Reference on EC 5.4.99.47 - parkeol synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Segura, M.J.; Lodeiro, S.; Meyer, M.M.; Patel, A.J.; Matsuda, S.P.
Directed evolution experiments reveal mutations at cycloartenol synthase residue His477 that dramatically alter catalysis
Org. Lett.
4
4459-4462
2002
Arabidopsis thaliana
Sawai, S.; Akashi, T.; Sakurai, N.; Suzuki, H.; Shibata, D.; Ayabe, S.; Aoki, T.
Plant lanosterol synthase: divergence of the sterol and triterpene biosynthetic pathways in eukaryotes
Plant Cell Physiol.
47
673-677
2006
Lotus japonicus
Khenkin, A.; Neumann, R.
Oxidosqualene Cyclase Residues that Promote Formation of Cycloartenol, Lanosterol, and Parkeol We are grateful to Bridget M. Joubert for advice regarding mutagenesis. We thank Elizabeth A. Hart for an authentic parkeol standard, and for chromatographic and spectroscopic information. This research was funded by the National Institutes of Health (grant no. AI 41598) and the Robert A. Welch Foundation (grant no. C-1323). M.M.M. was an American Society of Pharmacognosy Undergraduate Fellow. M.J.R.S. was a Robert A. Welch Fellow and was supported by an NIH Biotechnology Training Grant (grant no. T32 GM08362).
Angew. Chem.
39
4090-4092
2000
Saccharomyces cerevisiae
Kimura, M.; Kushiro, T.; Shibuya, M.; Ebizuka, Y.; Abe, I.
Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase
Biochem. Biophys. Res. Commun.
391
899-902
2010
Aspergillus fumigatus
Wu, T.; Liu, Y.; Chang, C.
Histidine residue at position 234 of oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae simultaneously influences cyclization, rearrangement, and deprotonation reactions
ChemBioChem
6
1177-1181
2005
Saccharomyces cerevisiae
Hart, E.; Hua, L.; Darr, L.; Wilson, W.; Pang, J.; Matsuda, S.
Directed evolution to investigate steric control of enzymatic oxidosqualene cyclization. An isoleucine-to-valine mutation in cycloartenol synthase allows lanosterol and parkeol biosynthesis
J. Am. Chem. Soc.
121
9887-9888
1999
Saccharomyces cerevisiae
-
Ito, R.; Mori, K.; Hashimoto, I.; Nakano, C.; Sato, T.; Hoshino, T.
Triterpene cyclases from Oryza sativa L.: cycloartenol, parkeol and achilleol B synthases
Org. Lett.
13
2678-2681
2011
Oryza sativa
Liu, Y.T.; Hu, T.C.; Chang, C.H.; Shie, W.S.; Wu, T.K.
Protein engineering of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase into parkeol synthase
Org. Lett.
14
5222-5225
2012
Saccharomyces cerevisiae
Xue, Z.; Tan, Z.; Huang, A.; Zhou, Y.; Sun, J.; Wang, X.; Thimmappa, R.B.; Stephenson, M.J.; Osbourn, A.; Qi, X.
Identification of key amino acid residues determining product specificity of 2,3-oxidosqualene cyclase in Oryza species
New Phytol.
218
1076-1088
2018
Oryza sativa Japonica Group (H2KWF1), Oryza sativa Japonica Group Zhonghua 11 (H2KWF1)
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