Information on EC 5.1.3.9 - N-Acylglucosamine-6-phosphate 2-epimerase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
5.1.3.9
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RECOMMENDED NAME
GeneOntology No.
N-Acylglucosamine-6-phosphate 2-epimerase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
N-Acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
epimerization
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Amino sugar and nucleotide sugar metabolism
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N-acetylneuraminate and N-acetylmannosamine degradation I
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metabolism of amino sugars and derivatives
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SYSTEMATIC NAME
IUBMB Comments
N-Acyl-D-glucosamine-6-phosphate 2-epimerase
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CAS REGISTRY NUMBER
COMMENTARY hide
37318-35-7
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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-
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Manually annotated by BRENDA team
strain B
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-
Manually annotated by BRENDA team
strain B
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-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-glucuronic acid
L-iduronic acid
show the reaction diagram
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-
-
-
?
N-acetyl-D-glucosamine 6-phosphate
N-acetyl-D-mannosamine 6-phosphate
show the reaction diagram
N-Acyl-D-glucosamine 6-phosphate
N-Acyl-D-mannosamine 6-phosphate
show the reaction diagram
N-Glycolyl-D-glucosamine 6-phosphate
N-Glycolyl-D-mannosamine 6-phosphate
show the reaction diagram
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-
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additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
D-glucuronic acid
L-iduronic acid
show the reaction diagram
-
-
-
-
?
N-acetyl-D-glucosamine 6-phosphate
N-acetyl-D-mannosamine 6-phosphate
show the reaction diagram
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.6
N-acetylglucosamine 6-phosphate
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2.4
N-acetylmannosamine 6-phosphate
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7 - 8.4
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about 50% of maximal activity at pH 7.0 and 8.4
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
no activity in cells grown on glucose medium
Manually annotated by BRENDA team
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no activity in cells grown on glucose medium
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM
UNIPROT
Clostridium perfringens (strain 13 / Type A)
Clostridium perfringens (strain 13 / Type A)
Clostridium perfringens (strain 13 / Type A)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
not stable to freezing and thawing, nor to dialysis
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
0°C, 1 week, most of the activity is lost
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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