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alpha-D-glucosamine 1-phosphate
alpha-D-glucosamine 6-phosphate
alpha-D-glucosamine 1-phosphate
D-glucosamine 6-phosphate
alpha-D-glucosamine 6-phosphate
alpha-D-glucosamine 1-phosphate
-
-
-
r
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
-
-
-
?
D-glucoamine 6-phosphate
D-glucosamine 1-phosphate
D-glucosamine 1,6-diphosphate
?
-
-
-
-
?
D-glucosamine 1-phosphate
D-glucosamine 6-phosphate
-
-
-
r
D-glucosamine 6-phosphate
D-glucosamine 1-phosphate
D-glucose 1,6-bisphosphate
?
-
-
-
-
?
D-glucose 1-phosphate
D-glucose 6-phosphate
D-Mannose 1-phosphate
D-Mannose 6-phosphate
-
5fold lower activity than phosphoglucosamine mutase activity
-
?
additional information
?
-
alpha-D-glucosamine 1-phosphate
alpha-D-glucosamine 6-phosphate
-
-
-
?
alpha-D-glucosamine 1-phosphate
alpha-D-glucosamine 6-phosphate
-
-
-
?
alpha-D-glucosamine 1-phosphate
alpha-D-glucosamine 6-phosphate
-
-
-
?
alpha-D-glucosamine 1-phosphate
alpha-D-glucosamine 6-phosphate
-
-
-
?
alpha-D-glucosamine 1-phosphate
D-glucosamine 6-phosphate
-
-
-
-
?
alpha-D-glucosamine 1-phosphate
D-glucosamine 6-phosphate
-
-
-
r
alpha-D-glucosamine 1-phosphate
D-glucosamine 6-phosphate
-
-
-
-
r
alpha-D-glucosamine 1-phosphate
D-glucosamine 6-phosphate
-
-
-
-
r
alpha-D-glucosamine 1-phosphate
D-glucosamine 6-phosphate
-
-
-
-
?
alpha-D-glucosamine 1-phosphate
D-glucosamine 6-phosphate
-
-
-
-
?
alpha-D-glucosamine 1-phosphate
D-glucosamine 6-phosphate
-
-
-
?
alpha-D-glucosamine 1-phosphate
D-glucosamine 6-phosphate
-
-
-
?
D-glucoamine 6-phosphate
D-glucosamine 1-phosphate
-
ping-pong bi-bi reaction mechanism
-
r
D-glucoamine 6-phosphate
D-glucosamine 1-phosphate
-
ping-pong bi-bi reaction mechanism
-
r
D-glucoamine 6-phosphate
D-glucosamine 1-phosphate
-
two basically different reaction sequences, 1. phosphate group transfer yielding the intermediate D-GlcN-1,6-diphosphate, 2. conversion to GlcN-1-phosphate
-
r
D-glucoamine 6-phosphate
D-glucosamine 1-phosphate
-
involved in formation of cell-wall precursor UDP-N-acetylglucosamine
-
r
D-glucoamine 6-phosphate
D-glucosamine 1-phosphate
-
involved in formation of cell-wall precursor UDP-N-acetylglucosamine
-
r
D-glucoamine 6-phosphate
D-glucosamine 1-phosphate
-
involved in formation of cell-wall precursor UDP-N-acetylglucosamine
-
r
D-glucoamine 6-phosphate
D-glucosamine 1-phosphate
-
involved in formation of cell-wall precursor UDP-N-acetylglucosamine
-
r
D-glucoamine 6-phosphate
D-glucosamine 1-phosphate
-
involved in formation of cell-wall precursor UDP-N-acetylglucosamine
-
r
D-glucoamine 6-phosphate
D-glucosamine 1-phosphate
-
involved in formation of cell-wall precursor UDP-N-acetylglucosamine
-
r
D-glucosamine 6-phosphate
D-glucosamine 1-phosphate
-
-
-
r
D-glucosamine 6-phosphate
D-glucosamine 1-phosphate
-
-
-
-
r
D-glucosamine 6-phosphate
D-glucosamine 1-phosphate
-
-
-
r
D-glucosamine 6-phosphate
D-glucosamine 1-phosphate
-
-
-
-
r
D-glucosamine 6-phosphate
D-glucosamine 1-phosphate
-
-
-
r
D-glucose 1-phosphate
D-glucose 6-phosphate
-
in the presence of Glc-1,6-diphosphate, 1400fold lower activity than for D-glucosamine 1-phosphate or D-glucosamine 1,6-diphosphate, ping-pong reaction mechanism
-
?
D-glucose 1-phosphate
D-glucose 6-phosphate
-
50fold lower activity than phosphoglucosamine mutase activity
-
?
additional information
?
-
activity of GlmU and GlmM from Lactobacillus casei in a coupled enzymatic assay
-
-
?
additional information
?
-
-
activity of GlmU and GlmM from Lactobacillus casei in a coupled enzymatic assay
-
-
?
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alpha-D-glucosamine 1-phosphate
alpha-D-glucosamine 6-phosphate
alpha-D-glucosamine 1-phosphate
D-glucosamine 6-phosphate
D-glucoamine 6-phosphate
D-glucosamine 1-phosphate
D-glucosamine 1-phosphate
D-glucosamine 6-phosphate
-
-
-
r
D-glucosamine 6-phosphate
D-glucosamine 1-phosphate
alpha-D-glucosamine 1-phosphate
alpha-D-glucosamine 6-phosphate
-
-
-
?
alpha-D-glucosamine 1-phosphate
alpha-D-glucosamine 6-phosphate
-
-
-
?
alpha-D-glucosamine 1-phosphate
alpha-D-glucosamine 6-phosphate
-
-
-
?
alpha-D-glucosamine 1-phosphate
alpha-D-glucosamine 6-phosphate
-
-
-
?
alpha-D-glucosamine 1-phosphate
D-glucosamine 6-phosphate
-
-
-
-
?
alpha-D-glucosamine 1-phosphate
D-glucosamine 6-phosphate
-
-
-
r
alpha-D-glucosamine 1-phosphate
D-glucosamine 6-phosphate
-
-
-
-
r
alpha-D-glucosamine 1-phosphate
D-glucosamine 6-phosphate
-
-
-
-
r
alpha-D-glucosamine 1-phosphate
D-glucosamine 6-phosphate
-
-
-
-
?
alpha-D-glucosamine 1-phosphate
D-glucosamine 6-phosphate
-
-
-
-
?
alpha-D-glucosamine 1-phosphate
D-glucosamine 6-phosphate
-
-
-
?
alpha-D-glucosamine 1-phosphate
D-glucosamine 6-phosphate
-
-
-
?
D-glucoamine 6-phosphate
D-glucosamine 1-phosphate
-
ping-pong bi-bi reaction mechanism
-
r
D-glucoamine 6-phosphate
D-glucosamine 1-phosphate
-
ping-pong bi-bi reaction mechanism
-
r
D-glucoamine 6-phosphate
D-glucosamine 1-phosphate
-
two basically different reaction sequences, 1. phosphate group transfer yielding the intermediate D-GlcN-1,6-diphosphate, 2. conversion to GlcN-1-phosphate
-
r
D-glucoamine 6-phosphate
D-glucosamine 1-phosphate
-
involved in formation of cell-wall precursor UDP-N-acetylglucosamine
-
r
D-glucoamine 6-phosphate
D-glucosamine 1-phosphate
-
involved in formation of cell-wall precursor UDP-N-acetylglucosamine
-
r
D-glucoamine 6-phosphate
D-glucosamine 1-phosphate
-
involved in formation of cell-wall precursor UDP-N-acetylglucosamine
-
r
D-glucoamine 6-phosphate
D-glucosamine 1-phosphate
-
involved in formation of cell-wall precursor UDP-N-acetylglucosamine
-
r
D-glucoamine 6-phosphate
D-glucosamine 1-phosphate
-
involved in formation of cell-wall precursor UDP-N-acetylglucosamine
-
r
D-glucoamine 6-phosphate
D-glucosamine 1-phosphate
-
involved in formation of cell-wall precursor UDP-N-acetylglucosamine
-
r
D-glucosamine 6-phosphate
D-glucosamine 1-phosphate
-
-
-
-
r
D-glucosamine 6-phosphate
D-glucosamine 1-phosphate
-
-
-
-
r
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malfunction
-
glmM mutation causes marked elongation of the streptococcal chains, enlargement of bacterial cells, increased distortion of the bacterial cell surface, and defects in cell separation
malfunction
-
enzyme knockdown results in a decline of cell growth
malfunction
-
enzyme knockdown results in a decline of cell growth
-
malfunction
-
glmM mutation causes marked elongation of the streptococcal chains, enlargement of bacterial cells, increased distortion of the bacterial cell surface, and defects in cell separation
-
metabolism
-
phosphoglucosamine mutase is involved in the formation of glucosamine-1-phosphate from glucosamine-6-phosphate, the second step in UDP-GlcNAc biosynthetic pathway
metabolism
-
phosphoglucosamine mutase is involved in the formation of glucosamine-1-phosphate from glucosamine-6-phosphate, the second step in UDP-GlcNAc biosynthetic pathway
-
physiological function
-
phosphoglucosamine mutase catalyzes the conversion of glucosamine 6-phosphate to glucosamine 1-phosphate, an early step in the formation of the nucleotide sugar UDP-N-acetylglucosamine, which is involved in peptidoglycan biosynthesis
physiological function
-
phosphoglucosamine mutase catalyzes the interconversion of glucosamine 6-phosphate to glucosamine 1-phosphate, an essential step in the biosynthetic pathway leading to the formation of the peptidoglycan precursor uridine 5'-diphospho-N-acetylglucosamine
physiological function
phosphoglucosamine mutase functions in the biosynthesis of peptidoglycan
physiological function
-
GlmM is involved in bacterial cell growth, morphology, biofilm formation, and sensitivity to penicillins
physiological function
-
the enzyme is essential for the growth of Mycobacterium smegmatis
physiological function
-
the enzyme is essential for the growth of Mycobacterium smegmatis
-
physiological function
-
GlmM is involved in bacterial cell growth, morphology, biofilm formation, and sensitivity to penicillins
-
physiological function
-
phosphoglucosamine mutase catalyzes the interconversion of glucosamine 6-phosphate to glucosamine 1-phosphate, an essential step in the biosynthetic pathway leading to the formation of the peptidoglycan precursor uridine 5'-diphospho-N-acetylglucosamine
-
physiological function
-
phosphoglucosamine mutase functions in the biosynthesis of peptidoglycan
-
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S100T
-
contributes to the specificity towards sugar- or aminosugar-phosphates, much more efficient in catalysis of the phosphoglucose mutase reaction
S100A
-
50fold less active
S100A
-
very low activity
S102A
-
completely inactive, loss of autophosphorylation ability
S102A
-
site of phosphorylation, no activity
glmM mutant
-
mutation resulted in increased sensitivity to polymorphonuclear leukocyte, PMN, -dependent killing, mutant induces increased superoxide anion production and lysozyme release by PMNs, mutant is more sensitive to lysozyme
glmM mutant
-
mutation resulted in increased sensitivity to polymorphonuclear leukocyte, PMN, -dependent killing, mutant induces increased superoxide anion production and lysozyme release by PMNs, mutant is more sensitive to lysozyme
-
glmM mutant
mutant shows an altered general phenotype, reduced growth rate and increased autolysis, mutation results in defect biofilm formation
glmM mutant
-
mutant shows an altered general phenotype, reduced growth rate and increased autolysis, mutation results in defect biofilm formation
-
additional information
metabolic engineering of Lactobacillus casei for production of UDP-N-acetylglucosamine
additional information
-
metabolic engineering of Lactobacillus casei for production of UDP-N-acetylglucosamine
additional information
-
generation of a glmM knockout strain with highly reduced enzyme activity, growth of the strain is inducible by tetracycline, cells show morphological changes, phenotype, overview
additional information
-
generation of a glmM knockout strain with highly reduced enzyme activity, growth of the strain is inducible by tetracycline, cells show morphological changes, phenotype, overview
-
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Tavares, I.M.; Jolly, L.; Pompeo, F.; Leitao, J.H.; Fialho, A.M.; Sa-Correia, I.; Mengin-Lecreulx, D.
Identification of the Pseudomonas aeruginosa glmM gene, encoding phosphoglucosamine mutase
J. Bacteriol.
182
4453-4457
2000
Pseudomonas aeruginosa
brenda
Jolly, L.; Pompeo, F.; van Heijenoort, J.; Fassy, F.; Mengin-Lecreulx, D.
Autophosphorylation of phosphoglucosamine mutase from Escherichia coli
J. Bacteriol.
182
1280-1285
2000
Escherichia coli
brenda
Jolly, L.; Ferrari, P.; Blanot, D.; van Heijenoort, J.; Fassy, F.; Mengin-Lecreulx, D.
Reaction mechanism of phosphoglucosamine mutase from Escherichia coli
Eur. J. Biochem.
262
202-210
1999
Escherichia coli
brenda
Jolly, L.; Wu, S.; van Heijenoort, J.; De Lencastre, H.; Mengin-Lcreulx, D.; Tomasz, A.
The femR315 gene from Staphylococcus aureus, the interruption of which results in reduced methicillin resistance, encodes a phophoglucosamine mutase
J. Bacteriol.
179
5321-5325
1997
Staphylococcus aureus
brenda
De Reuse, H.; Labigne, A.; Mengin-Lecreulx, D.
The Helicobacter pylori ureC gene codes for a phosphoglucosamine mutase
J. Bacteriol.
179
3488-3493
1997
Helicobacter pylori
brenda
Mengin-Lecreulx, D.; van Heijenoort, J.
Characterization of the essential gene glmM encoding phosphoglucosamine mutase in Escherichia coli
J. Biol. Chem.
271
32-39
1996
Escherichia coli
brenda
Shimazu, K.; Takahashi, Y.; Uchikawa, Y.; Shimazu, Y.; Yajima, A.; Takashima, E.; Aoba, T.; Konishi, K.
Identification of the Streptococcus gordonii glmM gene encoding phosphoglucosamine mutase and its role in bacterial cell morphology, biofilm formation, and sensitivity to antibiotics
FEMS Immunol. Med. Microbiol.
53
166-177
2008
Streptococcus gordonii (A9CQM6), Streptococcus gordonii, Streptococcus gordonii DL1 (A9CQM6)
brenda
Namboori, S.C.; Graham, D.E.
Acetamido sugar biosynthesis in the Euryarchaea
J. Bacteriol.
190
2987-2996
2008
Methanococcus maripaludis (Q6LYB4), Methanococcus maripaludis
brenda
Mehra-Chaudhary, R.; Neace, C.E.; Beamer, L.J.
Crystallization and initial crystallographic analysis of phosphoglucosamine mutase from Bacillus anthracis
Acta Crystallogr. Sect. F
65
733-735
2009
Bacillus anthracis
brenda
Yajima, A.; Takahashi, Y.; Shimazu, K.; Urano-Tashiro, Y.; Uchikawa, Y.; Karibe, H.; Konishi, K.
Contribution of phosphoglucosamine mutase to the resistance of Streptococcus gordonii DL1 to polymorphonuclear leukocyte killing
FEMS Microbiol. Lett.
297
196-202
2009
Streptococcus gordonii, Streptococcus gordonii DL1
brenda
Liu, X.D.; Duan, J.; Guo, L.H.
Role of phosphoglucosamine mutase on virulence properties of Streptococcus mutans
Oral Microbiol. Immunol.
24
272-277
2009
Streptococcus mutans (Q8DTC6), Streptococcus mutans, Streptococcus mutans UA159 (Q8DTC6)
brenda
Mehra-Chaudhary, R.; Mick, J.; Beamer, L.J.
Crystal structure of phosphoglucosamine mutase from B. anthracis, an enzyme in the peptidoglycan biosynthetic pathway
J. Bacteriol.
193
4081-4087
2011
Bacillus anthracis (Q81VN7), Bacillus anthracis
brenda
Shimazu, K.; Takahashi, Y.; Karibe, H.; Mitsuhashi, F.; Konishi, K.
Contribution of phosphoglucosamine mutase to determination of bacterial cell morphology in Streptococcus gordonii
Odontology
100
28-33
2012
Streptococcus gordonii, Streptococcus gordonii DL1
brenda
Rodriguez-Diaz, J.; Rubio-del-Campo, A.; Yebra, M.J.
Metabolic engineering of Lactobacillus casei for production of UDP-N-acetylglucosamine
Biotechnol. Bioeng.
109
1704-1712
2012
Lacticaseibacillus casei (B3WD16), Lacticaseibacillus casei
brenda
Kang, J.; Xu, L.; Yang, S.; Yu, W.; Liu, S.; Xin, Y.; Ma, Y.
Effect of phosphoglucosamine mutase on biofilm formation and antimicrobial susceptibilities in M. smegmatis glmM gene knockdown strain
PLoS ONE
8
e61589
2013
Mycolicibacterium smegmatis, Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
brenda
Hasan, A.; Mazumder, H.H.; Khan, A.; Hossain, M.U.; Chowdhury, H.K.
Molecular characterization of legionellosis drug target candidate enzyme phosphoglucosamine mutase from Legionella pneumophila (strain Paris) an in silico approach
Genomics Inform.
12
268-275
2014
Legionella pneumophila (Q5X1A3), Legionella pneumophila, Legionella pneumophila Paris (Q5X1A3)
brenda
Sridharan, U.; Kuramitsu, S.; Yokoyama, S.; Kumarevel, T.; Ponnuraj, K.
Crystal structure of Aquifex aeolicus gene product Aq1627 a putative phosphoglucosamine mutase reveals a unique C-terminal end-to-end disulfide linkage
Mol. Biosyst.
13
1370-1376
2017
Aquifex aeolicus (O67549), Aquifex aeolicus, Aquifex aeolicus VFS (O67549)
brenda