Information on EC 5.4.3.4 - D-lysine 5,6-aminomutase

for references in articles please use BRENDA:EC5.4.3.4
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:


The expected taxonomic range for this enzyme is: Acetoanaerobium sticklandii

EC NUMBER
COMMENTARY hide
5.4.3.4
transferred to EC 5.4.3.3
RECOMMENDED NAME
GeneOntology No.
D-lysine 5,6-aminomutase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate
show the reaction diagram
(1)
-
-
-
D-lysine = (2R,5S)-2,5-diaminohexanoate
show the reaction diagram
CAS REGISTRY NUMBER
COMMENTARY hide
9075-70-1
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
metabolism
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-lysine
2,5-diaminohexanoate
show the reaction diagram
-
-
-
-
r
additional information
?
-
-
5-fluorolysine as substrate binding in the active site: computational simulations, the enzyme 5,6-LAM abstracts the hydrogen atom rather than the fluorine at C5 of 5-fluorolysine and subsequent rearrangement mimicking the similar mechanism as the natural substrate of the enzyme
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
D-lysine
2,5-diaminohexanoate
show the reaction diagram
-
-
-
-
r
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5'-deoxyadenosylcobalamin
-
dependent on
pyridoxal 5'-phosphate
-
dependent on, molecular modeling in the reaction
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.63
D-Lysine
-
pH and temperature not specified in the publication