Information on EC 5.3.3.3 - vinylacetyl-CoA DELTA-isomerase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
5.3.3.3
-
RECOMMENDED NAME
GeneOntology No.
vinylacetyl-CoA DELTA-isomerase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
vinylacetyl-CoA = (E)-but-2-enoyl-CoA
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
intramolecular oxidoreduction
-
-
-
-
isomerization
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Butanoate metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
vinylacetyl-CoA Delta3-Delta2-isomerase
Also acts on 3-methyl-vinylacetyl-CoA.
CAS REGISTRY NUMBER
COMMENTARY hide
9023-73-8
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
i.e. Cavia porcellus, component of the beta-oxidation enzyme complex
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-butenoyl N-acetylcysteamine
?
show the reaction diagram
-
-
-
-
-
3-Hexenoyl-CoA
?
show the reaction diagram
-
-
-
-
-
Beta-Methylvinylacetyl-CoA
Beta-Methylvinylacetyl-CoA
show the reaction diagram
-
ir
-
-
cis-3-octenoyl-CoA
?
show the reaction diagram
vinylacetyl N-acetylcysteamine
?
show the reaction diagram
-
-
-
-
-
Vinylacetyl pantetheine
?
show the reaction diagram
-
-
-
-
-
additional information
?
-
-
not 4-pentenoyl-CoA, beta-methylvinylacetate, beta-vinylacetyl ethyl ester, 5-androstan-3,17-dione, 5-cholestenone, 5-pregnene-3,20-dione
-
-
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
no cofactor
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-butynoyl N-acetylcysteamine
-
-
beta-methylcrotonyl-CoA
-
-
N-ethylmaleimide
-
-
p-chloromercuribenzoate
-
-
additional information
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.05
vinylacetyl-CoA
-
beta-methylvinylacetyl-CoA
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2.6
-
strain K-12YMel, substrate cis-3-octenoyl-CoA
7.5
-
strain fad B64, substrate cis-3-octenoyl-CoA
9.8
-
substrate cis-3-octenoyl-CoA
32
-
substrate beta-vinylacetyl-CoA
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8 - 9
-
-
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
232000
bifunctional enzyme possessing 4-hydroxybutyryl-CoA dehydratase and vinylacetyl DELTA-isomerase activity, gel filtration
237000
-
bifunctional enzyme possessing 4-hydroxybutyryl-CoA dehydratase and vinylacetyl DELTA-isomerase activity, gel filtration
240000
-
fatty acid oxidation complex consisting of EC 4.2.1.17, EC 1.1.1.35, EC 2.3.1.16, EC 5.1.2.3, EC 5.3.3.3, gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oligomer
-
fatty acid oxidation complex consisting of EC 4.2.1.17, EC 1.1.1.35, EC 2.3.1.16, EC 5.1.2.3, EC 5.3.3.3, SDS-PAGE
tetramer
OXIDATION STABILITY
ORGANISM
UNIPROT
LITERATURE
oxygen irreversibly inactivates
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
frozen or at 5°C, stable for months
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
bifunctional enzyme possessing 4-hydroxybutyryl-CoA dehydratase and vinylacetyl DELTA-isomerase activity
fatty acid oxidation complex consisting of EC 4.2.1.17, EC 1.1.1.35, EC 2.3.1.16, EC 5.1.2.3, EC 5.3.3.3
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