Information on EC 5.1.3.16 - UDP-glucosamine 4-epimerase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
5.1.3.16
-
RECOMMENDED NAME
GeneOntology No.
UDP-glucosamine 4-epimerase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-alpha-D-glucosamine = UDP-alpha-D-galactosamine
show the reaction diagram
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
epimerization
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-
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SYSTEMATIC NAME
IUBMB Comments
UDP-glucosamine 4-epimerase
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UDP-galactose
UDP-glucose
show the reaction diagram
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-
-
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UDPglucosamine
UDPgalactosamine
show the reaction diagram
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NAD+
-
dependent on catalytic amounts, Km: 0.0002 mM, not replaceable by NADH
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADH
-
-
PCMB
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-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.05
UDPgalactose
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-
0.09
UDPglucose
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-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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16200 U/mg, measured as increase of extinction at 340 nm of 0.001/min, with UDPglucose dehydrogenase and NAD+
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8 - 9.6
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, 0.5 M glycylglycine buffer, pH 7.5, 1-2 weeks stable
-
-20°C, lyophilized, stable for at least 3 months
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE