Reference on EC 5.1.1.17 - isopenicillin-N epimerase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cantwell, C.; Beckmann, R.; Whiteman, P.; Queener, S.W.; Abraham, E.P.
Isolation of deacetoxycephalosporin-c from fermentation broths of Penicillium chrysogenum transformants - construction of a new fungal biosynthetic-pathway
Proc. R. Soc. Lond. B Biol. Sci.
248
283-289
1992
Streptomyces microflavus
Yeh, W.K.; Ghag, S.K.; Queener, S.W.
Enzymes for epimerization of isopenicillin N, ring expansion of penicillin N, and 3'-hydroxylation of deacetoxycephalosporin C. Function, evolution, refolding, and enzyme engineering
Ann. N. Y. Acad. Sci.
672
396-408
1992
Streptomyces clavuligerus
-
Jensen, S.E.; Westlake, D.W.S.; Wolfe, S.
Partial purification and characterization of isopenicillin N epimerase activity from Streptomyces clavuligerus
Can. J. Microbiol.
29
1526-1531
1983
Streptomyces clavuligerus
Castro, J.M.; Liras, P.; Cortes, J.; Martin, J.F.
Regulation of a-aminoadipyl-cysteinyl-valine, isopenicillin N synthetase, isopenicillin N isomerase and deacetoxycephalosporin C synthetase by nitrogen sources in Streptomyces lactamdurans
Appl. Microbiol. Biotechnol.
22
32-40
1985
Amycolatopsis lactamdurans
-
Ramos, F.R.; Lopez-Nieto, M.J.; Martin, J.F.
Coordinate increase of isopenicillin N synthetase, isopenicillin N epimerase and deacetoxycephalosporin C synthetase in a high cephalosporin-producing mutant of Acremonium chrysogenum and simultaneous loss of the three enzymes in a non-producing mutant
FEMS Microbiol. Lett.
35
123-127
1986
Acremonium chrysogenum
-
Usui, S.; Yu, C.A.
Purification and properties of isopenicillin-N epimerase from Streptomyces clavuligerus
Biochim. Biophys. Acta
999
78-85
1989
Streptomyces clavuligerus
Laiz, L.; Liras, P.; Castro, J.M.; Martin, J.F.
Purification and characterization of the isopenicillin-N epimerase from Nocardia lactamdurans
J. Gen. Microbiol.
136
663-671
1990
Amycolatopsis lactamdurans
-
Mehta, P.K.; Christen, P.
Homology of 1-aminocyclopropane-1-carboxylate synthase, 8-amino-7-oxononanoate synthase, 2-amino-6-caprolactam racemase, 2,2-dialkylglycine decarboxylase, glutamate-1-semialdehyde 2,1-aminomutase and isopenicillin-N-epimerase with aminotransferases
Biochem. Biophys. Res. Commun.
198
138-143
1994
Streptomyces clavuligerus
Ullan, R.V.; Casqueiro, J.; Banuelos, O.; Fernandez, F.J.; Gutierrez, S.; Martin, J.F.
A novel epimerization system in fungal secondary metabolism involved in the conversion of isopenicillin N into penicillin N in Acremonium chrysogenum
J. Biol. Chem.
277
46216-46225
2002
Acremonium chrysogenum, Amycolatopsis lactamdurans
Martin, J.F.; Ullan, R.V.; Casqueiro, J.
Novel genes involved in cephalosporin biosynthesis: the three-component isopenicillin N epimerase system
Adv. Biochem. Eng. Biotechnol.
88
91-109
2004
Acremonium chrysogenum
Ullan, R.V.; Casqueiro, J.; Naranjo, L.; Vaca, I.; Martin, J.F.
Expression of cefD2 and the conversion of isopenicillin N into penicillin N by the two-component epimerase system are rate-limiting steps in cephalosporin biosynthesis
Mol. Genet. Genomics
272
562-570
2004
Acremonium chrysogenum, Acremonium chrysogenum C10 / ATCC 48272
Ullan, R.V.; Campoy, S.; Casqueiro, J.; Fernandez, F.J.; Martin, J.F.
Deacetylcephalosporin C production in Penicillium chrysogenum by expression of the isopenicillin N epimerization, ring expansion, and acetylation genes
Chem. Biol.
14
329-339
2007
Acremonium chrysogenum
Liras, P.; Demain, A.L.
Enzymology of beta-lactam compounds with cephem structure produced by actinomycete
Methods Enzymol.
458
401-429
2009
Actinomyces sp.
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