Reference on EC 5.3.99.2 - Prostaglandin-D synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Shimizu, T.; Yamamoto, S.; Hayaishi, O.
Purification of PGH-PDG isomerase from rat brain
Methods Enzymol.
86
73-77
1982
Cavia porcellus, Oryctolagus cuniculus, Felis catus, Platyrrhini, Mus musculus, Rattus norvegicus
Christ-Hazelhof, E.; Nugteren, D.H.
Isolation of PGH-PGS isomerase from rat spleen
Methods Enzymol.
86
77-84
1982
Rattus norvegicus
Shimizu, T.; Yamamoto, S.; Hayaishi, O.
Purification and properties of prostaglandin D synthetase from rat brain
J. Biol. Chem.
254
5222-5228
1979
Rattus norvegicus
Ruzicka, T.; Printz, M.P.
Arachidonic acid metabolism in guinea pig skin
Biochim. Biophys. Acta
711
391-397
1982
Cavia porcellus
Toh, H.; Kubodera, H.; Nakajima, N.; Sekiya, T.; Eguchi, N.; Tanaka, T.; Urade, Y.; Hayaishi, O.
Glutathione-independent prostaglandin D synthase as a lead molecule for designing new functional proteins
Protein Eng.
9
1067-1082
1996
Ursus sp., Felis catus, Homo sapiens, Mus musculus, Rattus norvegicus, Xenopus sp.
Tokugawa, Y.; Kunishige, I.; Kubota, Y.; Shimoya, K.; Nobunaga, T.; Kimura, T.; Saji, F.; Murata, Y.; Eguchi, N.; Oda, H.; Urade, Y.; Hayaishi, O.
Lipocalin-type prostaglandin D synthase in human male reproductive organs and seminal plasma
Biol. Reprod.
58
600-607
1998
Homo sapiens
Gerana, R.L.; Irikura, D.; Urade, Y.; Eguchi, N.; Chapman, D.A.; Killian, G.J.
Identification of a fertility-associated protein in bull seminal plasma as lipocalin-type prostaglandin D synthetase
Biol. Reprod.
58
826-833
1998
Bos taurus
Hayaishi, O.; Matsumura, H.; Urade, Y.
Prostaglandin D synthase is the key enzyme in the promotion of physiological sleep
J. Lipid Mediat. Cell Signal.
6
429-431
1993
Homo sapiens, Rattus norvegicus
Hayaishi, O.
Prostaglandin D synthase, beta-trace and sleep
Recent Adv. Prostaglandin Thromboxane Leukotriene Res.
1998
347-350
1998
Homo sapiens, Rattus norvegicus
-
Ujihara, M.; Tsuchida, S.; Satoh, K.; Sato, K.; Urade, Y.
Biochemical and immunological demonstration of prostaglandin D2, E2, and F2alpha formation from prostaglandin H2 by various rat glutathione S-transferase isoenzymes
Arch. Biochem. Biophys.
264
428-437
1988
Rattus norvegicus
Islam, F.; Watanabe, Y.; Morii, H.; Hayaishi, O.
Inhibition of rat brain prostaglandin D synthase by inorganic selenocompounds
Arch. Biochem. Biophys.
289
161-166
1991
Rattus norvegicus
Islam, F.; Urade, Y.; Watanabe, Y.; Hayaishi, O.
A particle concentration fluorescence immunoassay for prostaglandin D synthase in the rat central nervous system
Arch. Biochem. Biophys.
277
290-295
1990
Rattus norvegicus
Suzuki, T.; Watanabe, K.; Kanaoka, Y.; Sato, T.; Hayaishi, O.
Induction of hematopoietic prostaglandin D synthase in human megakaryocytic cells by phorbol ester
Biochem. Biophys. Res. Commun.
241
288-293
1997
Homo sapiens
Watanabe, K.; Urade, Y.; Mder, M.; Murphy, C.; Hayaishi, O.
Identification of beta-trace as prostaglandin D synthase
Biochem. Biophys. Res. Commun.
203
1110-1116
1994
Homo sapiens
Takahata, R.; Matsumura, H.; Kantha, S.S.; Kubo, E.; Kawase, K.; Sakai, T.; Hayaishi, O.
Intravenous administration of inorganic selenium compounds, inhibitors of prostaglandin D synthase, inhibits sleep in freely moving rats
Brain Res.
623
65-71
1993
Rattus norvegicus
Gerashchenko, D.Y.; Beuckmann, C.T.; Marcheselli, V.L.; Gordon, W.C.; Kanaoka, Y.; Eguchi, N.; Urade, Y.; Hayaishi, O.; Bazan, N.G.
Localization of lipocalin-type prostaglandin D synthase (beta-trace) in iris ciliary body, and eye fluids
Invest. Ophthalmol. Vis. Sci.
39
198-203
1998
Rattus norvegicus
Vesin, M.F.; Droz, B.
Immunodetection of prostaglandin D synthase conditions of localization in a defined subclass of primary sensory neurons
J. Histochem. Cytochem.
43
681-687
1995
Gallus gallus
Hoffmann, A.; Conradt, H.S.; Gross, G.; Nimtz, M.; Lottspeich, F.; Wurster, U.
Purification and chemical characterization of beta-trace protein from human cerebrospinal fluid: its identification as prostaglandin D synthase
J. Neurochem.
61
451-456
1993
Homo sapiens
Beuckmann, C.T.; Gordon, W.C.; Kanaoka, Y.; Eguchi, N.; Marcheselli, V.L.; Gerashchenko, D.Y.; Urade, Y.; Hayaishi, O.; Bazan, N.G.
Lipocalin-type prostaglandin D synthase (beta-trace) is located in pigment epithelial cells of rat retina and accumulates within interophotoreceptor matrix
J. Neurosci.
16
6119-6124
1996
Rattus norvegicus (P22057)
Matsumura, H.; Takahata, R.; Hayaishi, O.
Inhibition of sleep in rats by inorganic selenium compounds, inhibitors of prostaglandin D synthase
Proc. Natl. Acad. Sci. USA
88
9046-9050
1991
Rattus norvegicus
Tanaka, T.; Urade, Y.; Kimura, H.; Eguchi, N.; Nishikawa, A.; Hayaishi, O.
Lipocalin-type prostaglandin D synthase (beta-trace) is a newly recognized type of retinoid transporter
J. Biol. Chem.
272
15789-15795
1997
Rattus norvegicus
Mahmud, I.; Ueda, N.; Yamaguchi, H.; Yamashita, R.; Yamamoto, S.; Kanaoka, Y.; Urade, Y.; Hayaishi, O.
Prostaglandin D synthase in human megakaryoblastic cells
J. Biol. Chem.
272
28263-28266
1997
Homo sapiens
Meyer, D.J.; Thomas, M.
Characterization of rat spleen prostaglandin H D-isomerase as a sigma-class GSH transferase
Biochem. J.
311
739-742
1995
Rattus norvegicus
Urade, Y.; Watanabe, K.; Hayaishi, O.
Prostaglandin D, E, and F synthases
J. Lipid Mediat. Cell Signal.
12
257-273
1995
Gallus gallus, Homo sapiens, Rattus norvegicus
Kanaoka, Y.; Ago, H.; Inagaki, E.; Nanayama, T.; Miyano, M.; Kikuno, R.; Eguchi, N.; Toh, H.; Urade, Y.; Hayaishi, O.
Cloning and crystal structure of hematopoietic prostaglandin D synthase
Cell
90
1085-1095
1997
Rattus norvegicus
Nagata, A.; Suzuki, Y.; Igarashi, M.; Eguchi, N.; Toh, H.; Urade, Y.; Hayaishi, O.
Human brain prostaglandin D synthase has been evolutionarily differentiated from lipophilic-ligand carrier proteins
Proc. Natl. Acad. Sci. USA
88
4020-4024
1991
Homo sapiens
Urade, Y.; Nagata, A.; Suzuki, Y.; Fujii, Y.; Hayaishi, O.
Primary structure of rat brain prostaglandin D synthetase deduced from cDNA sequence
J. Biol. Chem.
264
1041-1045
1989
Rattus norvegicus
Steinhoff, M.M.; Lee, L.H.; Jakschik, B.A.
Enzymatic formation of prostaglandin D2 by rat basophilic leukemia cells and normal rat mast cells
Biochim. Biophys. Acta
618
28-34
1980
Rattus norvegicus
Inui, T.; Ohkubo, T.; Urade, Y.; Hayaishi, O.
Enhancement of lipocalin-type prostaglandin D synthase enzyme activity by guanidine hydrochloride
Biochem. Biophys. Res. Commun.
266
641-646
1999
Homo sapiens, Mus musculus (O09114), Mus musculus
Thomson, A.M.; Meyer, D.J.; Hayes, J.D.
Sequence, catalytic properties and expression of chicken glutathione-dependent prostaglandin D2 synthase, a novel class sigma glutathione S-transferase
Biochem. J.
333
317-325
1998
Gallus gallus (O73888)
-
Jowsey, I.R.; Thomson, A.M.; Flanagan, J.U.; Murdock, P.R.; Moore, G.B.T.; Meyer, D.J.; Murphy, G.J.; Smith, S.A.; Hayes, J.D.
Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases
Biochem. J.
359
507-516
2001
Homo sapiens, Rattus norvegicus (O35543)
Beuckmann, C.T.; Aoyagi, M.; Okazaki, I.; Hiroike, T.; Toh, H.; Hayaishi, O.; Urade, Y.
Binding of biliverdin, bilirubin, and thyroid hormones to lipocalin-type prostaglandin D synthase
Biochemistry
38
8006-8013
1999
Rattus norvegicus
Samy, E.T.; Li, J.C.H.; Grima, J.; Lee, W.M.; Silvestrini, B.; Cheng, C.Y.
Sertoli cell prostaglandin D2 synthetase is a multifunctional molecule: its expression and regulation
Endocrinology
141
710-721
2000
Rattus norvegicus
Pinzar, E.; Miyano, M.; Kanaoka, Y.; Urade, Y.; Hayaishi, O.
Structural basis of hematopoietic prostaglandin D synthase activity elucidated by site-directed mutagenesis
J. Biol. Chem.
275
31239-31244
2000
Rattus norvegicus (O35543)
Inoue, T.; Irikura, D.; Okazaki, N.; Kinugasa, S.; Matsumura, H.; Uodome, N.; Yamamoto, M.; Kumasaka, T.; Miyano, M.; Kai, Y.; Urade, Y.
Mechanism of metal activation of human hematopoietic prostaglandin D synthase
Nat. Struct. Biol.
10
291-296
2003
Homo sapiens (O60760), Homo sapiens
Ragolia, L.; Palaia, T.; Koutrouby, T.B.; Maesaka, J.K.
Inhibition of cell cycle progression and migration of vascular smooth muscle cells by prostaglandin D2 synthase: resistance in diabetic Goto-Kakizaki rats
Am. J. Physiol.
287
C1273-1281
2004
Rattus norvegicus
Chen, D.Y.; Wang, J.J.; Huang, Y.F.; Zhou, K.Y.
Relationship between lipocalin-type prostaglandin D synthase and alpha-glucosidase in azoospermia seminal plasma
Clin. Chim. Acta
354
69-76
2005
Homo sapiens
Harrington, M.G.; Fonteh, A.N.; Biringer, R.G.; AF, R.H.; Cowan, R.P.
Prostaglandin D synthase isoforms from cerebrospinal fluid vary with brain pathology
Dis. Markers
22
281-289
2006
Homo sapiens (P41222)
-
Zhu, H.; Ma, H.; Ni, H.; Ma, X.H.; Mills, N.; Yang, Z.M.
L-prostaglandin D synthase expression and regulation in mouse testis and epididymis during sexual maturation and testosterone treatment after castration
Endocrine
24
39-45
2004
Mus musculus
Nagasaka, T.; Hiraide, M.; Sugimoto, T.; Shindo, K.; Shiozawa, Z.; Yokota, S.
Localization of lipocaline-type prostaglandin D synthase in rat brain: immunoelectron microscopic study
Histochem. Cell Biol.
121
483-491
2004
Rattus norvegicus
Inoue, T.; Okano, Y.; Kado, Y.; Aritake, K.; Irikura, D.; Uodome, N.; Okazaki, N.; Kinugasa, S.; Shishitani, H.; Matsumura, H.; Kai, Y.; Urade, Y.
First determination of the inhibitor complex structure of human hematopoietic prostaglandin D synthase
J. Biochem.
135
279-283
2004
Homo sapiens
Muraki, T.; Fujimori, K.; Ishizaka, M.; Ohe, Y.; Urade, Y.; Okajima, F.; Ishikawa, K.
Effects of interleukin-1beta and prostaglandin E2 on prostaglandin D synthase production in cultivated rat leptomeningeal cells
J. Cereb. Blood Flow Metab.
24
409-418
2004
Rattus norvegicus
Kagitani-Shimono, K.; Mohri, I.; Oda, H.; Ozono, K.; Suzuki, K.; Urade, Y.; Taniike, M.
Lipocalin-type prostaglandin D synthase (beta-trace) is upregulated in the alphaB-crystallin-positive oligodendrocytes and astrocytes in the chronic multiple sclerosis
Neuropathol. Appl. Neurobiol.
32
64-73
2006
Homo sapiens
Nantel, F.; Fong, C.; Lamontagne, S.; Wright, D.H.; Giaid, A.; Desrosiers, M.; Metters, K.M.; O'Neill, G.P.; Gervais, F.G.
Expression of prostaglandin D synthase and the prostaglandin D2 receptors DP and CRTH2 in human nasal mucosa
Prostaglandins Other Lipid Mediat.
73
87-101
2004
Homo sapiens
Chen, D.Y.; Zhu, M.Y.; Cui, Y.D.; Huang, T.H.
Relationship between contents of lipocalin-type prostaglandin D synthase on the surface of infertility sperm and in seminal plasma
Biochemistry (Moscow)
72
215-218
2007
Homo sapiens
Malki, S.; Bibeau, F.; Notarnicola, C.; Roques, S.; Berta, P.; Poulat, F.; Boizet-Bonhoure, B.
Expression and biological role of the prostaglandin D synthase/SOX9 pathway in human ovarian cancer cells
Cancer Lett.
255
182-193
2007
Homo sapiens
Park, J.M.; Kanaoka, Y.; Eguchi, N.; Aritake, K.; Grujic, S.; Materi, A.M.; Buslon, V.S.; Tippin, B.L.; Kwong, A.M.; Salido, E.; French, S.W.; Urade, Y.; Lin, H.J.
Hematopoietic prostaglandin D synthase suppresses intestinal adenomas in ApcMin/+ mice
Cancer Res.
67
881-889
2007
Homo sapiens, Mus musculus
Fujimori, K.; Inui, T.; Uodome, N.; Kadoyama, K.; Aritake, K.; Urade, Y.
Zebrafish and chicken lipocalin-type prostaglandin D synthase homologues: Conservation of mammalian gene structure and binding ability for lipophilic molecules, and difference in expression profile and enzyme activity
Gene
375
14-25
2006
Mus musculus, Gallus gallus (Q8QFM7), Gallus gallus, Danio rerio (Q8QGV4), Danio rerio
Shimamoto, S.; Yoshida, T.; Inui, T.; Gohda, K.; Kobayashi, Y.; Fujimori, K.; Tsurumura, T.; Aritake, K.; Urade, Y.; Ohkubo, T.
NMR solution structure of lipocalin-type prostaglandin D synthase: evidence for partial overlapping of catalytic pocket and retinoic acid-binding pocket within the central cavity
J. Biol. Chem.
282
31373-31379
2007
Mus musculus (O09114), Mus musculus
Kengni, J.H.; St-Louis, I.; Parent, S.; Leblanc, V.; Shooner, C.; Asselin, E.
Regulation of prostaglandin D synthase and prostacyclin synthase in the endometrium of cyclic, pregnant, and pseudopregnant rats and their regulation by sex steroids
J. Endocrinol.
195
301-311
2007
Rattus norvegicus
Joo, M.; Kwon, M.; Sadikot, R.T.; Kingsley, P.J.; Marnett, L.J.; Blackwell, T.S.; Peebles, R.S.; Urade, Y.; Christman, J.W.
Induction and function of lipocalin prostaglandin D synthase in host immunity
J. Immunol.
179
2565-2575
2007
Mus musculus
Mohri, I.; Taniike, M.; Okazaki, I.; Kagitani-Shimono, K.; Aritake, K.; Kanekiyo, T.; Yagi, T.; Takikita, S.; Kim, H.S.; Urade, Y.; Suzuki, K.
Lipocalin-type prostaglandin D synthase is up-regulated in oligodendrocytes in lysosomal storage diseases and binds gangliosides
J. Neurochem.
97
641-651
2006
Mus musculus
Qu, W.M.; Huang, Z.L.; Xu, X.H.; Aritake, K.; Eguchi, N.; Nambu, F.; Narumiya, S.; Urade, Y.; Hayaishi, O.
Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep
Proc. Natl. Acad. Sci. USA
103
17949-17954
2006
Mus musculus
Trivedi, S.G.; Newson, J.; Rajakariar, R.; Jacques, T.S.; Hannon, R.; Kanaoka, Y.; Eguchi, N.; Colville-Nash, P.; Gilroy, D.W.
Essential role for hematopoietic prostaglandin D2 synthase in the control of delayed type hypersensitivity
Proc. Natl. Acad. Sci. USA
103
5179-5184
2006
Mus musculus
Schlatterer, J.C.; Baeker, R.; Schlatterer, B.; Klose, J.; Kehler, W.; Schlatterer, K.
Purification of prostaglandin D synthase by ceramic- and size exclusion chromatography
Prostaglandins Other Lipid Mediat.
81
80-89
2006
Bos taurus, Homo sapiens
Ragolia, L.; Hall, C.E.; Palaia, T.
Post-translational modification regulates prostaglandin D2 synthase apoptotic activity: characterization by site-directed mutagenesis
Prostaglandins Other Lipid Mediat.
83
25-32
2007
Rattus norvegicus
Liu, J.; Lin, K.; Guo, C.; Gao, H.; Yao, Y.; Lin, D.
Expression and purification of cysteine mutation isoforms of rat lipocalin-type prostaglandin D synthase for nuclear magnetic resonance study
Acta Biochim. Biophys. Sin.
40
489-496
2008
Rattus norvegicus
Zayed, N.; Li, X.; Chabane, N.; Benderdour, M.; Martel-Pelletier, J.; Pelletier, J.P.; Duval, N.; Fahmi, H.
Increased expression of lipocalin-type prostaglandin D2 synthase in osteoarthritic cartilage
Arthritis Res. Ther.
10
R146
2008
Homo sapiens
Inoue, T.; Eguchi, Y.; Matsumoto, T.; Kijima, Y.; Kato, Y.; Ozaki, Y.; Waseda, K.; Oda, H.; Seiki, K.; Node, K.; Urade, Y.
Lipocalin-type prostaglandin D synthase is a powerful biomarker for severity of stable coronary artery disease
Atherosclerosis
201
385-391
2008
Homo sapiens
Liu, J.; Guo, C.; Yao, Y.; Lin, D.
Effects of removing a conserved disulfide bond on the biological characteristics of rat lipocalin-type prostaglandin D synthase
Biochimie
90
1637-1646
2008
Rattus norvegicus
Iida, T.; Nishimura, S.; Mochizuki, M.; Uchiyama, S.; Ohkubo, T.; Urade, Y.; Tanaka, A.; Inui, T.
Thermal unfolding mechanism of lipocalin-type prostaglandin D synthase
FEBS J.
275
233-241
2008
Mus musculus (O09114)
Ohinata, K.; Takagi, K.; Biyajima, K.; Fujiwara, Y.; Fukumoto, S.; Eguchi, N.; Urade, Y.; Asakawa, A.; Fujimiya, M.; Inui, A.; Yoshikawa, M.
Central prostaglandin D(2) stimulates food intake via the neuropeptide Y system in mice
FEBS Lett.
582
679-684
2008
Mus musculus
Fujimori, K.; Aritake, K.; Urade, Y.
Enhancement of prostaglandin D(2) production through cyclooxygenase-2 and lipocalin-type prostaglandin D synthase by upstream stimulatory factor 1 in human brain-derived TE671 cells under serum starvation
Gene
426
72-80
2008
Homo sapiens
Inoue, K.; Yagi, N.; Urade, Y.; Inui, T.
Compact packing of lipocalin-type prostaglandin D synthase induced by binding of lipophilic ligands
J. Biochem.
145
169-175
2009
Mus musculus
Irikura, D.; Aritake, K.; Nagata, N.; Maruyama, T.; Shimamoto, S.; Urade, Y.
Biochemical, functional and pharmacological characterization of AT-56, an orally active and selective inhibitor of lipocalin-type prostaglandin d synthase
J. Biol. Chem.
284
7623-7630
2009
Homo sapiens, Mus musculus (O09114), Mus musculus
Hohwy, M.; Spadola, L.; Lundquist, B.; Hawtin, P.; Dahmen, J.; Groth-Clausen, I.; Nilsson, E.; Persdotter, S.; von Wachenfeldt, K.; Folmer, R.H.; Edman, K.
Novel prostaglandin D synthase inhibitors generated by fragment-based drug design
J. Med. Chem.
51
2178-2186
2008
Homo sapiens (O60760)
Huang, Y.C.; Lyu, R.K.; Tseng, M.Y.; Chang, H.S.; Hsu, W.C.; Kuo, H.C.; Chu, C.C.; Wu, Y.R.; Ro, L.S.; Huang, C.C.; Chen, C.M.
Decreased intrathecal synthesis of prostaglandin D(2) synthase in the cerebrospinal fluid of patients with acute inflammatory demyelinating polyneuropathy
J. Neuroimmunol.
206
100-105
2009
Homo sapiens
Heshmat, S.M.; Mullen, J.B.; Jarvi, K.A.; Soosaipillai, A.; Diamandis, E.P.; Hamilton, R.J.; Lo, K.C.
Seminal plasma lipocalin-type prostaglandin D synthase: a potential new marker for the diagnosis of obstructive azoospermia
J. Urol.
179
1077-1080
2008
Homo sapiens
Li, W.; Malpica-Llanos, T.M.; Gundry, R.; Cotter, R.J.; Sacktor, M.; Mc Arthur, J.; Nath, A.
Nitrosative stress with HIV dementia causes decreased L-prostaglandin D synthase activity
Neurology
70
1753-1762
2008
Homo sapiens
Li, W.; Mase, M.; Inui, T.; Shimoda, M.; Isomura, K.; Oda, H.; Yamada, K.; Urade, Y.
Pharmacokinetics of recombinant human lipocalin-type prostaglandin D synthase/beta-trace in canine
Neurosci. Res.
61
289-293
2008
Homo sapiens
Eichele, K.; Ramer, R.; Hinz, B.
Decisive role of cyclooxygenase-2 and lipocalin-type prostaglandin D synthase in chemotherapeutics-induced apoptosis of human cervical carcinoma cells
Oncogene
27
3032-3044
2008
Homo sapiens
Ragolia, L.; Hall, C.E.; Palaia, T.
Lipocalin-type prostaglandin D(2) synthase stimulates glucose transport via enhanced GLUT4 translocation
Prostaglandins Other Lipid Mediat.
87
34-41
2008
Mus musculus, Rattus norvegicus
Nakayama, H.; Echizen, H.; Gomi, T.; Shibuya, Y.; Nakamura, Y.; Nakano, K.; Arashi, H.; Itai, T.; Ohnishi, S.; Tanaka, M.; Orii, T.
Urinary lipocalin-type prostaglandin D synthase: a potential marker for early gentamicin-induced renal damage?
Ther. Drug Monit.
31
126-130
2009
Homo sapiens
Shimura, C.; Satoh, T.; Igawa, K.; Aritake, K.; Urade, Y.; Nakamura, M.; Yokozeki, H.
Dendritic cells express hematopoietic prostaglandin D synthase and function as a source of prostaglandin D2 in the skin
Am. J. Pathol.
176
227-237
2010
Homo sapiens
Han, F.; Takeda, K.; Ishikawa, K.; Ono, M.; Date, F.; Yokoyama, S.; Furuyama, K.; Shinozawa, Y.; Urade, Y.; Shibahara, S.
Induction of lipocalin-type prostaglandin D synthase in mouse heart under hypoxemia
Biochem. Biophys. Res. Commun.
385
449-453
2009
Mus musculus
Jrgensen, A.; Nielsen, J.E.; Nielsen, B.F.; Morthorst, J.E.; Bjerregaard, P.; Leffers, H.
Expression of prostaglandin synthases (pgds and pges) during zebrafish gonadal differentiation
Comp. Biochem. Physiol. A
157
102-108
2010
Danio rerio
Weber, J.E.; Oakley, A.J.; Christ, A.N.; Clark, A.G.; Hayes, J.D.; Hall, R.; Hume, D.A.; Board, P.G.; Smythe, M.L.; Flanagan, J.U.
Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase
Eur. J. Med. Chem.
45
447-454
2010
Homo sapiens (O60760), Homo sapiens
Takeda, K.; Takahashi, N.H.; Yoshizawa, M.; Shibahara, S.
Lipocalin-type prostaglandin D synthase as a regulator of the retinoic acid signaling in melanocytes
J. Biochem.
148
139-148
2010
Homo sapiens
Kumasaka, T.; Aritake, K.; Ago, H.; Irikura, D.; Tsurumura, T.; Yamamoto, M.; Miyano, M.; Urade, Y.; Hayaishi, O.
Structural basis of the catalytic mechanism operating in open-closed conformers of lipocalin type prostaglandin D synthase
J. Biol. Chem.
284
22344-22352
2009
Mus musculus (O09114), Mus musculus
Uchida, Y.; Urade, Y.; Mori, S.; Kohzuma, T.
UV resonance Raman studies on the activation mechanism of human hematopoietic prostaglandin D(2) synthase by a divalent cation, Mg(2+)
J. Inorg. Biochem.
104
331-340
2010
Homo sapiens (O60760), Homo sapiens
Hokari, R.; Nagata, N.; Kurihara, C.; Watanabe, C.; Komoto, S.; Okada, Y.; Kawaguchi, A.; Nagao, S.; Hibi, T.; Nagata, K.; Urade, Y.; Miura, S.
Increased expression and cellular localization of lipocalin-type prostaglandin D synthase in Helicobacter pylori-induced gastritis
J. Pathol.
219
417-426
2009
Homo sapiens
Gao, W.; Schmidtko, A.; Wobst, I.; Lu, R.; Angioni, C.; Geisslinger, G.
Prostaglandin D2 produced by hematopoietic prostaglandin D synthase contributes to LPS-induced fever
J. Physiol. Pharmacol.
60(2)
145-150
2009
Rattus norvegicus
Miyamoto, Y.; Nishimura, S.; Inoue, K.; Shimamoto, S.; Yoshida, T.; Fukuhara, A.; Yamada, M.; Urade, Y.; Yagi, N.; Ohkubo, T.; Inui, T.
Structural analysis of lipocalin-type prostaglandin D synthase complexed with biliverdin by small-angle X-ray scattering and multi-dimensional NMR
J. Struct. Biol.
169
209-218
2010
Mus musculus (O09114)
Saleem, S.; Shah, Z.A.; Urade, Y.; Dore, S.
Lipocalin-prostaglandin D synthase is a critical beneficial factor in transient and permanent focal cerebral ischemia
Neuroscience
160
248-254
2009
Mus musculus
Liu, M.; Eguchi, N.; Yamasaki, Y.; Urade, Y.; Hattori, N.; Urabe, T.
Protective role of hematopoietic prostaglandin D synthase in transient focal cerebral ischemia in mice
Neuroscience
163
296-307
2009
Mus musculus
Takahashi, S.; Tsurumura, T.; Aritake, K.; Furubayashi, N.; Sato, M.; Yamanaka, M.; Hirota, E.; Sano, S.; Kobayashi, T.; Tanaka, T.; Inaka, K.; Tanaka, H.; Urade, Y.
High-quality crystals of human haematopoietic prostaglandin D synthase with novel inhibitors
Acta Crystallogr. Sect. F
66
846-850
2010
Homo sapiens
Hokari, R.; Kurihara, C.; Nagata, N.; Aritake, K.; Okada, Y.; Watanabe, C.; Komoto, S.; Nakamura, M.; Kawaguchi, A.; Nagao, S.; Urade, Y.; Miura, S.
Increased expression of lipocalin-type-prostaglandin D synthase in ulcerative colitis and exacerbating role in murine colitis
Am. J. Physiol. Gastrointest. Liver Physiol.
300
G401-G408
2011
Homo sapiens, Mus musculus
Chowdhury, A.A.; Hossain, M.S.; Rahman, M.S.; Nishimura, K.; Jisaka, M.; Nagaya, T.; Shono, F.; Yokota, K.
Sustained expression of lipocalin-type prostaglandin D synthase in the antisense direction positively regulates adipogenesis in cloned cultured preadipocytes
Biochem. Biophys. Res. Commun.
411
287-292
2011
Mus musculus
Kajiwara, D.; Aoyagi, H.; Shigeno, K.; Togawa, M.; Tanaka, K.; Inagaki, N.; Miyoshi, K.
Role of hematopoietic prostaglandin D synthase in biphasic nasal obstruction in guinea pig model of experimental allergic rhinitis
Eur. J. Pharmacol.
667
389-395
2011
Cavia porcellus
Zhou, Y.; Shaw, N.; Li, Y.; Zhao, Y.; Zhang, R.; Liu, Z.J.
Structure-function analysis of human l-prostaglandin D synthase bound with fatty acid molecules
FASEB J.
24
4668-4677
2010
Homo sapiens (P41222), Homo sapiens
Mathurin, K.; Gallant, M.A.; Germain, P.; Allard-Chamard, H.; Brisson, J.; Iorio-Morin, C.; de Brum Fernandes, A.; Caron, M.G.; Laporte, S.A.; Parent, J.L.
An interaction between L-prostaglandin D synthase and arrestin increases PGD2 production
J. Biol. Chem.
286
2696-2706
2011
Homo sapiens, Mus musculus
Christ, A.N.; Labzin, L.; Bourne, G.T.; Fukunishi, H.; Weber, J.E.; Sweet, M.J.; Smythe, M.L.; Flanagan, J.U.
Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D2 synthases
J. Med. Chem.
53
5536-5548
2010
Homo sapiens, Mus musculus
Fukuhara, A.; Yamada, M.; Fujimori, K.; Miyamoto, Y.; Kusumoto, T.; Nakajima, H.; Inui, T.
Lipocalin-type prostaglandin D synthase protects against oxidative stress-induced neuronal cell death
Biochem. J.
443
75-84
2012
Homo sapiens (P41222)
Kume, S.; Lee, Y.H.; Miyamoto, Y.; Fukada, H.; Goto, Y.; Inui, T.
Systematic interaction analysis of human lipocalin-type prostaglandin D synthase with small lipophilic ligands
Biochem. J.
446
279-289
2012
Homo sapiens (P41222), Homo sapiens
Kume, S.; Lee, Y.H.; Nakatsuji, M.; Teraoka, Y.; Yamaguchi, K.; Goto, Y.; Inui, T.
Fine-tuned broad binding capability of human lipocalin-type prostaglandin D synthase for various small lipophilic ligands
FEBS Lett.
588
962-969
2014
Homo sapiens (P41222), Homo sapiens
Lim, S.M.; Chen, D.; Teo, H.; Roos, A.; Jansson, A.E.; Nyman, T.; Tresaugues, L.; Pervushin, K.; Nordlund, P.
Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase
J. Lipid Res.
54
1630-1643
2013
Homo sapiens (P41222), Homo sapiens
Virtue, S.; Masoodi, M.; Velagapudi, V.; Tan, C.Y.; Dale, M.; Suorti, T.; Slawik, M.; Blount, M.; Burling, K.; Campbell, M.; Eguchi, N.; Medina-Gomez, G.; Sethi, J.K.; Ore?i?, M.; Urade, Y.; Griffin, J.L.; Vidal-Puig, A.
Lipocalin prostaglandin D synthase and PPARgamma2 coordinate to regulate carbohydrate and lipid metabolism in vivo
PLoS ONE
7
e39512
2012
Mus musculus, Mus musculus C57BL/6
Perduca, M.; Bovi, M.; Bertinelli, M.; Bertini, E.; Destefanis, L.; Carrizo, M.E.; Capaldi, S.; Monaco, H.L.
High-resolution structures of mutants of residues that affect access to the ligand-binding cavity of human lipocalin-type prostaglandin D synthase
Acta Crystallogr. Sect. D
70
2125-2138
2014
Homo sapiens (P41222), Homo sapiens
Davani, D.; Kumar, S.; Palaia, T.; Hall, C.; Ragolia, L.
Lipocalin-type prostaglandin D2 synthase reduces glucagon secretion in alpha TC-1 clone 6 cells via the DP1 receptor
Biochem. Biophys. Rep.
4
224-227
2015
Mus musculus (O09114)
Yamamoto, K.; Higashiura, A.; Suzuki, M.; Aritake, K.; Urade, Y.; Nakagawa, A.
Molecular structure of a prostaglandin D synthase requiring glutathione from the brown planthopper, Nilaparvata lugens
Biochem. Biophys. Res. Commun.
492
166-171
2017
Nilaparvata lugens (J9Q529), Nilaparvata lugens
Edfeldt, F.; Evenaes, J.; Lepistoe, M.; Ward, A.; Petersen, J.; Wissler, L.; Rohman, M.; Sivars, U.; Svensson, K.; Perry, M.; Feierberg, I.; Zhou, X.H.; Hansson, T.; Narjes, F.
Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS)
Bioorg. Med. Chem. Lett.
25
2496-2500
2015
Homo sapiens (O60760), Homo sapiens
Mazari, A.M.; Hegazy, U.M.; Mannervik, B.
Identification of new inhibitors for human hematopoietic prostaglandin D2 synthase among FDA-approved drugs and other compounds
Chem. Biol. Interact.
229
91-99
2015
Homo sapiens (O60760), Homo sapiens
Morell-Garcia, D.; Bauca, J.M.; Sastre, M.P.; Yanez, A.; Llompart, I.
Sample-dependent diagnostic accuracy of prostaglandin D synthase in cerebrospinal fluid leak
Clin. Biochem.
50
27-31
2017
Homo sapiens
Pires, A.; Santos, R.; Nogueira, A.; Abranches, R.
Production of human lipocalin-type prostaglandin D synthase in the model plant Medicago truncatula
In Vitro Cell. Dev. Biol. Plant
50
276-281
2014
Homo sapiens (P41222)
-
Virtue, S.; Masoodi, M.; de Weijer, B.A.; van Eijk, M.; Mok, C.Y.; Eiden, M.; Dale, M.; Pirraco, A.; Serlie, M.J.; Griffin, J.L.; Vidal-Puig, A.
Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans
Int. J. Obes.
39
1151-1160
2015
Homo sapiens (O60760), Homo sapiens, Mus musculus (Q9JHF7), Mus musculus
Omori, K.; Morikawa, T.; Kunita, A.; Nakamura, T.; Aritake, K.; Urade, Y.; Fukayama, M.; Murata, T.
Lipocalin-type prostaglandin D synthase-derived PGD2 attenuates malignant properties of tumor endothelial cells
J. Pathol.
244
84-96
2018
Mus musculus
Mizoguchi, M.; Nakatsuji, M.; Takano, J.; Ishibashi, O.; Wada, K.; Inui, T.
Development of pH-independent drug release formulation using lipocalin-type prostaglandin D synthase
J. Pharm. Sci.
105
2735-2742
2016
Homo sapiens (P41222)
Elmes, M.W.; Volpe, A.D.; d'Oelsnitz, S.; Sweeney, J.M.; Kaczocha, M.
Lipocalin-type prostaglandin D synthase is a novel phytocannabinoid-binding protein
Lipids
53
353-360
2018
Homo sapiens
Saxty, G.; Norton, D.; Affleck, K.; Clapham, D.; Cleasby, A.; Coyle, J.; Day, P.; Frederickson, M.; Hancock, A.; Hobbs, H.; Hutchinson, J.; Le, J.; Leveridge, M.; McMenamin, R.; Mortenson, P.; Page, L.; Richardson, C.; Russell, L.; Sherriff, E.; Teague, S
Identification of orally bioavailable small-molecule inhibitors of hematopoietic prostaglandin D2 synthase using X-ray fragment based drug discovery
MedChemComm
5
134-141
2014
Homo sapiens
-
Teraoka, Y.; Kume, S.; Lin, Y.; Atsuji, S.; Inui, T.
Comprehensive evaluation of the binding of lipocalin-type prostaglandin D synthase to poorly water-soluble drugs
Mol. Pharm.
14
3558-3567
2017
Homo sapiens (P41222)
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