Information on EC 5.3.1.17 - 5-dehydro-4-deoxy-D-glucuronate isomerase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
5.3.1.17
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RECOMMENDED NAME
GeneOntology No.
5-dehydro-4-deoxy-D-glucuronate isomerase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
intramolecular oxidoreduction
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isomerization
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
4-deoxy-L-threo-hex-4-enopyranuronate degradation
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Pentose and glucuronate interconversions
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SYSTEMATIC NAME
IUBMB Comments
5-dehydro-4-deoxy-D-glucuronate aldose-ketose-isomerase
The enzyme is involved in the degradation of polygalacturonate, a later stage in the degradation of pectin by many microorganisms.
CAS REGISTRY NUMBER
COMMENTARY hide
37318-44-8
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
ATCC 14968
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
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the KduI enzyme facilitates the conversion of galacturonate and glucuronate and facilitates the growth of Escherichia coli on galacturonate and glucuronate in the presence of osmotically active sucrose
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-Deoxy-L-threo-hexosulose uronate
3-Deoxy-D-glycero-2,5-hexodiulosonate
show the reaction diagram
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5-dehydro-4-deoxy-D-glucuronate
(4S)-4,6-dihydroxy-2,5-dioxohexanoate
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
5-dehydro-4-deoxy-D-glucuronate
(4S)-4,6-dihydroxy-2,5-dioxohexanoate
show the reaction diagram
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7 - 7.5
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PDB
SCOP
CATH
ORGANISM
UNIPROT
Enterococcus faecalis (strain ATCC 700802 / V583)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
165000
hexamer, dynamic light scattering measurements
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
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x * 31000, SDS-PAGE
hexamer
6 * 31000, crystal structure, SDS-PAGE
Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
0-3°C, stable for 1 month
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Ni-CAM chelating resin chromatography
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21 cells
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expressed in Escherichia coli JM109 or KRX cells
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expression in Escherichia coli, strain B348
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
50 mM glucuronate induces kduI gene expression 7-11fold under aerobic conditions and 19-54fold under anaerobic conditions
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