Information on EC 5.1.2.7 - tagaturonate epimerase

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The expected taxonomic range for this enzyme is: Thermotoga maritima

EC NUMBER
COMMENTARY hide
5.1.2.7
-
RECOMMENDED NAME
GeneOntology No.
tagaturonate epimerase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-tagaturonate = D-fructuronate
show the reaction diagram
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-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
pectin degradation III
-
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myo-inositol degradation II
-
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Pentose and glucuronate interconversions
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
D-tagaturonate 3-epimerase
The enzyme, present in bacteria, is involved in a degradation pathway of D-galacturonate.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
expression of UxaE complements the Escherichia coli uxaB knockout mutant strain and restores growth on galacturonate. An inferred galacturonate to mannonate catabolic pathway in Thermotoga maritima can be reconstituted in vitro using a mixture of recombinant purified enzymes UxaE, UxaC and UxuB
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-fructuronate
D-tagaturonate
show the reaction diagram
-
-
-
r
D-tagaturonate
D-fructuronate
show the reaction diagram
-
-
-
r
additional information
?
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.68
D-fructuronate
pH 8.5, 22°C
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6.5
D-fructuronate
pH 8.5, 22°C
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
9.1
D-fructuronate
pH 8.5, 22°C
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
90
40% of maximum activity
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE