Information on EC 5.99.1.2 - DNA topoisomerase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
5.99.1.2
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RECOMMENDED NAME
GeneOntology No.
DNA topoisomerase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
isomerization
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transesterification
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typ IB topoisomerases generate a tyrosyl-3'-phosphodiester. Recombinant MimiTopIB relaxes supercoiled DNA
SYSTEMATIC NAME
IUBMB Comments
DNA topoisomerase
These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.99.1.3 DNA topoisomerase (ATP-hydrolysing).
CAS REGISTRY NUMBER
COMMENTARY hide
80449-01-0
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Automatic Mining of ENzyme DAta
a parasite of Acanthamoeba polyphaga
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Bacillus cereus ATCC14579
ATCC14579
UniProt
Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
strain YIT4006
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Manually annotated by BRENDA team
strain YIT4006
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
camptothecin non producing plant
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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gene topA
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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contains two topoisomerase III genes
UniProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain FMC2
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Manually annotated by BRENDA team
strain FMC2
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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strain NRRL B-11,022
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Manually annotated by BRENDA team
strain NRRL B-11,022
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Mus musculus BALB/c
male mice
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Manually annotated by BRENDA team
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1251911 A+, 1361631 A+, 1361949 A+, 1361988 A+, 1362008 A+, 1362133 A+, 1362312 A+, 1362533 A+, 1362877 A+, 1362878 A+, 1362920 A+, 1362969 A+, 1363046 A+, 1363108 A+, 1363238 A+, 2136580 A+, 2136691 A+, 2136768 A+, 2136905 A+, 2136922 A+, 2137027 A+, 2137096 A+, 2137487 A+, 2341108 A+, 2405257 A+, 2413536 A+, 2493060 A+, 2493297 A+, 2493597 A+, 2493660 A+, 2493706 A+, 2494033 A+, 2494116 A+, 2494277 A+, 2494507 A+, 2494763 A+, 798620 A+, 799435 A+, 799576 A+, 799694 A+, 799734 A+, 799877 A+, 799898 A+, 1290890 A++, 1361622 A++, 1362276 A++, 1362528 A++, 2136365 A++, 2136728 A++, 2137111 A++, 2137537 A++, 2494732 A++, 798817 A++, 799269 A++, 799520 A++, 799759 A++, 1361819 A++, 1361850 A++, 1361865 A++, 1361870 A++, 1361894 A++, 1361920 A++, 1361948 A++, 1362066 A++, 1362232 A++, 1362303 A++, 1362337 A++, 1362585 A++, 1362693 A++, 1362777 A++, 1363114 A++, 2136036 A++, 2136074 A++, 2136108 A++, 2136315 A++, 2136354 A++, 2136370 A++, 2136503 A++, 2136516 A++, 2136521 A++, 2136599 A++, 2136614 A++, 2136634 A++, 2136648 A++, 2136651 A++, 2136696 A++, 2136761 A++, 2137085 A++, 2137148 A++, 2341274 A++, 2493027 A++, 2493058 A++, 2493182 A++, 2493286 A++, 2493290 A++, 2493298 A++, 2493313 A++, 2493352 A++, 2493370 A++, 2493412 A++, 2493428 A++, 2493453 A++, 2493473 A++, 2493502 A++, 2493721 A++, 2493801 A++, 2493828 A++, 2494008 A++, 2494089 A++, 2494128 A++, 2494207 A++, 2494315 A++, 2494523 A++, 2494566 A++, 2494673 A++, 798519 A++, 798665 A++, 798999 A++, 799019 A++, 799123 A++, 799159 A++, 799208 A++, 799318 A++, 799452 A++, 799811 A++, 864665 A++, 928992 A++, 799025 A++++, 799273 A++++, 799379 A++++, 799560 A++++, 799646 A++++, 799842 A++++
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Automatic Mining of ENzyme DAta
Erdman strain
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Manually annotated by BRENDA team
gene MtbTopA or Rv3646
UniProt
Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
camptothecin non producing plant
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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1361671 A+, 1362001 A+, 1362133 A+, 1362728 A+, 1362945 A+, 1363018 A+, 210528 A+, 2107218 A+, 2136580 A+, 2136731 A+, 2136999 A+, 2137113 A+, 2137197 A+, 2137229 A+, 2493484 A+, 2493522 A+, 2493682 A+, 2493785 A+, 2494790 A+, 798674 A+, 798803 A+, 799875 A+, 799923 A+, 800142 A+, 800648 A+, 1087396 A++, 1361740 A++, 1361770 A++, 1361808 A++, 1361833 A++, 1361861 A++, 1361884 A++, 1361885 A++, 1361966 A++, 1362116 A++, 1362132 A++, 1362609 A++, 2136076 A++, 2136143 A++, 2136149 A++, 2136318 A++, 2136353 A++, 2136445 A++, 2136521 A++, 2136582 A++, 2136624 A++, 2136639 A++, 2137329 A++, 2138026 A++, 2493091 A++, 2493108 A++, 2493144 A++, 2493282 A++, 2493436 A++, 2493801 A++, 2493857 A++, 2493888 A++, 2494566 A++, 649334 A++, 799430 A++, 800505 A++, 1151504 A++, 1361611 A++, 1361623 A++, 1361651 A++, 1361710 A++, 1361792 A++, 1361799 A++, 1362170 A++, 2105507 A++, 2136015 A++, 2136047 A++, 2136048 A++, 2136077 A++, 2136096 A++, 2136098 A++, 2136106 A++, 2136112 A++, 2136118 A++, 2136119 A++, 2136121 A++, 2136123 A++, 2136152 A++, 2136153 A++, 2136155 A++, 2136194 A++, 2136209 A++, 2136217 A++, 2136231 A++, 2136393 A++, 2493019 A++, 2493021 A++, 2493041 A++, 2493109 A++, 2493137 A++, 2493355 A++, 2493685 A++, 2494732 A++, 3796 A++, 3807 A++, 661734 A++, 798622 A++, 798652 A++, 798795 A++, 798796 A++, 798824 A++, 798888 A++, 798895 A++, 798919 A++, 798925 A++, 799202 A++, 799368 A++, 798889 A+++, 799728 A+++, 3800 A++++, 798565 A++++, 798576 A++++, 798698 A++++, 798732 A++++, 798752 A++++, 798758 A++++, 798761 A++++, 798767 A++++, 798772 A++++, 798793 A++++, 798951 A++++, 799161 A++++
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
salmon
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
Sea urchin
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Manually annotated by BRENDA team
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1151281 A+, 1185335 A+, 1361594 A+, 1361602 A+, 1361684 A+, 1361720 A+, 1361742 A+, 1361749 A+, 1361754 A+, 1361761 A+, 1361772 A+, 1361775 A+, 1361777 A+, 1361797 A+, 1361798 A+, 1361838 A+, 1362148 A+, 1362368 A+, 2136390 A+, 2136623 A+, 2137347 A+, 2137426 A+, 2137488 A+, 2393579 A+, 2493008 A+, 2493211 A+, 2493295 A+, 798717 A+, 800010 A+, 800104 A+, 800137 A+, 1174110 A++, 1183307 A++, 1232854 A++, 1361652 A++, 1361666 A++, 1361705 A++, 1361747 A++, 1361760 A++, 1361767 A++, 1361926 A++, 1361930 A++, 1362044 A++, 1362122 A++, 1362389 A++, 1362488 A++, 1362746 A++, 1954 A++, 2136057 A++, 2136088 A++, 2136117 A++, 2136244 A++, 2136567 A++, 2137330 A++, 2493108 A++, 2493365 A++, 2493454 A++, 798800 A++, 798987 A++, 800190 A++, 1177872 A++, 1361596 A++, 1361678 A++, 1361682 A++, 1361713 A++, 1361763 A++, 1361768 A++, 1361771 A++, 1361799 A++, 1361807 A++, 1361937 A++, 1362550 A++, 2136024 A++, 2136040 A++, 2136042 A++, 2136067 A++, 2136077 A++, 2136094 A++, 2136131 A++, 2136152 A++, 2136285 A++, 2136303 A++, 2136361 A++, 2136404 A++, 2136426 A++, 2136739 A++, 2137230 A++, 2493042 A++, 2493601 A++, 798515 A++, 798552 A++, 798629 A++, 798659 A++, 798732 A++, 798741 A++, 798900 A++, 798922 A++, 799084 A++, 799111 A++, 691006 A+++, 799577 A+++, 798517 A++++, 798535 A++++, 798574 A++++, 798640 A++++, 798648 A++++, 798663 A++++, 798676 A++++, 798700 A++++, 798709 A++++, 798773 A++++, 798793 A++++, 798842 A++++, 798901 A++++, 798923 A++++, 798924 A++++, 798990 A++++, 798996 A++++, 799081 A++++, 799082 A++++, 799147 A++++, 799223 A++++, 799409 A++++, 799581 A++++
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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UniProt
Manually annotated by BRENDA team
strain M145
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Manually annotated by BRENDA team
E233, spontaneous uracil-auxotrophic mutant derived from Sulfolobus islandicus Rey15A
SwissProt
Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta