Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 5.3.1.8 - mannose-6-phosphate isomerase and Organism(s) Pyrobaculum aerophilum and UniProt Accession Q8ZWV0

for references in articles please use BRENDA:EC5.3.1.8
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
A zinc protein.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Pyrobaculum aerophilum
UNIPROT: Q8ZWV0
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Pyrobaculum aerophilum
The enzyme appears in selected viruses and cellular organisms
Synonyms
phosphomannose isomerase, mannose phosphate isomerase, mannose-6-phosphate isomerase, phosphohexoisomerase, phosphomannoisomerase, phosphomannose-isomerase, phosphohexomutase, gtmpi, type i phosphomannose isomerase, type i pmi, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D-mannose-6-phosphate ketol-isomerase
-
-
-
-
Isomerase, mannose phosphate
-
-
-
-
Mannose phosphate isomerase
-
-
-
-
Phosphohexoisomerase
-
-
-
-
Phosphohexomutase
-
-
-
-
Phosphomannoisomerase
-
-
-
-
Phosphomannose isomerase
-
-
-
-
Phosphphexomutase
-
-
-
-
PMI
-
-
-
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-Mannose 6-phosphate = D-fructose 6-phosphate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
isomerization
-
-
-
-
intramolecular oxidoreduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
D-mannose-6-phosphate aldose-ketose-isomerase
A zinc protein.
CAS REGISTRY NUMBER
COMMENTARY hide
9023-88-5
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-fructose 6-phosphate
D-mannose 6-phosphate
show the reaction diagram
-
-
-
-
r
D-Mannose 6-phosphate
D-Fructose 6-phosphate
show the reaction diagram
-
-
-
-
r
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5-phosphoarabinonate
-
6-phosphogluconate
-
-
erythrose 4-phosphate
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.06 - 0.3
D-fructose 6-phosphate
0.06
D-mannose 6-phosphate
-
pH 7.4, 80°C
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.11
6-phosphogluconate
-
pH 7.4, 50°C
0.0014
erythrose-4-phosphate
-
pH 7.4, 50°C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.3 - 8.8
-
more than 50% of maximum activity in this range
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
33548
-
2 * 36000, SDS-PAGE, 2 * 33548, calculated
36000
-
2 * 36000, SDS-PAGE, 2 * 33548, calculated
65000
-
sedimentation equilibrium, analytical ultracentrifugation
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
-
2 * 36000, SDS-PAGE, 2 * 33548, calculated
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
both in complex with fructose 6-phosphate and with glucose 6-phosphate
both native form and in complex with 5-phosphoarabinonate
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100
-
melting temperature for thermal unfolding, 60 min, 50% residual activity
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Swan, M.K.; Hansen, T.; Schonheit, P.; Davies, C.
Crystallization and preliminary X-ray diffraction analysis of phosphoglucose/phosphomannose isomerase from Pyrobaculum aerophilum
Acta Crystallogr. Sect. D
60
1481-1483
2004
Pyrobaculum aerophilum
Manually annotated by BRENDA team
Swan, M.K.; Hansen, T.; Schonheit, P.; Davies, C.
Structural basis for phosphomannose isomerase activity in phosphoglucose isomerase from Pyrobaculum aerophilum: a subtle difference between distantly related enzymes
Biochemistry
43
14088-14095
2004
Pyrobaculum aerophilum (Q8ZWV0), Pyrobaculum aerophilum
Manually annotated by BRENDA team
Hansen, T.; Urbanke, C.; Schonheit, P.
Bifunctional phosphoglucose/phosphomannose isomerase from the hyperthermophilic archaeon Pyrobaculum aerophilum
Extremophiles
8
507-512
2004
Pyrobaculum aerophilum
Manually annotated by BRENDA team
Swan, M.K.; Hansen, T.; Schonheit, P.; Davies, C.
A novel phosphoglucose isomerase (PGI)/phosphomannose isomerase from the crenarchaeon Pyrobaculum aerophilum is a member of the PGI superfamily: structural evidence at 1.16-A resolution
J. Biol. Chem.
279
39838-39845
2004
Pyrobaculum aerophilum (Q8ZWV0)
Manually annotated by BRENDA team