Information on EC 5.1.3.25 - dTDP-L-rhamnose 4-epimerase

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The expected taxonomic range for this enzyme is: Burkholderia thailandensis

EC NUMBER
COMMENTARY hide
5.1.3.25
-
RECOMMENDED NAME
GeneOntology No.
dTDP-L-rhamnose 4-epimerase
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
dTDP-6-deoxy-beta-L-talose = dTDP-beta-L-rhamnose
show the reaction diagram
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of antibiotics
-
-
Polyketide sugar unit biosynthesis
-
-
SYSTEMATIC NAME
IUBMB Comments
dTDP-6-deoxy-beta-L-talose 4-epimerase
The equilibrium is strongly towards dTDP-beta-L-rhamnose.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene BTH_I1476
UniProt
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
dTDP-6-deoxy-beta-L-talose
dTDP-beta-L-rhamnose
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
dTDP-6-deoxy-beta-L-talose
dTDP-beta-L-rhamnose
show the reaction diagram
Q2SYH7
-
-
-
r
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0247
dTDP-6-deoxy-beta-L-talose
pH 8.2, temperature not specified in the publication
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.9
dTDP-6-deoxy-beta-L-talose
Burkholderia thailandensis
Q2SYH7
pH 8.2, temperature not specified in the publication
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
36.4
dTDP-6-deoxy-beta-L-talose
Burkholderia thailandensis
Q2SYH7
pH 8.2, temperature not specified in the publication
11856
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.8 - 8.4
in phosphate buffer
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
gene BTH_I1476, DNA and amino acid sequence determination and analysis