Information on EC 5.4.2.5 - phosphoglucomutase (glucose-cofactor)

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
5.4.2.5
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RECOMMENDED NAME
GeneOntology No.
phosphoglucomutase (glucose-cofactor)
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
alpha-D-glucose 1-phosphate = D-glucose 6-phosphate
show the reaction diagram
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
group transfer
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intermolecular, phosphate group
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isomerization
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Amino sugar and nucleotide sugar metabolism
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Biosynthesis of antibiotics
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Biosynthesis of secondary metabolites
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glycogen biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
alpha-D-glucose 1,6-phosphomutase (glucose-cofactor)
The enzyme is activated by D-glucose, which probably acts as an acceptor for a phosphate residue from the substrate, thus being itself converted into the product. cf. EC 5.4.2.2, phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent).
CAS REGISTRY NUMBER
COMMENTARY hide
37278-22-1
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-Deoxy-D-glucose + alpha-D-glucose 1-phosphate
D-Glucose + 2-deoxy-D-glucose 6-phosphate
show the reaction diagram
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-
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3-O-Methyl-D-glucose + alpha-D-glucose 1-phosphate
3-O-Methyl-D-glucose 6-phosphate + D-glucose
show the reaction diagram
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-
-
-
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alpha-D-Glucose 1-phosphate + D-glucose
?
show the reaction diagram
alpha-D-Glucose 1-phosphate + D-glucose
D-Glucose + alpha-D-glucose 6-phosphate
show the reaction diagram
alpha-Methyl-D-glucoside + alpha-D-glucose 1-phosphate
alpha-Methyl-D-glucoside 6-phosphate + D-glucose
show the reaction diagram
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-
-
-
-
beta-Methyl-D-glucoside + alpha-D-glucose 1-phosphate
beta-Methyl-D-glucoside 6-phosphate + D-glucose
show the reaction diagram
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-
-
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D-Fructose + alpha-D-glucose 1-phosphate
D-Fructose 6-phosphate + D-glucose
show the reaction diagram
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-
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D-Galactose + alpha-D-glucose 1-phosphate
D-Galactose 6-phosphate + D-glucose
show the reaction diagram
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D-Mannose + alpha-D-glucose 1-phosphate
D-Mannose 6-phosphate + D-glucose
show the reaction diagram
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-
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Fructose 1-phosphate + D-glucose
D-glucose 6-phosphate + fructose
show the reaction diagram
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-
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L-Sorbose + alpha-D-glucose 1-phosphate
L-Sorbose 6-phosphate + D-glucose
show the reaction diagram
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additional information
?
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no substrates are 6-deoxy-D-glucose, D-ribose, D-xylose, DL-serine, cytidine, adenosine, uridine, guanosine
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
alpha-D-Glucose 1-phosphate + D-glucose
?
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
no requirement for Mg2+, Mn2+, Fe2+
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
F-
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strong inhibitor
iodoacetate
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additional information
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no inhibition by NaN3
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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no effect on the rate of reaction found for cysteine, glutathione, 2-mercaptoethanol, glucose 1,6-diphosphate, ribose 1,5-diphosphate
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
8.5 - 17
alpha-D-glucose
0.9 - 1.1
alpha-D-glucose 1-phosphate
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5
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direct assay with unreacted glucose 1-phosphate
6.5
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assay coupled with glucose-6-phosphate dehydrogenase, following NADPH formation
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-15°C, 3 years stable
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0°C, 3 months stable
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE