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Information on EC 6.1.1.13 - D-alanine-poly(phosphoribitol) ligase and Organism(s) Bacillus subtilis and UniProt Accession P39581

for references in articles please use BRENDA:EC6.1.1.13
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IUBMB Comments
A thioester bond is formed transiently between D-alanine and the sulfhydryl group of the 4'-phosphopantetheine prosthetic group of D-alanyl carrier protein during the activation of the alanine. Involved in the synthesis of teichoic acids.
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Bacillus subtilis
UNIPROT: P39581
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The taxonomic range for the selected organisms is: Bacillus subtilis
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
d-alanyl carrier protein, d-alanine-activating enzyme, d-alanine-membrane acceptor ligase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D-Alanine-activating enzyme
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D-Alanine-membrane acceptor ligase
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D-Alanine: membrane acceptor ligase
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D-alanyl carrier protein
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D-Alanyl-poly-(phosphoribitol) synthetase
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DAE
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Dcl
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DCP
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acid-thiol ligation
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PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
D-alanine:poly(phosphoribitol) ligase (AMP-forming)
A thioester bond is formed transiently between D-alanine and the sulfhydryl group of the 4'-phosphopantetheine prosthetic group of D-alanyl carrier protein during the activation of the alanine. Involved in the synthesis of teichoic acids.
CAS REGISTRY NUMBER
COMMENTARY hide
9023-65-8
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + D-Ala + D-alanyl carrier protein
D-Alanyl-D-alanyl carrier protein + AMP + diphosphate
show the reaction diagram
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two-step reaction with a high-energy D-Ala-AMP intermediate
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?
ATP + D-alanine + D-alanyl teichoic acid
AMP + diphosphate + D-alanyl teichoic acid
show the reaction diagram
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + D-alanine + D-alanyl teichoic acid
AMP + diphosphate + D-alanyl teichoic acid
show the reaction diagram
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?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Perego, M.; Glaser, P.; Minutello, A.; Strauch, M.A.; Leopold, K.; Fischer, W.
Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis
J. Biol. Chem.
270
15598-15606
1995
Bacillus subtilis
Manually annotated by BRENDA team
Guariglia-Oropeza, V.; Helmann, J.D.
Bacillus subtilis delta(V) confers lysozyme resistance by activation of two cell wall modification pathways, peptidoglycan O-acetylation and D-alanylation of teichoic acids
J. Bacteriol.
193
6223-6232
2011
Bacillus subtilis, Bacillus subtilis 168
Manually annotated by BRENDA team