Information on EC 5.5.1.24 - tocopherol cyclase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY hide
5.5.1.24
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RECOMMENDED NAME
GeneOntology No.
tocopherol cyclase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
delta-tocopherol = 2-methyl-6-phytylbenzene-1,4-diol
show the reaction diagram
(1)
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-
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delta-tocotrienol = 6-geranylgeranyl-2-methylbenzene-1,4-diol
show the reaction diagram
(3)
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gamma-tocopherol = 2,3-dimethyl-6-phytylbenzene-1,4-diol
show the reaction diagram
(2)
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gamma-tocotrienol = 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol
show the reaction diagram
(4)
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
cyclization
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
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Metabolic pathways
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Ubiquinone and other terpenoid-quinone biosynthesis
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vitamin E biosynthesis (tocopherols)
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vitamin E biosynthesis (tocotrienols)
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vitamin E metabolism
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SYSTEMATIC NAME
IUBMB Comments
delta/gamma-tocopherol lyase (decyclizing)
The enzyme has been described from plants and cyanobacteria. It has similar activity with all four listed benzoquinol substrates. Involved in the biosynthesis of vitamin E (tocopherols and tocotrienols).
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
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Manually annotated by BRENDA team
cider gun, lines 870 665 and 941 366
UniProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
ssp. japonica, cultivar TP309
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,3,5-trimethyl-6-[(2E,7S,11S)-3,7,11,15-tetramethylhexadec-2-en-1-yl]benzene-1,4-diol
alpha-tocopherol
show the reaction diagram
-
-
-
-
?
2,3-dimethyl-5-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzene-1,4-diol
(2R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2,7,8-trimethyl-3,4-dihydro-2H-chromen-6-ol
show the reaction diagram
-
-
-
-
?
2,3-dimethyl-5-[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl]benzene-1,4-diol
(2R)-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl]-3,4-dihydro-2H-chromen-6-ol
show the reaction diagram
-
-
-
-
?
2,3-dimethyl-6-phytylbenzene-1,4-diol
gamma-tocopherol
show the reaction diagram
2,5-dimethyl-3-[(2E,7S,11S)-3,7,11,15-tetramethylhexadec-2-en-1-yl]benzene-1,4-diol
beta-tocopherol
show the reaction diagram
-
-
-
-
?
2-methyl-6-phytylbenzene-1,4-diol
delta-tocopherol
show the reaction diagram
2-methyl-6-[(2E,7S,11S)-3,7,11,15-tetramethylhexadec-2-en-1-yl]benzene-1,4-diol
delta-tocopherol
show the reaction diagram
-
-
-
-
?
2-[(2E,7S,11S)-3,7,11,15-tetramethylhexadec-2-en-1-yl]benzene-1,4-diol
tocol
show the reaction diagram
-
-
-
-
?
3,5-dimethyl-2-[(2E,7S,11S)-3,7,11,15-tetramethylhexadec-2-en-1-yl]benzene-1,4-diol
zeta-tocopherol
show the reaction diagram
-
-
-
-
?
6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol
gamma-tocotrienol
show the reaction diagram
-
-
-
?
plastoquinol
plastoquinol
show the reaction diagram
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?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2,3-dimethyl-6-phytylbenzene-1,4-diol
gamma-tocopherol
show the reaction diagram
2-methyl-6-phytylbenzene-1,4-diol
delta-tocopherol
show the reaction diagram
6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol
gamma-tocotrienol
show the reaction diagram
Q94FY7
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?
plastoquinol
plastoquinol
show the reaction diagram
-
-
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?
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.5
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calculated from amino acid sequence
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
42000
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x * 42000, SDS-PAGE
56700
x * 56700, calculated from amino acid sequence
56760
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x * 56760, calculated from amino acid sequence
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Mono Q column chromatography, Mono P column chromatography, and gel filtration
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Brassica napus
expressed in Escherichia coli C43 (DE3) cells
expressed in Escherichia coli M15(pREP4) cells
expressed in Lactuca sativa
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expressed in leaves of Nicotiana tabacum variant xanthi
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expressed in Nicotiana tabacum
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme expression is fast downregulated by cold (6.5fold at 4°C)
enzyme expression level in lettuce is increased under high light and drought treatment
photooxidative stress results in an increase in enzyme activity
the enzyme is induced significantly by abiotic stresses such as high salt, H2O2, drought, cold, absisic acid and salicylic acid
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the expression level of the enzyme peaks after 6 days of high light treatment (light intensity: 0.28 mM m-2 s-1) and 9 days of drought (no irrigation) treatment, declining thereafter
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