Reference on EC 5.3.3.5 - cholestenol DELTA-isomerase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lee, W.H.; Kammereck, R.; Lutsky, B.N.; McCloskey, J.A.; Schroepfer, G.J.Jr.
Studies on the mechanism of the enzymatic conversion of DELTA8-cholesten-3beta-ol to DELTA7-cholesten-3beta-ol
J. Biol. Chem.
244
2033-2040
1969
Rattus norvegicus
Wilton, D.C.; Rahimtula, A.D.; Akhtar, M.
The reversibility of the DELTA8-cholestenol-DELTA7-cholestenol isomerase reaction in cholesterol biosynthesis
Biochem. J.
114
71-73
1969
Rattus norvegicus
Scala, A.; Galli-Kienle, M.; Anastasia, M.; Galli, G.
The reversibility of the isomerization of the DELTA8 to DELTA7 bond in cholesterol biosynthesis
Eur. J. Biochem.
48
263-269
1974
Rattus norvegicus
Bae, S.H.; Seong, J.; Paik, Y.K.
Cholesterol biosynthesis from lanosterol: molecular cloning, chromosomal localization, functional expression and liver-specific gene regulation of rat sterol DELTA8-isomerase, a cholesterogenic enzyme with multiple functions
Biochem. J.
353
689-699
2001
Rattus norvegicus (Q9JJ46)
Nes, W.D.; Zhou, W.; Dennis, A.L.; Li, H.; Jia, Z.; Keith, R.A.; Piser, T.M.; Furlong, S.T.
Purification, characterization and catalytic properties of human sterol 8-isomerase
Biochem. J.
367
587-599
2002
Homo sapiens (Q15125)
Moebius, F.F.; Soellner, K.E.M.; Fiechtner, B.; Huck, C.W.; Bonn, G.; Glossmann, H.
Histidine77, glutamic acid81, glutamic acid123, threonine126, asparagine194, and tryptophan197 of the human emopamil binding protein are required for in vivo sterol DELTA8-DELTA7 isomerization
Biochemistry
38
1119-1127
1999
Homo sapiens (Q15125), Homo sapiens
Cho, S.Y.; Kim, J.H.; Paik, Y.K.
Cholesterol biosynthesis from lanosterol: differential inhibition of sterol DELTA8-isomerase and other lanosterol-converting enzymes by tamoxifen
Mol. Cells
8
233-239
1998
Rattus norvegicus
Moebius, F.F.; Reiter, R.J.; Bermoser, K.; Glossmann, H.; Cho, S.Y.; Paik, Y.K.
Pharmacological analysis of sterol DELTA8-DELTA7-isomerase proteins with [3H]ifenprodil
Mol. Pharmacol.
54
591-598
1998
Saccharomyces cerevisiae, Mus musculus (P70245), Homo sapiens (Q15125), Homo sapiens, Cavia porcellus (Q60490)
Grebenok, R.J.; Ohnmeiss, T.E.; Yamamoto, A.; Huntley, E.D.; Galbraith, D.W.; Della Penna, D.
Isolation and characterization of an Arabidopsis thaliana C-8,7 sterol isomerase: functional and structural similarities to mammalian C-8,7 sterol isomerase/emopamil-binding protein
Plant Mol. Biol.
38
807-815
1998
Arabidopsis thaliana
Kedjouar, B.; de Medina, P.; Oulad-Abdelghani, M.; Payre, B.; Silvente-Poirot, S.; Favre, G.; Faye, J.C.; Poirot, M.
Molecular characterization of the microsomal tamoxifen binding site
J. Biol. Chem.
279
34048-34061
2004
Homo sapiens
Rahier, A.; Pierre, S.; Riveill, G.; Karst, F.
Identification of essential amino acid residues in a sterol 8,7-isomerase from Zea mays reveals functional homology and diversity with the isomerases of animal and fungal origin
Biochem. J.
414
247-259
2008
Saccharomyces cerevisiae, Zea mays
Berardi, F.; Abate, C.; Ferorelli, S.; de Robertis, A.F.; Leopoldo, M.; Colabufo, N.A.; Niso, M.; Perrone, R.
Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as DELTA8-DELTA7 sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity
J. Med. Chem.
51
7523-7531
2008
Homo sapiens
Abate, C.; Niso, M.; Contino, M.; Colabufo, N.A.; Ferorelli, S.; Perrone, R.; Berardi, F.
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed sigma and human DELTA8-DELTA7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity
ChemMedChem
6
73-80
2011
Homo sapiens
Krojer, M.; Mueller, C.; Bracher, F.
Steroidomimetic aminomethyl spiroacetals as novel inhibitors of the enzyme DELTA8,7-sterol isomerase in cholesterol biosynthesis
Arch. Pharm.
347
108-122
2014
Homo sapiens
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