Information on EC 5.4.99.58 - methylornithine synthase

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The expected taxonomic range for this enzyme is: Methanosarcina

EC NUMBER
COMMENTARY hide
5.4.99.58
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RECOMMENDED NAME
GeneOntology No.
methylornithine synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-lysine = (3R)-3-methyl-D-ornithine
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
L-pyrrolysine biosynthesis
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Lysine biosynthesis
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Microbial metabolism in diverse environments
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SYSTEMATIC NAME
IUBMB Comments
L-lysine carboxy-aminomethylmutase
The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes. Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The reaction is part of the biosynthesis pathway of pyrrolysine, a naturally occurring amino acid found in some archaeal methyltransferases.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
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the pylB gene is required for tRNA-independent pyrrolysine synthesis
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-lysine
(3R)-3-methyl-D-ornithine
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
S-adenosyl-L-methionine
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
expressed in Escherichia coli BL21 Tuner(DE3) cells
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