Information on EC 5.1.2.6 - isocitrate epimerase

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The expected taxonomic range for this enzyme is: Penicillium purpurogenum var. rubrisclerotium

EC NUMBER
COMMENTARY hide
5.1.2.6
-
RECOMMENDED NAME
GeneOntology No.
isocitrate epimerase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate = (1S,2S)-1-hydroxypropane-1,2,3-tricarboxylate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
epimerization
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
(1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate 1-epimerase
(1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate is the commonly occurring isomer of isocitrate.
CAS REGISTRY NUMBER
COMMENTARY hide
81210-68-6
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(1R,2S)-1-Hydroxypropane-1,2,3-tricarboxylate
(1S, 2S)-1-Hydroxypropane-1,2,3-tricarboxylate
show the reaction diagram
-
i.e. threo-D-isocitrate
i.e. erythro-L-isocitrate
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
-
slight stimulation
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4.7 - 5.6
-
synthesis of erythro-isocitrate
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3 - 8
-
3: about 35% of maximal activity, 8: about 30% of maximal activity, synthesis of erythro-isocitrate
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
20
-
room temperature, half life: 12 h, with 30% glycerol, and 1 mM DTT, half-life: less than 3 h, without stabilizers
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
30% v/v glycerol plus 1 mM DTT stabilize against heat inactivation, slight protection by leupeptin, pepstatin, and PMSF
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE