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Synonyms
acyl-coa synthetase, acetyl-coa synthetase, acss2, acetyl-coa synthase, acetyl coa synthetase, acetyl-coenzyme a synthetase, codh/acs, acecs2, acetyl coenzyme a synthetase, acecs1,
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ATP + 3-bromopropanoate + CoA
AMP + diphosphate + 3-bromopropanoyl-CoA
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ATP + 3-chloropropanoate + CoA
AMP + diphosphate + 3-chloropropanoyl-CoA
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ATP + acetate + CoA
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enzyme form Acs1p is primarily responsible for acetate activation during gluconeogenic growth. Enzyme form Acs2p is likely to be the major producer of cytosolic acetyl-CoA
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ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
ATP + acrylate + CoA
AMP + diphosphate + acryloyl-CoA
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ATP + fluoroacetate + CoA
AMP + diphosphate + fluoroacetyl-CoA
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ATP + methacrylic acid + CoA
AMP + diphosphate + methacryloyl-CoA
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ATP + propanoate + CoA
AMP + diphosphate + propanoyl-CoA
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ATP + propionate + CoA
AMP + diphosphate + propionyl-CoA
ATP + tetrapolyphosphate
adenosine 5'-pentaphosphate
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ATP + tripolyphosphate
adenosine 5'-tetraphosphate
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additional information
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ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
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ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
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554, 556, 559, 561, 564, 566, 570, 573, 577, 582, 693035, 744651 -
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ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
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ATP + propionate + CoA
AMP + diphosphate + propionyl-CoA
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ATP + propionate + CoA
AMP + diphosphate + propionyl-CoA
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nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription. Acs2p is the major acetyl-CoA source for HATs in glucose
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additional information
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may contribute to the adenosine 5'-tetraphosphate synthesis and adenosine 5'-pentaphosphate synthesis during yeast sporulation
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additional information
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the enzyme also forms a carbon-nitrogen bond, reaction of EC 6.3.1 acid-ammonia (or amide) ligase, i.e. amide synthase, and EC 6.3.2 acid-amino acid ligase, i.e. peptide synthase, comprising the amino group of the cysteine and the carboxyl group of the acid, overview
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Patel, S.S.; Walt, D.R.
Substrate specificity of acetyl coenzyme A synthetase
J. Biol. Chem.
262
7132-7134
1987
Saccharomyces cerevisiae
brenda
Frenkel, E.P.; Kitchens, R.L.
Acetyl-CoA synthetase from bakers yeast (Saccharomyces cerevisiae)
Methods Enzymol.
71
317-324
1981
Saccharomyces cerevisiae
brenda
Satyanarayana, T.; Chervenka, C.H.; Klein, H.P.
Subunit specificity of the two acetyl-CoA synthetases of yeast as revealed by an immunological approach
Biochim. Biophys. Acta
614
601-606
1980
Saccharomyces cerevisiae, Saccharomyces cerevisiae LK2G12
brenda
Frenkel, E.P.; Kitchens, R.L.
Purification and properties of acetyl coenzyme A synthetase from bakers yeast
J. Biol. Chem.
252
504-507
1977
Saccharomyces cerevisiae
brenda
Satyanarayana, T.; Klein, H.P.
Studies on the aerobic acetyl-coenzyme A synthetase of Saccharomyces cerevisiae: purification, crystallization, and physical properties of the enzyme
Arch. Biochem. Biophys.
174
480-490
1976
Saccharomyces cerevisiae, Saccharomyces cerevisiae LK2G12
brenda
Satyanarayana, T.; Mandel, A.D.; Klein, H.P.
Evidence for two immunologically distinct acetyl-coenzyme A synthetases in yeast
Biochim. Biophys. Acta
341
396-401
1974
Saccharomyces cerevisiae, Saccharomyces cerevisiae LK2G12
brenda
Satyanarayana, T.; Klein, H.P.
Studies on acetyl-coenzyme A synthetase of yeast: inhibition by long-chain acyl-coenzyme A esters
J. Bacteriol.
115
600-606
1973
Saccharomyces cerevisiae, Saccharomyces cerevisiae LK2G12
brenda
Focke, M.; Feld, A.; Lichtenthaler, H.K.
Allicin, a naturally occuring antibiotic from garlic, specifically inhibits acetyl-CoA synthetase
FEBS Lett.
261
106-108
1990
Bos taurus, Saccharomyces cerevisiae, Hordeum vulgare
brenda
Van den Berg, M.A.; de Jong-Gubbels, P.; Kortland, C.J.; van Dijken, J.P.; Pronk, J.T.; Steensma, H.Y.
The two acetyl-coenzyme A synthetases of Saccharomyces cerevisiae differ with respect to kinetic properties and transcriptional regulation
J. Biol. Chem.
271
28953-28959
1996
Saccharomyces cerevisiae
brenda
Guranowski, A.; Gunther Sillero, M.A.; Sillero, A.
Adenosine 5'-tetraphosphate and adenosine 5'-pentaphosphate are synthesized by yeast acetyl coenzyme A synthetase
J. Bacteriol.
176
2986-2990
1994
Saccharomyces cerevisiae
brenda
Klein, H.P.; Jahnke, L.
Effects of aeration on formation and localization of the acetyl coenzyme A synthetases of Saccharomyces cerevisiae
J. Bacteriol.
137
179-184
1979
Saccharomyces cerevisiae
brenda
Starai, V.J.; Takahashi, H.; Boeke, J.D.; Escalante-Semerena, J.C.
Short-chain fatty acid activation by acyl-coenzyme A synthetases requires SIR2 protein function in Salmonella enterica and Saccharomyces cerevisiae
Genetics
163
545-555
2003
Saccharomyces cerevisiae
brenda
Jogl, G.; Tong, L.
Crystal structure of yeast acetyl-coenzyme A synthetase in complex with AMP
Biochemistry
43
1425-1431
2004
Saccharomyces cerevisiae (Q01574), Saccharomyces cerevisiae
brenda
Takahashi, H.; McCaffery, J.M.; Irizarry, R.A.; Boeke, J.D.
Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription
Mol. Cell
23
207-217
2006
Saccharomyces cerevisiae
brenda
Abe, T.; Hashimoto, Y.; Hosaka, H.; Tomita-Yokotani, K.; Kobayashi, M.
Discovery of amide (peptide) bond synthetic activity in acyl-CoA synthetase
J. Biol. Chem.
283
11312-11321
2008
Saccharomyces cerevisiae
brenda
Falcon, A.A.; Chen, S.; Wood, M.S.; Aris, J.P.
Acetyl-coenzyme A synthetase 2 is a nuclear protein required for replicative longevity in Saccharomyces cerevisiae
Mol. Cell. Biochem.
333
99-108
2010
Saccharomyces cerevisiae
brenda
Mirzaei, H.; Longo, V.D.
Acetyl-CoA synthetase is a conserved regulator of autophagy and life span
Cell Metab.
19
555-557
2014
Saccharomyces cerevisiae
brenda
Ding, J.; Holzwarth, G.; Penner, M.H.; Patton-Vogt, J.; Bakalinsky, A.T.
Overexpression of acetyl-CoA synthetase in Saccharomyces cerevisiae increases acetic acid tolerance
FEMS Microbiol. Lett.
362
1-7
2015
Saccharomyces cerevisiae (P52910), Saccharomyces cerevisiae
brenda