Information on EC 6.2.1.25 - Benzoate-CoA ligase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY
6.2.1.25
-
RECOMMENDED NAME
GeneOntology No.
Benzoate-CoA ligase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
ATP + benzoate + CoA = AMP + diphosphate + benzoyl-CoA
show the reaction diagram
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-
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REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Acid-thiol ligation
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-
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PATHWAY
KEGG Link
MetaCyc Link
Aminobenzoate degradation
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anaerobic aromatic compound degradation (Thauera aromatica)
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benzoate biosynthesis I (CoA-dependent, beta-oxidative)
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Benzoate degradation
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benzoate degradation II (aerobic and anaerobic)
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Metabolic pathways
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Microbial metabolism in diverse environments
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salicortin biosynthesis
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tetrahydroxyxanthone biosynthesis (from benzoate)
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SYSTEMATIC NAME
IUBMB Comments
Benzoate:CoA ligase (AMP-forming)
Also acts on 2-, 3- and 4-fluorobenzoate, but only very slowly on the corresponding chlorobenzoates.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
BamY
Geobacter metallireducens strain GS-15
Q39TQ2
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Bcl
Magnetospirillum sp. strainTS-6
Q25C16
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benzoate CoA ligase
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-
benzoate CoA ligase
A1EAJ3
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benzoate CoA ligase
Xanthomonas albilineans LS155
A1EAJ3
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Benzoate coenzyme A ligase
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-
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Benzoate-CoA ligase (AMP-forming)
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-
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Benzoyl coenzyme A synthetase
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Benzoyl-CoA ligase
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Benzoyl-CoA synthetase
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BzdA enzyme
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BzdA enzyme
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Synthetase, benzoyl coenzyme A
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XabE
A1EAJ3
gene name
XabE
Xanthomonas albilineans LS155
A1EAJ3
gene name
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CAS REGISTRY NUMBER
COMMENTARY
95329-17-2
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
Anaerobic bacterium
a strictly anaerobic, obligate synthrophic mixed culture
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Manually annotated by BRENDA team
gram-negative, nitrate-reducing strain Asl-3
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Manually annotated by BRENDA team
strain LB400
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Manually annotated by BRENDA team
annual California plant
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-
Manually annotated by BRENDA team
ATCC 53774, DSM 7210
UniProt
Manually annotated by BRENDA team
Geobacter metallireducens strain GS-15
ATCC 53774, DSM 7210
UniProt
Manually annotated by BRENDA team
strainTS-6
TrEMBL
Manually annotated by BRENDA team
Magnetospirillum sp. strainTS-6
strainTS-6
TrEMBL
Manually annotated by BRENDA team
an anaerobically induced benzoate-CoA ligase and an aerobically induced benzoate-CoA ligase with different properties; strain KB740
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Manually annotated by BRENDA team
Pseudomonas-like strain S100
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Manually annotated by BRENDA team
strain KB740
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Manually annotated by BRENDA team
Pseudomonas sp. KB740
strain KB740
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Manually annotated by BRENDA team
male Wistar LAT1
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Manually annotated by BRENDA team
strain SB, in syntropic association with Methanospillum hungatei strain JF1
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Manually annotated by BRENDA team
strain DSM 6984
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Manually annotated by BRENDA team
diverse mutant strains, gene xabE
UniProt
Manually annotated by BRENDA team
Xanthomonas albilineans LS155
diverse mutant strains, gene xabE
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
metabolism
A1EAJ3, -
regulatory and synthase genes downstream of xabE, overview
metabolism
-, Q39TQ2
BamY is involved in benzene metabolism, detailed pathway overview
metabolism
Geobacter metallireducens strain GS-15
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BamY is involved in benzene metabolism, detailed pathway overview
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metabolism
Xanthomonas albilineans LS155
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regulatory and synthase genes downstream of xabE, overview
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physiological function
A1EAJ3, -
XabE is similar to benzoate CoA ligases and is essential for albicidin production and pathogenicity
physiological function
Xanthomonas albilineans LS155
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XabE is similar to benzoate CoA ligases and is essential for albicidin production and pathogenicity
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COFACTOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
Ki VALUE [mM]
Ki VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.016
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2-Hydroxybenzoate
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TEMPERATURE OPTIMUM
TEMPERATURE OPTIMUM MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
37
-
Anaerobic bacterium
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-
TEMPERATURE RANGE
TEMPERATURE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
22
45
Anaerobic bacterium
-
22°C: about 40% of maximal activity, 45°C: about 20% of maximal activity
PDB
SCOP
CATH
ORGANISM
Burkholderia xenovorans (strain LB400)
Crystallization/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
sitting-drop vapor diffusion method at 18 °C in 23% PEG 3350 K and 0.2 M sodium formate
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ENGINEERING
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
additional information
A1EAJ3, -
insertional mutation in gene xabE, using suicide-vector pJP-XabE, leads to complete loss of albicidin production ability. The mutant fails to induce symptoms of leaf scald in maize plants, in contrast to wild-type Xanthomonas albilineans, which elicits characteristic white pencil line symptoms in inoculated maize leaves
additional information
Xanthomonas albilineans LS155
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insertional mutation in gene xabE, using suicide-vector pJP-XabE, leads to complete loss of albicidin production ability. The mutant fails to induce symptoms of leaf scald in maize plants, in contrast to wild-type Xanthomonas albilineans, which elicits characteristic white pencil line symptoms in inoculated maize leaves
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