Information on EC 5.1.1.22 - 4-hydroxyproline betaine 2-epimerase

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The expected taxonomic range for this enzyme is: Rhodobacteraceae

EC NUMBER
COMMENTARY hide
5.1.1.22
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RECOMMENDED NAME
GeneOntology No.
4-hydroxyproline betaine 2-epimerase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-proline betaine = D-proline betaine
show the reaction diagram
(2)
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trans-4-hydroxy-L-proline betaine = cis-4-hydroxy-D-proline betaine
show the reaction diagram
(1)
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
L-proline betaine degradation
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SYSTEMATIC NAME
IUBMB Comments
4-hydroxyproline betaine 2-epimerase
The enzyme, characterized from the bacteria Pelagibaca bermudensis and Paracoccus denitrificans, specifically catalyses racemization of trans-4-hydroxy-L-proline betaine and L-proline betaine at the C-2 position.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-proline betaine
D-proline betaine
show the reaction diagram
trans-4-hydroxy-L-proline betaine
cis-4-hydroxy-D-proline betaine
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-proline betaine
D-proline betaine
show the reaction diagram
trans-4-hydroxy-L-proline betaine
cis-4-hydroxy-D-proline betaine
show the reaction diagram
additional information
?
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
8
L-proline betaine
pH not specified in the publication, temperature not specified in the publication
42
trans-4-hydroxy-L-proline betaine
pH not specified in the publication, temperature not specified in the publication
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5.3
L-proline betaine
pH not specified in the publication, temperature not specified in the publication
330
trans-4-hydroxy-L-proline betaine
pH not specified in the publication, temperature not specified in the publication
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.7
L-proline betaine
pH not specified in the publication, temperature not specified in the publication
7.8
trans-4-hydroxy-L-proline betaine
pH not specified in the publication, temperature not specified in the publication
Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
2.0 A crystal structure of unliganded HpbD and the 1.6 A and 1.7 A structures of the complexes of HpbD with L-proline betaine and with cis4-hydroxyprolinebetaine, respectively
structure of apo protein and modeling of ligands
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE