Information on EC 5.3.1.22 - Hydroxypyruvate isomerase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
5.3.1.22
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RECOMMENDED NAME
GeneOntology No.
Hydroxypyruvate isomerase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Hydroxypyruvate = 2-hydroxy-3-oxopropanoate
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
intramolecular oxidoreduction
-
-
-
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isomerization
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-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Glyoxylate and dicarboxylate metabolism
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
hydroxypyruvate aldose-ketose-isomerase
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CAS REGISTRY NUMBER
COMMENTARY hide
74812-48-9
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain DSM 83
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Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Hydroxypyruvate
2-Hydroxy-3-oxopropanoate
show the reaction diagram
-
r
r
-
tartronic semialdehyde
hydroxypyruvate
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
tartronic semialdehyde
hydroxypyruvate
show the reaction diagram
-
-
-
-
?
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Cu2+
-
0.1 mM, 57% inhibition
Fe2+
-
0.1 mM, 18% inhibition
hydroxylamine
-
20 mM, 60% inhibition
iodoacetate
-
0.7 mM, 100% inhibition
NaCN
-
2.5 mM, 21% inhibition
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
10
Hydroxypyruvate
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-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.6 - 7.4
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-
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.4 - 8.5
-
50% of maximal activity at pH 5.4 and 8.5
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
PDB
SCOP
CATH
ORGANISM
UNIPROT
Brucella abortus (strain 2308)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
45000
-
6 * 45000, SDS-PAGE
265000
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gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexamer
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6 * 45000, SDS-PAGE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
67
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10 min stable
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
loss of activity by vacuum dialysis at 4°C or by freezing
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, stable for 1 month
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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