Information on EC 6.2.1.28 - 3alpha,7alpha-Dihydroxy-5beta-cholestanate-CoA ligase

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The expected taxonomic range for this enzyme is: Rattus norvegicus

EC NUMBER
COMMENTARY hide
6.2.1.28
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RECOMMENDED NAME
GeneOntology No.
3alpha,7alpha-Dihydroxy-5beta-cholestanate-CoA ligase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha-dihydroxy-5beta-cholestanoyl-CoA
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
thioester formation
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
bile acid biosynthesis, neutral pathway
SYSTEMATIC NAME
IUBMB Comments
(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate:CoA ligase (AMP-forming)
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CAS REGISTRY NUMBER
COMMENTARY hide
118732-03-9
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 3alpha,7alpha-dihydroxy-5beta-cholestanate + CoA
?
show the reaction diagram
-
-
-
-
-
ATP + 3alpha,7alpha-dihydroxy-5beta-cholestanate + CoA
AMP + diphosphate + 3alpha,7alpha-dihydroxy-5beta-cholestanoyl-CoA
show the reaction diagram
-
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 3alpha,7alpha-dihydroxy-5beta-cholestanate + CoA
?
show the reaction diagram
-
-
-
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0015
-
activity of microsomal fraction
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE