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Information on EC 6.2.1.1 - acetate-CoA ligase and Organism(s) Arabidopsis thaliana and UniProt Accession B9DGD6

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EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.1 acetate-CoA ligase
IUBMB Comments
Also acts on propanoate and propenoate.
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This record set is specific for:
Arabidopsis thaliana
UNIPROT: B9DGD6
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Word Map
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
acyl-coa synthetase, acetyl-coa synthetase, acss2, acetyl-coa synthase, acetyl coa synthetase, acetyl-coenzyme a synthetase, codh/acs, acecs2, acetyl coenzyme a synthetase, acecs1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acetyl-CoA synthetase
-
acetyl-coenzyme A synthetase
-
AceCS
-
-
-
-
Acetate thiokinase
-
-
-
-
Acetate--CoA ligase
-
-
-
-
Acetic thiokinase
-
-
-
-
Acetyl activating enzyme
-
-
-
-
Acetyl CoA ligase
-
-
-
-
Acetyl CoA synthase
-
-
-
-
Acetyl coenzyme A synthetase
-
-
-
-
Acetyl-CoA synthase
-
-
-
-
Acetyl-CoA synthetase
-
-
-
-
Acetyl-coenzyme A synthase
-
-
-
-
Acyl-activating enzyme
-
-
-
-
Short chain fatty acyl-CoA synthetase
-
-
-
-
Short-chain acyl-coenzyme A synthetase
-
-
-
-
Synthetase, acetyl coenzyme A
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acid-thiol ligation
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
acetate:CoA ligase (AMP-forming)
Also acts on propanoate and propenoate.
CAS REGISTRY NUMBER
COMMENTARY hide
9012-31-1
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
show the reaction diagram
additional information
?
-
role of ACS in destroying fermentative intermediates
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
show the reaction diagram
-
no relationship between the enzyme level and the capacity of the plants to incorporate CO2 into labeled fatty acids. Very limited role of the enzyme in the biosynthesis of lipids
-
?
additional information
?
-
role of ACS in destroying fermentative intermediates
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene acs1
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
from plants with altered ACS levels
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ACS_ARATH
743
0
81889
Swiss-Prot
Chloroplast (Reliability: 1)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
a constructed acs1 knockout mutant has a disruption in the plastidic acetyl-CoA synthetase gene leading to 90% decreased ACS activity and largely blocked incorporation of exogenous 14C-acetate and 14C-ethanol into fatty acids. Whereas the disruption has no significant effect on the synthesis of bulk seed triacylglycerols, the acs1 plants are smaller and flowered later. The acs1 mutant shows increased sensitivity to exogenous acetate, ethanol, and acetaldehyde compared to wild-type plants, phenotype, overview
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Behal, R.H.; Lin, M.; Back, S.; Oliver, D.J.
Role of acetyl-coenzyme A synthetase in leaves of Arabidopsis thaliana
Arch. Biochem. Biophys.
402
259-267
2002
Arabidopsis thaliana, Pisum sativum
Manually annotated by BRENDA team
Lin, M.; Oliver, D.J.
The role of acetyl-coenzyme A synthetase in Arabidopsis
Plant Physiol.
147
1822-1829
2008
Arabidopsis thaliana (B9DGD6)
Manually annotated by BRENDA team