periconception Cadmium and Mercury Co-Administration to Mice on Indices of Chronic Diseases in Male Offspring at Maturity.
Insulin Resistance
Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance.
Insulin Resistance
Fatty acid handling protein expression in adipose tissue, fatty acid composition of adipose tissue and serum, and markers of insulin resistance.
Insulin Resistance
Fatty Acid Transport Proteins: Targeting FATP2 as a Gatekeeper Involved in the Transport of Exogenous Fatty Acids.
Insulin Resistance
Functional analysis of long-chain acyl-coa synthetase 1 in 3T3-L1 adipocytes.
Insulin Resistance
Genetic and structural evaluation of fatty acid transport protein-4 in relation to markers of the insulin resistance syndrome.
Insulin Resistance
Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle.
Insulin Resistance
Increasing skeletal muscle fatty acid transport protein 1 (FATP1) targets fatty acids to oxidation and does not predispose mice to diet-induced insulin resistance.
Insulin Resistance
Palmitate activation by fatty acid transport protein 4 as a model system for hepatocellular apoptosis and steatosis.
Insulin Resistance
SUMO-Specific Protease 2 (SENP2) Is an Important Regulator of Fatty Acid Metabolism in Skeletal Muscle.
Intellectual Disability
A third MRX family (MRX68) is the result of mutation in the long chain fatty acid-CoA ligase 4 (FACL4) gene: proposal of a rapid enzymatic assay for screening mentally retarded patients.
Intellectual Disability
Acsl, the Drosophila ortholog of intellectual-disability-related ACSL4, inhibits synaptic growth by altered lipids.
Intellectual Disability
dAcsl, the Drosophila ortholog of acyl-CoA synthetase long-chain family member 3 and 4, inhibits synapse growth by attenuating bone morphogenetic protein signaling via endocytic recycling.
Intellectual Disability
Drosophila homolog of the intellectual disability-related long-chain acyl-CoA synthetase 4 is required for neuroblast proliferation.
Intellectual Disability
FACL4, a new gene encoding long-chain acyl-CoA synthetase 4, is deleted in a family with Alport syndrome, elliptocytosis, and mental retardation.
Intellectual Disability
No association between polymorphisms in the FACL4 (fatty acid-CoA ligase 4) gene and nonspecific mental retardation in Qin-Ba mountain region of China.
Ischemic Stroke
Inhibition of Acyl-CoA Synthetase Long-Chain Family Member 4 Facilitates Neurological Recovery After Stroke by Regulation Ferroptosis.
Leber Congenital Amaurosis
Inverse correlation between fatty acid transport protein 4 and vision in Leber congenital amaurosis associated with RPE65 mutation.
Leiomyosarcoma
The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells.
Leukemia
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Leukemia, Lymphoid
Eight genes are highly associated with BMD variation in postmenopausal Caucasian women.
Leukemia, Myeloid, Acute
Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer.
Leukemia, T-Cell
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Lipid Metabolism Disorders
Generation of Acsl4 Gene Knockout Mouse Model by CRISPR/Cas9-Mediated Genome Engineering.
Liver Cirrhosis
MicroRNA-34a Promotes Hepatic Stellate Cell Activation via Targeting ACSL1.
Liver Cirrhosis
MiR-34c promotes hepatic stellate cell activation and Liver Fibrogenesis by suppressing ACSL1 expression.
Liver Diseases
Bile acids mediated potential functional interaction between FXR and FATP5 in the regulation of Lipid Metabolism.
Liver Diseases
FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase.
Liver Diseases
Prevention Mechanism of 2,3,5,4'-Tetrahydroxy-stilbene-2-O-?-D-glucoside on Lipid Accumulation in Steatosis Hepatic L-02 Cell.
Liver Diseases
Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia.
Liver Diseases
TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation.
Liver Diseases
[The expression and the significance of L-FABP and FATP4 in the development of nonalcoholic fatty liver disease in rats]
Liver Neoplasms
MiR-205 modulates abnormal lipid metabolism of hepatoma cells via targeting acyl-CoA synthetase long-chain family member 1 (ACSL1) mRNA.
Liver Neoplasms
The effect of fatty acid-CoA ligase 4 on the growth of hepatic cancer cells.
long-chain-fatty-acid-coa ligase deficiency
Abnormal uterus with polycysts, accumulation of uterine prostaglandins, and reduced fertility in mice heterozygous for acyl-CoA synthetase 4 deficiency.
long-chain-fatty-acid-coa ligase deficiency
Acyl-CoA Synthetase 1 is Induced by Gram-Negative Bacteria and Lipopolysaccharide and is Required for Phospholipid Turnover in Stimulated Macrophages.
long-chain-fatty-acid-coa ligase deficiency
Adipocyte-specific inactivation of the acyl-CoA-synthetase fatty acid transport protein 4 (Fatp4) in mice causes adipose hypertrophy and alterations in metabolism of complex lipids under high-fat diet.
long-chain-fatty-acid-coa ligase deficiency
Compartmentalized acyl-CoA metabolism in skeletal muscle regulates systemic glucose homeostasis.
long-chain-fatty-acid-coa ligase deficiency
Defective fatty acid oxidation in mice with muscle-specific acyl-CoA synthetase 1 deficiency increases amino acid use and impairs muscle function.
long-chain-fatty-acid-coa ligase deficiency
Disturbed epidermal structure in mice with temporally controlled fatp4 deficiency.
long-chain-fatty-acid-coa ligase deficiency
Fatty acid transport protein 4 is the principal very long chain fatty acyl-CoA synthetase in skin fibroblasts.
long-chain-fatty-acid-coa ligase deficiency
Fatty acid transporters in skin development, function and disease.
long-chain-fatty-acid-coa ligase deficiency
Identification of a novel function of hepatic long-chain acyl-CoA synthetase-1 (ACSL1) in bile acid synthesis and its regulation by bile acid-activated farnesoid X receptor.
long-chain-fatty-acid-coa ligase deficiency
Methionine- and Choline-Deficient Diet Enhances Adipose Lipolysis and Leptin Release in aP2-Cre Fatp4-Knockout Mice.
long-chain-fatty-acid-coa ligase deficiency
Mutations in the fatty acid transport protein 4 gene cause the ichthyosis prematurity syndrome.
Lung Neoplasms
Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis.
Lung Neoplasms
Metabolic enzyme ACSL3 is a prognostic biomarker and correlates with anticancer effectiveness of statins in non-small cell lung cancer.
Lung Neoplasms
MicroRNA-Dependent Regulation of Transcription in Non-Small Cell Lung Cancer.
Lung Neoplasms
Roles of acyl-CoA synthetase long-chain family member 5 and colony stimulating factor 2 in inhibition of palmitic or stearic acids in lung cancer cell proliferation and metabolism.
Lung Neoplasms
Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer.
Lung Neoplasms
The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer.
Lung Neoplasms
Very long-chain acyl-CoA synthetase 3: overexpression and growth dependence in lung cancer.
Lupus Erythematosus, Systemic
High ACSL5 transcript levels associate with systemic lupus erythematosus and apoptosis in Jurkat T lymphocytes and peripheral blood cells.
Melanoma
Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2.
Melanoma
Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer.
Mental Retardation, X-Linked
A third MRX family (MRX68) is the result of mutation in the long chain fatty acid-CoA ligase 4 (FACL4) gene: proposal of a rapid enzymatic assay for screening mentally retarded patients.
Mental Retardation, X-Linked
dAcsl, the Drosophila ortholog of acyl-CoA synthetase long-chain family member 3 and 4, inhibits synapse growth by attenuating bone morphogenetic protein signaling via endocytic recycling.
Mental Retardation, X-Linked
FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation.
Metabolic Syndrome
A Promoter Polymorphism in the Liver-specific Fatty Acid Transport Protein 5 is Associated with Features of the Metabolic Syndrome and Steatosis.
Metabolic Syndrome
Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan.
Metabolic Syndrome
Gene-nutrient interactions with dietary fat modulate the association between genetic variation of the ACSL1 gene and metabolic syndrome.
Migraine Disorders
A splice variant in the ACSL5 gene relates migraine with fatty acid activation in mitochondria.
Multiple Myeloma
Translocation t(11;14) (q13;q32) and genomic imbalances in multi-ethnic multiple myeloma patients: a Malaysian study.
Muscle Weakness
Defective fatty acid oxidation in mice with muscle-specific acyl-CoA synthetase 1 deficiency increases amino acid use and impairs muscle function.
Myotoxicity
Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis.
Neoplasm Metastasis
Characterization of the mouse promoter region of the acyl-CoA synthetase 4 gene: Role of Sp1 and CREB.
Neoplasm Metastasis
Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases.
Neoplasm Metastasis
Metabolic reprogramming of ovarian cancer involves ACSL1-mediated metastasis stimulation through upregulated protein myristoylation.
Neoplasm Metastasis
Upregulation of Fatty Acid Transporters is Associated With Tumor Progression in Non-Muscle-Invasive Bladder Cancer.
Neoplasms
3'UTR Polymorphism in ACSL1 Gene Correlates with Expression Levels and Poor Clinical Outcome in Colon Cancer Patients.
Neoplasms
ACSL1 Regulates TNF?-Induced GM-CSF Production by Breast Cancer MDA-MB-231 Cells.
Neoplasms
ACSL3-PAI-1 signaling axis mediates tumor-stroma cross-talk promoting pancreatic cancer progression.
Neoplasms
Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells Upon Endoplasmic Reticulum Stress.
Neoplasms
Acyl-CoA Synthetase 5 Promotes the Growth and Invasion of Colorectal Cancer Cells.
Neoplasms
Acyl-CoA synthetase-4, a new regulator of mTOR and a potential therapeutic target for enhanced estrogen receptor function in receptor-positive and -negative breast cancer.
Neoplasms
BMP4 Upregulation Is Associated with Acquired Drug Resistance and Fatty Acid Metabolism in EGFR-Mutant Non-Small-Cell Lung Cancer Cells.
Neoplasms
Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan.
Neoplasms
Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2.
Neoplasms
Characterization of the mouse promoter region of the acyl-CoA synthetase 4 gene: Role of Sp1 and CREB.
Neoplasms
Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer.
Neoplasms
Development and validation of a lipogenic genes panel for diagnosis and recurrence of colorectal cancer.
Neoplasms
Expression and vitamin D(3) regulation of long-chain fatty-acid-CoA ligase 3 in human prostate cancer cells.
Neoplasms
Fatty acid activation in carcinogenesis and cancer development: Essential roles of long-chain acyl-CoA synthetases.
Neoplasms
Ferroptosis-Related Genes in Lung Adenocarcinoma: Prognostic Signature and Immune, Drug Resistance, Mutation Analysis.
Neoplasms
Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1.
Neoplasms
High Membranous Expression of Fatty Acid Transport Protein 4 Is Associated with Tumorigenesis and Tumor Progression in Clear Cell Renal Cell Carcinoma.
Neoplasms
Identification of developmental competence-related genes in mature porcine oocytes.
Neoplasms
Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases.
Neoplasms
Integrated metabolomics and lipidomics analyses reveal metabolic reprogramming in human glioma with IDH1 mutation.
Neoplasms
Lack of association between certain candidate gene polymorphisms and the metabolic syndrome.
Neoplasms
Levels of acyl-coenzyme A synthetase 5 in urothelial cells and corresponding neoplasias reflect cellular differentiation.
Neoplasms
Long-Chain Acyl-CoA Synthetase 4-Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway-Independent Prostate Cancer.
Neoplasms
Long-chain fatty acyl-CoA synthetase 1 promotes prostate cancer progression by elevation of lipogenesis and fatty acid beta-oxidation.
Neoplasms
Low acyl-CoA synthetase 5 expression in colorectal carcinomas is prognostic for early tumour recurrence.
Neoplasms
Metabolic reprogramming of ovarian cancer involves ACSL1-mediated metastasis stimulation through upregulated protein myristoylation.
Neoplasms
Multigenerational maternal obesity increases the incidence of HCC in offspring via miR-27a-3p.
Neoplasms
New inhibitor targeting Acyl-CoA synthetase 4 reduces breast and prostate tumor growth, therapeutic resistance and steroidogenesis.
Neoplasms
Persistent activity modification of phosphatidate phosphohydrolase and fatty acyl-CoA synthetase on incubation of adipocytes with the tumour promoter 12-O-tetradecanoylphorbol 13-acetate.
Neoplasms
Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions.
Neoplasms
Regulation of ROS in myeloid-derived suppressor cells through targeting fatty acid transport protein 2 enhanced anti-PD-L1 tumor immunotherapy.
Neoplasms
Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer.
Neoplasms
Targeting Oct1 genomic function inhibits androgen receptor signaling and castration-resistant prostate cancer growth.
Neoplasms
The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells.
Neoplasms
The functional interaction between Acyl-CoA synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth: a novel therapeutic target.
Neoplasms
Upregulation of Fatty Acid Transporters is Associated With Tumor Progression in Non-Muscle-Invasive Bladder Cancer.
Neoplasms
Utilization of adipocyte-derived lipids and enhanced intracellular trafficking of fatty acids contribute to breast cancer progression.
Nephritis, Hereditary
FACL4, a new gene encoding long-chain acyl-CoA synthetase 4, is deleted in a family with Alport syndrome, elliptocytosis, and mental retardation.
Neuroblastoma
RNA interference of long-chain acyl-CoA synthetase 6 suppresses the neurite outgrowth of mouse neuroblastoma NB41A3 cells.
Neuroinflammatory Diseases
Acyl-CoA synthetase 6 is required for brain docosahexaenoic acid retention and neuroprotection during aging.
Non-alcoholic Fatty Liver Disease
Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Beneficial effects of neomangiferin on high fat diet-induced nonalcoholic fatty liver disease in rats.
Non-alcoholic Fatty Liver Disease
FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase.
Non-alcoholic Fatty Liver Disease
FATP2-targeted therapies - A role beyond fatty liver disease.
Non-alcoholic Fatty Liver Disease
Genome-wide analysis of DNA methylation in human peripheral leukocytes identifies potential biomarkers of nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Prevention Mechanism of 2,3,5,4'-Tetrahydroxy-stilbene-2-O-?-D-glucoside on Lipid Accumulation in Steatosis Hepatic L-02 Cell.
Non-alcoholic Fatty Liver Disease
Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia.
Non-alcoholic Fatty Liver Disease
TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation.
Non-alcoholic Fatty Liver Disease
[The expression and the significance of L-FABP and FATP4 in the development of nonalcoholic fatty liver disease in rats]
Obesity
Acute effects of epigallocatechin gallate from green tea on oxidation and tissue incorporation of dietary lipids in mice fed a high-fat diet.
Obesity
Acyl CoA synthetase 5 (ACSL5) ablation in mice increases energy expenditure and insulin sensitivity and delays fat absorption.
Obesity
Acyl-CoA synthetase long-chain 5 genotype is associated with body composition changes in response to lifestyle interventions in postmenopausal women with overweight and obesity: a genetic association study on cohorts Montréal-Ottawa New Emerging Team, and Complications Associated with Obesity.
Obesity
An Essential Role of the N-Terminal Region of ACSL1 in Linking Free Fatty Acids to Mitochondrial ?-Oxidation in C2C12 Myotubes.
Obesity
Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development.
Obesity
Diet and Exercise Training Influence Skeletal Muscle Long-Chain acyl-CoA Synthetases.
Obesity
Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance.
Obesity
Fatty acid transport protein-2 regulates glycemic control and diabetic kidney disease progression.
Obesity
Increased rates of fatty acid uptake and plasmalemmal fatty acid transporters in obese Zucker rats.
Obesity
Liver fatty acid-binding protein gene-ablated female mice exhibit increased age-dependent obesity.
Obesity
Long chain acyl CoA synthetase 1 and gelsolin are oppositely regulated in adipogenesis and lipogenesis.
Obesity
Mice deleted for Fatty Acid transport protein 5 have defective bile Acid conjugation and are protected from obesity.
Obesity
SUMO-Specific Protease 2 (SENP2) Is an Important Regulator of Fatty Acid Metabolism in Skeletal Muscle.
Obesity
The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise.
Obesity
Trans-resveratrol induces a potential anti-lipogenic effect in lipopolysaccharide-stimulated enterocytes.
Obesity, Abdominal
Fatty acid handling protein expression in adipose tissue, fatty acid composition of adipose tissue and serum, and markers of insulin resistance.
Ovarian Neoplasms
Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer.
Overweight
Acyl-CoA synthetase long-chain 5 genotype is associated with body composition changes in response to lifestyle interventions in postmenopausal women with overweight and obesity: a genetic association study on cohorts Montréal-Ottawa New Emerging Team, and Complications Associated with Obesity.
Overweight
Skeletal muscle fatty acid transporter protein expression in type 2 diabetes patients compared with overweight, sedentary men and age-matched, endurance-trained cyclists.
Pancreatic Neoplasms
LOX and ACSL5 as potential relapse markers for pancreatic cancer patients.
Peroxisomal Disorders
cDNA cloning and mRNA distribution of a mouse very long-chain acyl-CoA synthetase.
Photosensitivity Disorders
Photodynamic effects of antioxidant substituted porphyrin photosensitizers on gram-positive and -negative bacterial.
Poliomyelitis
Increased long chain acyl-Coa synthetase activity and fatty acid import is linked to membrane synthesis for development of picornavirus replication organelles.
Premature Birth
Fatty acid transport protein 1 can compensate for fatty acid transport protein 4 in the developing mouse epidermis.
Premature Birth
Requirement of fatty acid transport protein 4 for development, maturation, and function of sebaceous glands in a mouse model of ichthyosis prematurity syndrome.
Primary Ovarian Insufficiency
Activity of Long-Chain Acyl-CoA Synthetase Is Required for Maintaining Meiotic Arrest in Xenopus laevis.
Primary Ovarian Insufficiency
Acyl-CoA synthetase long-chain family member 6 is associated with premature ovarian failure.
Prostatic Neoplasms
A Role of the Heme Degradation Pathway in Shaping Prostate Inflammatory Responses and Lipid Metabolism.
Prostatic Neoplasms
Expression and vitamin D(3) regulation of long-chain fatty-acid-CoA ligase 3 in human prostate cancer cells.
Prostatic Neoplasms
Expression of Long-chain Fatty Acyl-CoA Synthetase 4 in Breast and Prostate Cancers Is Associated with Sex Steroid Hormone Receptor Negativity.
Prostatic Neoplasms
Long-Chain Acyl-CoA Synthetase 4-Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway-Independent Prostate Cancer.
Prostatic Neoplasms
Long-chain fatty acyl-CoA synthetase 1 promotes prostate cancer progression by elevation of lipogenesis and fatty acid beta-oxidation.
Prostatic Neoplasms
Targeting Oct1 genomic function inhibits androgen receptor signaling and castration-resistant prostate cancer growth.
Prostatic Neoplasms
The role of long-chain fatty-acid-CoA ligase 3 in vitamin D3 and androgen control of prostate cancer LNCaP cell growth.
Prostatic Neoplasms
Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long-chain fatty-acid-CoA ligase 3 in prostate cancer cells.
Pulmonary Disease, Chronic Obstructive
Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan.
Reperfusion Injury
Inhibition of long chain fatty acyl-CoA synthetase (ACSL) and ischemia reperfusion injury.
Retinal Degeneration
Fatty acid transport proteins in disease: New insights from invertebrate models.
Retinal Dystrophies
Inverse correlation between fatty acid transport protein 4 and vision in Leber congenital amaurosis associated with RPE65 mutation.
Retinoblastoma
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Rhabdomyosarcoma
The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells.
Sarcoma
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Sarcoma
The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells.
Sepsis
Long-Chain Acyl-CoA Synthetase 1 Role in Sepsis and Immunity: Perspectives From a Parallel Review of Public Transcriptome Datasets and of the Literature.
Skin Abnormalities
Elevation of blood lipids in hepatocyte-specific fatty acid transport 4-deficient mice fed with high glucose diets.
Skin Abnormalities
Keratinocyte-specific expression of fatty acid transport protein 4 rescues the wrinkle-free phenotype in Slc27a4/Fatp4 mutant mice.
Starvation
Effect of starvation on hepatic acyl-CoA synthetase, carnitine palmitoyltransferase-I, and acetyl-CoA carboxylase mRNA levels in rats.
Starvation
Fatty acid uptake in Escherichia coli: regulation by recruitment of fatty acyl-CoA synthetase to the plasma membrane.
Stomach Neoplasms
ONECUT2 upregulation is associated with CpG hypomethylation at promoter-proximal DNA in gastric cancer and triggers ACSL5.
Stomach Neoplasms
Tumor-suppressive functions of long-chain acyl-CoA synthetase 4 in gastric cancer.
Stroke
Inhibition of Acyl-CoA Synthetase Long-Chain Family Member 4 Facilitates Neurological Recovery After Stroke by Regulation Ferroptosis.
Thymoma
Characterization of an arachidonic acid-selective acyl-CoA synthetase from murine T lymphocytes.
Triple Negative Breast Neoplasms
ACSL family: The regulatory mechanisms and therapeutic implications in cancer.
Triple Negative Breast Neoplasms
Regulatory mechanisms leading to differential Acyl-CoA synthetase 4 expression in breast cancer cells.
Tuberculosis
Attenuation of Mycobacterium tuberculosis functionally disrupted in a fatty acyl-coenzyme A synthetase gene fadD5.
Tuberculosis
Dissecting the role of critical residues and substrate preference of a Fatty Acyl-CoA Synthetase (FadD13) of Mycobacterium tuberculosis.
Tuberculosis
Long-Chain Fatty Acyl Coenzyme A Ligase FadD2 Mediates Intrinsic Pyrazinamide Resistance in Mycobacterium tuberculosis.
Tuberculosis
Solution and Membrane Interaction Dynamics of Mycobacterium tuberculosis Fatty Acyl-CoA Synthetase FadD13.
Tuberculosis
The Mycobacterium tuberculosis very-long-chain fatty acyl-CoA synthetase: structural basis for housing lipid substrates longer than the enzyme.
Ureteral Obstruction
Involvement of FATP2-mediated tubular lipid metabolic reprogramming in renal fibrogenesis.
Urinary Bladder Neoplasms
Levels of acyl-coenzyme A synthetase 5 in urothelial cells and corresponding neoplasias reflect cellular differentiation.
Vascular Calcification
Palmitic acid induces osteoblastic differentiation in vascular smooth muscle cells through ACSL3 and NF-?B, novel targets of eicosapentaenoic acid.
Vascular Diseases
Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1.
Vesicular Stomatitis
The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association.
Vitamin B Deficiency
Maternal micronutrients and omega 3 fatty acids affect placental fatty acid desaturases and transport proteins in Wistar rats.
Wiskott-Aldrich Syndrome
The fadD2 Gene Is Required for Efficient Mycobacterium avium Invasion of Mucosal Epithelial Cells.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). RGL2_MOUSE
778
0
83826
Swiss-Prot
Secretory Pathway (Reliability: 1)
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cano, F.; Poderoso, C.; Cornejo Maciel, F.; Castilla, R.; Maloberti, P.; Castillo, F.; Neuman, I.; Paz, C.; Podesta, E.J.
Protein tyrosine phosphatases regulate arachidonic acid release, StAR induction and steroidogenesis acting on a hormone-dependent arachidonic acid-preferring acyl-CoA synthetase
J. Steroid Biochem. Mol. Biol.
99
197-202
2006
Mus musculus (Q61193)
brenda
EXTERNAL LINKS (specific for EC-Number 6.2.1.3)
Transporter Classification Database (TCDB): 4.C.1.1.4, 4.C.1.1.15, 4.C.1.1.9, 4.C.1.1.5, 4.C.1.1.12, 4.C.1.1.10, 4.C.1.1.1, 4.C.1.1.13, 4.C.1.1.8, 4.C.1.1.11, 4.C.1.1.3, 4.C.1.1.14
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
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