Information on EC 5.4.99.56 - tirucalladienol synthase

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The expected taxonomic range for this enzyme is: Arabidopsis thaliana

EC NUMBER
COMMENTARY hide
5.4.99.56
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RECOMMENDED NAME
GeneOntology No.
tirucalladienol synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(3S)-2,3-epoxy-2,3-dihydrosqualene = tirucalla-7,24-dien-3beta-ol
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Sesquiterpenoid and triterpenoid biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, tirucalla-7,24-dien-3beta-ol-forming)
The product from Arabidopsis thaliana is 85% tirucalla-7,24-dien-3beta-ol with trace amounts of other triterpenoids.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(3S)-oxidosqualene
tirucalla-7,24-dien-3beta-ol
show the reaction diagram
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the enzyme LUP5 makes a 2:2:1 product ratio of tirucalla-7,24-dien-3beta-ol, isotirucallol, and (1S,4S,8beta,9beta,13alpha,14beta,17alpha,20S)-9,10,14-trimethyl-4,9-cyclo-9,10-secocholesta-5,24-dien-1-ol, with minor products including butyrospermol, tirucallol, and 13betaH-malabarica-14(27),17,21-trien-3beta-ol, the enzyme PEN3 produces 85% tirucalla-7,24-dien-3beta-ol and several minor products (6% butyrospermol, 6% tirucallol, 1.5% isotirucallol, 1% 13betaH-malabarica-14(27),17,21-trien-3beta-ol, and 0.5% dammara-20,24-dien-3beta-ol)
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(3S)-oxidosqualene
tirucalla-7,24-dien-3beta-ol + isotirucallol + (1S,4S,8beta,9beta,13alpha,14beta,17alpha,20S)-9,10,14-trimethyl-4,9-cyclo-9,10-secocholesta-5,24-dien-1-ol
show the reaction diagram
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the enzyme LUP5 makes a 2:2:1 product ratio of tirucalla-7,24-dien-3beta-ol, isotirucallol, and (1S,4S,8beta,9beta,13alpha,14beta,17alpha,20S)-9,10,14-trimethyl-4,9-cyclo-9,10-secocholesta-5,24-dien-1-ol, with minor products including butyrospermol, tirucallol, and 13betaH-malabarica-14(27),17,21-trien-3beta-ol
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