Information on EC 5.4.99.49 - glutinol synthase

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The expected taxonomic range for this enzyme is: Kalanchoe daigremontiana

EC NUMBER
COMMENTARY hide
5.4.99.49
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RECOMMENDED NAME
GeneOntology No.
glutinol synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(3S)-2,3-epoxy-2,3-dihydrosqualene = glutinol
show the reaction diagram
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
pentacyclic triterpene biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, glutinol-forming)
The enzyme from Kalanchoe daigremontiana also gives traces of other triterpenoids.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(3S)-2,3-epoxy-2,3-dihydrosqualene
glutinol
show the reaction diagram
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main product is glutinol with 66% yield, minor products are friedelin (14%), beta-amyrin (11%), and taraxerol (8%)
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?
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
the enzyme is expressed only in the epidermis layers lining the upper and lower surfaces of the leaf blade
Manually annotated by BRENDA team
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Saccharomyces cerevisiae