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EC Tree
The taxonomic range for the selected organisms is: Homo sapiens The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
acetoacetyl-coa synthetase, slaacs, acetoacetate-coa ligase, acetoacetyl coa synthetase, acetoacetyl-coa ligase,
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Acetoacetyl-CoA synthetase
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Acetoacetate--CoA ligase
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Acetoacetyl CoA synthetase
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Acetoacetyl-CoA ligase
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Acetoacetyl-CoA synthase
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Acetoacetyl-CoA synthetase
Acetoacetyl-coenzyme A synthetase
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Synthetase, acetoacetyl coenzyme A
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Acetoacetyl-CoA synthetase
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Acetoacetyl-CoA synthetase
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Acid-thiol ligation
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acetoacetate:CoA ligase (AMP-forming)
Also acts, more slowly, on L-3-hydroxybutanoate.
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ATP + acetoacetate + CoA
AMP + diphosphate + acetoacetyl-CoA
ATP + acetoacetate + CoA
AMP + diphosphate + acetoacetyl-CoA
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ATP + acetoacetate + CoA
AMP + diphosphate + acetoacetyl-CoA
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ATP + acetoacetate + CoA
AMP + diphosphate + acetoacetyl-CoA
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ATP + acetoacetate + CoA
AMP + diphosphate + acetoacetyl-CoA
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Neoplasms
Role of acetoacetyl-CoA synthetase in acetoacetate utilization by tumor cells.
Neuroblastoma
Transcriptional regulation of acetoacetyl-CoA synthetase by Sp1 in neuroblastoma cells.
Non-alcoholic Fatty Liver Disease
Identification of Potential Plasma Biomarkers for Nonalcoholic Fatty Liver Disease by Integrating Transcriptomics and Proteomics in Laying Hens.
Obesity
Genetic obesity affects neural ketone body utilization in the rat brain.
Obesity
High-fat diet-induced obesity stimulates ketone body utilization in osteoclasts of the mouse bone.
Obesity
Leptin controls ketone body utilization in hypothalamic neuron.
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GenBank
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89% homology with AACS from rat
GenBank
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expression is particularly abundant in white adipose tissue
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AACS gene expression is particularly abundant in white adipose tissue, as it is induced during adipocyte differentiation
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malfunction
knockdown of SREBP-2, which orchestrates cholesterol synthesis, results in the downregulation of AACS mRNA levels. Knockdown of AACS results in a decrease in histone deacetylase 9, associated with gene silencing
physiological function
acetoacetyl-CoA synthetase (AACS) is the enzyme responsible for cholesterol and fatty acid synthesis in the cytosol. AACS has an important role in normal neuronal development. Specificity protein 1 (Sp1) regulates gene expression of AACS in Neuro-2a cells and ketone body utilization affects the balance of histone acetylation
physiological function
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acetoacetyl-CoA synthetase activates ketone bodies and incorporates them into cholesterol and fatty acids in the cytosol of lipogenic tissue
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AACS_HUMAN
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75144
Swiss-Prot
other Location (Reliability: 2 )
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75143
x * 75143, deduced from DNA sequence
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x * 75143, deduced from DNA sequence
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expression of a cDNA isolated from human carcinoma HepG2 in Escherichia coli
gene AACS, analysis of the transcriptional mechanism of AACS in Neuro-2a neuroblastoma cells. The minimal core promoter of the mouse AACS gene is located in a region with 110 bps upstream from the transcription start site. Mutagenesis studies show that the Sp1 binding site is crucial for AACS promoter activity. Sp1 binds to the Sp1 binding site on the promoter region of AACS. Overexpression of Sp1 increases AACS mRNA levels. Real-time PCR enzyme expression analysis. Functional analysis of the 5'-flanking region of AACS in Neuro-2a cells
AACS DNa and amino acid sequence determination and analysis, and promoter identification and cloning, the human AACS promoter is a peroxisome-proliferator-activated receptor gamm, PPARgamma, target gene, the nuclear receptor is recruited to the AACS promoter by direct interaction with stimulating protein-1, Sp-1
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specificity protein 1 (Sp1) binds to the Sp1 binding site on the promoter region of AACS. Overexpression of Sp1 increases AACS mRNA levels
specificity protein 1 (Sp1) regulates gene expression of AACS in Neuro-2a cells, investigation of promoter activity of AACS, overview
peroxisome-proliferator-activated receptor gamm, PPARgamma, induces AACS and adipogenesis. A PPAR-responsive element, PPRE-independent mechanism might be involved in PPARgamma-mediated AACS gene expression. PPARgamma-dependent activation of the human AACS gene is mediated by the GC boxes
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the human AACS promoter is a PPARgamma target gene. Nuclear receptor PPARgamma is recruited to the AACS promoter by direct interaction with Sp1
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Bergstrom, J.D.; Edmond, J.
A radiochemical assay for acetoacetyl-CoA synthetase
Anal. Biochem.
149
358-364
1985
Homo sapiens, Rattus norvegicus, Zoogloea ramigera, Zoogloea ramigera 1-16-M / ATCC 19623
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Ohgami, M.; Takahashi, N.; Yamasaki, M.; Fukui, T.
Expression of acetoacetyl-CoA synthetase, a novel cytosolic ketone body-utilizing enzyme, in human brain
Biochem. Pharmacol.
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989-994
2003
Homo sapiens (Q86V21), Homo sapiens
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Aguilo, F.; Camarero, N.; Relat, J.; Marrero, P.F.; Haro, D.
Transcriptional regulation of the human acetoacetyl-CoA synthetase gene by PPARgamma
Biochem. J.
427
255-264
2010
Homo sapiens
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Hasegawa, S.; Imai, M.; Yamasaki, M.; Takahashi, N.; Fukui, T.
Transcriptional regulation of acetoacetyl-CoA synthetase by Sp1 in neuroblastoma cells
Biochem. Biophys. Res. Commun.
495
652-658
2018
Homo sapiens (Q86V21)
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