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Information on EC 6.1.1.2 - tryptophan-tRNA ligase and Organism(s) Streptomyces coelicolor and UniProt Accession Q8CJX0

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This record set is specific for:
Streptomyces coelicolor
UNIPROT: Q8CJX0 not found.
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Word Map
The taxonomic range for the selected organisms is: Streptomyces coelicolor
The enzyme appears in selected viruses and cellular organisms
Synonyms
tryptophanyl-trna synthetase, trprs, wars2, mini-trprs, t2-trprs, tryptophanyl trna synthetase, htrprs, trprs1, trprs ii, trp-rs, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
tryptophanyl-tRNA synthetase1
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(Mt)TrpRS
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-
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hWRS
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IFP53
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Synthetase, tryptophanyl-transfer ribonucleate
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-
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TrpRS
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-
-
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TrpRS2
Tryptophan translase
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Tryptophan--tRNA ligase
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Tryptophanyl ribonucleic synthetase
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-
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Tryptophanyl-transfer ribonucleate synthetase
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-
-
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Tryptophanyl-transfer ribonucleic acid synthetase
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-
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Tryptophanyl-transfer ribonucleic synthetase
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-
-
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Tryptophanyl-transfer RNA synthetase
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Tryptophanyl-tRNA synthase
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-
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Tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase2
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
esterification
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-
-
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Aminoacylation
PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
L-tryptophan:tRNATrp ligase (AMP-forming)
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CAS REGISTRY NUMBER
COMMENTARY hide
9023-44-3
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
show the reaction diagram
-
-
-
?
ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
show the reaction diagram
-
-
-
?
ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
chuangxinmycin
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indolmycin
additional information
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indolmycin, a potential antibacterial drug, completely inhibits bacterial tryptophanyl-tRNA synthetases, identifying indolmycin resistance genes leads to the discovery of a gene encoding an indolmycin-resistant isoform of tryptophanyl-tRNA synthetase
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
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the auxiliary, antibiotic-resistant tryptophanyl-tRNA synthetase gene trpRS1 in Streptomyces coelicolor is regulated by a ribosome-mediated attenuator in the 5' leader of its mRNA region, overview. This regulatory element controls gene transcription in response to the physiological effects of indolmycin and chuangxinmycin, two antibiotic enzyme inhibitors. Tryptophanyl-tRNA synthetase activity is inversely correlated with antitermination of trpRS1 transcription
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
H48N
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naturally occuring mutation of TrpRS2
H48Q
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naturally occuring mutation of TrpRS2
TrpRS2(H48N)
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ORF mutant, constructed for analysing the indolmycin resistance
TrpRS2(H48Q)
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ORF mutant, constructed for analysing the indolmycin resistance
TrpRS2(L9F)
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ORF mutant, constructed for analysing the indolmycin resistance
TrpRS2(L9F/H48Q)
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ORF mutant, constructed for analysing the indolmycin resistance
TrpRS2(L9F/Q13K)
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ORF mutant, constructed for analysing the indolmycin resistance
TrpRS2(Q13K)
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ORF mutant, constructed for analysing the indolmycin resistance
TrpRS2[C(-17)A/H48Q]
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locus mutant, constructed for analysing the indolmycin resistance
TrpRS2[C(-17)A/L9F]
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locus mutant, constructed for analysing the indolmycin resistance
TrpRS2[C(-17)A]
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locus mutant, constructed for analysing the indolmycin resistance
TrpRS2[G(-13)T/H48Q]
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locus mutant, constructed for analysing the indolmycin resistance
TrpRS2[G(-13)T/L9F]
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locus mutant, constructed for analysing the indolmycin resistance
TrpRS2[G(-13)T]
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locus mutant, constructed for analysing the indolmycin resistance
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene trpRS1, DNA and amino acid sequence determination and analysis, the auxiliary, antibiotic-resistant tryptophanyl-tRNA synthetase gene trpRS1 in Streptomyces coelicolor is regulated by a ribosome-mediated attenuator in the 5' leader of its mRNA region, overview. This regulatory element controls gene transcription in response to the physiological effects of indolmycin and chuangxinmycin, two antibiotic enzyme inhibitors. The trpRS1 locus is a widely distributed and self-regulating antibiotic resistance cassette. Cloning of several orthologues of trpRS1
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the vectors pMS81, pIJ10257, and pBluescript KS+ are used
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
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as producers of nearly half of the 10000 known antibiotics, Streptomyces bacteria have been particularly important in drug discovery and are a major source of drug resistance genes
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vecchione, J.J.; Sello, J.K.
A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin
Antimicrob. Agents Chemother.
53
3972-3980
2009
Streptomyces coelicolor, Streptomyces griseus (B1VQY7)
Manually annotated by BRENDA team
Vecchione, J.J.; Sello, J.K.
Characterization of an inducible, antibiotic-resistant aminoacyl-tRNA synthetase gene in Streptomyces coelicolor
J. Bacteriol.
190
6253-6257
2008
Streptomyces coelicolor (Q8CJX0), Streptomyces coelicolor (Q9KZA7)
Manually annotated by BRENDA team
Vecchione, J.J.; Sello, J.K.
Regulation of an auxiliary, antibiotic-resistant tryptophanyl-tRNA synthetase gene via ribosome-mediated transcriptional attenuation
J. Bacteriol.
192
3565-3573
2010
Streptomyces coelicolor, Streptomyces avermitilis (Q82HU1), Streptomyces avermitilis, Streptomyces coelicolor M600, Streptomyces avermitilis ATCC 31267 (Q82HU1)
Manually annotated by BRENDA team