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Synonyms
prors, prolyl-trna synthetase, glutamyl-prolyl-trna synthetase, glutamyl-prolyl trna synthetase, gluprors, prolyl trna synthetase, prorstt, procysrs, bifunctional aminoacyl-trna synthetase, class ii prolyl-trna synthetase,
more
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ATP + L-proline + tRNAGlu
AMP + diphosphate + L-prolylyl-tRNAGlu
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ATP + L-proline + tRNAPro
AMP + diphosphate + L-prolyl-tRNAPro
ATP + L-alanine + tRNAPro
AMP + diphosphate + L-alanyl-tRNAPro
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very low activity
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?
ATP + L-proline + tRNAPro
AMP + diphosphate + L-prolyl-tRNAPro
additional information
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ATP + L-proline + tRNAPro
AMP + diphosphate + L-prolyl-tRNAPro
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ATP + L-proline + tRNAPro
AMP + diphosphate + L-prolyl-tRNAPro
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ATP + L-proline + tRNAPro
AMP + diphosphate + L-prolyl-tRNAPro
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?
ATP + L-proline + tRNAPro
AMP + diphosphate + L-prolyl-tRNAPro
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?
ATP + L-proline + tRNAPro
AMP + diphosphate + L-prolyl-tRNAPro
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?
ATP + L-proline + tRNAPro
AMP + diphosphate + L-prolyl-tRNAPro
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ATP + L-proline + tRNAPro
AMP + diphosphate + L-prolyl-tRNAPro
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semi-synthetic human tRNAPro prepared by annealing a 5'-57-mer fragment to a 3'-16-mer. The 5'-57-mer is prepared by in vitro transcription
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additional information
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no activity with L-cysteine, the enzyme also performs the ATP-diphosphate exchange reaction, enzyme possesses no editing activity against L-alanine and to prevent from misincorporation of alanine into proteins
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additional information
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in addition to enzymic activity, glutamyl-prolyl-tRNA synthetase is phosphorylated in response to interferon-gamma, binds the ceruloplasmin 3'-untranslated region in an mRNP containing three additional proteins, and silences ceruloplasmin mRNA translation
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additional information
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the glutamyl-prolyl tRNA synthetase determines the specificity of the heterotetrameric GAIT complex suppressing translation of selected mRNAs in interferon-gamma-activated monocytic cells by binding to a 3' UTR element in target mRNAs, critical role of EPRS WHEP domains in targeting and regulating GAIT complex binding to RNA, mechanism, overview. The enzyme is essential in regulating inflammatory gene expression
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additional information
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determination of Pro-AMP and Ala-AMP hydrolysis activities, overview
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additional information
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substrate specificity, reducing effects of diverse different phosphorothioate substitutions in the 3'-strand of human tRNAPro on aminoacylation efficiency, mechanism, overview
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additional information
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the upstream WHEP pair of EPRS directs high-affinity binding to GAIT element-bearing mRNAs, while the overlapping, downstream pair binds NSAP1, which inhibits mRNA binding. Interaction of EPRS with ribosomal protein L13a and GAPDH induces a conformational witch that rescues mRNA binding and restores translational control, interaction analysis, overview
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ATP + L-proline + tRNAGlu
AMP + diphosphate + L-prolylyl-tRNAGlu
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-
-
?
ATP + L-proline + tRNAPro
AMP + diphosphate + L-prolyl-tRNAPro
ATP + L-proline + tRNAPro
AMP + diphosphate + L-prolyl-tRNAPro
additional information
?
-
ATP + L-proline + tRNAPro
AMP + diphosphate + L-prolyl-tRNAPro
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-
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?
ATP + L-proline + tRNAPro
AMP + diphosphate + L-prolyl-tRNAPro
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-
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?
ATP + L-proline + tRNAPro
AMP + diphosphate + L-prolyl-tRNAPro
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-
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?
ATP + L-proline + tRNAPro
AMP + diphosphate + L-prolyl-tRNAPro
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?
ATP + L-proline + tRNAPro
AMP + diphosphate + L-prolyl-tRNAPro
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?
additional information
?
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-
in addition to enzymic activity, glutamyl-prolyl-tRNA synthetase is phosphorylated in response to interferon-gamma, binds the ceruloplasmin 3'-untranslated region in an mRNP containing three additional proteins, and silences ceruloplasmin mRNA translation
-
-
?
additional information
?
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-
the glutamyl-prolyl tRNA synthetase determines the specificity of the heterotetrameric GAIT complex suppressing translation of selected mRNAs in interferon-gamma-activated monocytic cells by binding to a 3' UTR element in target mRNAs, critical role of EPRS WHEP domains in targeting and regulating GAIT complex binding to RNA, mechanism, overview. The enzyme is essential in regulating inflammatory gene expression
-
-
?
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3-(3,3-dimethylbutanamido)-N-[(naphthalen-1-yl)methyl]pyrazine-2-carboxamide
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3-[(cyclohexanecarbonyl)amino]-N-(2,3-dihydro-1H-inden-2-yl)pyrazine-2-carboxamide
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N-[(4-chlorophenyl)methyl]-3-[(cyclohexanecarbonyl)amino]pyrazine-2-carboxamide
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2-(2-chloro-thiophene)-4-quinolinecarboxylic acid
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weak inhibition
2-(3,4-dichloro-phenyl)-4-quinolinecarboxylic acid
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weak inhibition
2-(4-bromo-phenyl)-4-quinolinecarboxylic acid
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weak inhibition
2-(4-bromo-phenyl)-5,7-dichloro-4-quinolinecarboxylic acid
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weak inhibition
2-(4-bromo-phenyl)-5-methyl-7-chloro-4-quinolinecarboxylic acid
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weak inhibition
2-(4-bromo-phenyl)-6,8-dimethyl-4-quinolinecarboxylic acid
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weak inhibition
2-(4-bromo-phenyl)-6-(4-hydroxyphenyl)-4-quinolinecarboxylic acid
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2-(4-bromo-phenyl)-6-(trifluoromethoxy)-4-quinolinecarboxylic acid
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weak inhibition
2-(4-bromo-phenyl)-6-alkenyl-4-quinolinecarboxylic acid
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2-(4-bromo-phenyl)-6-amino-4-quinolinecarboxylic acid
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2-(4-bromo-phenyl)-6-bromo-4-quinolinecarboxylic acid
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2-(4-bromo-phenyl)-6-bromo-8-(trifluoromethyl)-4-quinolinecarboxylic acid
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2-(4-bromo-phenyl)-6-chloro-4-quinolinecarboxylic acid
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2-(4-bromo-phenyl)-6-chloro-8-hydroxymethyl-4-quinolinecarboxylic acid
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weak inhibition
2-(4-bromo-phenyl)-6-chloro-8-methyl-4-quinolinecarboxylic acid
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2-(4-bromo-phenyl)-6-iodo-4-quinolinecarboxylic acid
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weak inhibition
2-(4-bromo-phenyl)-6-methyl-8-chloro-4-quinolinecarboxylic acid
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2-(4-bromo-phenyl)-7-bromo-8-methyl-4-quinolinecarboxylic acid
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2-(4-bromo-phenyl)-7-fluoro-8-methyl-4-quinolinecarboxylic acid
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2-(4-methoxy-phenyl)-4-quinolinecarboxylic acid
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weak inhibition
2-(4-[trifluoromethyl]-phenyl)-4-quinolinecarboxylic acid
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weak inhibition
2-furyl-4-quinolinecarboxylic acid
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weak inhibition
2-naphthyl-4-quinolinecarboxylic acid
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weak inhibition
2-phenyl-4-quinolinecarboxylic acid
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weak inhibition
2-pyridyl-4-quinolinecarboxylic acid
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weak inhibition
halofuginone
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competitive inhibitor
additional information
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MAZ1310 has no inhibitory effect on enzyme activity
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halofuginone
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halofuginone
strong inhibition at 0.001 mM
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Aneurysm
Validation of the Simbionix PROcedure Rehearsal Studio sizing module: A comparison of software for endovascular aneurysm repair sizing and planning.
Carcinogenesis
EPRS is a critical regulator of cell proliferation and estrogen signaling in ER+ breast cancer.
Coccidiosis
Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.
Coinfection
A potent prolyl tRNA synthetase inhibitor antagonizes Chikungunya and Dengue viruses.
COVID-19
The Prolyl-tRNA Synthetase Inhibitor Halofuginone Inhibits SARS-CoV-2 Infection.
Cryptosporidiosis
Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.
Dengue
A potent prolyl tRNA synthetase inhibitor antagonizes Chikungunya and Dengue viruses.
Diffuse Cerebral Sclerosis of Schilder
The genotypic and phenotypic spectrum of PARS2-related infantile-onset encephalopathy.
Diffuse Cerebral Sclerosis of Schilder
Whole exome sequencing reveals mutations in NARS2 and PARS2, encoding the mitochondrial asparaginyl-tRNA synthetase and prolyl-tRNA synthetase, in patients with Alpers syndrome.
Gastroenteritis
Identification of a gamma interferon-activated inhibitor of translation-like RNA motif at the 3' end of the transmissible gastroenteritis coronavirus genome modulating innate immune response.
Idiopathic Pulmonary Fibrosis
Glutamyl-Prolyl-tRNA Synthetase Regulates Epithelial Expression of Mesenchymal Markers and Extracellular Matrix Proteins: Implications for Idiopathic Pulmonary Fibrosis.
Intestinal Volvulus
Genomic analyses of aminoacyl tRNA synthetases from human-infecting helminths.
Leishmaniasis
Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.
Malaria
Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.
Malaria
Halofuginone - the multifaceted molecule.
Malaria
Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase.
Malaria
Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.
Malaria
The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.
Neoplasms
EPRS is a critical regulator of cell proliferation and estrogen signaling in ER+ breast cancer.
Neoplasms
EPRS/GluRS promotes gastric cancer development via WNT/GSK-3?/?-catenin signaling pathway.
Neoplasms
Specific protein carbonylation in human breast cancer tissue compared to adjacent healthy epithelial tissue.
Neoplasms
The tumor antigen repertoire identified in tumor-bearing neu transgenic mice predicts human tumor antigens.
Neurodegenerative Diseases
The genotypic and phenotypic spectrum of PARS2-related infantile-onset encephalopathy.
Starvation
Halofuginone - the multifaceted molecule.
Starvation
Halofuginone-induced amino acid starvation regulates Stat3-dependent Th17 effector function and reduces established autoimmune inflammation.
Toxoplasmosis
Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.
Virus Diseases
Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity.
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Kerjan, P.; Triconnet, M.; Waller, J.P.
Mammalian prolyl-tRNA synthetase corresponds to the approximately 150 kDa subunit of the high-Mr aminoacyl-tRNA synthetase complex
Biochimie
74
195-205
1992
Ovis aries, Homo sapiens, Mammalia
brenda
Yu, X.Y.; Hill, J.M.; Yu, G.; Yang, Y.; Kluge, A.F.; Keith, D.; Finn, J.; Gallant, P.; Silverman, J.; Lim, A.
A series of quinoline analogues as potent inhibitors of C. albicans prolyl tRNA synthetase
Bioorg. Med. Chem. Lett.
11
541-544
2001
Candida albicans, Homo sapiens
brenda
Beuning, P.J.; Musier-Forsyth, K.
Species-specific differences in amino acid editing by class II prolyl-tRNA synthetase
J. Biol. Chem.
276
30779-30785
2001
Escherichia coli, Homo sapiens, Methanocaldococcus jannaschii
brenda
Sampath, P.; Mazumder, B.; Seshadri, V.; Gerber, C.A.; Chavatte, L.; Kinter, M.; Ting, S.M.; Dignam, J.D.; Kim, S.; Driscoll, D.M.; Fox, P.L.
Noncanonical function of glutamyl-prolyl-tRNA synthetase: Gene-specific silencing of translation
Cell
119
195-208
2004
Homo sapiens
brenda
Splan, K.E.; Ignatov, M.E.; Musier-Forsyth, K.
Transfer RNA modulates the editing mechanism used by class II prolyl-tRNA synthetase
J. Biol. Chem.
283
7128-7134
2008
Escherichia coli, Homo sapiens, Methanocaldococcus jannaschii
brenda
Jia, J.; Arif, A.; Ray, P.S.; Fox, P.L.
WHEP domains direct noncanonical function of glutamyl-prolyl tRNA synthetase in translational control of gene expression
Mol. Cell
29
679-690
2008
Homo sapiens
brenda
An, S.; Barany, G.; Musier-Forsyth, K.
Evolution of acceptor stem tRNA recognition by class II prolyl-tRNA synthetase
Nucleic Acids Res.
36
2514-2521
2008
Homo sapiens
brenda
Son, J.; Lee, E.H.; Park, M.; Kim, J.H.; Kim, J.; Kim, S.; Jeon, Y.H.; Hwang, K.Y.
Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone
Acta Crystallogr. Sect. D
69
2136-2145
2013
Homo sapiens (P07814), Homo sapiens
brenda
Keller, T.L.; Zocco, D.; Sundrud, M.S.; Hendrick, M.; Edenius, M.; Yum, J.; Kim, Y.J.; Lee, H.K.; Cortese, J.F.; Wirth, D.F.; Dignam, J.D.; Rao, A.; Yeo, C.Y.; Mazitschek, R.; Whitman, M.
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase
Nat. Chem. Biol.
8
311-317
2012
Homo sapiens
brenda
Adachi, R.; Okada, K.; Skene, R.; Ogawa, K.; Miwa, M.; Tsuchinaga, K.; Ohkubo, S.; Henta, T.; Kawamoto, T.
Discovery of a novel prolyl-tRNA synthetase inhibitor and elucidation of its binding mode to the ATP site in complex with L-proline
Biochem. Biophys. Res. Commun.
488
393-399
2017
Homo sapiens (P07814), Homo sapiens
brenda
Lee, E.Y.; Lee, H.C.; Kim, H.K.; Jang, S.Y.; Park, S.J.; Kim, Y.H.; Kim, J.H.; Hwang, J.; Kim, J.H.; Kim, T.H.; Arif, A.; Kim, S.Y.; Choi, Y.K.; Lee, C.; Lee, C.H.; Jung, J.U.; Fox, P.L.; Kim, S.; Lee, J.S.; Kim, M.H.
Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity
Nat. Immunol.
17
1252-1262
2016
Homo sapiens (P07814), Mus musculus (Q8CGC7), Mus musculus C57BL/6 (Q8CGC7)
brenda