Information on EC 5.4.3.7 - leucine 2,3-aminomutase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
5.4.3.7
-
RECOMMENDED NAME
GeneOntology No.
leucine 2,3-aminomutase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2S)-alpha-leucine = (3R)-beta-leucine
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
group transfer
-
-
intramolecular, amino group
-
isomerization
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
L-leucine degradation II
-
-
leucine metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
(2S)-alpha-leucine 2,3-aminomutase
Requires a cobamide coenzyme.
CAS REGISTRY NUMBER
COMMENTARY hide
59125-53-0
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Lolium sp.
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
no activity in Canis familiaris
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
alpha-Leu
?
show the reaction diagram
alpha-Leu
beta-Leu
show the reaction diagram
beta-Leu
?
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
alpha-Leu
?
show the reaction diagram
beta-Leu
?
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Cobalamin
cobamide
-
i.e. adenosylcobalamin, required
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Intrinsic factors
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal phosphate
-
slight stimulation
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
high activity
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
trace amounts detected
Manually annotated by BRENDA team
-
high activity
Manually annotated by BRENDA team
-
very low activity
Manually annotated by BRENDA team
additional information
-
no activity in erythrocytes
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
activity is 100fold lower than in cytosol of liver
Manually annotated by BRENDA team
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
60
-
10 min stable, enzyme in crude extract
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
enzyme in crude extract is stable to freezing and thawing
-
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, enzyme in tissue extract is stable for several months
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
analysis
-
separation by high-performance liquid chromatography of alpha-amino acids and beta-amino acids and the application to the assay of leucine 2,3-aminomutase