Reference on EC 6.1.1.1 - tyrosine-tRNA ligase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Deak, F.; Denes, G.
Purification and some properties of rat liver tyrosyl-tRNA synthetase
Biochim. Biophys. Acta
526
626-634
1978
Rattus norvegicus
Grosse, F.; Krauss, G.; Kownatzki, R.; Maass, G.
The binding of tyrosinyl-5'-AMP to tyrosyl synthetase (E. coli)
Nucleic Acids Res.
6
1631-1638
1979
Escherichia coli
Bhat, T.N.; Blow, D.M.; Brick, P.
Tyrosyl-tRNA synthetase forms a mononucleotide-binding old
J. Mol. Biol.
158
699-709
1982
Geobacillus stearothermophilus
Jones, D.H.; McMillan, A.J.; Fersht, A.R.
Reversible dissociation of dimeric tyrosyl-tRNA synthetase by mutagenesis at the subunit interface
Biochemistry
24
5852-5857
1985
Geobacillus stearothermophilus
Brown, K.A.; Vrielink, A.; Blow, D.M.
Crystal structure of two factitious mutants of tyrosyl-tRNA synthetase
Biochem. Soc. Trans.
14
1228-1229
1985
Geobacillus stearothermophilus
-
Ward, W.H.J.; Fersht, A.R.
Asymmetry of tyrosyl-tRNA synthetase in solution
Biochemistry
27
1041-1049
1988
Geobacillus stearothermophilus
Ward, W.H.J.; Fersht, A.R.
Tyrosyl-tRNA synthetase acts as an asymetric dimer in charging tRNA. A rationale for half-of-the-sites activity
Biochemistry
27
5525-5530
1988
Geobacillus stearothermophilus
Chousterman, S.; Chapeville, F.
Tyrosyl-tRNA synthetase of Escherichia coli B. Role of magnesium in the reaction catalyzed by the enzyme
Eur. J. Biochem.
35
46-50
1988
Escherichia coli
Beikirch, H.; v.d.Haar, F.; Cramer, F.
Tyrosyl-tRNA synthetase
Methods Enzymol.
34B
503-506
1974
Saccharomyces cerevisiae
-
Reid, B.R.; Koch, G.L.E.; Boulanger, Y.; Hartley, B.S.; Blow, D.M.
Crystallization and preliminary X-ray diffraction studies on tyrosyl-transfer RNA synthetase from Bacillus stearothermophilus
J. Mol. Biol.
80
199-201
1973
Geobacillus stearothermophilus
Bhanot, O.S.; Kucan, Z.; Aoyagi, S.; Lee, F.C.; Chambers, R.W.
Purification of tyrosine:tRNA ligase, valine:tRNA ligase, alanine:tRNA ligase, and isoleucine:tRNA ligase from Saccharomyces cerevisiae alphaS288C
Methods Enzymol.
29E
547-576
1974
Saccharomyces cerevisiae
-
Salazar, O.; Sagredo, B.; Jedlicki, E.; Sll, D.; Weygand-Durasevic, I.; Orellana, O.
Thiobacillus ferrooxydans tyrosyl-tRNA synthetase functions in vivo in Escherichia coli
J. Bacteriol.
176
4409-4415
1994
Acidithiobacillus ferrooxidans
Avis, J.M.; Day, A.G.; Garcia, G.A.; Fersht, A.R.
Reaction of modified and unmodified tRNATyr substrates with tyrosyl-tRNA synthetase (Bacillus stearothermophilus)
Biochemistry
32
5312-5320
1993
Geobacillus stearothermophilus
First, E.A.; Fersht, A.R.
Involvement of threonine 234 in catalysis of threonyl adenylate formation by tyrosyl-tRNA synthetase
Biochemistry
32
13644-13650
1993
Geobacillus stearothermophilus
First, E.A.; Fersht, A.R.
Mutation of lysine 233 to alanine introduces positive cooperativity into tyrosyl-tRNA synthetase
Biochemistry
32
13651-13657
1993
Geobacillus stearothermophilus
First, E.A.; Fersht, A.R.
Mutational and kinetic analysis of a mobile loop in tyrosyl-tRNA synthetase
Biochemistry
32
13658-13663
1993
Geobacillus stearothermophilus
Wells, T.N.C.; Knill-Jones, J.W.; Gray, T.E.; Fersht, A.R.
Kinetic and thermodynamic properties of wild-type and engineered mutants of tyrosyl-tRNA synthetase analyzed by pyrophosphate exchange kinetics
Biochemistry
30
5151-5156
1991
Geobacillus stearothermophilus
Fothergill, M.D.; Fersht, A.R.
Correlations between kinetics and X-ray analyses of engineered enzymes - crystal structures of mutants Cys-->Gly35 and Tyr-->Phe34 of tyrosyl-tRNA synthetase
Biochemistry
30
5157-5164
1991
Geobacillus stearothermophilus
First, E.; Fersht, A.R.
Analysis of the role of the KMSKS loop in the catalytic mechanism of the tyrosyl-tRNA synthetase using multimutant cycles
Biochemistry
34
5030-5043
1995
Geobacillus stearothermophilus
Brick, P.; Bhat, T.N.; Blow, D.M.
Structure of tyrosyl-tRNA synthetase refined at 2.3 A resolution
J. Mol. Biol.
208
83-98
1988
Saccharomyces cerevisiae
Garcia, G.A.; Leatherbarrow, R.J.; Eckstein, F.; Fersht, A.R.
Metal ion dependence of phosphorothioate ATP analogues in the Bacillus stearothermophilus tyrosyl-tRNA synthetase reaction
Biochemistry
29
1643-1648
1990
Geobacillus stearothermophilus
Freist, W.; Sternbach, H.
Tyrosyl-tRNA synthetase from bakers yeast. Order of substrate addition, discrimination of 20 amino acids in aminoacylation of tRNATyr-C-C-A and tRNATyr-C-C-A(3'NH2)
Eur. J. Biochem.
177
425-433
1988
Saccharomyces cerevisiae
Quivy, J.P.; Chroboczek, J.
Tyrosyl-tRNA synthetase from wheat germ
J. Biol. Chem.
263
15277-15281
1988
Triticum aestivum
De Prat, G.; Duckworth, H.W.; Fersht, A.R.
Modification of amino acid specificity of tyrosyl-tRNA synthetase by protein engineering
FEBS Lett.
318
167-171
1993
Geobacillus stearothermophilus
Allen, H.E.; Glassman, E.; Schweet, R.S.
Incorporation of amino acids into ribonucleic acid
J. Biol. Chem.
235
1061-1067
1960
Cavia porcellus
Chousterman, S.; Chapeville, F.
Escherichia coli tyrosyl-tRNA synthetase. Influence of magnesium ions on the enzme activity
FEBS Lett.
17
153-157
1971
Escherichia coli
Beikirch, H.; Haar, F.; Cramer, F.
Tyrosyl-tRNA synthetase from baker's yeast
Eur. J. Biochem.
26
182-190
1972
Saccharomyces cerevisiae
Buonocore, V.; Harris, M.H.; Schlesinger, S.
Properties of tyrosyl transfer ribonucleic acid synthetase from two tyrS mutants of Escherichia coli K-12
J. Biol. Chem.
247
843-4849
1972
Escherichia coli
-
Cowles, J.R.; Key, J.L.
Demonstration of two tyrosyl-tRNA synthetases of pea roots
Biochim. Biophys. Acta
281
33-44
1972
Pisum sativum
Kucan, Z.; Chambers, R.W.
Purification of tyrosine: tRNA ligase from Saccharomyces cerevisiae
J. Biochem.
73
811-819
1973
Saccharomyces cerevisiae
Chousterman, S.; Chapeville, F.
Tyrosyl-tRNA synthetase of Escherichia coli B
Eur. J. Biochem.
35
51-56
1973
Escherichia coli
Koch, G.L.E.
Tyrosyl transfer ribonucleic acid synthetase from Bacillus stearothermophilus. Preparation and properties of the crystallizable enzyme
Biochemistry
13
2307-2312
1974
Geobacillus stearothermophilus
Jakes, R.; Fersht, A.R.
Tyrosyl-tRNA synthetase from Escherichia coli. Stoichiometry of ligand binding and of half-of-the-sites reactivity in aminoacylation
Biochemistry
14
3344-3350
1975
Escherichia coli
Bruton, C.; Jakes, R.; Atkinson, T.
Gram-scale purification of methionyl-tRNA and tyrosyl-tRNA synthetases from Escherichia coli
Eur. J. Biochem.
59
327-333
1975
Escherichia coli
Warner, C.K.; Jacobson, K.B.
Mechanism of suppression in Drosophila. IV. Specificity and properies of tyrosyl-tRNA synthetase
Can. J. Biochem.
54
650-656
1976
Drosophila melanogaster
Irwin, M.J.; Nyborg, J.; Reid, B.R.; Blow, D.M.
The crystal structure of tyrosyl-transfer RNA synthetase at 2.7 A resolution
J. Mol. Biol.
105
577-586
1976
Geobacillus stearothermophilus
Faulhammer, G.H.; Cramer, F.
Tyrosyl-tRNA synthetase from baker's yeast. Rapid isolation by affinity elution, molecular weight of the enzyme and determination of essential sulfhydryl groups
Eur. J. Biochem.
75
561-570
1977
Saccharomyces cerevisiae
Prasada Rao, Y.S.; Srinivasan, P.R.
Purification and properies of tyrosyl tRNA synthetase of rat liver
Nucleic Acids Res.
4
3887-3900
1977
Rattus norvegicus
Locy, R.D.; Cherry, J.H.
Purification and characterization of two tyrosyl-tRNA synthetase activities from soybean cotyledons
Phytochemistry
17
19-27
1978
Glycine max
-
Monteilhet, C.; Blow, D.M.
Binding of tyrosine, adenosine triphosphate and analogues to crystalline tyrosyl transfer RNA synthetase
J. Mol. Biol.
122
407-417
1978
Geobacillus stearothermophilus
Freist, W.; von der Haar, F.; Faulhammer, H.; Cramer, F.
Valyl-tRNA, isoleucyl-tRNA and tyrosyl-tRNA synthetase from baker's yeast. Substrate specificity with regard to ATP analogs and mechanism of the aminoacylation reaction
Eur. J. Biochem.
66
493-497
1976
Saccharomyces cerevisiae
Fechter, P.; Rudinger-Thirion, J.; Theobald-Dietrich, A.; Giege, R.
Identity of tRNA for yeast tyrosyl-tRNA synthetase: tyrosylation is more sensitive to identity nucleotides than to structural features
Biochemistry
39
1725-1733
2000
Saccharomyces cerevisiae
Ewalt, K.L.; Schimmel, P.
Activation of angiogenic signaling pathways by two human tRNA synthetases
Biochemistry
41
13344-13349
2002
Homo sapiens
Airas, R.K.
Chloride affects the interaction between tyrosyl-tRNA synthetase and tRNA
Biochim. Biophys. Acta
1472
51-61
1999
Geobacillus stearothermophilus, Escherichia coli
Brown, P.; Richardson, C.M.; Mensah, L.M.; O'Hanlon, P.J.; Osborne, N.F.; Pope, A.J.; Walker, G.
Molecular recognition of tyrosinyl adenylate analogues by prokaryotic tyrosyl tRNA synthetases
Bioorg. Med. Chem.
7
2473-2485
1999
Geobacillus stearothermophilus, Staphylococcus aureus
Jarvest, R.L.; Berge, J.M.; Houge-Frydrych, C.S.; Janson, C.; Mensah, L.M.; O'Hanlon, P.J.; Pope, A.; Saldanha, A.; Qiu, X.
Interaction of tyrosyl aryl dipeptides with S. aureus tyrosyl tRNA synthetase: inhibition and crystal structure of a complex
Bioorg. Med. Chem. Lett.
9
2859-2862
1999
Staphylococcus aureus
Yaremchuk, A.; Kriklivyi, I.; Tukalo, M.; Cusack, S.
Class I tyrosyl-tRNA synthetase has a class II mode of cognate tRNA recognition
EMBO J.
21
3829-3840
2002
Thermus thermophilus, Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
Salazar, J.C.; Zuniga, R.; Lefimil, C.; Soll, D.; Orellana, O.
Conserved amino acids near the carboxy terminus of bacterial tyrosyl-tRNA synthetase are involved in tRNA and Tyr-AMP binding
FEBS Lett.
491
257-260
2001
Acidithiobacillus ferrooxidans
Ohno, S.; Yokogawa, T.; Nishikawa, K.
Changing the amino acid specificity of yeast tyrosyl-tRNA synthetase by genetic engineering
J. Biochem.
130
417-423
2001
Saccharomyces cerevisiae
Park, Y.C.; Bedouelle, H.
Dimeric tyrosyl-tRNA synthetase from Bacillus stearothermophilus unfolds through a monomeric intermediate. A quantitative analysis under equilibrium conditions
J. Biol. Chem.
273
18052-18059
1998
Geobacillus stearothermophilus
Hamano-Takaku, F.; Iwama, T.; Saito-Yano, S.; Takaku, K.; Monden, Y.; Kitabatake, M.; Soll, D.; Nishimura, S.
A mutant Escherichia coli tyrosyl-tRNA synthetase utilizes the unnatural amino acid azatyrosine more efficiently than tyrosine
J. Biol. Chem.
275
40324-40328
2000
Escherichia coli
Austin, J.; First, E.A.
Catalysis of tyrosyl-adenylate formation by the human tyrosyl-tRNA synthetase
J. Biol. Chem.
277
14812-14820
2002
Homo sapiens
Austin, J.; First, E.A.
Comparison of the catalytic roles played by the KMSKS motif in the human and Bacillus stearothermophilus trosyl-tRNA synthetases
J. Biol. Chem.
277
28394-28399
2002
Geobacillus stearothermophilus, Homo sapiens
Xin, Y.; Li, W.; First, E.A.
Stabilization of the transition state for the transfer of tyrosine to tRNATyr by tyrosyl-tRNA synthetase
J. Mol. Biol.
303
299-310
2000
Geobacillus stearothermophilus
Zhang, D.; Vaidehi, N.; Goddard, W.A.3rd.; Danzer, J.F.; Debe, D.
Structure-based design of mutant Methanococcus jannaschii tyrosyl-tRNA synthetase for incorporation of O-methyl-L-tyrosine
Proc. Natl. Acad. Sci. USA
99
6579-6584
2002
Methanocaldococcus jannaschii (Q57834), Methanocaldococcus jannaschii
Kiga, D.; Sakamoto, K.; Kodama, K.; Kigawa, T.; Matsuda, T.; Yabuki, T.; Shirouzu, M.; Harada, Y.; Nakayama, H.; Takio, K.; Hasegawa, Y.; Endo, Y.; Hirao, I.; Yokoyama, S.
An engineered Escherichia coli tyrosyl-tRNA synthetase for site-specific incorporation of an unnatural amino acid into proteins in eukaryotic translation and its application in a wheat germ cell-free system
Proc. Natl. Acad. Sci. USA
99
9715-9720
2002
Escherichia coli
Jia, J.; Li, B.; Jin, Y.; Wang, D.
Expression, purification, and characterization of human tyrosyl-tRNA synthetase
Protein Expr. Purif.
27
104-108
2003
Homo sapiens
Qiu, X.; Janson, C.A.; Smith, W.W.; Green, S.M.; McDevitt, P.; Johanson, K.; Carter, P.; Hibbs, M.; Lewis, C.; Chalker, A.; Fosberry, A.; Lalonde, J.; Berge, J.; Brown, P.; Houge-Frydrych, C.S.; Jarvest, R.L.
Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors
Protein Sci.
10
2008-2016
2001
Staphylococcus aureus
Bonnefond, L.; Fender, A.; Rudinger-Thirion, J.; Giege, R.; Florentz, C.; Sissler, M.
Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS
Biochemistry
44
4805-4816
2005
Homo sapiens (Q9Y2Z4), Homo sapiens
Abergel, C.; Chenivesse, S.; Byrne, D.; Suhre, K.; Arondel, V.; Claverie, J.M.
Mimivirus TyrRS: preliminary structural and functional characterization of the first amino-acyl tRNA synthetase found in a virus
Acta Crystallogr. Sect. F
F61
212-215
2005
Mimivirus
Kobayashi, T.; Takimura, T.; Sekine, R.; Kelly, V.P.; Kamata, K.; Sakamoto, K.; Nishimura, S.; Yokoyama, S.
Structural snapshots of the KMSKS loop rearrangement for amino acid activation by bacterial tyrosyl-tRNA synthetase
J. Mol. Biol.
346
105-117
2005
Escherichia coli (P0AGJ9), Escherichia coli
Kuratani, M.; Sakai, H.; Takahashi, M.; Yanagisawa, T.; Kobayashi, T.; Murayama, K.; Chen, L.; Liu, Z.J.; Wang, B.C.; Kuroishi, C.; Kuramitsu, S.; Terada, T.; Bessho, Y.; Shirouzu, M.; Sekine, S.; Yokoyama, S.
Crystal structures of tyrosyl-tRNA synthetases from Archaea
J. Mol. Biol.
355
395-408
2006
Archaeoglobus fulgidus (O29482), Archaeoglobus fulgidus, Pyrococcus horikoshii (O58739), Pyrococcus horikoshii, Aeropyrum pernix (Q9YA64), Aeropyrum pernix
Paukstelis, P.J.; Coon, R.; Madabusi, L.; Nowakowski, J.; Monzingo, A.; Robertus, J.; Lambowitz, A.M.
A tyrosyl-tRNA synthetase adapted to function in group I intron splicing by acquiring a new RNA binding surface
Mol. Cell
17
417-428
2005
Neurospora crassa
Zhang, Y.; Wang, L.; Schultz, P.G.; Wilson, I.A.
Crystal structures of apo wild-type M. jannaschii tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O-methyl-L-tyrosine
Protein Sci.
14
1340-1349
2005
Methanocaldococcus jannaschii (Q57834), Methanocaldococcus jannaschii
Kordysh, M.; Kornelyuk, A.
Conformational flexibility of cytokine-like C-module of tyrosyl-tRNA synthetase monitored by Trp144 intrinsic fluorescence
J. Fluoresc.
16
705-711
2006
Bos taurus
Abergel, C.; Rudinger-Thirion, J.; Giege, R.; Claverie, J.M.
Virus-encoded aminoacyl-tRNA synthetases: structural and functional characterization of mimivirus TyrRS and MetRS
J. Virol.
81
12406-12417
2007
Acanthamoeba polyphaga Mimivirus (Q5UPJ7)
Jordanova, A.; Irobi, J.; Thomas, F.P.; Van Dijck, P.; Meerschaert, K.; Dewil, M.; Dierick, I.; Jacobs, A.; De Vriendt, E.; Guergueltcheva, V.; Rao, C.V.; Tournev, I.; Gondim, F.A.; DHooghe, M.; Van Gerwen, V.; Callaerts, P.; Van Den Bosch, L.; Timmermans, J.P.; Robberecht, W.; Gettemans, J.; The, T.h.e.v.
Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy
Nat. Genet.
38
197-202
2006
Homo sapiens
Tsunoda, M.; Kusakabe, Y.; Tanaka, N.; Ohno, S.; Nakamura, M.; Senda, T.; Moriguchi, T.; Asai, N.; Sekine, M.; Yokogawa, T.; Nishikawa, K.; Nakamura, K.T.
Structural basis for recognition of cognate tRNA by tyrosyl-tRNA synthetase from three kingdoms
Nucleic Acids Res.
35
4289-4300
2007
Saccharomyces cerevisiae (P36421), Saccharomyces cerevisiae
Turner, J.M.; Graziano, J.; Spraggon, G.; Schultz, P.G.
Structural plasticity of an aminoacyl-tRNA synthetase active site
Proc. Natl. Acad. Sci. USA
103
6483-6488
2006
Methanocaldococcus jannaschii (Q57834)
Bonnefond, L.; Frugier, M.; Touze, E.; Lorber, B.; Florentz, C.; Giege, R.; Sauter, C.; Rudinger-Thirion, J.
Crystal structure of human mitochondrial tyrosyl-tRNA synthetase reveals common and idiosyncratic features
Structure
15
1505-1516
2007
Homo sapiens
Cheng, G.; Zhang, H.; Yang, X.; Tzima, E.; Ewalt, K.L.; Schimmel, P.; Faber, J.E.
Effect of mini-tyrosyl-tRNA synthetase on ischemic angiogenesis, leukocyte recruitment, and vascular permeability
Am. J. Physiol. Regul. Integr. Comp. Physiol.
295
R1138-R1146
2008
Mus musculus
Goerke, A.R.; Swartz, J.R.
High-level cell-free synthesis yields of proteins containing site-specific non-natural amino acids
Biotechnol. Bioeng.
102
400-416
2008
Methanocaldococcus jannaschii
Li, T.; Froeyen, M.; Herdewijn, P.
Comparative structural dynamics of Tyrosyl-tRNA synthetase complexed with different substrates explored by molecular dynamics
Eur. Biophys. J.
38
25-35
2008
Staphylococcus aureus (A6QHR2), Staphylococcus aureus
Greenberg, Y.; King, M.; Kiosses, W.B.; Ewalt, K.; Yang, X.; Schimmel, P.; Reader, J.S.; Tzima, E.
The novel fragment of tyrosyl tRNA synthetase, mini-TyrRS, is secreted to induce an angiogenic response in endothelial cells
FASEB J.
22
1597-1605
2008
Bos taurus
Hauenstein, S.I.; Hou, Y.M.; Perona, J.J.
The homotetrameric phosphoseryl-tRNA synthetase from Methanosarcina mazei exhibits half-of-the-sites activity
J. Biol. Chem.
283
21997-22006
2008
Methanosarcina mazei
Paukstelis, P.J.; Chen, J.; Chase, E.; Lambowitz, A.M.; Golden, B.L.
Structure of a tyrosyl-tRNA synthetase splicing factor bound to a group I intron RNA
Nature
451
94-97
2008
Neurospora crassa (P12063), Neurospora crassa
Paukstelis, P.J.; Lambowitz, A.M.
Identification and evolution of fungal mitochondrial tyrosyl-tRNA synthetases with group I intron splicing activity
Proc. Natl. Acad. Sci. USA
105
6010-6015
2008
Histoplasma capsulatum, Aspergillus nidulans, Coccidioides posadasii
Park, H.; Davidson, E.; King, M.P.
Overexpressed mitochondrial leucyl-tRNA synthetase suppresses the A3243G mutation in the mitochondrial tRNA(Leu(UUR)) gene
RNA
14
2407-2416
2008
Methanocaldococcus jannaschii
Bonnefond, L.; Florentz, C.; Giege, R.; Rudinger-Thirion, J.
Decreased aminoacylation in pathology-related mutants of mitochondrial tRNATyr is associated with structural perturbations in tRNA architecture
RNA
14
641-648
2008
Homo sapiens
Sun, R.; Zheng, H.; Fang, Z.; Yao, W.
Rational design of aminoacyl-tRNA synthetase specific for p-acetyl-L-phenylalanine
Biochem. Biophys. Res. Commun.
391
709-715
2010
Methanocaldococcus jannaschii (Q57834), Methanocaldococcus jannaschii
Melancon, C.E.; Schultz, P.G.
One plasmid selection system for the rapid evolution of aminoacyl-tRNA synthetases
Bioorg. Med. Chem. Lett.
19
3845-3847
2009
Methanocaldococcus jannaschii
Kapoor, M.; Otero, F.J.; Slike, B.M.; Ewalt, K.L.; Yang, X.L.
Mutational separation of aminoacylation and cytokine activities of human tyrosyl-tRNA synthetase
Chem. Biol.
16
531-539
2009
Homo sapiens (P54577), Homo sapiens
Kamijo, S.; Fujii, A.; Onodera, K.; Wakabayashi, K.
Analyses of conditions for KMSSS loop in tyrosyl-tRNA synthetase by building a mutant library
J. Biochem.
146
241-250
2009
Methanocaldococcus jannaschii
Sharma, G.; First, E.
Thermodynamic analysis reveals a temperature-dependent change in the catalytic mechanism of Bacillus stearothermophilus tyrosyl-tRNA synthetase
J. Biol. Chem.
284
4179-4190
2009
Geobacillus stearothermophilus
Chadee, A.B.; Bhaskaran, H.; Russell, R.
Protein roles in group I intron RNA folding: the tyrosyl-tRNA synthetase CYT-18 stabilizes the native state relative to a long-lived misfolded structure without compromising folding kinetics
J. Mol. Biol.
395
656-670
2010
Neurospora crassa (P12063), Neurospora crassa
Kim, J.H.; Kim, Y.Y.; Kim, S.J.
High glucose inhibits gene expression of tyrosyl-tRNA synthetase in osteoblast cells
Methods Find. Exp. Clin. Pharmacol.
31
639-644
2009
Rattus norvegicus
Iraha, F.; Oki, K.; Kobayashi, T.; Ohno, S.; Yokogawa, T.; Nishikawa, K.; Yokoyama, S.; Sakamoto, K.
Functional replacement of the endogenous tyrosyl-tRNA synthetase-tRNATyr pair by the archaeal tyrosine pair in Escherichia coli for genetic code expansion
Nucleic Acids Res.
38
3682-3691
2010
Escherichia coli (P0AGJ9), Escherichia coli, Methanocaldococcus jannaschii, Saccharomyces cerevisiae
Storkebaum, E.; Leitao-Goncalves, R.; Godenschwege, T.; Nangle, L.; Mejia, M.; Bosmans, I.; Ooms, T.; Jacobs, A.; Van Dijck, P.; Yang, X.L.; Schimmel, P.; Norga, K.; Timmerman, V.; Callaerts, P.; Jordanova, A.
Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy
Proc. Natl. Acad. Sci. USA
106
11782-11787
2009
Saccharomyces cerevisiae, Drosophila melanogaster, Homo sapiens
Paukstelis, P.J.; Chari, N.; Lambowitz, A.M.; Hoffman, D.
NMR structure of the C-terminal domain of a tyrosyl-tRNA synthetase that functions in group I intron splicing
Biochemistry
50
3816-3826
2011
Aspergillus nidulans
Xiao, Z.P.; Ouyang, H.; Wang, X.D.; Lv, P.C.; Huang, Z.J.; Yu, S.R.; Yi, T.F.; Yang, Y.L.; Zhu, H.L.
4-Alkoxy-3-arylfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: Synthesis, molecular docking and antibacterial evaluation
Bioorg. Med. Chem.
19
3884-3891
2011
Staphylococcus aureus, Staphylococcus aureus ATCC 25923
Vo, M.N.; Yang, X.L.; Schimmel, P.
Dissociating quaternary structure regulates cell-signaling functions of a secreted human tRNA synthetase
J. Biol. Chem.
286
11563-11568
2011
Homo sapiens
Kuhn, S.M.; Rubini, M.; Fuhrmann, M.; Theobald, I.; Skerra, A.
Engineering of an orthogonal aminoacyl-tRNA synthetase for efficient incorporation of the non-natural amino acid O-methyl-L-tyrosine using fluorescence-based bacterial cell sorting
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The double-length tyrosyl-tRNA synthetase from the eukaryote Leishmania major forms an intrinsically asymmetric pseudo-dimer
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Leishmania major
Iwaki, J.; Suzuki, R..; Fujimoto, Z.; Momma, M.; Kuno, A.; Hasegawa, T.
Overexpression, purification and crystallization of tyrosyl-tRNA synthetase from the hyperthermophilic archaeon Aeropyrum pernix K1
Acta Crystallogr. Sect. F
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Aeropyrum pernix (Q9YA64), Aeropyrum pernix DSM 11879 (Q9YA64)
Wang, X.D.; Deng, R.C.; Dong, J.J.; Peng, Z.Y.; Gao, X.M.; Li, S.T.; Lin, W.Q.; Lu, C.L.; Xiao, Z.P.; Zhu, H.L.
3-Aryl-4-acyloxyethoxyfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: synthesis, molecular docking and antibacterial evaluation
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Staphylococcus aureus
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The N-terminal fragment of Acanthamoeba polyphaga mimivirus tyrosyl-tRNA synthetase (TyrRS(apm)) is a monomer in solution
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Acanthamoeba polyphaga Mimivirus
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Studies on crenarchaeal tyrosylation accuracy with mutational analyses of tyrosyl-tRNA synthetase and tyrosine tRNA from Aeropyrum pernix
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Aeropyrum pernix, Aeropyrum pernix (Q9YA64), Aeropyrum pernix DSM 11879 (Q9YA64)
Savytskyi, O.V.; Yesylevskyy, S.O.; Kornelyuk, A.I.
Asymmetric structure and domain binding interfaces of human tyrosyl-tRNA synthetase studied by molecular dynamics simulations
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Homo sapiens (P54577), Homo sapiens
Kobayashi, T.; Nureki, O.; Ishitani, R.; Yaremchuk, A.; Tukalo, M.; Cusack, S.;, Sakamoto K, Yokoyama S.
Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion
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Methanocaldococcus jannaschii (Q57834), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661 (Q57834)
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A brief perspective of the determination of crystal structures of site-directed mutants of tyrosyl-tRNA synthetase
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Geobacillus stearothermophilus (P00952)
Barros-Alvarez, X.; Kerchner, K.M.; Koh, C.Y.; Turley, S.; Pardon, E.; Steyaert, J.; Ranade, R.M.; Gillespie, J.R.; Zhang, Z.; Verlinde, C.L.M.J.; Fan, E.; Buckner, F.S.; Hol, W.G.J.
Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts
Biochimie
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Leishmania donovani
Venkat, S.; Gregory, C.; Gan, Q.; Fan, C.
Biochemical characterization of the lysine acetylation of tyrosyl-tRNA synthetase in Escherichia coli
ChemBioChem
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Escherichia coli (P0AGJ9), Escherichia coli
Mykuliak, V.V.; Dragan, A.I.; Kornelyuk, A.I.
Structural states of the flexible catalytic loop of M. tuberculosis tyrosyl-tRNA synthetase in different enzyme-substrate complexes
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Mycobacterium tuberculosis (P9WFT1), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (P9WFT1)
Xiao, Z.P.; Wei, W.; Wang, P.F.; Shi, W.K.; Zhu, N.; Xie, M.Q.; Sun, Y.W.; Li, L.X.; Xie, Y.X.; Zhu, L.S.; Tang, N.; Ouyang, H.; Li, X.H.; Wang, G.C.; Zhu, H.L.
Synthesis and evaluation of new tyrosyl-tRNA synthetase inhibitors as antibacterial agents based on a N2-(arylacetyl)glycinanilide scaffold
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Staphylococcus aureus
Ling, Z.; Yanling, Z.; Zhe, F.; Kui, C.; Xiushi, Z.; Min, Y.; Wei, M.
Recombinant human tyrosyl-tRNA synthetase, a novel thrombopoietic agent
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Homo sapiens
Raina, M.; Moghal, A.; Kano, A.; Jerums, M.; Schnier, P.D.; Luo, S.; Deshpande, R.; Bondarenko, P.V.; Lin, H.; Ibba, M.
Reduced amino acid specificity of mammalian tyrosyl-tRNA synthetase is associated with elevated mistranslation of Tyr codons
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Cricetulus griseus (G3H935), Cricetulus griseus
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Twin attributes of tyrosyl-tRNA synthetase of Leishmania donovani a housekeeping protein translation enzyme and a mimic of host chemokine
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Leishmania donovani (E9BC28), Leishmania donovani, Leishmania donovani BPK282A1 (E9BC28)
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Probing the stereospecificity of tyrosyl- and glutaminyl-tRNA synthetase with molecular dynamics
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Methanocaldococcus jannaschii (Q57834), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii TCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440 (Q57834)
Sun, J.; Liu, J.; Zhou, W.; Guo, F.; Wang, X.; Zhu, H.
4-Hydroxy-3-(naphthalen-1-ylmethyl)thiophen-2(5H)-one as inhibitors of tyrosyl-tRNA synthase Synthesis, molecular docking and antibacterial evaluation
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Staphylococcus aureus, Staphylococcus aureus ATCC 25923
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Datt, M.; Sharma, A.
Conformational landscapes for KMSKS loop in tyrosyl-tRNA synthetases
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Pyrococcus horikoshii (O58739), Leishmania major (Q4QFJ7), Pyrococcus horikoshii ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3 (O58739)
Skupinska, M.; Stepniak, P.; Letowska, I.; Rychlewski, L.; Barciszewska, M.; Barciszewski, J.; Giel-Pietraszuk, M.
Natural compounds as inhibitors of tyrosyl-tRNA synthetase
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Escherichia coli (P0AGJ9), Escherichia coli, Pseudomonas aeruginosa (Q9HWP3), Pseudomonas aeruginosa, Pseudomonas aeruginosa ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1 (Q9HWP3), Staphylococcus aureus
Wei, Z.; Xu, Z.; Liu, X.; Lo, W.S.; Ye, F.; Lau, C.F.; Wang, F.; Zhou, J.J.; Nangle, L.A.; Yang, X.L.; Zhang, M.; Schimmel, P.
Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase
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Homo sapiens (P54577), Homo sapiens
Tsukahara, T.; Yamagishi, S.; Neyama, H.; Ueda, H.
Tyrosyl-tRNA synthetase A potential kyotorphin synthetase in mammals
Peptides
101
60-68
2018
Homo sapiens
Simonson, T.; Ye-Lehmann, S.; Palmai, Z.; Amara, N.; Wydau-Dematteis, S.; Bigan, E.; Druart, K.; Moch, C.; Plateau, P.
Redesigning the stereospecificity of tyrosyl-tRNA synthetase
Proteins
84
240-253
2016
Escherichia coli (P0AGJ9), Escherichia coli
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