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Disease on EC 6.2.1.15 - arachidonate-CoA ligase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma.
Adenocarcinoma of Lung
High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma.
Adenoma
Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma.
arachidonate-coa ligase deficiency
Liver-specific knockdown of long-chain acyl-CoA synthetase 4 reveals its key role in VLDL-TG metabolism and phospholipid synthesis in mice fed a high-fat diet.
Long-chain acyl-CoA synthetase 4 participates in the formation of highly unsaturated fatty acid-containing phospholipids in murine macrophages.
Tissue Specific Ablation of ACSL4 Results in Disturbed Steroidogenesis.
Atherosclerosis
Rosiglitazone inhibits acyl-CoA synthetase activity and fatty acid partitioning to diacylglycerol and triacylglycerol via a peroxisome proliferator-activated receptor-gamma-independent mechanism in human arterial smooth muscle cells and macrophages.
Verification of ferroptosis and pyroptosis and identification of PTGS2 as the hub gene in human coronary artery atherosclerosis.
Brain Edema
Acyl-CoA synthetase long chain family member 4 plays detrimental role in early brain injury after subarachnoid hemorrhage in rats by inducing ferroptosis.
Brain Infarction
Inhibition of Acyl-CoA Synthetase Long-Chain Family Member 4 Facilitates Neurological Recovery After Stroke by Regulation Ferroptosis.
Brain Injuries
ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation.
Acyl-CoA synthetase long chain family member 4 plays detrimental role in early brain injury after subarachnoid hemorrhage in rats by inducing ferroptosis.
Brain Ischemia
ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation.
Breast Neoplasms
17?-estradiol-induced ACSL4 protein expression promotes an invasive phenotype in estrogen receptor positive mammary carcinoma cells.
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition.
Acyl-CoA synthetase-4 mediates radioresistance of breast cancer cells by regulating FOXM1.
Acyl-CoA synthetase-4, a new regulator of mTOR and a potential therapeutic target for enhanced estrogen receptor function in receptor-positive and -negative breast cancer.
An Evaluation of Fatty Acid-CoA Ligase 4 in Breast Cancer.
Association of long-chain acyl-coenzyme A synthetase 5 expression in human breast cancer by estrogen receptor status and its clinical significance.
Expression of Long-chain Fatty Acyl-CoA Synthetase 4 in Breast and Prostate Cancers Is Associated with Sex Steroid Hormone Receptor Negativity.
Functional interaction between acyl-CoA synthetase 4, lipooxygenases and cyclooxygenase-2 in the aggressive phenotype of breast cancer cells.
Long chain fatty Acyl-CoA synthetase 4 is a biomarker for and mediator of hormone resistance in human breast cancer.
PADI2 gene confers susceptibility to breast cancer and plays tumorigenic role via ACSL4, BINC3 and CA9 signaling.
Polyphyllin ?-Induced Ferroptosis in MDA-MB-231 Triple-Negative Breast Cancer Cells can Be Protected Against by KLF4-Mediated Upregulation of xCT.
Predictive and prognostic impact of ferroptosis-related genes ACSL4 and GPX4 on breast cancer treated with neoadjuvant chemotherapy.
Regulatory mechanisms leading to differential Acyl-CoA synthetase 4 expression in breast cancer cells.
The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells.
The functional interaction between Acyl-CoA synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth: a novel therapeutic target.
Tyrosine phosphatase SHP2 regulates the expression of acyl-CoA synthetase ACSL4.
Carcinogenesis
Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma.
Fatty acid-CoA ligase 4 is overexpressed in human hepatocellular carcinoma.
Functional interaction between acyl-CoA synthetase 4, lipooxygenases and cyclooxygenase-2 in the aggressive phenotype of breast cancer cells.
Intracellular unesterified arachidonic acid signals apoptosis.
Involvement of fatty acid-CoA ligase 4 in hepatocellular carcinoma growth: roles of cyclic AMP and p38 mitogen-activated protein kinase.
PADI2 gene confers susceptibility to breast cancer and plays tumorigenic role via ACSL4, BINC3 and CA9 signaling.
Regulation of cell growth by fatty acid-CoA ligase 4 in human hepatocellular carcinoma cells.
The functional interaction between Acyl-CoA synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth: a novel therapeutic target.
The positive feedback between ACSL4 expression and O-GlcNAcylation contributes to the growth and survival of hepatocellular carcinoma.
Tyrosine phosphatase SHP2 regulates the expression of acyl-CoA synthetase ACSL4.
Carcinoma
17?-estradiol-induced ACSL4 protein expression promotes an invasive phenotype in estrogen receptor positive mammary carcinoma cells.
Oleanolic acid inhibits cervical cancer Hela cell proliferation through modulation of the ACSL4 ferroptosis signaling pathway.
The effect of fatty acid-CoA ligase 4 on the growth of hepatic cancer cells.
Carcinoma, Hepatocellular
ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma.
ACSL4 promotes hepatocellular carcinoma progression via c-Myc stability mediated by ERK/FBW7/c-Myc axis.
ACSL4 reprograms fatty acid metabolism in hepatocellular carcinoma via c-Myc/SREBP1 pathway.
Fatty acid-CoA ligase 4 is overexpressed in human hepatocellular carcinoma.
Human MicroRNA-548p Decreases Hepatic Apolipoprotein B Secretion and Lipid Synthesis.
Identification of MiR-211-5p as a tumor suppressor by targeting ACSL4 in Hepatocellular Carcinoma.
Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases.
Involvement of cholesterol in hepatitis B virus X protein-induced abnormal lipid metabolism of hepatoma cells via up-regulating miR-205-targeted ACSL4.
Involvement of fatty acid-CoA ligase 4 in hepatocellular carcinoma growth: roles of cyclic AMP and p38 mitogen-activated protein kinase.
Overexpression of Acyl-CoA Ligase 4 (ACSL4) in Patients with Hepatocellular Carcinoma and its Prognosis.
Regulation of cell growth by fatty acid-CoA ligase 4 in human hepatocellular carcinoma cells.
Signature molecules expressed differentially in a liver disease stage-specific manner by HIV-1 and HCV co-infection.
Simultaneous silencing of ACSL4 and induction of GADD45B in hepatocellular carcinoma cells amplifies the synergistic therapeutic effect of aspirin and sorafenib.
The positive feedback between ACSL4 expression and O-GlcNAcylation contributes to the growth and survival of hepatocellular carcinoma.
Cholangiocarcinoma
Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases.
Colonic Neoplasms
Cytoglobin promotes sensitivity to ferroptosis by regulating p53-YAP1 axis in colon cancer cells.
Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma.
Fatty acid-CoA ligase 4 is overexpressed in human hepatocellular carcinoma.
Colorectal Neoplasms
Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer.
Epilepsy
Array-CGH in unclear syndromic nephropathies identifies a microdeletion in Xq22.3-q23.
Erythema
Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema.
Fatty Liver
Comparative transcriptomic analysis reveals an association of gibel carp fatty liver with ferroptosis pathway.
Identification of p115 as a novel ACSL4 interacting protein and its role in regulating ACSL4 degradation.
Therapeutic Targeting of Hepatic ACSL4 Ameliorates Non-alcoholic Steatohepatitis in Mice.
Fibrosarcoma
The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells.
Triacsin C: a differential inhibitor of arachidonoyl-CoA synthetase and nonspecific long chain acyl-CoA synthetase.
Glioblastoma
Dihydroartemisinin initiates ferroptosis in glioblastoma through GPX4 inhibition.
MicroRNA-670-3p suppresses ferroptosis of human glioblastoma cells through targeting ACSL4.
Glioma
ACSL4 suppresses glioma cells proliferation via activating ferroptosis.
Integrated metabolomics and lipidomics analyses reveal metabolic reprogramming in human glioma with IDH1 mutation.
Regulation and role of Acyl-CoA synthetase 4 in glial cells.
Hemoglobinuria
Induction of two independent immunological cell death signaling following hemoglobinuria -induced acute kidney injury: In vivo study.
Hepatitis B
Involvement of cholesterol in hepatitis B virus X protein-induced abnormal lipid metabolism of hepatoma cells via up-regulating miR-205-targeted ACSL4.
Hypersensitivity
Inhibition of ferroptosis-like cell death attenuates neuropathic pain reactions induced by peripheral nerve injury in rats.
Infarction, Middle Cerebral Artery
Inhibition of Acyl-CoA Synthetase Long-Chain Family Member 4 Facilitates Neurological Recovery After Stroke by Regulation Ferroptosis.
Intellectual Disability
A novel 47.2 Mb duplication on chromosomal bands Xq21.1-25 associated with mental retardation.
A third MRX family (MRX68) is the result of mutation in the long chain fatty acid-CoA ligase 4 (FACL4) gene: proposal of a rapid enzymatic assay for screening mentally retarded patients.
dAcsl, the Drosophila ortholog of acyl-CoA synthetase long-chain family member 3 and 4, inhibits synapse growth by attenuating bone morphogenetic protein signaling via endocytic recycling.
Decreased expression of genes associated with memory and x-linked mental retardation in boys with non-syndromic cryptorchidism and high infertility risk.
FACL4, a new gene encoding long-chain acyl-CoA synthetase 4, is deleted in a family with Alport syndrome, elliptocytosis, and mental retardation.
FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation.
Identification and characterization of mouse orthologs of the AMMECR1 and FACL4 genes deleted in AMME syndrome: orthology of Xq22.3 and MmuXF1-F3.
Intellectual disability, midface hypoplasia, facial hypotonia, and Alport syndrome are associated with a deletion in Xq22.3.
Localization of a non-syndromic X-linked mental retardation gene (MRX80) to Xq22-q24.
No association between polymorphisms in the FACL4 (fatty acid-CoA ligase 4) gene and nonspecific mental retardation in Qin-Ba mountain region of China.
The XLMR gene ACSL4 plays a role in dendritic spine architecture.
X linked mental retardation: a clinical guide.
Xq22.3-q23 deletion including ACSL4 in a patient with intellectual disability.
Ischemic Attack, Transient
Inhibition of Acyl-CoA Synthetase Long-Chain Family Member 4 Facilitates Neurological Recovery After Stroke by Regulation Ferroptosis.
Ischemic Stroke
ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation.
Kidney Diseases
XJB-5-131 inhibited ferroptosis in tubular epithelial cells after ischemia-reperfusion injury.
Leiomyosarcoma
The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells.
Lissencephaly
Array-CGH in unclear syndromic nephropathies identifies a microdeletion in Xq22.3-q23.
Liver Diseases
Identification of p115 as a novel ACSL4 interacting protein and its role in regulating ACSL4 degradation.
Signature molecules expressed differentially in a liver disease stage-specific manner by HIV-1 and HCV co-infection.
Liver Neoplasms
A Novel TIP30 Protein Complex Regulates EGF Receptor Signaling and Endocytic Degradation.
The effect of fatty acid-CoA ligase 4 on the growth of hepatic cancer cells.
Lung Injury
Inhibition of ACSL4 attenuates ferroptotic damage after pulmonary ischemia-reperfusion.
Lung Neoplasms
Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer.
Mental Retardation, X-Linked
A third MRX family (MRX68) is the result of mutation in the long chain fatty acid-CoA ligase 4 (FACL4) gene: proposal of a rapid enzymatic assay for screening mentally retarded patients.
Analyses of mental dysfunction-related ACSl4 in Drosophila reveal its requirement for Dpp/BMP production and visual wiring in the brain.
Drosophila Acyl-CoA synthetase long-chain family member 4 regulates axonal transport of synaptic vesicles and is required for synaptic development and transmission.
FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation.
The XLMR gene ACSL4 plays a role in dendritic spine architecture.
[Monogenic causes of nonspecific X-linked mental retardation molecular aspects]
[Relationship between FACL4 and non-specific X-linked mental retardation]
Mouth Neoplasms
Non-classical platinum-based compound 56MESS, with preferential cytotoxic effect on oral cancer cells by downregulating FACL4 expression.
Muscle Hypotonia
Disruption of DMD and deletion of ACSL4 causing developmental delay, hypotonia, and multiple congenital anomalies.
Intellectual disability, midface hypoplasia, facial hypotonia, and Alport syndrome are associated with a deletion in Xq22.3.
Neoplasm Metastasis
ACSL4 reprograms fatty acid metabolism in hepatocellular carcinoma via c-Myc/SREBP1 pathway.
Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases.
Neoplasms
ACSL family: The regulatory mechanisms and therapeutic implications in cancer.
ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma.
ACSL4 promotes hepatocellular carcinoma progression via c-Myc stability mediated by ERK/FBW7/c-Myc axis.
Acyl-CoA synthetase-4 is implicated in drug resistance in breast cancer cell lines involving the regulation of energy-dependent transporter expression.
Acyl-CoA synthetase-4, a new regulator of mTOR and a potential therapeutic target for enhanced estrogen receptor function in receptor-positive and -negative breast cancer.
Evaluation of long-chain acyl-coenzyme A synthetase 4 (ACSL4) expression in human breast cancer.
Fatty acid activation in carcinogenesis and cancer development: Essential roles of long-chain acyl-CoA synthetases.
Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma.
Fatty acid-CoA ligase 4 is overexpressed in human hepatocellular carcinoma.
High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma.
Identification of MiR-211-5p as a tumor suppressor by targeting ACSL4 in Hepatocellular Carcinoma.
Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases.
Long chain fatty Acyl-CoA synthetase 4 is a biomarker for and mediator of hormone resistance in human breast cancer.
Long-Chain Acyl-CoA Synthetase 4-Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway-Independent Prostate Cancer.
New inhibitor targeting Acyl-CoA synthetase 4 reduces breast and prostate tumor growth, therapeutic resistance and steroidogenesis.
Overexpression of Acyl-CoA Ligase 4 (ACSL4) in Patients with Hepatocellular Carcinoma and its Prognosis.
PADI2 gene confers susceptibility to breast cancer and plays tumorigenic role via ACSL4, BINC3 and CA9 signaling.
Predictive and prognostic impact of ferroptosis-related genes ACSL4 and GPX4 on breast cancer treated with neoadjuvant chemotherapy.
Role of acyl-CoA synthetase ACSL4 in arachidonic acid metabolism.
The effect of fatty acid-CoA ligase 4 on the growth of hepatic cancer cells.
The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells.
The functional interaction between Acyl-CoA synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth: a novel therapeutic target.
Tumor suppressor miR-424-5p abrogates ferroptosis in ovarian cancer through targeting ACSL4.
Tumor-suppressive functions of long-chain acyl-CoA synthetase 4 in gastric cancer.
Nephritis, Hereditary
Array-CGH in unclear syndromic nephropathies identifies a microdeletion in Xq22.3-q23.
FACL4, a new gene encoding long-chain acyl-CoA synthetase 4, is deleted in a family with Alport syndrome, elliptocytosis, and mental retardation.
Identification and characterization of a highly conserved protein absent in the Alport syndrome (A), mental retardation (M), midface hypoplasia (M), and elliptocytosis (E) contiguous gene deletion syndrome (AMME).
Identification and characterization of mouse orthologs of the AMMECR1 and FACL4 genes deleted in AMME syndrome: orthology of Xq22.3 and MmuXF1-F3.
Intellectual disability, midface hypoplasia, facial hypotonia, and Alport syndrome are associated with a deletion in Xq22.3.
Neuroinflammatory Diseases
ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation.
Tetrahydroxy stilbene glycoside ameliorates Alzheimer's disease in APP/PS1 mice via glutathione peroxidase related ferroptosis.
Neuromuscular Diseases
Disruption of DMD and deletion of ACSL4 causing developmental delay, hypotonia, and multiple congenital anomalies.
Non-alcoholic Fatty Liver Disease
Genome-wide analysis of DNA methylation in human peripheral leukocytes identifies potential biomarkers of nonalcoholic fatty liver disease.
Hepatic gene expression of Caucasian and African-American patients with obesity-related non-alcoholic fatty liver disease.
Identification of p115 as a novel ACSL4 interacting protein and its role in regulating ACSL4 degradation.
Therapeutic Targeting of Hepatic ACSL4 Ameliorates Non-alcoholic Steatohepatitis in Mice.
Obesity
Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects.
Ovarian Neoplasms
Systems biology of ferroptosis: A modeling approach.
Tumor suppressor miR-424-5p abrogates ferroptosis in ovarian cancer through targeting ACSL4.
Pancreatic Neoplasms
Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis.
Prostatic Neoplasms
ACSL4 promotes prostate cancer growth, invasion and hormonal resistance.
Acyl-CoA synthetase-4 is implicated in drug resistance in breast cancer cell lines involving the regulation of energy-dependent transporter expression.
Expression of Long-chain Fatty Acyl-CoA Synthetase 4 in Breast and Prostate Cancers Is Associated with Sex Steroid Hormone Receptor Negativity.
LncRNA NEAT1 promotes docetaxel resistance in prostate cancer by regulating ACSL4 via sponging miR-34a-5p and miR-204-5p.
Long-Chain Acyl-CoA Synthetase 4-Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway-Independent Prostate Cancer.
Rhabdomyosarcoma
The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells.
Sarcoma
The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells.
Sepsis
Long-Chain Acyl-CoA Synthetase 1 Role in Sepsis and Immunity: Perspectives From a Parallel Review of Public Transcriptome Datasets and of the Literature.
Stomach Neoplasms
Tumor-suppressive functions of long-chain acyl-CoA synthetase 4 in gastric cancer.
Stroke
An ACSL4 Hemizygous Intragenic Deletion in a Patient With Childhood Stroke.
Inhibition of Acyl-CoA Synthetase Long-Chain Family Member 4 Facilitates Neurological Recovery After Stroke by Regulation Ferroptosis.
Subarachnoid Hemorrhage
Acyl-CoA synthetase long chain family member 4 plays detrimental role in early brain injury after subarachnoid hemorrhage in rats by inducing ferroptosis.
Triple Negative Breast Neoplasms
Long chain fatty Acyl-CoA synthetase 4 is a biomarker for and mediator of hormone resistance in human breast cancer.
Regulatory mechanisms leading to differential Acyl-CoA synthetase 4 expression in breast cancer cells.
Uterine Cervical Neoplasms
Oleanolic acid inhibits cervical cancer Hela cell proliferation through modulation of the ACSL4 ferroptosis signaling pathway.