Information on EC 5.1.1.19 - O-ureido-serine racemase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Streptomyces lavendulae subsp. lavendulae

EC NUMBER
COMMENTARY hide
5.1.1.19
-
RECOMMENDED NAME
GeneOntology No.
O-ureido-serine racemase
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
O-ureido-L-serine = O-ureido-D-serine
show the reaction diagram
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of antibiotics
-
-
D-cycloserine biosynthesis
SYSTEMATIC NAME
IUBMB Comments
(2S)-2-amino-3-[(carbamoylamino)oxy]propanoate 2-epimerase
The enzyme employs a two-base mechanism, with a thiolate-thiol pair in the active site. It participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
O-ureido-L-serine
O-ureido-D-serine
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
O-ureido-L-serine
O-ureido-D-serine
show the reaction diagram
-
the enzyme is involved in the biosynthesis of the antibiotic D-cycloserine
-
-
r
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-[[(carbamoylamino)oxy]methyl]oxiran-2-carboxylic acid
-
irreversible inhibition
Hg2+
-
0.01 mM, complete inhibition
iodoacetamide
-
complete inhibition
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
17
O-ureido-D-serine
-
pH 7.9, 30°C
110
O-ureido-L-serine
-
pH 7.9, 30°C
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
29
O-ureido-D-serine
Streptomyces lavendulae subsp. lavendulae
-
pH 7.9, 30°C
158
O-ureido-L-serine
Streptomyces lavendulae subsp. lavendulae
-
pH 7.9, 30°C
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.71
O-ureido-D-serine
Streptomyces lavendulae subsp. lavendulae
-
pH 7.9, 30°C
10418
1.44
O-ureido-L-serine
Streptomyces lavendulae subsp. lavendulae
-
pH 7.9, 30°C
15356
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
31205
-
x * 31205, ESI-TOF mass spectrometry
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 31205, ESI-TOF mass spectrometry
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
-