Information on EC 5.1.3.15 - glucose-6-phosphate 1-epimerase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY hide
5.1.3.15
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RECOMMENDED NAME
GeneOntology No.
glucose-6-phosphate 1-epimerase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
alpha-D-Glucose 6-phosphate = beta-D-glucose 6-phosphate
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of antibiotics
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Biosynthesis of secondary metabolites
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Glycolysis / Gluconeogenesis
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Metabolic pathways
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Microbial metabolism in diverse environments
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pentose phosphate pathway
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SYSTEMATIC NAME
IUBMB Comments
D-glucose-6-phosphate 1-epimerase
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CAS REGISTRY NUMBER
COMMENTARY hide
37259-65-7
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
no activity in Rattus norvegicus
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
alpha-D-glucose 6-phosphate
beta-D-glucose 6-phosphate
show the reaction diagram
additional information
?
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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in contrast to glucosephosphate isomerase, glucose-6-phosphate 1-epimerase is not inhibited by D-erythrose 4-phosphate and D-gluconate 6-phosphate
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.144
alpha-D-glucose 6-phosphate
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0.0555
beta-D-glucose 6-phosphate
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1950
alpha-D-glucose 6-phosphate
Saccharomyces cerevisiae
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446
beta-D-glucose 6-phosphate
Saccharomyces cerevisiae
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
PDB
SCOP
CATH
ORGANISM
UNIPROT
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
35000
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gel filtration
45000
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two forms with MW of 30000 and 45000, gel filtration
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
80
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10 min, complete loss of activity
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
incubation with trypsin and alpha-chymotrypsin, 10 min, at 25 C, completely destroys activity
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Show AA Sequence (324 entries)
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