Information on EC 5.4.99.33 - cucurbitadienol synthase

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The expected taxonomic range for this enzyme is: Cucurbita pepo

EC NUMBER
COMMENTARY hide
5.4.99.33
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RECOMMENDED NAME
GeneOntology No.
cucurbitadienol synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(3S)-2,3-epoxy-2,3-dihydrosqualene = cucurbitadienol
show the reaction diagram
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-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
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Sesquiterpenoid and triterpenoid biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
(S)-2,3-epoxysqualene mutase (cyclizing, cucurbitadienol-forming)
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
cucurbitadienol synthase, the first committed enzyme for cucurbitacin biosynthesis, is a distinct enzyme from cycloartenol synthase for phytosterol biosynthesis
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-squalene-2,3-epoxide
cucurbitadienol
show the reaction diagram
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-
-
?
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in lanosterol synthase deficient (erg7) Saccharomyces cerevisiae strain GIL77
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
I489V
the mutation does not result in the change of product-specificity
L488P
the mutation does not result in the change of product-specificity
LI488/489PV
the mutation does not result in the change of product-specificity