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Information on EC 5.3.3.5 - cholestenol DELTA-isomerase and Organism(s) Mus musculus and UniProt Accession P70245

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EC Tree
     5 Isomerases
         5.3 Intramolecular oxidoreductases
             5.3.3 Transposing C=C bonds
                5.3.3.5 cholestenol DELTA-isomerase
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This record set is specific for:
Mus musculus
UNIPROT: P70245 not found.
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The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
emopamil binding protein, emopamil-binding protein, delta8-delta7 sterol isomerase, c-8,7 sterol isomerase, erg2p, delta8-delta7 isomerase, d8d7i, 8,7si, cholestenol delta-isomerase, d8-d7 sterol isomerase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
DELTA8-DELTA7 isomerase
-
Cholestenol delta-isomerase
-
-
-
-
D8-D7 sterol isomerase
-
-
-
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DELTA8-Cholestenol-DELTA7-cholestenol isomerase
-
-
-
-
Delta8-delta7 sterol isomerase
-
-
-
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Emopamil binding protein
-
-
-
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Isomerase, cholestenol DELTA-
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
isomerization
-
-
-
-
intramolecular oxidoreduction
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
DELTA7-Cholestenol DELTA7-DELTA8-isomerase
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CAS REGISTRY NUMBER
COMMENTARY hide
37318-47-1
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(+)-emopamil
-
(+)-verapamil
-
(-)-emopamil
-
(-)-verapamil
-
amiodarone
-
CuCl2
IC50: 0.0011 mM, ifenprodil-labled enzyme
ditolylguanidine
-
haloperidol
-
opipramol
-
Trifluoperazine
-
verapamil
-
ZnCl2
IC50: 0.001 mM, ifenprodil-labeled enzyme
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000077
(+)-emopamil
-
0.00363
(+)-verapamil
-
0.000023
(-)-emopamil
-
0.00152
(-)-verapamil
-
0.00006
amiodarone
-
0.0043
ditolylguanidine
-
0.000435
haloperidol
-
0.000047
opipramol
-
0.0000077
Trifluoperazine
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0011
CuCl2
Mus musculus
IC50: 0.0011 mM, ifenprodil-labled enzyme
0.001
ZnCl2
Mus musculus
IC50: 0.001 mM, ifenprodil-labeled enzyme
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
Uniprot
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
EBP_MOUSE
230
5
26215
Swiss-Prot
other Location (Reliability: 5)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Moebius, F.F.; Reiter, R.J.; Bermoser, K.; Glossmann, H.; Cho, S.Y.; Paik, Y.K.
Pharmacological analysis of sterol DELTA8-DELTA7-isomerase proteins with [3H]ifenprodil
Mol. Pharmacol.
54
591-598
1998
Cavia porcellus (Q60490), Homo sapiens (Q15125), Homo sapiens, Mus musculus (P70245), Saccharomyces cerevisiae
Manually annotated by BRENDA team