Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Reference on EC 5.4.99.2 - methylmalonyl-CoA mutase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Poston, J.M.
Coenzyme B12-dependent enzymes in potatoes: leucine 2,3-aminomutase and methylmalonyl-CoA mutase
Phytochemistry
17
401-402
1978
Solanum tuberosum
-
Manually annotated by BRENDA team
Wilkemeyer, M.F.; Crane, A.M.; Ledley, F.D.
Primary structure and activity of mouse methylmalonyl-CoA mutase
Biochem. J.
271
449-455
1990
Mus musculus
Manually annotated by BRENDA team
Zagalak, B.; Retey, J.; Sund, H.; Zagalak, B.; Retey, J.; Sund, H.
Studies on methylmalonyl-CoA mutase from Propionibacterium shermanii
Eur. J. Biochem.
44
529-535
1974
Propionibacterium freudenreichii subsp. shermanii
Manually annotated by BRENDA team
Sato, K.; Ueda, S.; Shimizu, S.
Methylmalonyl-CoA mutase in a methanol-utilizing bacterium, Protaminobacter ruber
FEBS Lett.
71
248-250
1976
Serratia plymuthica
Manually annotated by BRENDA team
Kolhouse, J.F.; Allen, R.H.
Recognition of two intracellular cobalamin binding proteins and their identification as methylmalonyl-CoA mutase and methionine synthetase
Proc. Natl. Acad. Sci. USA
74
921-925
1977
Oryctolagus cuniculus
Manually annotated by BRENDA team
Murthy, V.V.; Jones, E.; Cole, T.W.; Johnson, J.
Purification of methylmalonyl-CoA mutase from Propionibacterium shermanii using affinity chromatography
Biochim. Biophys. Acta
483
487-491
1977
Propionibacterium freudenreichii subsp. shermanii
Manually annotated by BRENDA team
Kolhouse, J.F.; Utley, C.; Allen, R.H.
Isolation and characterization of methylmalonyl-CoA mutase from human placenta
J. Biol. Chem.
255
2708-2712
1980
Homo sapiens
Manually annotated by BRENDA team
Gaudemer, A.; Zylber, J.; Zylber, N.; Baran-Marszac, M.; Hull, W.E.; Fountoulakis, M.; König, A.; Wölfle, K.; Retey, J.
Reversible cleavage of the cobalt-carbon bond of coenzyme B12 catalyzed by methylmalonyl-CoA mutase from Propionibacterium shermanii. The use of coenzyme B12 stereospecifically deuterated in position 5'
Eur. J. Biochem.
119
279-285
1981
Propionibacterium freudenreichii subsp. shermanii
Manually annotated by BRENDA team
Retey, J.
Methylmalonyl-CoA mutase
B12 (Dolphin, D. ed. ) Wiley, New York
2
357-379
1982
Ovis aries, Mammalia, Propionibacterium freudenreichii subsp. shermanii
-
Manually annotated by BRENDA team
Fenton, W.A.; Hack, A.M.; Willard, H.F.; Gertler, A.; Rosenberg, L.E.
Purification and properties of methylmalonyl coenzyme A mutase from human liver
Arch. Biochem. Biophys.
214
815-823
1982
Homo sapiens
Manually annotated by BRENDA team
Hunaiti, A.A.; Kolattukudy, P.E.
Source of methylmalonyl-coenzyme A for erythromycin synthesis: methylmalonyl-coenzyme A mutase from Streptomyces erythreus
Antimicrob. Agents Chemother.
25
173-178
1984
Saccharopolyspora erythraea
Manually annotated by BRENDA team
Michenfelder, M.; Retey, J.
Methylmalonyl-carba(dethia)-coenzyme-A als Substrat der Coenzyme-B12-abhängigen Methylmalonyl-CoA-mutase: enzymatische Umlagerung einer beta- zu einer gamma-Ketosäure
Angew. Chem.
98
337-338
1986
Mammalia
-
Manually annotated by BRENDA team
Francalanci, F.; Davis, N.K.; Fuller, J.Q.; Murfitt, D.; Leadlay, P.F.
The subunit structure of methylmalonyl-CoA mutase from Propionibacterium shermanii
Biochem. J.
236
489-494
1986
Propionibacterium freudenreichii subsp. shermanii
Manually annotated by BRENDA team
Marsh, N.; Leadlay, P.F.; Evans, P.R.
Crystallization and preliminary diffraction data for adenosylcobalamin-dependent methylmalonyl-CoA mutase from Propionibacterium shermanii
J. Mol. Biol.
200
421-422
1988
Propionibacterium freudenreichii subsp. shermanii
Manually annotated by BRENDA team
Ledley, F.D.; Lumetta, M.; Nguyen, P.N.; Kolhouse, J.F.; Allen, R.H.
Molecular cloning of L-methylmalonyl-CoA mutase: gene transfer and analysis of mut cell lines
Proc. Natl. Acad. Sci. USA
85
3518-3521
1988
Homo sapiens
Manually annotated by BRENDA team
Kolhouse, J.F.; Stabler, S.P.; Allen, R.H.
L-Methylmalonyl-CoA mutase from human placenta
Methods Enzymol.
166
407-414
1988
Homo sapiens
Manually annotated by BRENDA team
McKie, N.; Keep, N.H.; Patchett, M.L.; Leadlay, P.F.
Adenosylcobalamin-dependent methylmalonyl-CoA mutase from Propionibacterium shermanii
Biochem. J.
269
293-298
1990
Propionibacterium freudenreichii subsp. shermanii
Manually annotated by BRENDA team
Mancia, F.; Keep, N.H.; Nakagawa, A.; Leadlay, P.F.; McSweeney, S.; Rasmussen, B.; Bösecke, P.; Diat, O.; Evans, P.R.
How coenzyme B12 radicals are generated: the crystal structure of methylmalonyl-coenzyme A mutase at 2 A resolution
Structure
4
339-350
1996
Propionibacterium freudenreichii subsp. shermanii
Manually annotated by BRENDA team
Marsh, E.N.; McKie, N.; Davis, N.K.; Leadlay, P.F.
Cloning and structural characterization of the genes coding for adenosylcobalamin-dependent methylmalonyl-CoA mutase from Propionibacterium shermanii
Biochem. J.
260
345-352
1989
Propionibacterium freudenreichii subsp. shermanii
Manually annotated by BRENDA team
Taoka, S.; Padmakumar, R.; Lai, M.; Liu, H.; Banerjee, R.
Inhibition of the human methylmalonyl-CoA mutase by various CoA-esters
J. Biol. Chem.
269
31630-31634
1994
Homo sapiens
Manually annotated by BRENDA team
Mancia F.; Evans, P.R.
Conformational changes on substrate binding to methylmalonyl CoA mutase and new insights into the free radical mechanism
Structure
6
711-720
1998
Propionibacterium freudenreichii subsp. shermanii
Manually annotated by BRENDA team
Poppe, L.; Stupperich, E.; Hull, W.E.; Buckel, T.; Retey, J.
A base-off analogue of coenzyme-B12 with a modified nucleotide loop. 1H-NMR structure analysis and kinetic studies with (R)-methylmalonyl-CoA mutase glycerol dehydratase, and diol dehydratase
Eur. J. Biochem.
250
303-307
1997
Propionibacterium freudenreichii subsp. shermanii
Manually annotated by BRENDA team
Abend, A.; Illich, V.; Retey, J.
Further insights into the mechanism of action of methylmalonyl-CoA mutase by electron paramagnetic resonance studies
Eur. J. Biochem.
249
180-186
1997
Propionibacterium freudenreichii subsp. shermanii
Manually annotated by BRENDA team
Zhao, Y.; Abend, A.; Kunz, M.; Such.P.; Retey, J.
Electron paramagnetic resonance studies of the methylmalonyl-CoA mutase reaction
Eur. J. Biochem.
225
891-896
1994
Propionibacterium freudenreichii subsp. shermanii
Manually annotated by BRENDA team
Janata, J.; Kogekar, N.; Fenton, W.A.
Expression and kinetic characterization of methylmalonyl-CoA mutase from patients with the mut-phenotype: evidence for naturally occuring interallelic complementation
Hum. Mol. Genet.
6
1457-1464
1997
Homo sapiens
Manually annotated by BRENDA team
Retey, J.; Smith, E.H.; Zagalak, B.
Investigation of the mechanism of the methylmalonyl-CoA mutase reaction with the substrate analogue: ethylmalonyl-CoA
Eur. J. Biochem.
83
437-451
1978
Propionibacterium freudenreichii subsp. shermanii
Manually annotated by BRENDA team
Miyamoto, E.; Watanabe, F.; Charles, T.C.; Yamaji, R.; Inui, H.; Nakano, Y.
Purification and characterization of homodimeric methylmalonyl-CoA mutase from Sinorhizobium meliloti
Arch. Microbiol.
180
151-154
2003
Sinorhizobium meliloti
Manually annotated by BRENDA team
Chowdhury, S.; Banerjee, R.
Role of the dimethylbenzimidazole tail in the reaction catalyzed by coenzyme B12-dependent methylmalonyl-CoA mutase
Biochemistry
38
15287-15294
1999
Propionibacterium freudenreichii subsp. shermanii
Manually annotated by BRENDA team
Mancia, F.; Smith, G.A.; Evans, P.R.
Crystal structure of substrate complexes of methylmalonyl-CoA mutase
Biochemistry
38
7999-8005
1999
Propionibacterium freudenreichii subsp. shermanii
Manually annotated by BRENDA team
Chowdhury, S.; Banerjee, R.
Thermodynamic and kinetic characterization of Co-C bond homolysis catalyzed by coenzyme B(12)-dependent methylmalonyl-CoA mutase
Biochemistry
39
7998-8006
2000
Propionibacterium freudenreichii subsp. shermanii
Manually annotated by BRENDA team
Thoma, N.H.; Evans, P.R.; Leadlay, P.F.
Protection of radical intermediates at the active site of adenosylcobalamin-dependent methylmalonyl-CoA mutase
Biochemistry
39
9213-9221
2000
Propionibacterium freudenreichii subsp. shermanii
Manually annotated by BRENDA team
Chowdhury, S.; Thomas, M.G.; Escalante-Semerena, J.C.; Banerjee, R.
The coenzyme b12 analog 5'-deoxyadenosylcobinamide-gdp supports catalysis by methylmalonyl-coa mutase in the absence of trans-ligand coordination
J. Biol. Chem.
276
1015-1019
2001
Propionibacterium freudenreichii subsp. shermanii
Manually annotated by BRENDA team
Vlasie, M.; Chowdhury, S.; Banerjee, R.
Importance of the histidine ligand to coenzyme B12 in the reaction catalyzed by methylmalonyl-CoA mutase
J. Biol. Chem.
277
18523-18527
2002
Propionibacterium freudenreichii subsp. shermanii
Manually annotated by BRENDA team
Korotkova, N.; Lidstrom, M.E.
MeaB is a component of the methylmalonyl-CoA mutase complex required for protection of the enzyme from inactivation
J. Biol. Chem.
279
13652-13658
2004
Halalkalibacterium halodurans, Geobacter metallireducens, Methylorubrum extorquens, Methylorubrum extorquens (Q6TMA2), Methylorubrum extorquens (Q84FZ1), Cupriavidus metallidurans, Thermobifida fusca, Paraburkholderia fungorum, Propionibacterium freudenreichii subsp. shermanii (P11652), Propionibacterium freudenreichii subsp. shermanii (P11653), Leptospira interrogans serovar lai str. 56601 (Q8F222), Ralstonia solanacearum (Q8Y2U5)
Manually annotated by BRENDA team
Vlasie, M.D.; Banerjee, R.
When a spectator turns killer: suicidal electron transfer from cobalamin in methylmalonyl-CoA mutase
Biochemistry
43
8410-8417
2004
Propionibacterium freudenreichii subsp. shermanii
Manually annotated by BRENDA team
Kambo, A.; Sharma, V.S.; Casteel, D.E.; Woods, V.L., Jr.; Pilz, R.B.; Boss, G.R.
Nitric oxide inhibits mammalian methylmalonyl-CoA mutase
J. Biol. Chem.
280
10073-10082
2005
Cricetulus sp.
Manually annotated by BRENDA team
Chandler, R.J.; Aswani, V.; Tsai, M.S.; Falk, M.; Wehrli, N.; Stabler, S.; Allen, R.; Sedensky, M.; Kazazian, H.H.; Venditti, C.P.
Propionyl-CoA and adenosylcobalamin metabolism in Caenorhabditis elegans: evidence for a role of methylmalonyl-CoA epimerase in intermediary metabolism
Mol. Genet. Metab.
89
64-73
2006
Caenorhabditis elegans
Manually annotated by BRENDA team
Deodato, F.; Boenzi, S.; Santorelli, F.M.; Dionisi-Vici, C.
Methylmalonic and propionic aciduria
Am. J. Med. Genet. C Semin. Med. Genet.
142C
104-112
2006
Homo sapiens
Manually annotated by BRENDA team
Padovani, D.; Banerjee, R.
Alternative pathways for radical dissipation in an active site mutant of B12-dependent methylmalonyl-CoA mutase
Biochemistry
45
2951-2959
2006
Propionibacterium freudenreichii subsp. shermanii
Manually annotated by BRENDA team
Padovani, D.; Banerjee, R.
Assembly and protection of the radical enzyme, methylmalonyl-CoA mutase, by its chaperone
Biochemistry
45
9300-9306
2006
Methylorubrum extorquens
Manually annotated by BRENDA team
Carlucci, F.; Rosi, F.; Tommassini, V.; Tabucchi, A.
CE assay of methylmalonyl-coenzyme-A mutase activity
Electrophoresis
28
1921-1925
2007
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Kwiecien, R.A.; Khavrutskii, I.V.; Musaev, D.G.; Morokuma, K.; Banerjee, R.; Paneth, P.
Computational insights into the mechanism of radical generation in B12-dependent methylmalonyl-CoA mutase
J. Am. Chem. Soc.
128
1287-1292
2006
Propionibacterium freudenreichii subsp. shermanii
Manually annotated by BRENDA team
Padovani, D.; Labunska, T.; Banerjee, R.
Energetics of interaction between the G-protein chaperone, MeaB, and B12-dependent methylmalonyl-CoA mutase
J. Biol. Chem.
281
17838-17844
2006
Methylorubrum extorquens
Manually annotated by BRENDA team
Dybala-Defratyka, A.; Paneth, P.; Banerjee, R.; Truhlar, D.G.
Coupling of hydrogenic tunneling to active-site motion in the hydrogen radical transfer catalyzed by a coenzyme B12-dependent mutase
Proc. Natl. Acad. Sci. USA
104
10774-10779
2007
Propionibacterium freudenreichii subsp. shermanii
Manually annotated by BRENDA team
Naranjo, V.; Acevedo-Whitehouse, K.; Vicente, J.; Gortazar, C.; de la Fuente, J.
Influence of methylmalonyl-CoA mutase alleles on resistance to bovine tuberculosis in the European wild boar (Sus scrofa)
Anim. Genet.
39
316-320
2008
Sus scrofa (Q8MI68), Sus scrofa
Manually annotated by BRENDA team
Paizs, C.; Diemer, T.; Retey, J.
The putative coenzyme B12-dependent methylmalonyl-CoA mutase from potatoes is a phosphatase
Bioorg. Chem.
36
261-264
2008
More
Manually annotated by BRENDA team
Nakao, M.; Hironaka, S.; Harada, N.; Adachi, T.; Bito, T.; Yabuta, Y.; Watanabe, F.; Miura, T.; Yamaji, R.; Inui, H.; Nakano, Y.
Cobalamin deficiency results in an abnormal increase in l-methylmalonyl-co-enzyme-A mutase expression in rat liver and COS-7 cells
Br. J. Nutr.
101
492-498
2009
Rattus norvegicus
Manually annotated by BRENDA team
Savvi, S.; Warner, D.F.; Kana, B.D.; McKinney, J.D.; Mizrahi, V.; Dawes, S.S.
Functional characterization of a vitamin B12-dependent methylmalonyl pathway in Mycobacterium tuberculosis: implications for propionate metabolism during growth on fatty acids
J. Bacteriol.
190
3886-3895
2008
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Manually annotated by BRENDA team
Froese, D.S.; Dobson, C.M.; White, A.P.; Wu, X.; Padovani, D.; Banerjee, R.; Haller, T.; Gerlt, J.A.; Surette, M.G.; Gravel, R.A.
Sleeping beauty mutase (sbm) is expressed and interacts with ygfd in Escherichia coli
Microbiol. Res.
164
1-8
2009
Escherichia coli
Manually annotated by BRENDA team
Bandarian, V.
Delivery of tailor-made cobalamin to methylmalonyl-CoA mutase
Nat. Chem. Biol.
4
158-159
2008
Methylorubrum extorquens
Manually annotated by BRENDA team
Miyamoto, E.; Tanioka, Y.; Nishizawa-Yokoi, A.; Yabuta, Y.; Ohnishi, K.; Misono, H.; Shigeoka, S.; Nakano, Y.; Watanabe, F.
Characterization of methylmalonyl-CoA mutase involved in the propionate photoassimilation of Euglena gracilis Z
Arch. Microbiol.
192
437-446
2010
Euglena gracilis (B7XBM0), Euglena gracilis Z (B7XBM0), Euglena gracilis Z
Manually annotated by BRENDA team
Zhang, H.; Boghigian, B.A.; Pfeifer, B.A.
Investigating the role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous polyketide production in Escherichia coli
Biotechnol. Bioeng.
105
567-573
2010
Escherichia coli
Manually annotated by BRENDA team
Botella, L.; Lindley, N.D.; Eggeling, L.
Formation and metabolism of methylmalonyl coenzyme A in Corynebacterium glutamicum
J. Bacteriol.
191
2899-2901
2009
Corynebacterium glutamicum
Manually annotated by BRENDA team
Mo, S.; Ban, Y.H.; Park, J.W.; Yoo, Y.J.; Yoon, Y.J.
Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor
J. Ind. Microbiol. Biotechnol.
36
1473-1482
2009
Streptomyces clavuligerus, Streptomyces clavuligerus CKD1119
Manually annotated by BRENDA team
Ballhausen, D.; Mittaz, L.; Boulat, O.; Bonafe, L.; Braissant, O.
Evidence for catabolic pathway of propionate metabolism in CNS: expression pattern of methylmalonyl-CoA mutase and propionyl-CoA carboxylase alpha-subunit in developing and adult rat brain
Neuroscience
164
578-587
2009
Rattus norvegicus
Manually annotated by BRENDA team
Takahashi-Iniguez, T.; Garcia-Arellano, H.; Trujillo-Roldan, M.A.; Flores, M.E.
Protection and reactivation of human methylmalonyl-CoA mutase by MMAA protein
Biochem. Biophys. Res. Commun.
404
443-447
2011
Homo sapiens
Manually annotated by BRENDA team
Froese, D.S.; Kochan, G.; Muniz, J.R.; Wu, X.; Gileadi, C.; Ugochukwu, E.; Krysztofinska, E.; Gravel, R.A.; Oppermann, U.; Yue, W.W.
Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation
J. Biol. Chem.
285
38204-38213
2010
Homo sapiens (P22033), Homo sapiens
Manually annotated by BRENDA team
de la Fuente, J.; Gortazar, C.; Vicente, J.; Villar, M.
Host expression of methylmalonyl-CoA mutase and tuberculosis: a missing link?
Med. Hypotheses
76
361-364
2011
Sus scrofa
Manually annotated by BRENDA team
Han, Y.; Hawkins, A.S.; Adams, M.W.; Kelly, R.M.
Epimerase (Msed_0639) and mutase (Msed_0638 and Msed_2055) convert (S)-methylmalonyl-coenzyme A (CoA) to succinyl-CoA in the Metallosphaera sedula 3-hydroxypropionate/4-hydroxybutyrate cycle
Appl. Environ. Microbiol.
78
6194-6202
2012
Metallosphaera sedula (A4YEG1 and A4YIE3), Metallosphaera sedula, Metallosphaera sedula DSM 5348 (A4YEG1 and A4YIE3)
Manually annotated by BRENDA team
Buck, N.E.; Wood, L.R.; Hamilton, N.J.; Bennett, M.J.; Peters, H.L.
Treatment of a methylmalonyl-CoA mutase stopcodon mutation
Biochem. Biophys. Res. Commun.
427
753-757
2012
Homo sapiens (P22033), Homo sapiens
Manually annotated by BRENDA team
Makins, C.; Pickering, A.V.; Mariani, C.; Wolthers, K.R.
Mutagenesis of a conserved glutamate reveals the contribution of electrostatic energy to adenosylcobalamin co-C bond homolysis in ornithine 4,5-aminomutase and methylmalonyl-CoA mutase
Biochemistry
52
878-888
2013
Homo sapiens (P22033), Homo sapiens
Manually annotated by BRENDA team
Ouattara, B.; Duplessis, M.; Girard, C.L.
Optimization and validation of a reversed-phase high performance liquid chromatography method for the measurement of bovine liver methylmalonyl-coenzyme a mutase activity
BMC Biochem.
14
25
2013
Bos taurus
Manually annotated by BRENDA team
Chandler, R.J.; Venditti, C.P.
Pre-clinical efficacy and dosing of an AAV8 vector expressing human methylmalonyl-CoA mutase in a murine model of methylmalonic acidemia (MMA)
Mol. Genet. Metab.
107
617-619
2012
Homo sapiens (P22033), Homo sapiens
Manually annotated by BRENDA team
Gotoh, K.; Nakajima, Y.; Tajima, G.; Hotta, Y.; Kataoka, T.; Kawade, Y.; Sugiyama, N.; Ito, T.; Kimura, K.; Maeda, Y.
Assay for methylmalonyl coenzyme A mutase activity based on determination of succinyl coenzyme A by ultrahigh-performance liquid chromatography tandem mass spectrometry
Anal. Bioanal. Chem.
407
5281-5286
2015
Homo sapiens (P22033), Homo sapiens
Manually annotated by BRENDA team
Takahashi-Iniguez, T.; Gonzalez-Noriega, A.; Michalak, C.; Flores, M.E.
Human MMAA induces the release of inactive cofactor and restores methylmalonyl-CoA mutase activity through their complex formation
Biochimie
142
191-196
2017
Homo sapiens (P22033), Homo sapiens
Manually annotated by BRENDA team
Yabuta, Y.; Kamei, Y.; Bito, T.; Arima, J.; Yoneda, K.; Sakuraba, H.; Ohshima, T.; Nakano, Y.; Watanabe, F.
Functional and structural characteristics of methylmalonyl-CoA mutase from Pyrococcus horikoshii
Biosci. Biotechnol. Biochem.
79
710-717
2015
Pyrococcus horikoshii (O74009 AND O58013), Pyrococcus horikoshii, Pyrococcus horikoshii ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3 (O74009 AND O58013)
Manually annotated by BRENDA team
Bito, T.; Yabuta, Y.; Ichiyanagi, T.; Kawano, T.; Watanabe, F.
A dodecylamine derivative of cyanocobalamin potently inhibits the activities of cobalamin-dependent methylmalonyl-CoA mutase and methionine synthase of Caenorhabditis elegans
FEBS open bio
4
722-729
2014
Caenorhabditis elegans (Q23381), Caenorhabditis elegans, Caenorhabditis elegans N2 Bristol (Q23381)
Manually annotated by BRENDA team