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Reference on EC 5.3.99.5 - thromboxane-A synthase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hecker, M.; Haurand, M.; Ullrich, V.; Diczfalusy, U.; Hammarstrm, S.
Products, kinetics, and substrate specificity of homogeneous thromboxane synthase from human platelets: development of a novel enzyme assay
Arch. Biochem. Biophys.
254
124-135
1987
Homo sapiens
Manually annotated by BRENDA team
Shen, R.F.; Tai, H.H.
Monoclonal antibodies to thromboxane synthase from porcine lung. Production and application to development of a tandem immunoradiometric assay
J. Biol. Chem.
261
11585-11591
1986
Sus scrofa
Manually annotated by BRENDA team
Shen, R.F.; Tai, H.H.
Immunoaffinity purification and characterization of thromboxane synthase from porcine lung
J. Biol. Chem.
261
11592-11599
1986
Sus scrofa
Manually annotated by BRENDA team
Hall, E.R.; Tuan, W.; Venton, D.L.
Production of platelet thromboxane A2 inactivates purified human platelet thromboxane synthase
Biochem. J.
233
637-641
1986
Homo sapiens
Manually annotated by BRENDA team
Haurand, M.; Ullrich, V.
Isolation and characterization of thromboxane synthase from human platelets as a cytochrome P-450 enzyme
J. Biol. Chem.
260
15059-15067
1985
Homo sapiens
Manually annotated by BRENDA team
Hecker, M.; Baader, W.J.; Weber, P.; Ullrich, V.
Thromboxane synthase catalyses hydroxylations of prostaglandin H2 analogs in the presence of iodosylbenzene
Eur. J. Biochem.
169
563-569
1987
Homo sapiens
Manually annotated by BRENDA team
Gorman, R.R.
Biology and biochemistry of thromboxane synthetase inhibitors
Adv. Prostaglandin Thromboxane Leukot. Res.
11
235-240
1983
Homo sapiens
Manually annotated by BRENDA team
Ullrich, V.; Haurand, M.
Thromboxane synthase as a cytochrome P450 enzyme
Adv. Prostaglandin Thromboxane Leukot. Res.
11
105-110
1983
Homo sapiens
Manually annotated by BRENDA team
Yashimoto, T.; Yamamoto, S.
Partial purification and assay of thromboxane A synthase from bovine platelets
Methods Enzymol.
86
106-109
1982
Bos taurus
Manually annotated by BRENDA team
Hall, E.R.; Tai, H.H.
Purification of thromboxane synthetase and evidence of two distinct mechanisms for the formation of 12-L-hydroxy-5,8,10-heptadecatrienoic acid by porcine lung microsomes
Biochim. Biophys. Acta
665
498-503
1981
Sus scrofa
Manually annotated by BRENDA team
Hammarstroem, S.
Enzymatic synthesis of 15-hydroperoxythromboxane A2 and 12-hydroperoxy-5,8,10-heptadecatrienoic acid
J. Biol. Chem.
255
518-521
1980
Homo sapiens
Manually annotated by BRENDA team
Hammarstroem, S.; Diczfalusy, U.
Inhibition and properties of thromboxane synthetase
Adv. Inflamm. Res.
1
431-438
1979
Homo sapiens
-
Manually annotated by BRENDA team
Wlodawer, P.; Hammarstroem, S.
Thromboxane synthase from bovine lung - solubilization and partial purification
Biochem. Biophys. Res. Commun.
80
525-532
1978
Bos taurus
Manually annotated by BRENDA team
Tai, H.H.; Yuan, B.
On the inhibitory potency of imidazole and its derivatives on thromboxane synthetase
Biochem. Biophys. Res. Commun.
80
236-242
1978
Homo sapiens
Manually annotated by BRENDA team
Diczfalusy, U.; Falardeau, P.; Hammarstrm, S.
Conversion of prostaglandin endoperoxides to C17-hydroxy acids catalyzed by human platelet thromboxane synthase
FEBS Lett.
84
271-274
1977
Homo sapiens
Manually annotated by BRENDA team
Diczfalusy, U.; Hammarstrm, S.
Inhibitors of thromboxane synthase in human platelets
FEBS Lett.
82
107-110
1977
Homo sapiens
Manually annotated by BRENDA team
Hammarstroem, S.; Falardeau, P.
Resolution of prostaglandin synthase and thromboxane synthase of human platelets
Proc. Natl. Acad. Sci. USA
74
3691-3695
1977
Homo sapiens
Manually annotated by BRENDA team
Yoshimoto, T.; Yamamoto, S.; Okuma, M.; Hayaishi, O.
Solubilization and resolution of thromboxane synthesizing system from microsomes of bovine blood platelets
J. Biol. Chem.
252
5871-5874
1977
Bos taurus
Manually annotated by BRENDA team
Sun, F.F.
Biosynthesis of thromboxanes in human platelets. I. Characterization and assay of thromboxane synthetase
Biochem. Biophys. Res. Commun.
74
1432-1440
1977
Homo sapiens
Manually annotated by BRENDA team
Ullrich, V.; Nusing, R.
Thromboxane synthase. From isolation to function
Stroke
21
IV134-IV138
1994
Homo sapiens
Manually annotated by BRENDA team
Sone, H.; Okuda, Y.; Kawakami, Y.; Yamashita, K.
Effects of high glucose concentration and a thromboxane synthase inhibitor on the production of thromboxane A2 and prostaglandin I2 and E2 by cultured retinal endothelial cells
Life Sci.
58
239-243
1996
Bos taurus
Manually annotated by BRENDA team
Umemura, K.; Nakashima, M.; Saruta, T.
Thromboxane A2 synthetase inhibition suppresses cough induced by angiotensin converting enzyme inhibitors
Life Sci.
60
1583-1588
1997
Homo sapiens
Manually annotated by BRENDA team
Ledergerber, D.; Hartmann, R.W.
Development of a screening assay for the in vitro evaluation of the thromboxane A2 synthase inhibitors
J. Enzyme Inhib.
9
253-261
1995
Homo sapiens
Manually annotated by BRENDA team
Yoshida, T.; Kameda, H.; Masashi, A.; Homma, M.; Ikeda, Y.
Improvement of renal function with selective thromboxane A2 synthetase inhibitor, DP-1904 in Lupus nephritis
Adv. Exp. Med. Biol.
433
113-117
1997
Homo sapiens
Manually annotated by BRENDA team
Miyata, A.; Yokoyama, C.; Ihara, H.; Bandoh, S.; Takeda, O.; Takahashi, E.I.; Tanabe, T.
Characterization of the human gene (TBXAS1) encoding thromboxane synthase
Eur. J. Biochem.
224
273-279
1994
Homo sapiens
Manually annotated by BRENDA team
Lee, S.J.; Konishi, Y.; Yu, D.T.; Miskowski, T.A.; Riviello, C.M.; Macina, O.T.; Frierson, M.R.; Kondo, K.; Sugitani, M.; Suvar, J.C.; Blazejewski, K.M.
Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities
J. Med. Chem.
38
3547-3557
1995
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Dickinson, R.P.; Dack, K.N.; Long, C.J.; Steele, J.
Thromboxane modulating agents. 3. 1H-Imidazol-1-ylalkyl- and 3-pyridinylalkyl-substituted 3-[2-[(arylsulfonyl)amino]ethyl]benzenepropanoic acid derivatives as dual thromboxane synthase inhibitor/thromboxane receptor antagonists
J. Med. Chem.
40
3442-3452
1997
Homo sapiens
Manually annotated by BRENDA team
Hall, E.R.; Townsend, G.L.; Tuan, W.M; Venton, D.L.
Immobilization of catalytically active thromboxane synthase
Prostaglandins Leukot. Essent. Fatty Acids
32
51-56
1988
Bos taurus
Manually annotated by BRENDA team
Ksander, G.M.; Erion, M.; Yuan, A.M.; Diefenbacher, C.G.; El-Chebabi, L.; Cote, D.; Levens, N.
Dual angiotensin converting enzyme/thromboxane synthase inhibitors
J. Med. Chem.
37
1823-1832
1994
Homo sapiens
Manually annotated by BRENDA team
Ruan, K.H.; Milfeld, K.; Kulmacz, R.J.; Wu, K.K.
Comparison of the construction of a 3-D model for human thromboxane synthase using P450cam and BM-3 as templates: implications for the substrate binding pocket
Protein Eng.
7
1345-1351
1994
Homo sapiens
Manually annotated by BRENDA team
Nusing, R.; Schneider-Voss, S.; Ullrich, V.
Immunoaffinity purification of human thromboxane synthase
Arch. Biochem. Biophys.
280
325-330
1990
Homo sapiens
Manually annotated by BRENDA team
Orlandi, M.; Bartolini, G.; Belletti, B.; Spisni, E.; Tomasi, V.
Thromboxane A2 synthase activity in platelet free human monocytes
Biochim. Biophys. Acta
1215
285-290
1994
Homo sapiens
Manually annotated by BRENDA team
Kamiya, S.; Matsui, H.; Shirahase, H.; Nakamura, S.; Wada, K.; Kanda, M.; Shimaji, H.; Kakeya, N.
Thromboxane A2 synthetase inhibitors with histamine H1-blocking activity: synthesis and evaluation of a new series of indole derivatives
Chem. Pharm. Bull.
43
1692-1695
1995
Oryctolagus cuniculus
Manually annotated by BRENDA team
Uematsu, T.; Kosuge, K.; Umemura, M.; Nakano, M.; Terakawa, M.; Nakashima, M.
Pharmacokinetic and pharmacodynamic properties of FK070(KDI-792), a novel thromboxane receptor antagonist/thromboxane synthetase inhibitor, after single and multiple oral administrations to healthy volunteers
J. Pharm. Pharmacol.
48
380-385
1996
Homo sapiens
Manually annotated by BRENDA team
Jones, D.A.; Fitzpatrick, F.A.
"Suicide" inactivation of thromboxane A2 synthase. Characteristics of mechanism-based inactivation with isolated enzyme and intact platelets
J. Biol. Chem.
265
20166-20171
1990
Bos taurus, Homo sapiens
Manually annotated by BRENDA team
Albuquerque, M.G.; Rodrigues.C.R.; Bicca de Alencastro, R.
Design of new potential 5-lipoxygenase inhibitors. Dual thromboxane synthase inhibitors, and thromboxane A2 receptor antagonists by AM1
Int. J. Quantum Chem.
22
181-190
1995
Mammalia
-
Manually annotated by BRENDA team
Haurand, M.; Ullrich, V.
Thromboxane synthase and prostacyclin synthase as P-450 enzymes with regard to the mechanisms of PGI2 and TXA2 biosynthesis
Front. Biotransform.
6
183-199
1992
Homo sapiens, Sus scrofa
-
Manually annotated by BRENDA team
Wade, M.L.; Fitzpatrick, F.A.
Nitric oxide modulates the activity of the hemoproteins prostaglandin I2 synthase and thromboxane A2 synthase
Arch. Biochem. Biophys.
347
174-180
1997
Homo sapiens
Manually annotated by BRENDA team
Michaux, C.; Norberg, B.; Dogne, J.M.; Durant, F.; Masereel, B.; Delarge, J.; Wouters, J.
Terbogrel, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition
Acta Crystallogr. Sect. C
56
1265-1266
2000
Homo sapiens
-
Manually annotated by BRENDA team
Michaux, C.; Dogne, J.M.; Norberg, B.; Durant, F.; Masereel, B.
N-tert-butyl-N'-(2-cyclohexylamino-5-nitrobenzenesulfonyl)urea, BM531, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition
Acta Crystallogr. Sect. C
58
o621-623
2002
Homo sapiens
Manually annotated by BRENDA team
Hsu, P.Y.; Tsai, A.L.; Wang, L.H.
Identification of thromboxane synthase amino acid residues involved in heme-propionate binding
Arch. Biochem. Biophys.
383
119-127
2000
Homo sapiens
Manually annotated by BRENDA team
Chen, Z.; Wang, L.H.; Schelvis, J.P.
Resonance Raman investigation of the interaction of thromboxane synthase with substrate analogues
Biochemistry
42
2542-2551
2003
Homo sapiens
Manually annotated by BRENDA team
Michaux, C.; Dogne, J.M.; Rolin, S.; Masereel, B.; Wouters, J.; Durant, F.
A pharmacophore model for sulphonyl-urea (-cyanoguanidine) compounds with dual action, thromboxane receptor antagonists and thromboxane synthase inhibitors
Eur. J. Med. Chem.
38
703-710
2003
Homo sapiens
Manually annotated by BRENDA team
Borsch-Haubold, A.G.; Pasquet, S.; Watson, S.P.
Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. SB 203580 also inhibits thromboxane synthase
J. Biol. Chem.
273
28766-28772
1998
Homo sapiens
Manually annotated by BRENDA team
Hsu, P.Y.; Tsai, A.L.; Kulmacz, R.J.; Wang, L.H.
Expression, purification, and spectroscopic characterization of human thromboxane synthase
J. Biol. Chem.
274
762-769
1999
Homo sapiens
Manually annotated by BRENDA team
Wang, L.H.; Tsai, A.L.; Hsu, P.Y.
Substrate binding is the rate-limiting step in thromboxane synthase catalysis
J. Biol. Chem.
276
14737-14743
2001
Homo sapiens
Manually annotated by BRENDA team
Takeuchi, K.; Kohn, T.J.; True, T.A.; Mais, D.E.; Wikel, J.H.; Utterback, B.G.; Wyss, V.L.; Jakubowski, J.A.
Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 3. Synthesis and biological activities of oxazolecarboxamide-substituted omega-phenyl-omega-(3-pyridyl)alkenoic acid derivatives and related compounds
J. Med. Chem.
41
5362-5374
1998
Homo sapiens
Manually annotated by BRENDA team
Soyka, R.; Guth, B.D.; Weisenberger, H.M.; Luger, P.; Muller, T.H.
Guanidine derivatives as combined thromboxane A2 receptor antagonists and synthase inhibitors
J. Med. Chem.
42
1235-1249
1999
Homo sapiens
Manually annotated by BRENDA team
Jacobs, C.; Frotscher, M.; Dannhardt, G.; Hartmann, R.W.
1-Imidazolyl(alkyl)-substituted di- and tetrahydroquinolines and analogues: syntheses and evaluation of dual inhibitors of thromboxane A(2) synthase and aromatase
J. Med. Chem.
43
1841-1851
2000
Homo sapiens
Manually annotated by BRENDA team
Dogne, J.M.; Wouters, J.; Rolin, S.; Michaux, C.; Pochet, L.; Durant, F.; Delarge, J.; Masereel, B.
Design, synthesis and biological evaluation of a sulfonylcyanoguanidine as thromboxane A2 receptor antagonist and thromboxane synthase inhibitor
J. Pharm. Pharmacol.
53
669-680
2001
Homo sapiens
Manually annotated by BRENDA team
Villalobos, M.A.; De La Cruz, J.P.; Escalante, R.; Arrebola, M.M.; Guerrero, A.; Sanchez de la Cuesta, F.
Effects of camonagrel, a selective inhibitor of platelet thromboxane synthase, on the platelet-subendothelium interaction
Pharmacology
69
44-50
2003
Homo sapiens
Manually annotated by BRENDA team
Yagi, A.; Kabash, A.; Mizuno, K.; Moustafa, S.M.; Khalifa, T.I.; Tsuji, H.
Radical scavenging glycoprotein inhibiting cyclooxygenase-2 and thromboxane A2 synthase from aloe vera gel
Planta Med.
69
269-271
2003
Aloe vera
Manually annotated by BRENDA team
Nie, D.; Che, M.; Zacharek, A.; Qiao, Y.; Li, L.; Li, X.; Lamberti, M.; Tang, K.; Cai, Y.; Guo, Y.; Grignon, D.; Honn, K.V.
Differential expression of thromboxane synthase in prostate carcinoma: role in tumor cell motility
Am. J. Pathol.
164
429-439
2004
Homo sapiens
Manually annotated by BRENDA team
Moussa, O.; Yordy, J.S.; Abol-Enein, H.; Sinha, D.; Bissada, N.K.; Halushka, P.V.; Ghoneim, M.A.; Watson, D.K.
Prognostic and functional significance of thromboxane synthase gene overexpression in invasive bladder cancer
Cancer Res.
65
11581-11587
2005
Homo sapiens
Manually annotated by BRENDA team
Stachowska, E.; Dolegowska, B.; Olszewska, M.; Gutowska, I.; Chlubek, D.
Isomers of trans fatty acids modify the activity of platelet 12-P lipoxygenase and cyclooxygenase/thromboxane synthase
Nutrition
20
570-571
2004
Homo sapiens
Manually annotated by BRENDA team
Murakami, S.; Nagaya, N.; Itoh, T.; Kataoka, M.; Iwase, T.; Horio, T.; Miyahara, Y.; Sakai, Y.; Kangawa, K.; Kimura, H.
Prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice
Am. J. Physiol.
290
L59-L65
2006
Mus musculus
Manually annotated by BRENDA team
Yeh, H.C.; Tsai, A.L.; Wang, L.H.
Reaction mechanisms of 15-hydroperoxyeicosatetraenoic acid catalyzed by human prostacyclin and thromboxane synthases
Arch. Biochem. Biophys.
461
159-168
2007
Homo sapiens
Manually annotated by BRENDA team
Kawka, D.W.; Ouellet, M.; Hetu, P.; Singer, I.I.; Riendeau, D.
Double-label expression studies of prostacyclin synthase, thromboxane synthase and COX isoforms in normal aortic endothelium
Biochim. Biophys. Acta
1771
45-54
2007
Canis lupus familiaris
Manually annotated by BRENDA team
Wang, X.; Yin, X.; Schiffer, R.B.; King, S.R.; Stocco, D.M.; Grammas, P.
Inhibition of thromboxane A synthase activity enhances steroidogenesis and steroidogenic acute regulatory gene expression in MA-10 mouse leydig cells
Endocrinology
149
851-857
2008
Mus musculus
Manually annotated by BRENDA team
Sakai, H.; Suzuki, T.; Takahashi, Y.; Ukai, M.; Tauchi, K.; Fujii, T.; Horikawa, N.; Minamimura, T.; Tabuchi, Y.; Morii, M.; Tsukada, K.; Takeguchi, N.
Upregulation of thromboxane synthase in human colorectal carcinoma and the cancer cell proliferation by thromboxane A2
FEBS Lett.
580
3368-3374
2006
Homo sapiens
Manually annotated by BRENDA team
Cailleteau, C.; Liagre, B.; Battu, S.; Jayat-Vignoles, C.; Beneytout, J.L.
Increased cyclooxygenase-2 and thromboxane synthase expression is implicated in diosgenin-induced megakaryocytic differentiation in human erythroleukemia cells
Anal. Biochem.
380
26-34
2008
Homo sapiens
Manually annotated by BRENDA team
Cheng, F.C.; Feng, J.J.; Chen, K.H.; Imanishi, H.; Fujishima, M.; Takekoshi, H.; Naoki, Y.; Shimoda, M.
Chlorella powder inhibits the activities of peptidase cathepsin S, PLA2, cyclooxygenase-2, thromboxane synthase, tyrosine phosphatases, tumor necrosis factor-alpha converting enzyme, calpain and kinases
Int. J. Food Sci. Nutr.
60 Suppl 1
89-98
2008
Homo sapiens
Manually annotated by BRENDA team
Genevieve, D.; Proulle, V.; Isidor, B.; Bellais, S.; Serre, V.; Djouadi, F.; Picard, C.; Vignon-Savoye, C.; Bader-Meunier, B.; Blanche, S.; de Vernejoul, M.C.; Legeai-Mallet, L.; Fischer, A.M.; Le Merrer, M.; Dreyfus, M.; Gaussem, P.; Munnich, A.; Cormier-Daire, V.
Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome)
Nat. Genet.
40
284-286
2008
Homo sapiens
Manually annotated by BRENDA team
Lee, J.J.; Yu, J.Y.; Lee, J.H.; Zhang, W.Y.; Kim, T.J.; Myung, C.S.; Yun, Y.P.
The protective effects of paclitaxel on platelet aggregation through the inhibition of thromboxane A2 synthase
Arch. Pharm. Res.
33
387-394
2010
Oryctolagus cuniculus
Manually annotated by BRENDA team
Vila, L.; Martinez-Perez, A.; Camacho, M.; Buil, A.; Alcolea, S.; Pujol-Moix, N.; Soler, M.; Anton, R.; Souto, J.C.; Fontcuberta, J.; Soria, J.M.
Heritability of thromboxane A2 and prostaglandin E2 biosynthetic machinery in a Spanish population
Arterioscler. Thromb. Vasc. Biol.
30
128-134
2010
Homo sapiens
Manually annotated by BRENDA team
Cyrus, T.; Ding, T.; Pratico, D.
Expression of thromboxane synthase, prostacyclin synthase and thromboxane receptor in atherosclerotic lesions: correlation with plaque composition
Atherosclerosis
208
376-381
2010
Mus musculus
Manually annotated by BRENDA team
Cathcart, M.C.; Reynolds, J.V.; OByrne, K.J.; Pidgeon, G.P.
The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer
Biochim. Biophys. Acta
1805
153-166
2010
Homo sapiens
Manually annotated by BRENDA team
Park, S.A.; Park, B.L.; Park, J.H.; Lee, T.K.; Sung, K.B.; Lee, Y.K.; Chang, H.S.; Park, C.S.; Shin, H.D.
Association of polymorphisms in thromboxane A2 receptor and thromboxane A synthase 1 with cerebral infarction in a Korean population
BMB Rep.
42
200-205
2009
Homo sapiens
Manually annotated by BRENDA team
Leung, K.C.; Hsin, M.K.; Chan, J.S.; Yip, J.H.; Li, M.; Leung, B.C.; Mok, T.S.; Warner, T.D.; Underwood, M.J.; Chen, G.G.
Inhibition of thromboxane synthase induces lung cancer cell death via increasing the nuclear p27
Exp. Cell Res.
315
2974-2981
2009
Homo sapiens
Manually annotated by BRENDA team
Wright, W.S.; McElhatten, R.M.; Harris, N.R.
Expression of thromboxane synthase and the thromboxane-prostanoid receptor in the mouse and rat retina
Exp. Eye Res.
89
532-537
2009
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Gabrielsen, A.; Qiu, H.; Baeck, M.; Hamberg, M.; Hemdahl, A.L.; Agardh, H.; Folkersen, L.; Swedenborg, J.; Hedin, U.; Paulsson-Berne, G.; Haeggstroem, J.Z.; Hansson, G.K.
Thromboxane synthase expression and thromboxane A2 production in the atherosclerotic lesion
J. Mol. Med.
88
795-806
2010
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Schauff, A.; Kim, E.; Leppert, J.; Nadrowitz, R.; Wuestenberg, R.; Brockmann, M.; Giese, A.
Inhibition of invasion-associated thromboxane synthase sensitizes experimental gliomas to gamma-radiation
J. Neurooncol.
91
241-249
2009
Homo sapiens
Manually annotated by BRENDA team
Schmidt, N.O.; Ziu, M.; Cargioli, T.; Westphal, M.; Giese, A.; Black, P.M.; Carroll, R.S.
Inhibition of thromboxane synthase activity improves glioblastoma response to alkylation chemotherapy
Transl. Oncol.
3
43-49
2010
Homo sapiens
Manually annotated by BRENDA team
Muzaffar, S.; Shukla, N.; Massey, Y.; Angelini, G.D.; Jeremy, J.Y.
NADPH oxidase 1 mediates upregulation of thromboxane A2 synthase in human vascular smooth muscle cells: inhibition with iloprost
Eur. J. Pharmacol.
658
187-192
2011
Homo sapiens
Manually annotated by BRENDA team
Chao, W.C.; Lu, J.F.; Wang, J.S.; Yang, H.C.; Pan, T.A.; Chou, S.C.; Wang, L.H.; Chou, P.T.
Probing ligand binding to thromboxane synthase
Biochemistry
52
1113-1121
2013
Homo sapiens
Manually annotated by BRENDA team
Das, A.; Varma, S.S.; Mularczyk, C.; Meling, D.D.
Functional investigations of thromboxane synthase (CYP5A1) in lipid bilayers of nanodiscs
ChemBioChem
15
892-899
2014
Homo sapiens
Manually annotated by BRENDA team
Cathcart, M.C.; Gately, K.; Cummins, R.; Kay, E.; OByrne, K.J.; Pidgeon, G.P.
Examination of thromboxane synthase as a prognostic factor and therapeutic target in non-small cell lung cancer
Mol. Cancer
10
25
2011
Homo sapiens
Manually annotated by BRENDA team
Sathler, P.; Santana, M.; Loureno, A.; Rodrigues, C.; Abreu, P.; Cabral, L.; Castro, H.
Human thromboxane synthase Comparative modeling and docking evaluation with the competitive inhibitors dazoxiben and ozagrel
J. Enzyme Inhib. Med. Chem.
29
527-531
2014
Homo sapiens
Manually annotated by BRENDA team
Son, D.J.; Akiba, S.; Hong, J.T.; Yun, Y.P.; Hwang, S.Y.; Park, Y.H.; Lee, S.E.
Piperine inhibits the activities of platelet cytosolic phospholipase A2 and thromboxane A2 synthase without affecting cyclooxygenase-1 activity different mechanisms of action are involved in the inhibition of platelet aggregation and macrophage inflammatory response
Nutrients
6
3336-3352
2014
Oryctolagus cuniculus
Manually annotated by BRENDA team