Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 5.3.3.12 - L-dopachrome isomerase and Organism(s) Rattus norvegicus and UniProt Accession P80254

for references in articles please use BRENDA:EC5.3.3.12
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     5 Isomerases
         5.3 Intramolecular oxidoreductases
             5.3.3 Transposing C=C bonds
                5.3.3.12 L-dopachrome isomerase
IUBMB Comments
A zinc enzyme. Stereospecific for L-dopachrome. Dopachrome methyl ester is a substrate, but dopaminochrome (2,3-dihydroindole-5,6-quinone) is not (see also EC 4.1.1.84, D-dopachrome decarboxylase).
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Rattus norvegicus
UNIPROT: P80254
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
trp-2, dopachrome tautomerase, d-dopachrome tautomerase, macrophage inhibitory factor, macrophage migration-inhibitory factor, dopachrome conversion factor, dopachrome oxidoreductase, tyrosine-related protein 2, dopachrome-rearranging enzyme, brown (b) locus protein, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D-dopachrome tautomerase
-
brown (b) locus protein
-
-
-
-
DCF
-
-
-
-
DCT
-
-
-
-
dopachrome conversion factor
-
-
-
-
dopachrome delta-isomerase
-
-
-
-
dopachrome DELTA7-DELTA2-isomerase
-
-
-
-
dopachrome oxidoreductase
-
-
-
-
dopachrome tautomerase
-
-
-
-
dopachrome-rearranging enzyme
-
-
-
-
isomerase, dopachrome DELTA-
-
-
-
-
L-dopachchrome-methyl ester tautomerase
-
-
-
-
SLATY locus protein
-
-
-
-
TRP2
-
-
-
-
tyrosine-related protein 2
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
intramolecular oxidoreduction
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
L-dopachrome keto-enol isomerase
A zinc enzyme. Stereospecific for L-dopachrome. Dopachrome methyl ester is a substrate, but dopaminochrome (2,3-dihydroindole-5,6-quinone) is not (see also EC 4.1.1.84, D-dopachrome decarboxylase).
CAS REGISTRY NUMBER
COMMENTARY hide
130122-81-5
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
male Wistar rats
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
increase in D-dopachrome tautomerase is a response to liver damage, accelerates melanin biosynthesis and protects the liver from oxidative stress induced by CCl4, overview
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DOPD_RAT
118
0
13133
Swiss-Prot
Chloroplast (Reliability: 1)
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
carbon tetrachloride treatment of livers lead to a 12fold increased expression level of dopachrome tautomerase in male rats, proteomic analysis, overview. The increase in DDT is a response to liver damage, accelerates melanin biosynthesis and protects the liver from oxidative stress induced by CCl4
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hiyoshi, M.; Konishi, H.; Uemura, H.; Matsuzaki, H.; Tsukamoto, H.; Sugimoto, R.; Takeda, H.; Dakeshita, S.; Kitayama, A.; Takami, H.; Sawachika, F.; Kido, H.; Arisawa, K.
D-Dopachrome tautomerase is a candidate for key proteins to protect the rat liver damaged by carbon tetrachloride
Toxicology
255
6-14
2009
Rattus norvegicus (P80254)
Manually annotated by BRENDA team