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EC Tree
IUBMB CommentsThis enzyme shows no 1-epimerase activity with D-glucose, L-rhamnose and D-fucose (cf. EC 5.1.3.3, aldose 1-epimerase) .
The taxonomic range for the selected organisms is: Escherichia coli
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
spfcsu, l-fucose mutarotase,
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L-fucose 1-epimerase
This enzyme shows no 1-epimerase activity with D-glucose, L-rhamnose and D-fucose (cf. EC 5.1.3.3, aldose 1-epimerase) [1].
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alpha-L-fucopyranose
beta-L-fucopyranose
additional information
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alpha-L-fucopyranose
beta-L-fucopyranose
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r
alpha-L-fucopyranose
beta-L-fucopyranose
FucU binds to both alpha- and beta-fucopyranose and accelerates the conversion between them
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r
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FucU exhibits a pyranase activity for D-ribose. No activity with D-glucose, L-rhamnose and D-fucose
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additional information
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the enzyme is a dual fucose mutarotase and ribose pyranase
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alpha-L-fucopyranose
beta-L-fucopyranose
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r
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27.9
alpha-L-fucopyranose
pH 7.5, temperature not specified in the publication
65.1
beta-L-fucopyranose
pH 7.5, temperature not specified in the publication
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SwissProt
brenda
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decamer
crystallograpic data, FucU forms a decameric toroid with each active site formed by two adjacent subunits
additional information
FucU seems to require multimeric or dimeric structures for its enzymatic activity, because the N-terminally His-tagged FucU is an inactive monomer
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crystal structures of in complex with L-fucose
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D64N
binding affinity of mutant enzyme is similar to that of wild-type enzyme
H22A
binding affinity of mutant enzyme is similar to that of wild-type enzyme
Y111F
reduced binding affinity
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expression in Escherichia coli
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Ryu, K.S.; Kim, C.; Kim, I.; Yoo, S.; Choi, B.S.; Park, C.
NMR application probes a novel and ubiquitous family of enzymes that alter monosaccharide configuration
J. Biol. Chem.
279
25544-25548
2004
Escherichia coli (P0AEN8)
brenda
Lee, K.H.; Ryu, K.S.; Kim, M.S.; Suh, H.Y.; Ku, B.; Song, Y.L.; Ko, S.; Lee, W., Oh, B.H.
Crystal structures and enzyme mechanisms of a dual fucose mutarotase/ribose pyranase
J. Mol. Biol.
391
178-191
2009
Escherichia coli (P0AEN8), Mus musculus (Q8R2K1)
brenda