Information on EC 5.4.99.55 - delta-amyrin synthase

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The expected taxonomic range for this enzyme is: Solanum lycopersicum

EC NUMBER
COMMENTARY hide
5.4.99.55
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RECOMMENDED NAME
GeneOntology No.
delta-amyrin synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(3S)-2,3-epoxy-2,3-dihydrosqualene = delta-amyrin
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
pentacyclic triterpene biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, delta-amyrin-forming)
The enzyme from tomato (Solanum lycopersicum) gives 48% delta-amyrin, 18% alpha-amyrin, 13% beta-amyrin and traces of three or four other triterpenoid alcohols [1]. See also EC 5.4.99.40, alpha-amyrin synthase and EC 5.4.99.39, beta-amyrin synthase.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
cultivars MicroTom, M82 and Ailsa Craig
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(3S)-2,3-epoxy-2,3-dihydrosqualene
delta-amyrin
show the reaction diagram
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the enzyme yields 48% delta-amyrin, 13% beta-amyrin, 18% alpha-amyrin, and 3% to 7% each of multiflorenol, C-taraxasterol, taraxasterol, and one unidentified triterpene alcohol isomer
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?
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Saccharomyces cerevisiae strain GIL77
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