Reference on EC 5.3.1.1 - triose-phosphate isomerase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rozacky, E.E.; Sawyer, T.H.; Barton, R.A.; Gracy, R.W.
Studies on human triosephosphate isomerase. I. Isolation and properties of the enzyme from erythrocytes
Arch. Biochem. Biophys.
146
312-320
1971
Homo sapiens
Fahey, R.C.; Kolb, E.; Harris, J.I.
Triose phosphate isomerase from Bacillus stearothermophilus
Biochem. J.
124
77P
1971
Geobacillus stearothermophilus
Snyder, R.; Lee, E.W.
Triosephosphate isomerase from human and horse liver
Methods Enzymol.
41B
430-434
1975
Equus caballus, Homo sapiens
Krietsch, W.K.G.
Triosephosphate isomerase from yeast
Methods Enzymol.
41B
434-438
1975
Saccharomyces cerevisiae
-
Krietsch, W.K.G.
Triosephosphate isomerase from rabbit liver
Methods Enzymol.
41B
438-442
1975
Oryctolagus cuniculus
-
Gracy, R.W.
Triosephosphate isomerase from human erythrocytes
Methods Enzymol.
41B
442-447
1975
Homo sapiens
Hartman, F.C.; Norton, I.L.
Triosephosphate isomerase from rabbit muscle
Methods Enzymol.
41B
447-453
1975
Oryctolagus cuniculus
Yuan, P.M.; Dewan, R.N.; Zaun, M.; Thompson, R.E.; Gracy, R.W.
Isolation and characterization of triosephosphate isomerase isozymes from human placenta
Arch. Biochem. Biophys.
198
42-52
1979
Homo sapiens
Tomlinson, J.D.; Turner, J.F.
Pea seed triose phosphate isomerase
Phytochemistry
18
1959-1962
1979
Pisum sativum
-
Artavanis-Tsakonas, S.; Harris, J.I.
Primary structure of triosephosphate isomerase from Bacillus stearothermophilus
Eur. J. Biochem.
108
599-611
1980
Geobacillus stearothermophilus
Eber, S.W.; Krietsch, W.K.G.
The isolation and characterization of the multiple forms of human skeletal muscle triosephosphate isomerase
Biochim. Biophys. Acta
614
173-184
1980
Homo sapiens
Esnouf, M.P.; Harris, R.P.; McVittie, J.D.
Triosephosphate isomerase from chicken and rabbit muscle
Methods Enzymol.
89
579-583
1982
Gallus gallus, Oryctolagus cuniculus
Pichersky, E.; Gottlieb, L.D.
Plant triose phosphate isomerase isozymes. Purification, immunological and structural characterization, and partial amino acid sequence
Plant Physiol.
74
340-347
1984
Apium graveolens, Lactuca sativa, Spinacia oleracea
Kurzok, H.G.; Feierabend, J.
Comparison of a cytosolic and a chloroplast triosephosphate isomerase isoenzyme from rye leaves. I. Purification and catalytic properties
Biochim. Biophys. Acta
788
214-221
1984
Secale cereale
-
Kurzok, H.G.; Feierabend, J.
Comparison of a cytosolic and a chloroplast triosephosphate isomerase isoenzyme from rye leaves. II. Molecular properties and phylogenetic relationship
Biochim. Biophys. Acta
788
222-233
1984
Secale cereale
-
Misset, O.; Opperdoes, F.R.
Simultaneous purification of hexokinase, class-I fructose-bisphosphate aldolase, triosephosphate isomerase and phosphoglycerate kinase from Trypanosoma brucei
Eur. J. Biochem.
144
475-483
1984
Trypanosoma brucei
Lambeir, A.M.; Opperdoes, F.R.; Wierenga, R.K.
Kinetic properties of triose-phosphate isomerase from Trypanosoma brucei brucei
Eur. J. Biochem.
168
69-74
1987
Trypanosoma brucei
Blacklow, S.C.; Raines, R.T.; Lim, W.A.; Zamore, Ph.D.; Knowles, J.R.
Triosephosphate isomerase catalysis is diffusion controlled
Biochemistry
27
1158-1167
1988
Gallus gallus
Nickbarg, E.B.; Knowles, J.R.
Triosephosphate isomerase: energetics of the reaction catalyzed by the yeast enzyme expressed in Escherichia coli
Biochemistry
27
5939-5947
1988
Saccharomyces cerevisiae
Kessler, H.; Matter, H.; Geyer, A.; Diehl, H.J.; Kck, M.; Kurz, G.; Opperdoes, F.R.; Callens, M.; Wierenga, R.K.
Selektive Inhibierung der trypanosomalen Triosephosphat-Isomerase durch ein Thiopeptid
Angew. Chem.
104
343-345
1992
Canis lupus familiaris, Oryctolagus cuniculus, Escherichia coli, Trypanosoma sp.
-
Zhou, Y.H.
Cloning and characterization of the nuclear gene and cDNAs for triosephosphate isomerase of the marine red alga Gracilaria verrucosa
Curr. Genet.
28
317-323
1995
Gracilaria gracilis
Gomez-Puyou, A.; Saavedra-Lira, E.; Becker, I.; Zubillaga, R.A.; Rojo-Dominguez, A.; Perez-Montfort, R.
Using evolutionary changes to achieve species-specific inhibition of enzyme action - studies with triosephosphate isomerase
Curr. Biol.
2
847-855
1995
Trypanosoma brucei
Henze, K.; Scharrenberger, C.; Kellermann, J.; Martin, W.
Chloroplast and cytosolic triosephosphate isomerases from spinach: purification, microsequencing and cDNA cloning of the chloroplast enzyme
Plant Mol. Biol.
26
1961-1973
1994
Spinacia oleracea, Trypanosoma brucei
Noble, M.E.M.; Zeelen, J.P.; Wierenga, R.K.
Structures of the "open" and "closed" state of trypanosomal triosephosphate isomerase, as observed in a new crystal form: implications for the reaction mechanism
Proteins Struct. Funct. Genet.
16
311-326
1993
Trypanosoma brucei, Trypanosoma sp.
Borchert, T.V.; Pratt, K.; Zeelen, J.P.; Callens, M.; Noble, M.E.M.; Opperdoes, F.R.; Michels, P.A.M.; Wierenga, R.K.
Overexpression of trypanosomal triosephosphate isomerase in Escherichia coli and characterisation of a dimer-interface mutant
Eur. J. Biochem.
211
703-710
1993
Trypanosoma brucei
Kuntz, D.A.; Osowski, R.; Schudok, M.; Wierenga, R.K.; Muller, K.; Kessler, H.; Opperdoes, F.R.
Inhibition of triosephosphate isomerase from Trypanosoma brucei wirth cyclic hexapeptides
Eur. J. Biochem.
207
441-447
1992
Canis lupus familiaris, Oryctolagus cuniculus, Escherichia coli, Trypanosoma brucei
Landa, A.; Rojo-Dominguez, A.; Jimenez, L.; Fernandez-Velasco, D.A.
Sequencing, expression and properties of triosephosphate isomerase from Entamoeba histolytica
Eur. J. Biochem.
247
348-355
1997
Entamoeba histolytica, Trypanosoma brucei
Carza-Ramos, G.; Perez-Montfort, R.; Rojo-Dominguez, A.; de Gomez-Puyou, M.T.; Gomez-Puyou, A.
Species-specific inhibition of homologous enzymes by modification of nonconserved amino acids residues. The cysteine residues of triosephosphate isomerase
Eur. J. Biochem.
241
114-120
1996
Saccharomyces cerevisiae, Gallus gallus, Oryctolagus cuniculus, Escherichia coli, Schizosaccharomyces pombe
Kohl, L.; Callens, M.; Wierenga, R.K.; Opperdoes, F.R.; Michels, P.A.M.
Triose-phosphate isomerase of Leishmania mexicana mexicana. Cloning and characterization of the gene, overexpression in Escherichia coli and analysis of the protein
Eur. J. Biochem.
220
331-338
1994
Leishmania mexicana
Alvarez, M.; Zeelen, J.P.; Mainfroid, V.; Rentier-Delrue, F.; Martial, J.A.; Wyns, L.; Wierenga, R.K.; Maes, D.
Triose-phosphate isomerase (TIM) of the psychrophilic bacterium Vibrio marinus
J. Biol. Chem.
273
2199-2206
1998
Escherichia coli, Moritella marina
Ostoa-Saloma, P.; Garza-Ramos, G.; Ramirez, J.; Becker, I.; Berzunza, M.; Landa, A.; Gomez-Puyou, A.; Tuena de Gomez-Puyou, M.; Perez-Montfort, R.
Cloning, expression, purification and characterization of triosephosphate isomerase from Trypanosoma cruzi
Eur. J. Biochem.
244
700-705
1997
Leishmania mexicana, Trypanosoma brucei, Trypanosoma cruzi
Borchert, T.V.; Abagyan, R.; Jaenicke, R.; Wierenga, R.K.
Design, creation, and characterization of a stable, monomeric triosephosphate isomerase
Proc. Natl. Acad. Sci. USA
91
1515-1518
1994
Trypanosoma brucei
Velanker, S.S.; Ray, S.S.; Gokhale, R.S.; Balaram, H.; Balaram, P.; Murthy, M.R.
Triosephosphate isomerase from Plasmodium falciparum: the crystal structure provides insights into antimalarial drug design
Structure
5
751-761
1997
Plasmodium falciparum
Delboni, L.F.; Mande, S.C.; Rentier-Delrue, F.; Mainfroid, V.; Turley, S.; Vellieux, F.M.; Martial, J.A.; Hol, W.G.
Crystal structure of recombinant triosephosphate isomerase from Bacillus stearotherophilus. An analysis of potential thermostability factors in six isomerases with known three-dimensional structures points to the importance of hydrophobic interactions
Protein Sci.
4
2594-2604
1995
Geobacillus stearothermophilus
Mande, S.C.; Mainfroid, V.; Kalk, K.H.; Goraj, K.; Martial, J.A.; Hol, W.G.
Crystal structure of recombinant human triosephosphate isomerase at 2.8 A resolution. Triosephosphate isomerase-related human genetic disorders and comparison with the trypanosomal enzyme
Protein Sci.
3
810-821
1994
Homo sapiens
Kishan, K.V.; Zeelen, J.P.; Noble, M.E.; Borchert, T.V.; Wierenga, R.K.
Comparison of the structures and the crystal contacts of trypanosomal triosephosphate isomerase in four different crystal forms
Protein Sci.
3
779-787
1994
Trypanosoma sp.
Zhang, Z.; Sugio, S.; Komives, E.A.; Liu, K.D.; Knowles, J.R.; Petsko, G.A.; Ringe, D.
Crystal structure of recombinant chicken triosephosphate isomerase-phosphoglycolohydroxamate complex at 1.8-A resolution
Biochemistry
33
2830-2837
1994
Gallus gallus
Thanki, N.; Zeelen, J.P.; Mathieu, M.; Jaenicke, R.; Abagyan, R.A.; Wierenga, R.K.; Schliebs, W.
Protein Engineering with monomeric triosephosphate isomerase (monoTIM): the modelling and structure verification of a seven-residue loop
Protein Eng.
10
159-167
1997
Trypanosoma sp.
Hooker, C.W.; Brindley, P.J.
Cloning and characterization of strain-specific transcripts encoding triosephosphate isomerase, a candidate vaccine antigen from Schistosoma japonicum
Mol. Biochem. Parasitol.
82
265-269
1996
Schistosoma japonicum
Bell, G.S.; Russell, R.J.; Kohlhoff, M.; Hensel, R.; Danson, M.J.; Hough, D.W.; Taylor, G.L.
Preliminary crystallographic studies of triosephosphate isomerase (TIM) from the hyperthermophilic archaeon Pyrococcus woesei
Acta Crystallogr. Sect. D
54
1419-1421
1998
Pyrococcus woesei
Aparicio, R.; Ferreira, S.T.; Leite, N.R.; Polikarpov, I.
Preliminary X-ray diffraction studies of rabbit muscle triose phosphate isomerase (TIM)
Acta Crystallogr. Sect. D
56
1492-1494
2000
Oryctolagus cuniculus
-
Parthasarathy, S.; Balaram, H.; Balaram, P.; Murthy, M.R.
Structures of Plasmodium falciparum triosephosphate isomerase complexed to substrate analogues: observation of the catalytic loop in the open conformation in the ligand-bound state
Acta Crystallogr. Sect. D
58
1992-2000
2002
Plasmodium falciparum (Q07412), Plasmodium falciparum
Najera, H.; Costas, M.; Fernandez-Velasco, D.A.
Thermodynamic characterization of yeast triosephosphate isomerase refolding: insights into the interplay between function and stability as reasons for the oligomeric nature of the enzyme
Biochem. J.
370
785-792
2003
Saccharomyces cerevisiae
Gokhale, R.S.; Ray, S.S.; Balaram, H.; Balaram, P.
Unfolding of Plasmodium falciparum triosephosphate isomerase in urea and guanidinium chloride: evidence for a novel disulfide exchange reaction in a covalently cross-linked mutant
Biochemistry
38
423-431
1999
Plasmodium falciparum
Benitez-Cardoza, C.G.; Rojo-Dominguez, A.; Hernandez-Arana, A.
Temperature-induced denaturation and renaturation of triosephosphate isomerase from Saccharomyces cerevisiae: evidence of dimerization coupled to refolding of the thermally unfolded protein
Biochemistry
40
9049-9058
2001
Saccharomyces cerevisiae (P00942), Saccharomyces cerevisiae
Hernandez-Alcantara, G.; Garza-Ramos, G.; Hernandez, G.M.; Gomez-Puyou, A.; Perez-Montfort, R.
Catalysis and stability of triosephosphate isomerase from Trypanosoma brucei with different residues at position 14 of the dimer interface. Characterization of a catalytically competent monomeric enzyme
Biochemistry
41
4230-4238
2002
Trypanosoma brucei
Moreau, V.H.; Rietveld, A.W.; Ferreira, S.T.
Persistent conformational heterogeneity of triosephosphate isomerase: separation and characterization of conformational isomers in solution
Biochemistry
42
14831-14837
2003
Oryctolagus cuniculus
Kursula, I.; Partanen, S.; Lambeir, A.M.; Antonov, D.M.; Augustyns, K.; Wierenga, R.K.
Structural determinants for ligand binding and catalysis of triosephosphate isomerase
Eur. J. Biochem.
268
5189-5196
2001
Leishmania mexicana (P48499)
Singh, S.K.; Maithal, K.; Balaram, H.; Balaram, P.
Synthetic peptides as inactivators of multimeric enzymes: inhibition of Plasmodium falciparum triosephosphate isomerase by interface peptides
FEBS Lett.
501
19-23
2001
Plasmodium falciparum (Q07412), Plasmodium falciparum
Kursula, I.; Partanen, S.; Lambeir, A.M.; Wierenga, R.K.
The importance of the conserved Arg191-Asp227 salt bridge of triosephosphate isomerase for folding, stability, and catalysis
FEBS Lett.
518
39-42
2002
Trypanosoma brucei (P04789)
Alvarez, M.; Wouters, J.; Maes, D.; Mainfroid, V.; Rentier-Delrue, F.; Wyns, L.; Depiereux, E.; Martial, J.A.
Lys13 plays a crucial role in the functional adaptation of the thermophilic triose-phosphate isomerase from Bacillus stearothermophilus to high temperatures
J. Biol. Chem.
274
19181-19187
1999
Geobacillus stearothermophilus, Thermotoga maritima
Kursula, I.; Wierenga, R.K.
Crystal structure of triosephosphate isomerase complexed with 2-phosphoglycolate at 0.83-A resolution
J. Biol. Chem.
278
9544-9551
2003
Leishmania mexicana
Rodriguez-Romero, A.; Hernandez-Santoyo, A.; del Pozo Yauner, L.; Kornhauser, A.; Fernandez-Velasco, D.A.
Structure and inactivation of triosephosphate isomerase from Entamoeba histolytica
J. Mol. Biol.
322
669-675
2002
Entamoeba histolytica
Aparicio, R.; Ferreira, S.T.; Polikarpov, I.
Closed conformation of the active site loop of rabbit muscle triosephosphate isomerase in the absence of substrate: evidence of conformational heterogeneity
J. Mol. Biol.
334
1023-1041
2003
Oryctolagus cuniculus (P00939), Oryctolagus cuniculus
Gao, X.G.; Maldonado, E.; Perez-Montfort, R.; Garza-Ramos, G.; de Gomez-Puyou, M.T.; Gomez-Puyou, A.; Rodriguez-Romero, A.
Crystal structure of triosephosphate isomerase from Trypanosoma cruzi in hexane
Proc. Natl. Acad. Sci. USA
96
10062-10067
1999
Trypanosoma cruzi (P52270), Trypanosoma cruzi
Sun, W.; Liu, S.; Brindley, P.J.; McManus, D.P.
Bacterial expression and characterization of functional recombinant triosephosphate isomerase from Schistosoma japonicum
Protein Expr. Purif.
17
410-413
1999
Schistosoma japonicum
Maes, D.; Zeelen, J.P.; Thanki, N.; Beaucamp, N.; Alvarez, M.; Thi, M.H.; Backmann, J.; Martial, J.A.; Wyns, L.; Jaenicke, R.; Wierenga, R.K.
The crystal structure of triosephosphate isomerase (TIM) from Thermotoga maritima: a comparative thermostability structural analysis of ten different TIM structures
Proteins Struct. Funct. Genet.
37
441-453
1999
Thermotoga maritima (P36204), Thermotoga maritima
Kinoshita, T.; Maruki, R.; Warizaya, M.; Nakajima, H.; Nishimura, S.
Structure of a high-resolution crystal form of human triosephosphate isomerase: Improvement of crystals using the gel-tube method
Acta Crystallogr. Sect. F
F61
346-349
2005
Homo sapiens
Mukherjee, S.; Sharma, S.; Kumar, S.; Guptasarma, P.
Slow irreversible unfolding of Pyrococcus furiosus triosephosphate isomerase: Separation and quantitation of conformers through a novel electrophoretic approach
Anal. Biochem.
347
49-59
2005
Pyrococcus furiosus
Xiang, J.; Jung, J.Y.; Sampson, N.S.
Entropy effects on protein hinges: the reaction catalyzed by triosephosphate isomerase
Biochemistry
43
11436-11445
2004
Gallus gallus
Gonzalez-Mondragon, E.; Zubillaga, R.A.; Saavedra, E.; Chanez-Cardenas, M.E.; Perez-Montfort, R.; Hernandez-Arana, A.
Conserved cysteine 126 in triosephosphate isomerase is required not for enzymatic activity but for proper folding and stability
Biochemistry
43
3255-3263
2004
Saccharomyces cerevisiae
Chanez-Cardenas, M.E.; Perez-Hernandez, G.; Sanchez-Rebollar, B.G.; Costas, M.; Vazquez-Contreras, E.
Reversible equilibrium unfolding of triosephosphate isomerase from Trypanosoma cruzi in guanidinium hydrochloride involves stable dimeric and monomeric intermediates
Biochemistry
44
10883-10892
2005
Trypanosoma cruzi
O'Donoghue, A.C.; Amyes, T.L.; Richard, J.P.
Hydron transfer catalyzed by triosephosphate isomerase. Products of isomerization of (R)-glyceraldehyde 3-phosphate in D2O
Biochemistry
44
2610-2621
2005
Oryctolagus cuniculus
Fonvielle, M.; Mariano, S.; Therisod, M.
New inhibitors of rabbit muscle triose-phosphate isomerase
Bioorg. Med. Chem. Lett.
15
2906-2909
2005
Oryctolagus cuniculus
Tellez-Valencia, A.; Olivares-Illana, V.; Hernandez-Santoyo, A.; Perez-Montfort, R.; Costas, M.; Rodriguez-Romero, A.; Lopez-Calahorra, F.; Tuena De Gomez-Puyou, M.; Gomez-Puyou, A.
Inactivation of triosephosphate isomerase from Trypanosoma cruzi by an agent that perturbs its dimer interface
J. Mol. Biol.
341
1355-1365
2004
Trypanosoma cruzi (P52270), Trypanosoma cruzi
Walden, H.; Taylor, G.L.; Lorentzen, E.; Pohl, E.; Lilie, H.; Schramm, A.; Knura, T.; Stubbe, K.; Tjaden, B.; Hensel, R.
Structure and function of a regulated archaeal triosephosphate isomerase adapted to high temperature
J. Mol. Biol.
342
861-875
2004
Thermoproteus tenax (Q8NKN9), Thermoproteus tenax
Bonnet, R.; Pavlovic, S.; Lehmann, J.; Rommelspacher, H.
The strong inhibition of triosephosphate isomerase by the natural beta-carbolines may explain their neurotoxic actions
Neuroscience
127
443-453
2004
Bos taurus
Anderson, L.E.; Gatla, N.; Carol, A.A.
Enzyme co-localization in pea leaf chloroplasts: glyceraldehyde-3-P dehydrogenase, triose-P isomerase, aldolase and sedoheptulose bisphosphatase
Photosynth. Res.
83
317-328
2005
Pisum sativum
Dorion, S.; Parveen; Jeukens, J.; Matton, D.P.; Rivoal, J.
Cloning and characterization of a cytosolic isoform of triosephosphate isomerase developmentally regulated in potato leaves
Plant Sci.
168
183-194
2004
Solanum chacoense
-
Mukherjee, S.; Guptasarma, P.
Direct proteolysis-based purification of an overexpressed hyperthermophile protein from Escherichia coli lysate: a novel exploitation of the link between structural stability and proteolytic resistance
Protein Expr. Purif.
40
71-76
2005
Pyrococcus furiosus
Lopez-Velazquez, G.; Molina-Ortiz, D.; Cabrera, N.; Hernandez-Alcantara, G.; Peon-Peralta, J.; Yepez-Mulia, L.; Perez-Montfort, R.; Reyes-Vivas, H.
An unusual triosephosphate isomerase from the early divergent eukaryote Giardia lamblia
Proteins
55
824-834
2004
Giardia intestinalis
Ravindra, G.; Balaram, P.
Plasmodium falciparum triosephosphate isomerase: new insights into an old enzyme
Pure Appl. Chem.
77
281-289
2005
Plasmodium falciparum (Q07412)
-
Gayathri, P.; Banerjee, M.; Vijayalakshmi, A.; Azeez, S.; Balaram, H.; Balaram, P.; Murthy, M.R.
Structure of triosephosphate isomerase (TIM) from Methanocaldococcus jannaschii
Acta Crystallogr. Sect. D
63
206-220
2007
Methanocaldococcus jannaschii (Q58923), Methanocaldococcus jannaschii
Liu, Q.Y.; Corjay, M.; Feuerstein, G.Z.; Nambi, P.
Identification and characterization of triosephosphate isomerase that specifically interacts with the integrin alphaIIb cytoplasmic domain
Biochem. Pharmacol.
72
551-557
2006
Homo sapiens
Casteleijn, M.G.; Alahuhta, M.; Groebel, K.; El-Sayed, I.; Augustyns, K.; Lambeir, A.M.; Neubauer, P.; Wierenga, R.K.
Functional role of the conserved active site proline of triosephosphate isomerase
Biochemistry
45
15483-15494
2006
Trypanosoma brucei (P04789)
Olivares-Illana, V.; Perez-Montfort, R.; Lopez-Calahorra, F.; Costas, M.; Rodriguez-Romero, A.; Tuena de Gomez-Puyou, M.; Gomez Puyou, A.
Structural differences in triosephosphate isomerase from different species and discovery of a multitrypanosomatid inhibitor
Biochemistry
45
2556-2560
2006
Leishmania mexicana, Trypanosoma brucei, Trypanosoma cruzi
Amyes, T.L.; Richard, J.P.
Enzymatic catalysis of proton transfer at carbon: activation of triosephosphate isomerase by phosphite dianion
Biochemistry
46
5841-5854
2007
Oryctolagus cuniculus
Vazquez-Perez, A.R.; Fernandez-Velasco, D.A.
Pressure and denaturants in the unfolding of triosephosphate isomerase: the monomeric intermediates of the enzymes from Saccharomyces cerevisiae and Entamoeba histolytica
Biochemistry
46
8624-8633
2007
Saccharomyces cerevisiae, Entamoeba histolytica
Najera, H.; Dagdug, L.; Fernandez-Velasco, D.A.
Thermodynamic and kinetic characterization of the association of triosephosphate isomerase: The role of diffusion
Biochim. Biophys. Acta
1774
985-994
2007
Saccharomyces cerevisiae
Gonzalez-Mondragon, E.; Zubillaga, R.A.; Hernandez-Arana, A.
Effect of a specific inhibitor on the unfolding and refolding kinetics of dimeric triosephosphate isomerase: establishing the dimeric and similarly structured nature of the main transition states on the forward and backward reactions
Biophys. Chem.
125
172-178
2007
Saccharomyces cerevisiae
Kathiresan, T.; Krishnan, K.; Krishnakumar, V.; Agrawal, R.; Anand, A.; Muralidhar, D.; Mishra, A.K.; Dhople, V.M.; Aggrawal, R.K.; Sharma, Y.
Triose phosphate isomerase, a novel enzyme-crystallin, and tau-crystallin in crocodile cornea. High accumulation of both proteins during late embryonic development
FEBS J.
273
3370-3380
2006
Crocodylus palustris
Mathur, D.; Malik, G.; Garg, L.C.
Biochemical and functional characterization of triosephosphate isomerase from Mycobacterium tuberculosis H37Rv
FEMS Microbiol. Lett.
263
229-235
2006
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Hoppe, S.; Steinhart, H.; Paschke, A.
Identification of a 28 kDa lychee allergen as a triose-phosphate isomerase
Food Agric. Immunol.
17
9-19
2006
Litchi chinensis
Schlpfer, B.S.; Zuber, H.
Cloning and sequencing of the genes encoding glyceraldehyde-3-phosphate dehydrogenase, phosphoglycerate kinase and triosephosphate isomerase (gap operon) from mesophilic Bacillus megaterium: comparison with corresponding sequences from thermophilic Bacillus stearothermophilus
Gene
122
53-62
1992
Priestia megaterium (P35144), Priestia megaterium, Priestia megaterium DSM 319 (P35144), Priestia megaterium DSM 319
Zheng, P.; Sun, J.; van den Heuvel, J.; Zeng, A.P.
Discovery and investigation of a new, second triose phosphate isomerase in Klebsiella pneumoniae
J. Biotechnol.
125
462-473
2006
Klebsiella pneumoniae, Klebsiella pneumoniae (Q7X216)
Rathinasabapathi, B.; Wu, S.; Sundaram, S.; Rivoal, J.; Srivastava, M.; Ma, L.Q.
Arsenic resistance in Pteris vittata L.: identification of a cytosolic triosephosphate isomerase based on cDNA expression cloning in Escherichia coli
Plant Mol. Biol.
62
845-857
2006
Pteris vittata (Q0H294), Pteris vittata
Gnerer, J.P.; Kreber, R.A.; Ganetzky, B.
wasted away, a Drosophila mutation in triosephosphate isomerase, causes paralysis, neurodegeneration, and early death
Proc. Natl. Acad. Sci. USA
103
14987-14993
2006
Drosophila melanogaster
Rozovsky, S.; McDermott, A.E.
Substrate product equilibrium on a reversible enzyme, triosephosphate isomerase
Proc. Natl. Acad. Sci. USA
104
2080-2085
2007
Saccharomyces cerevisiae
Chu, C.H.; Lai, Y.J.; Huang, H.; Sun, Y.J.
Kinetic and structural properties of triosephosphate isomerase from Helicobacter pylori
Proteins
71
396-406
2008
Helicobacter pylori (P56076), Helicobacter pylori
Zomosa-Signoret, V.; Aguirre-Lopez, B.; Hernandez-Alcantara, G.; Perez-Montfort, R.; Tuena de Gomez-Puyou, M.; Gomez-Puyou, A.
Crosstalk between the subunits of the homodimeric enzyme triosephosphate isomerase
Proteins Struct. Funct. Bioinform.
67
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2007
Trypanosoma brucei, Trypanosoma cruzi
Alahuhta, M.; Casteleijn, M.G.; Neubauer, P.; Wierenga, R.K.
Structural studies show that the A178L mutation in the C-terminal hinge of the catalytic loop-6 of triosephosphate isomerase (TIM) induces a closed-like conformation in dimeric and monomeric TIM
Acta Crystallogr. Sect. D
64
178-188
2008
Trypanosoma brucei (P04789)
Samie, A.; Obi, C.L.; Franasiak, J.; Archbald-Pannone, L.; Bessong, P.O.; Alcantara-Warren, C.; Guerrant, R.L.
PCR detection of Clostridium difficile triose phosphate isomerase (tpi), toxin A (tcdA), toxin B (tcdB), binary toxin (cdtA, cdtB), and tcdC genes in Vhembe District, South Africa
Am. J. Trop. Med. Hyg.
78
577-585
2008
Clostridioides difficile
Tellez, L.A.; Blancas-Mejia, L.M.; Carrillo-Nava, E.; Mendoza-Hernandez, G.; Cisneros, D.A.; Fernandez-Velasco, D.A.
Thermal unfolding of triosephosphate isomerase from Entamoeba histolytica: dimer dissociation leads to extensive unfolding
Biochemistry
47
11665-11673
2008
Entamoeba histolytica (O02611), Entamoeba histolytica
Cansu, S.; Doruker, P.
Dimerization affects collective dynamics of triosephosphate isomerase
Biochemistry
47
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2008
Gallus gallus (P00940)
Cabrera, N.; Hernandez-Alcantara, G.; Mendoza-Hernandez, G.; Gomez-Puyou, A.; Perez-Montfort, R.
Key residues of loop 3 in the interaction with the interface residue at position 14 in triosephosphate isomerase from Trypanosoma brucei
Biochemistry
47
3499-3506
2008
Trypanosoma brucei
Peimbert, M.; Dominguez-Ramirez, L.; Fernandez-Velasco, D.A.
Hydrophobic repacking of the dimer interface of triosephosphate isomerase by in silico design and directed evolution
Biochemistry
47
5556-5564
2008
Saccharomyces cerevisiae (P00942), Saccharomyces cerevisiae
Hernandez-Alcantara, G.; Rodriguez-Romero, A.; Reyes-Vivas, H.; Peon, J.; Cabrera, N.; Ortiz, C.; Enriquez-Flores, S.; De la Mora-De la Mora, I.; Lopez-Velazquez, G.
Unraveling the mechanisms of tryptophan fluorescence quenching in the triosephosphate isomerase from Giardia lamblia
Biochim. Biophys. Acta
1784
1493-1500
2008
Giardia intestinalis (P36186), Giardia intestinalis
Shaeri, J.; Wright, I.; Rathbone, E.B.; Wohlgemuth, R.; Woodley, J.M.
Characterization of enzymatic D-xylulose 5-phosphate synthesis
Biotechnol. Bioeng.
101
761-767
2008
Oryctolagus cuniculus
Sleutel, M.; Vanhee, C.; Van de Weerdt, C.; Decanniere, K.; Maes, D.; Wyns, L.; Willaert, R.
The role of surface diffusion in the growth mechanism of triosephosphate isomerase crystals
Cryst. Growth Des.
8
1173-1180
2008
Thermotoga maritima (P36204)
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Seigle, J.L.; Celotto, A.M.; Palladino, M.J.
Degradation of functional triose phosphate isomerase protein underlies sugarkill pathology
Genetics
179
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2008
Drosophila melanogaster
Solem, C.; Koebmann, B.; Jensen, P.R.
Control analysis of the role of triosephosphate isomerase in glucose metabolism in Lactococcus lactis
IET Syst. Biol.
2
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2008
Lactococcus lactis
Rodriguez-Almazan, C.; Arreola, R.; Rodriguez-Larrea, D.; Aguirre-Lopez, B.; de Gomez-Puyou, M.T.; Perez-Montfort, R.; Costas, M.; Gomez-Puyou, A.; Torres-Larios, A.
Structural basis of human triosephosphate isomerase deficiency: mutation E104D is related to alterations of a conserved water network at the dimer interface
J. Biol. Chem.
283
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2008
Homo sapiens (P60174), Homo sapiens
Wang, X.; Lu, Y.; Yang, J.; Shi, Y.; Lan, M.; Liu, Z.; Zhai, H.; Fan, D.
Identification of triosephosphate isomerase as an anti-drug resistance agent in human gastric cancer cells using functional proteomic analysis
J. Cancer Res. Clin. Oncol.
134
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2008
Homo sapiens
Enriquez-Flores, S.; Rodriguez-Romero, A.; Hernandez-Alcantara, G.; De la Mora-De la Mora, I.; Gutierrez-Castrellon, P.; Carvajal, K.; Lopez-Velazquez, G.; Reyes-Vivas, H.
Species-specific inhibition of Giardia lamblia triosephosphate isomerase by localized perturbation of the homodimer
Mol. Biochem. Parasitol.
157
179-186
2008
Giardia intestinalis (P36186), Giardia intestinalis
ODonoghue, A.C.; Amyes, T.L.; Richard, J.P.
Slow proton transfer from the hydrogen-labelled carboxylic acid side chain (Glu-165) of triosephosphate isomerase to imidazole buffer in D2O
Org. Biomol. Chem.
6
391-396
2008
Oryctolagus cuniculus
Alahuhta, M.; Salin, M.; Casteleijn, M.G.; Kemmer, C.; El-Sayed, I.; Augustyns, K.; Neubauer, P.; Wierenga, R.K.
Structure-based protein engineering efforts with a monomeric TIM variant: the importance of a single point mutation for generating an active site with suitable binding properties
Protein Eng. Des. Sel.
21
257-266
2008
Trypanosoma brucei (P04789)
Shi, Y.; Liu, J.H.; Zhang, H.J.; Ding, Y.
Equilibrium unfolding mechanism of chicken muscle triose phosphate isomerase
Protein Pept. Lett.
15
365-370
2008
Gallus gallus
Chu, C.; Lai, Y.; Huang, H.; Sun, Y.
Kinetic and structural properties of triosephosphate isomerase from Helicobacter pylori
Proteins Struct. Funct. Bioinform.
71
396-406
2008
Helicobacter pylori (P56076), Helicobacter pylori
Reyes-Lopez, C.A.; Gonzalez-Mondragon, E.; Benitez-Cardoza, C.G.; Chanez-Cardenas, M.E.; Cabrera, N.; Perez-Montfort, R.; Hernandez-Arana, A.
The conserved salt bridge linking two C-terminal beta /alpha units in homodimeric triosephosphate isomerase determines the folding rate of the monomer
Proteins Struct. Funct. Bioinform.
72
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2008
Saccharomyces cerevisiae
Reis, E.A.; Mauadi Carmo, T.A.; Athanazio, R.; Reis, M.G.; Harn, D.A.
Schistosoma mansoni triose phosphate isomerase peptide MAP4 is able to trigger naive donor immune response towards a type-1 cytokine profile
Scand. J. Immunol.
68
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2008
Schistosoma mansoni
Gayathri, P.; Banerjee, M.; Vijayalakshmi, A.; Balaram, H.; Balaram, P.; Murthy, M.R.
Biochemical and structural characterization of residue 96 mutants of Plasmodium falciparum triosephosphate isomerase: active-site loop conformation, hydration and identification of a dimer-interface ligand-binding site
Acta Crystallogr. Sect. D
65
847-857
2009
Plasmodium falciparum (Q07412), Plasmodium falciparum
Mukherjee, S.; Dutta, D.; Saha, B.; Das, A.K.
Expression, purification, crystallization and preliminary X-ray diffraction studies of triosephosphate isomerase from methicillin-resistant Staphylococcus aureus (MRSA252)
Acta Crystallogr. Sect. F
65
398-401
2009
Staphylococcus aureus
Espinoza-Fonseca, L.M.; Wong-Ramirez, C.; Trujillo-Ferrara, J.G.
Tyr74 is essential for the formation, stability and function of Plasmodium falciparum triosephosphate isomerase dimer
Arch. Biochem. Biophys.
494
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2010
Plasmodium falciparum (Q07412), Plasmodium falciparum
Zarate-Perez, F.; Chanez-Cardenas, M.E.; Arreola, R.; Torres-Larios, A.; Vazquez-Contreras, E.
Different catalytic properties of two highly homologous triosephosphate isomerase monomers
Biochem. Biophys. Res. Commun.
382
626-630
2009
Trypanosoma cruzi (P52270)
Wang, Y.; Berlow, R.B.; Loria, J.P.
Role of loop-loop interactions in coordinating motions and enzymatic function in triosephosphate isomerase
Biochemistry
48
4548-4556
2009
Gallus gallus
Go, M.K.; Amyes, T.L.; Richard, J.P.
Hydron transfer catalyzed by triosephosphate isomerase. Products of the direct and phosphite-activated isomerization of [1-(13)C]-glycolaldehyde in D2O
Biochemistry
48
5769-5778
2009
Gallus gallus
Chandrayan, S.K.; Guptasarma, P.
Attenuation of ionic interactions profoundly lowers the kinetic thermal stability of Pyrococcus furiosus triosephosphate isomerase
Biochim. Biophys. Acta
1794
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2009
Pyrococcus furiosus
Gayosso-De-Lucio, J.; Torres-Valencia, M.; Rojo-Dominguez, A.; Najera-Pena, H.; Aguirre-Lopez, B.; Salas-Pacheco, J.; Avitia-Dominguez, C.; Tellez-Valencia, A.
Selective inactivation of triosephosphate isomerase from Trypanosoma cruzi by brevifolin carboxylate derivatives isolated from Geranium bellum Rose
Bioorg. Med. Chem. Lett.
19
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2009
Trypanosoma cruzi
Zhang, X.Z.; Xiao, Z.F.; Li, C.; Xiao, Z.Q.; Yang, F.; Li, D.J.; Li, M.Y.; Li, F.; Chen, Z.C.
Triosephosphate isomerase and peroxiredoxin 6, two novel serum markers for human lung squamous cell carcinoma
Cancer Sci.
100
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2009
Homo sapiens
Banerjee, M.; Balaram, H.; Balaram, P.
Structural effects of a dimer interface mutation on catalytic activity of triosephosphate isomerase. The role of conserved residues and complementary mutations
FEBS J.
276
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Plasmodium falciparum (Q07412), Plasmodium falciparum
Knobeloch, D.; Schmidt, A.; Scheerer, P.; Krauss, N.; Wessner, H.; Scholz, C.h.; Kuettner, G.; von Rintelen, T.; Wessel, A.; Hoehne, W.
A coleopteran triosephosphate isomerase: X-ray structure and phylogenetic impact of insect sequences
Insect Mol. Biol.
19
35-48
2010
Tenebrio molitor (Q8MPF2), Tenebrio molitor
Del Buono, D.; Prinsi, B.; Espen, L.; Scarponi, L.
Triosephosphate isomerases in Italian ryegrass (Lolium multiflorum): characterization and susceptibility to herbicides
J. Agric. Food Chem.
57
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2009
Lolium multiflorum
Xu, Y.; Lorieau, J.; McDermott, A.E.
Triosephosphate isomerase: 15N and 13C chemical shift assignments and conformational change upon ligand binding by magic-angle spinning solid-state NMR spectroscopy
J. Mol. Biol.
397
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2010
Saccharomyces cerevisiae (P00942), Saccharomyces cerevisiae
Furuya, H.; Ikeda, R.
Interaction of triosephosphate isomerase from the cell surface of Staphylococcus aureus and alpha-(1->3)-mannooligosaccharides derived from glucuronoxylomannan of Cryptococcus neoformans
Microbiology
155
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2009
Staphylococcus aureus, Staphylococcus aureus RN4220
Galland, N.; de Walque, S.; Voncken, F.G.; Verlinde, C.L.; Michels, P.A.
An internal sequence targets Trypanosoma brucei triosephosphate isomerase to glycosomes
Mol. Biochem. Parasitol.
171
45-49
2010
Trypanosoma brucei
Park, S.A.; Park, H.W.; Kim, N.H.; Kim, Y.H.; Kwak, M.J.; Shin, J.S.; Kim, C.W.
Effects of Tau on the activity of triose phosphate isomerase (TPI) in brain cells
Neurochem. Int.
56
886-892
2010
Mus musculus
Chen, M.; Thelen, J.J.
The plastid isoform of triose phosphate isomerase is required for the postgerminative transition from heterotrophic to autotrophic growth in Arabidopsis
Plant Cell
22
77-90
2010
Arabidopsis thaliana (P48491), Arabidopsis thaliana
Thakur, S.; Deepalakshmi, P.; Gayathri, P.; Banerjee, M.; Murthy, M.; Balaram, P.
Detection of the protein dimers, multiple monomeric states and hydrated forms of plasmodium falciparum triosephosphate isomerase in the gas phase
Protein Eng. Des. Sel.
22
289-304
2009
Plasmodium falciparum (Q07412), Plasmodium falciparum
Alahuhta, M.; Wierenga, R.K.
Atomic resolution crystallography of a complex of triosephosphate isomerase with a reaction-intermediate analog: new insight in the proton transfer reaction mechanism
Proteins
78
1878-1888
2010
Leishmania mexicana (P48499)
Lee, W.H.; Choi, J.S.; Byun, M.R.; Koo, K.T.; Shin, S.; Lee, S.K.; Surh, Y.J.
Functional inactivation of triosephosphate isomerase through phosphorylation during etoposide-induced apoptosis in HeLa cells: Potential role of Cdk2
Toxicology
278
224-228
2010
Homo sapiens
Kumar, K.; Bhargava, P.; Roy, U.
In Vitro Refolding of Triosephosphate Isomerase from L. donovani
Appl. Biochem. Biotechnol.
164
1207-1214
2011
Leishmania donovani (Q0ZAG6), Leishmania donovani, Leishmania donovani MHOM/IN/80/Dd8 (Q0ZAG6)
Go, M.K.; Koudelka, A.; Amyes, T.L.; Richard, J.P.
The role of Lys-12 in catalysis by triosephosphate isomerase: a two-part substrate approach
Biochemistry
49
5377-5389
2010
Saccharomyces cerevisiae
Malabanan, M.M.; Go, M.K.; Amyes, T.L.; Richard, J.P.
Wildtype and engineered monomeric triosephosphate isomerase from Trypanosoma brucei: partitioning of reaction intermediates in D2O and activation by phosphite Dianion
Biochemistry
50
5767-5779
2011
Trypanosoma brucei brucei
Wierenga, R.K.; Kapetaniou, E.G.; Venkatesan, R.
Triosephosphate isomerase: a highly evolved biocatalyst
Cell. Mol. Life Sci.
67
3961-3982
2010
Entamoeba histolytica (O02611), Oryctolagus cuniculus (P00939), Gallus gallus (P00940), Saccharomyces cerevisiae (P00942), Geobacillus stearothermophilus (P00943), Trypanosoma brucei brucei (P04789), Escherichia coli (P0A858), Giardia intestinalis (P36186), Thermotoga maritima (P36204), Leishmania mexicana (P48499), Moritella marina (P50921), Trypanosoma cruzi (P52270), Helicobacter pylori (P56076), Homo sapiens (P60174), Pyrococcus woesei (P62003), Mycobacterium tuberculosis (P9WG43), Plasmodium falciparum (Q07412), Caenorhabditis elegans (Q10657), Methanocaldococcus jannaschii (Q58923), Bartonella henselae (Q8L1Z5), Tenebrio molitor (Q8MPF2), Thermoproteus tenax (Q8NKN9), Mycobacterium tuberculosis H37Rv (P9WG43)
Samanta, M.; Murthy, M.R.; Balaram, H.; Balaram, P.
Revisiting the mechanism of the triosephosphate isomerase reaction: the role of the fully conserved glutamic acid 97 residue
ChemBioChem
12
1886-1896
2011
Plasmodium falciparum (Q07412), Plasmodium falciparum
Alvarez, G.; Aguirre-Lopez, B.; Varela, J.; Cabrera, M.; Merlino, A.; Lopez, G.V.; Lavaggi, M.L.; Porcal, W.; Di Maio, R.; Gonzalez, M.; Cerecetto, H.; Cabrera, N.; Perez-Montfort, R.; de Gomez-Puyou, M.T.; Gomez-Puyou, A.
Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity
Eur. J. Med. Chem.
45
5767-5772
2010
Homo sapiens, Trypanosoma cruzi, Trypanosoma cruzi T2
Samanta, M.; Banerjee, M.; Murthy, M.R.; Balaram, H.; Balaram, P.
Probing the role of the fully conserved Cys126 in triosephosphate isomerase by site-specific mutagenesis--distal effects on dimer stability
FEBS J.
278
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2011
Plasmodium falciparum (Q07412), Plasmodium falciparum
Moraes, J.; Arreola, R.; Cabrera, N.; Saramago, L.; Freitas, D.; Masuda, A.; da Silva Vaz, I.; Tuena de Gomez-Puyou, M.; Perez-Montfort, R.; Gomez-Puyou, A.; Logullo, C.
Structural and biochemical characterization of a recombinant triosephosphate isomerase from Rhipicephalus (Boophilus) microplus
Insect Biochem. Mol. Biol.
41
400-409
2011
Rhipicephalus microplus (A8B3A8), Rhipicephalus microplus
Aguirre, B.; Costas, M.; Cabrera, N.; Mendoza-Hernandez, G.; Helseth, D.L.; Fernandez, P.; Tuena de Gomez-Puyou, M.; Perez-Montfort, R.; Torres-Larios, A.; Gomez Puyou, A.
A Ribosomal misincorporation of Lys for Arg in human triosephosphate isomerase expressed in Escherichia coli gives rise to two protein populations
PLoS ONE
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2011
Homo sapiens
Banerjee, M.; Balaram, H.; Joshi, N.V.; Balaram, P.
Engineered dimer interface mutants of triosephosphate isomerase: the role of inter-subunit interactions in enzyme function and stability
Protein Eng. Des. Sel.
24
463-472
2011
Plasmodium falciparum (Q07412), Plasmodium falciparum
Kouril, T.; Esser, D.; Kort J.; Westerhoff, H.V.; Siebers, B.; Snoep, J.L.
Intermediate instability at high temperature leads to low pathway efficiency for an in vitro reconstituted system of gluconeogenesis in Sulfolobus solfataricus
FEBS J.
280
4666-4680
2013
Saccharolobus solfataricus (Q97VM8), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q97VM8)
Connor, S.E.; Capodagli, G.C.; Deaton, M.K.; Pegan, S.D.
Structural and functional characterization of Mycobacterium tuberculosis triosephosphate isomerase
Acta Crystallogr. Sect. D
67
1017-1022
2011
Mycobacterium tuberculosis (P9WG43), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WG43)
Nguyen, T.N.; Abendroth, J.; Leibly, D.J.; Le, K.P.; Guo, W.; Kelley, A.; Stewart, L.; Myler, P.J.; Van Voorhis, W.C.
Structure of triosephosphate isomerase from Cryptosporidium parvum
Acta Crystallogr. Sect. F
67
1095-1099
2011
Cryptosporidium parvum (Q5CSE7), Cryptosporidium parvum
Zhai, X.; Amyes, T.L.; Wierenga, R.K.; Loria, J.P.; Richard, J.P.
Structural mutations that probe the interactions between the catalytic and dianion activation sites of triosephosphate isomerase
Biochemistry
52
5928-5940
2013
Gallus gallus, Trypanosoma brucei brucei
Mukherjee, S.; Roychowdhury, A.; Dutta, D.; Das, A.K.
Crystal structures of triosephosphate isomerase from methicillin resistant Staphylococcus aureus MRSA252 provide structural insights into novel modes of ligand binding and unique conformations of catalytic loop
Biochimie
94
2532-2544
2012
Staphylococcus aureus (Q6GIL6), Staphylococcus aureus, Staphylococcus aureus MRSA252 (Q6GIL6), Staphylococcus aureus MRSA252
Kumar, K.; Bhargava, P.; Roy, U.
Cloning, overexpression and characterization of Leishmania donovani triosephosphate isomerase
Exp. Parasitol.
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2012
Leishmania donovani, Leishmania donovani MHOM/IN/80/Dd8
Kohlhoff, M.; Dahm, A.; Hensel, R.
Tetrameric triosephosphate isomerase from hyperthermophilic Archaea
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Methanothermus fervidus, Methanobacterium bryantii (O74025), Methanobacterium bryantii, Pyrococcus woesei (P62003), Pyrococcus woesei, Methanothermus fervidus DSM 2088, Pyrococcus woesei DSM 3773 (P62003)
Malabanan, M.M.; Amyes, T.L.; Richard, J.P.
Mechanism for activation of triosephosphate isomerase by phosphite dianion: the role of a ligand-driven conformational change
J. Am. Chem. Soc.
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2011
Trypanosoma brucei brucei
Yu, J.P.; Ladapo, J.; Whitman, W.B.
Pathway of glycogen metabolism in Methanococcus maripaludis
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Methanococcus maripaludis
Sullivan, B.J.; Durani, V.; Magliery, T.J.
Triosephosphate isomerase by consensus design: dramatic differences in physical properties and activity of related variants
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Saccharomyces cerevisiae
Zaffagnini, M.; Michelet, L.; Sciabolini, C.; Di Giacinto, N.; Morisse, S.; Marchand, C.H.; Trost, P.; Fermani, S.; Lemaire, S.D.
High-resolution crystal structure and redox properties of chloroplastic triosephosphate isomerase from Chlamydomonas reinhardtii
Mol. Plant
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101-120
2014
Chlamydomonas reinhardtii (Q5S7Y5), Chlamydomonas reinhardtii
Garcia-Torres, I.; Cabrera, N.; Torres-Larios, A.; Rodriguez-Bolanos, M.; Diaz-Mazariegos, S.; Gomez-Puyou, A.; Perez-Montfort, R.
Identification of amino acids that account for long-range interactions in two triosephosphate isomerases from pathogenic trypanosomes
PLoS ONE
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2011
Trypanosoma brucei, Trypanosoma cruzi
Sharma, P.; Guptasarma, P.
Super-perfect enzymes: Structural stabilities and activities of recombinant triose phosphate isomerases from Pyrococcus furiosus and Thermococcus onnurineus produced in Escherichia coli
Biochem. Biophys. Res. Commun.
460
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2015
Thermococcus onnurineus (B6YUE5), Thermococcus onnurineus, Pyrococcus furiosus (P62002), Pyrococcus furiosus
Dhaunta, N.; Arora, K.; Chandrayan, S.; Guptasarma, P.
Introduction of a thermophile-sourced ion pair network in the fourth beta/alpha unit of a psychophile-derived triosephosphate isomerase from Methanococcoides burtonii significantly increases its kinetic thermal stability
Biochim. Biophys. Acta
1834
1023-1033
2013
Methanococcoides burtonii (Q12UK2), Methanococcoides burtonii, Methanococcoides burtonii DSM 6242 (Q12UK2)
Krause, M.; Kiema, T.R.; Neubauer, P.; Wierenga, R.K.
Crystal structures of two monomeric triosephosphate isomerase variants identified via a directed-evolution protocol selecting for L-arabinose isomerase activity
Acta Crystallogr. Sect. F
72
490-499
2016
Trypanosoma brucei brucei (P04789)
Bandyopadhyay, D.; Prakash, S.; Gupta, K.; Balaram, P.
Mass spectrometric analysis of dimer-disrupting mutations in Plasmodium triosephosphate isomerase
Anal. Biochem.
500
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2016
Plasmodium falciparum (Q07412), Plasmodium falciparum
Jiang, H.; Ma, N.; Shang, Y.; Zhou, W.; Chen, T.; Guan, D.; Li, J.; Wang, J.; Zhang, E.; Feng, Y.; Yin, F.; Yuan, Y.; Fang, Y.; Qiu, L.; Xie, D.; Wei, D.
Triosephosphate isomerase 1 suppresses growth, migration and invasion of hepatocellular carcinoma cells
Biochem. Biophys. Res. Commun.
482
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Homo sapiens
Zhai, X.; Go, M.K.; ODonoghue, A.C.; Amyes, T.L.; Pegan, S.D.; Wang, Y.; Loria, J.P.; Mesecar, A.D.; Richard, J.P.
Enzyme architecture the effect of replacement and deletion mutations of loop 6 on catalysis by triosephosphate isomerase
Biochemistry
53
3486-3501
2014
Gallus gallus (P00940), Gallus gallus
Aqvist, J.
Cold adaptation of triosephosphate isomerase
Biochemistry
56
4169-4176
2017
Saccharomyces cerevisiae (P00942), Saccharomyces cerevisiae, Moritella marina (P50921), Moritella marina, Saccharomyces cerevisiae 288c (P00942)
Jimenez-Sandoval, P.; Vique-Sanchez, J.L.; Hidalgo, M.L.; Velazquez-Juarez, G.; Diaz-Quezada, C.; Arroyo-Navarro, L.F.; Moran, G.M.; Fattori, J.; Jessica Diaz-Salazar, A.; Rudino-Pinera, E.; Sotelo-Mundo, R.; Figueira, A.C.M.; Lara-Gonzalez, S.; Benitez-Cardoza, C.G.; Brieba, L.G.
A competent catalytic active site is necessary for substrate induced dimer assembly in triosephosphate isomerase
Biochim. Biophys. Acta
1865
1423-1432
2017
Trichomonas vaginalis (A2EGX9), Trichomonas vaginalis (A2FT29), Trichomonas vaginalis
Labastida-Polito, A.; Garza-Ramos, G.; Camarillo-Cadena, M.; Zubillaga, R.; Hernández-Arana, A.
Complex kinetics and residual structure in the thermal unfolding of yeast triosephosphate isomerase
BMC Biochem.
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20
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Saccharomyces cerevisiae
Pareek, V.; Samanta, M.; Joshi, N.V.; Balaram, H.; Murthy, M.R.; Balaram, P.
Connecting active-site loop conformations and catalysis in triosephosphate isomerase Insights from a rare variation at residue 96 in the plasmodial enzyme
ChemBioChem
17
620-629
2016
Plasmodium falciparum (Q07412), Plasmodium falciparum
Aguilera, E.; Varela, J.; Birriel, E.; Serna, E.; Torres, S.; Yaluff, G.; de Bilbao, N.; Aguirre-Lopez, B.; Cabrera, N.; Diaz Mazariegos, S.; de Gomez-Puyou, M.; Gomez-Puyou, A.; Perez-Montfort, R.; Minini, L.; Merlino, A.; Cerecetto, H.; Gonzalez, M.; Alvarez, G.
Potent and selective inhibitors of Trypanosoma cruzi triosephosphate isomerase with concomitant inhibition of cruzipain Inhibition of parasite growth through multitarget activity
ChemMedChem
17
1328-1338
2016
Trypanosoma cruzi, Trypanosoma cruzi Tulahuen 2
Bandyopadhyay, D.; Murthy, M.R.; Balaram, H.; Balaram, P.
Probing the role of highly conserved residues in triosephosphate isomerase - analysis of site specific mutants at positions 64 and 75 in the Plasmodial enzyme
FEBS J.
282
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2015
Plasmodium falciparum (Q07412)
Bao, S.; Chen, D.; Yu, S.; Chen, H.; Tan, L.; Hu, M.; Qiu, X.; Song, C.; Ding, C.
Characterization of triosephosphate isomerase from Mycoplasma gallisepticum
FEMS Microbiol. Lett.
362
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2015
Mycoplasma gallisepticum (Q7NAQ4), Mycoplasma gallisepticum, Mycoplasma gallisepticum passage 15 (Q7NAQ4)
Dumont, S.; Bykova, N.; Pelletier, G.; Dorion, S.; Rivoal, J.
Cytosolic triosephosphate isomerase from Arabidopsis thaliana is reversibly modified by glutathione on cysteines 127 and 218
Front. Plant Sci.
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1942
2016
Arabidopsis thaliana (P48491)
Miranda-Ozuna, J.F.; Hernandez-Garcia, M.S.; Brieba, L.G.; Benitez-Cardoza, C.G.; Ortega-Lopez, J.; Gonzalez-Robles, A.; Arroyo, R.
The glycolytic enzyme triosephosphate isomerase of Trichomonas vaginalis is a surface-associated protein induced by glucose that functions as a laminin- and fibronectin-binding protein
Infect. Immun.
84
2878-2894
2016
Trichomonas vaginalis (A2EGX9), Trichomonas vaginalis (A2FT29), Trichomonas vaginalis
Zhai, X.; Amyes, T.L.; Richard, J.P.
Role of loop-clamping side chains in catalysis by triosephosphate isomerase
J. Am. Chem. Soc.
137
15185-15197
2015
Saccharomyces cerevisiae (P00942)
Kulkarni, Y.S.; Liao, Q.; Petrovi?, D.; Krueger, D.M.; Strodel, B.; Amyes, T.L.; Richard, J.P.; Kamerlin, S.C.L.
Enzyme architecture Modeling the operation of a hydrophobic clamp in catalysis by triosephosphate isomerase
J. Am. Chem. Soc.
139
10514-10525
2017
Saccharomyces cerevisiae (P00942), Saccharomyces cerevisiae 288c (P00942)
Kulkarni, Y.S.; Liao, Q.; Bylehn, F.; Amyes, T.L.; Richard, J.P.; Kamerlin, S.C.L.
Role of ligand-driven conformational changes in enzyme catalysis Modeling the reactivity of the catalytic cage of triosephosphate isomerase
J. Am. Chem. Soc.
140
3854-3857
2018
Saccharomyces cerevisiae (P00942), Saccharomyces cerevisiae 288c (P00942)
Patil, Y.; Junghare, M.; Mller, N.
Fermentation of glycerol by Anaerobium acetethylicum and its potential use in biofuel production
Microb. Biotechnol.
10
203-217
2017
Anaerobium acetethylicum (A0A1D3TX75)
Gruening, N.M.; Du, D.; Keller, M.A.; Luisi, B.F.; Ralser, M.
Inhibition of triosephosphate isomerase by phosphoenolpyruvate in the feedback-regulation of glycolysis
Open biology
4
130232
2014
Homo sapiens, Oryctolagus cuniculus (P00939)
Rodriguez-Bolanos, M.; Cabrera, N.; Perez-Montfort, R.
Identification of the critical residues responsible for differential reactivation of the triosephosphate isomerases of two trypanosomes
Open biology
6
160161
2016
Trypanosoma brucei brucei (P04789), Trypanosoma cruzi (P52270), Trypanosoma cruzi
Lara-Gonzalez, S.; Estrella, P.; Portillo, C.; Cruces, M.E.; Jimenez-Sandoval, P.; Fattori, J.; Migliorini-Figueira, A.C.; Lopez-Hidalgo, M.; Diaz-Quezada, C.; Lopez-Castillo, M.; Trasvina-Arenas, C.H.; Sanchez-Sandoval, E.; Gomez-Puyou, A.; Ortega-Lopez, J.; Arroyo, R.; Benitez-Cardoza, C.G.; Brieba, L.
Substrate-induced dimerization of engineered monomeric variants of triosephosphate isomerase from Trichomonas vaginalis
PLoS ONE
10
e0141747
2015
Trichomonas vaginalis (A2EGX9), Trichomonas vaginalis
Park, S.H.; Kim, H.S.; Park, M.S.; Moon, S.; Song, M.K.; Park, H.S.; Hahn, H.; Kim, S.J.; Bae, E.; Kim, H.J.; Han, B.W.
Structure and stability of the dimeric triosephosphate isomerase from the thermophilic archaeon Thermoplasma acidophilum
PLoS ONE
10
e0145331
2015
Thermoplasma acidophilum (Q9HLB6), Thermoplasma acidophilum, Thermoplasma acidophilum DSM 17280 (Q9HLB6)
Diaz-Mazariegos, S.; Cabrera, N.; Perez-Montfort, R.
Three unrelated and unexpected amino acids determine the susceptibility of the interface cysteine to a sulfhydryl reagent in the triosephosphate isomerases of two trypanosomes
PLoS ONE
13
e0189525
2018
Trypanosoma brucei brucei (P04789), Trypanosoma cruzi (P52270)
Guzman-Luna, V.; Quezada, A.G.; Diaz-Salazar, A.J.; Cabrera, N.; Perez-Montfort, R.; Costas, M.
The effect of specific proline residues on the kinetic stability of the triosephosphate isomerases of two trypanosomes
Proteins
85
571-579
2017
Trypanosoma brucei brucei (P04789), Trypanosoma cruzi (P52270), Trypanosoma cruzi
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